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This meeting took place in 2011



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TGF-beta in Immune Responses: From Bench to Bedside (A2)


Organizer(s) Wanjun Chen, Howard L. Weiner and Richard A. Flavell
January 7—12, 2011
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 14, 2010
Late Abstract Deadline: Oct 11, 2010
Scholarship Deadline: Sep 14, 2010
Early Registration Deadline: Nov 8, 2010

Sponsored by Genzyme Corporation and ImClone Systems Corporation

Summary of Meeting:
The recent discovery of TGF-beta as a key regulator in immune responses (particularly in regulatory T cell and Th17 cell differentiation) has put TGF-beta at the center stage of immunology, a position it deserves. Despite great progress in the field, key questions related to TGF-beta re-programming T cells are largely unknown. In this regard, it is imperative to understand the molecular mechanisms by which TGF-beta controls such diverse T cell programming. Elucidation of these pathways would allow us to apply the knowledge and information acquired from basic studies to understand the pathogenesis of human immune-associated diseases and develop therapeutic practices in experimental and ultimately clinical settings. In addition, roles for TGF-beta in innate immunity, the mucosal immune system, autoimmunity and inflammation, anti-tumor immunity, and HIV-mediated immune deficiency have been gradually disclosed and appreciated. Thus, it is necessary to gather experts in the field together to discuss new findings and update the pivotal role of TGF-beta in the immune system, with the aim to lay out the critical and key questions and point out possible directions. The Keystone Symposium is the ideal platform to reach this goal.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 7

15:00—19:30
Registration
18:15—19:15
Refreshments
19:15—19:45
Orientation and Overview
* Wanjun Chen, NIDCR, National Institutes of Health, USA

Michael B. Sporn, Dartmouth Medical School, USA
The Discovery of TGF-beta

19:45—20:45
Opening Remarks and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Joan Massagué, HHMI/Memorial Sloan-Kettering Cancer Center, USA
TGF-beta Receptors, Mediators and Targets


SATURDAY, JANUARY 8

07:00—08:00
Breakfast
08:00—11:00
Basic Mechanisms of TGF-beta Signal Transduction
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rik Derynck, University of California, San Francisco, USA
TGF-beta-Induced Smad and Non-Smad Signaling Pathways

Daniel B. Rifkin, New York University, USA
TGF-beta Bioavailability: Latency and Activation

Xin-Hua Feng, Baylor College of Medicine, USA
Molecular Basis of Smad Signal Transduction and Termination

Caroline S. Hill, Cancer Research UK, UK
Regulation of TGF-beta and BMP Signalling Pathways

Gerald J. Prud'homme, St. Michael's Hospital, Canada
Short Talk: Neuropilin-1 Exerts TGF-beta Activating and Coreceptor Functions

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 1: TGF-beta and Other Cytokines in T Cell Development, Differentiation
* Herman Waldmann, University of Oxford, UK

Nathalie Schmitt, Baylor Institute for Immunology Research, USA
Activated Dendritic Cells Promote the Generation of Human T Follicular Helper Cells in Collaboration with TGF-beta

Shomyseh Sanjabi, Gladstone Institutes, University of California San Francisco, USA
TGF-beta Signaling in CD8+ T Cell Biology

Mizuko Mamura, Gachon University of Medicine and Science, South Korea
Divergent Roles of Smad2 and Smad3 in Stat Activation in Arthritogenic T Helper 17 Cells

Erica L. Stone, University of California, San Diego, USA
Foxo1 Controls T Regulatory Cell Development and Function

Julie Stockis, de Duve Institute, Belgium
Membrane Protein GARP is a Receptor for Latent TGF-beta on the Surface of Activated Human Treg

Frederico S. Regateiro, University of Oxford, UK
Anti-Inflammatory Adenosine Generation by Leukocytes is Tightly Regulated by TGF-beta and is Independent of Foxp3

William A. Faubion, Mayo Clinic, USA
Antigen Oxidation Converts the Established TGFbeta Suppressive Effect on Naïve T Cells to an Immunostimulatory Effect Leading to the Generation of Treg Cells

Joanne E. Konkel, NIDCR, National Institutes of Health, USA
TGF-beta is Required for Foxp3 Induction in Thymocytes

16:30—17:00
Coffee Available
17:00—19:15
TGF-beta Regulation of T and B Cell Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard A. Flavell, HHMI, Yale University School of Medicine, USA
TGF-beta in CD4 and CD8 T Cells

Tim R. Mosmann, University of Rochester Medical Center, USA
Long- and Short-Term Regulation of T Cell Cytokine Patterns

Alexander Y. Rudensky, HHMI/Memorial Sloan-Kettering Cancer Center, USA
TGF-beta Regulation of T Cells: Treg-Dependent and -Independent Pathways

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Role of TGF-beta in Inducing Novel T Cell Subsets

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

SUNDAY, JANUARY 9

07:00—08:00
Breakfast
08:00—11:00
TGF-beta and Regulatory T Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Wanjun Chen, NIDCR, National Institutes of Health, USA
The Molecular Mechanisms in TGF-beta Induction of Foxp3 Gene

* Ethan M. Shevach, NIAID, National Institutes of Health, USA
Control of Immune Response by TGF-beta Induced Treg Cells

Li Yang, NCI, National Institutes of Health, USA

Julien C. Marie, Cancer Research Center of Lyon, France
Short Talk: The Fate of Natural Regulatory T Cells is Dictated by Transforming Growth Factor Beta Signaling

Hongbo Chi, St. Jude Children's Research Hospital, USA
Short Talk: S1P1-mTOR Axis Directs the Reciprocal Differentiation of TH1 and Regulatory T Cells by Antagonizing TGF-beta-Smad3 Signaling

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 2: TGF-beta Effects on Antigen-Presenting Cells
* Lucienne Chatenoud, INSERM U1013, Hôpital Necker-Enfants Malades, France

Sylvain Perruche, INSERM, France
TGF-beta-Exposed Plasmacytoid Dendritic Cells Participate to Th17 Commitment

Tom Simones, University of Montana, USA
Aryl Hydrocarbon Receptor-Activated Dendritic Cells Generate CD4+ CD25+ FoxP3+ Regulatory T Cells

Junda M. Kel, Erasmus Medical Center, Netherlands
TGF-beta Controls Dendritic Cell Function to Maintain Self Tolerance

Aleh Bobr, University of Minnesota, USA
Autocrine TGF-beta is Required to Maintain Langerhans Cell Immaturity

Andrew C. Melton, BioMarin, USA
Activation of TGF-beta by Integrin alpha(v)beta8 on Dendritic Cells is Required for Th17 Development in Mice

Rajalakshmy Ramalingam, University of Arizona, USA
Lack of TGF-beta Signaling in Dendritic Cells Leads to Multiorgan Autoimmune Inflammatory Disease

Dominika G. Lukas, Institut für Molekulare Medizin, Germany
Conditional Deletion of the TGFbeta Inhibitor Smad7 in T Cells or Dendritic Cells Limits Autoimmune CNS Inflammation by Induction of Regulatory T Cells

16:30—17:00
Coffee Available
17:00—19:15
TGF-beta in Innate Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Steven M. Albelda, University of Pennsylvania, USA
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-beta: Implications for Anti-Tumor Immunity

* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Mucosal DCs and TGF-beta in Infection

Peter M. Henson, National Jewish Health Center and University of Colorado Denver, USA
TGF-beta as a Mediator of Responses to Apoptotic Cells

Herbert Strobl, Medical University Vienna, Austria
Short Talk: Transcriptional Mechanism Underlying TGF-beta1- Dependent Langerhans Dendritic Cell Differentiation: A Key Role of KLF4

Alexei Gratchev, University Medical Center Mannheim, University of Heidelberg, Germany
Short Talk: TGF-beta Signaling in Macrophages

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

MONDAY, JANUARY 10

07:00—08:00
Breakfast
08:00—11:15
TGF-beta and Th17 and Th9 Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dan R. Littman, HHMI/New York University School of Medicine, USA
TGF-beta and RORgammaT in Murine and Human T Cells

Matthias G. von Herrath, Novo Nordisk, USA
TGF-beta and Ox40 Modulation Enhance Virus-Specific T Cell Responses in a Chronic Virus Infection Model

Tobias Bopp, University Medical Center of the Johannes Gutenberg-University, Germany
TGF-beta Promotes IRF4-Dependent Development of IL-9-Producing Th9 Cells

David A. Hafler, Yale University School of Medicine, USA
A Role for TGF-beta in Human IL-9 Producing TH17 Cells

Ming O. Li, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Autocrine TGF-beta1 Promotes in vivo Th17 Cell Differentiation

Akihiko Yoshimura, Keio University, Japan
Short Talk: Role of TGF-beta-Smad2/3 Dependent and Independent Signaling in Helper T Cell Function and Differentiation

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 3: TGF-beta in Autoimmune Diseases, Infection and Cancer
* Wanjun Chen, NIDCR, National Institutes of Health, USA

Song Guo Zheng, University of Southern California, USA
Therapeutic Effects of TGF-beta-Induced Regulatory T Cells on the Established Autoimmune Diseases

Kristian P. Doyle, University of Arizona, USA
TGFbeta Signaling Increases in Aging and Signals to Innate Immune Cells in the Weeks after Stroke

Daniel A. Kahn, David Geffen School of Medicine, University of California Los Angeles, USA
Pregnancy Dramatically Enhances T Regulatory Cell Function

Troy D. Cline, St. Jude Children's Research Hospital, USA
Activation of TGF-beta by Influenza Virus Neuraminidase and its Role in Influenza Virus Pathogenesis

Hong-Hua Mu, University of Utah School of Medicine, USA
Blockade of Plasminogen-Activator Inhibitor Type-1 Results in TGF-beta-Mediated Suppression of Lethal Toxicity by Mycoplasma Arthritidis

Petr Nachtigal, Charles University in Prague, Czech Republic
Endoglin (Type III TGF-beta Receptor) Expression is Related to Decreased Atherogenesis in ApoE/LDLR Double Knockout Mice

Erica B. Wilson, Leeds Institute of Molecular Medicine, UK
Ovarian Tumor Microenvironment Associated Modulation of Natural Killer Cells

Stephen H. Bartelmez, BetaStem Therapeutics, USA
Transient Inhibition of Transforming Growth Factor-Beta-1 in Human Blood-Derived CD34+ Cells Enhances Vascular Reparative Functions In Vivo

16:30—17:00
Coffee Available
17:00—19:15
TGF-beta in Mucosal Immunity and Tolerance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Howard L. Weiner, Brigham & Women’s Hospital, USA
Induction of Tregs by Mucosal Administration of Aryl Hydrocarbon Receptor Ligands and Anti-CD3 Monoclonal Antibody in Animals and Humans

Fiona M. Powrie, University of Oxford, UK
Regulation of IBD by TGF-beta

Warren Strober, National Institutes of Health, USA
Molecular Regulation of TGF-beta/Retinoic Acid Induction of Foxp3 Expression

Xiao-Jing Wang, University of Colorado Denver, USA
Short Talk: Role of TGFbeta1 in Inflammation in Skin and Oral Mucosa

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

TUESDAY, JANUARY 11

07:00—08:00
Breakfast
08:00—11:15
TGF-beta in Autoimmunity, Inflammation and Transplantation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Dean Sheppard, University of California, San Francisco, USA
Regulation of T Cell Differentiation by the alphavbeta8 Integrin on Dendritic Cells

Herman Waldmann, University of Oxford, UK
TGF-beta Signaling to T Cells in Long-Term Acceptance of Allografts

Lucienne Chatenoud, INSERM U1013, Hôpital Necker-Enfants Malades, France
CD3-Antibody, TGF-beta and Tregs in Type I Diabetes

* John J. O'Shea, NIAMS, National Institutes of Health, USA
TGF-beta and Furin in T Cells

Mark A. Travis, University of Manchester, UK
Short Talk: Lack of Integrin-Mediated TGF-beta Activation by Dendritic Cells Results in Protection from Chronic Gastrointestinal Parasite Infection

Bapi Pahar, Tulane National Primate Research Center, USA
Short Talk: TGF-beta and IL-10 Produced by Regulatory B Cells are TLR2 Dependent and are Capable in Suppressing Th1 Responses

09:20—09:40
Coffee Break
 
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
TGF-beta in Human Immune Cells and Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Induced Regulatory T Cells: Novel Populations and Clinical Implications

Michael B. Sporn, Dartmouth Medical School, USA
Synthetic Triterpenoids and Inflammatory Diseases: Interactions with Immune Cells and TGF-beta

* John M. McPherson, Genzyme Corporation, USA
Safety Considerations for the Clinical Use of Anti-TGF-beta Antibodies for Treatment of Fibrotic Diseases and Cancer

Hideki Ueno, Baylor Institute for Immunology Research, USA
Short Talk: Subsets of Human Blood CXCR5+ CD4+ T Cells and their Alteration in Autoimmune Disease

19:00—20:15
Social Hour with Lite Bites
20:00—23:00
Entertainment

WEDNESDAY, JANUARY 12

 
Departure

*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


Anita Roberts Memorial Fund
Cell Signaling Technology, Inc.
Genzyme Corporation ImClone Systems Corporation
JDRF
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI091030-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genzyme Corporation


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2668

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Phone:+1 970-262-2676