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This meeting took place in 2011



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Frontiers of NMR in Biology (A3)


Organizer(s) Michael F. Summers, Dorothee Kern and David E. Wemmer
January 8—13, 2011
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 15, 2010
Late Abstract Deadline: Oct 12, 2010
Scholarship Deadline: Sep 15, 2010
Early Registration Deadline: Nov 9, 2010

Supported by the Directors’ Fund

Summary of Meeting:
Nuclear magnetic resonance (NMR) spectroscopy is now a well-established tool for determining structures of small to moderate size biomacromolecules. The horizon is expanding, however, through recent methodological advances, including the evolution of approaches that combine NMR with computational, X-ray crystallographic, cryo-electron microscopic, and single molecule methodologies. These have led to unprecedented insights into structure, dynamics, and mechanisms, even in large systems, making NMR a premier tool for studying macromolecular function. This symposium will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches. Emphasis will be placed on systems that challenge the current technology, including high-molecular weights, membrane proteins, folding and dynamics, transient states, and drug discovery. In addition, the symposium will provide a forum for discussions on the needs and efforts to consolidate the best approaches, and on the latest advances and new trends in biological NMR.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 8

15:00—19:30
Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert Kaptein, University of Utrecht, Netherlands

Juli Feigon, University of California, Los Angeles, USA
Structure and Dynamics of Telomerase and Riboswitch RNAs

Gerhard Wagner, Harvard Medical School, USA
NMR for Elucidating Molecular Mechanism


SUNDAY, JANUARY 9

07:00—08:00
Breakfast

08:00—11:00
New Methods for Studying Structure and Dynamics I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Erik R. P. Zuiderweg, University of Michigan, USA

Robert G. Griffin, Massachusetts Institute of Technology, USA
Development and Applications of DNP in Solid State NMR

Christopher P. Jaroniec, Ohio State University, USA
Magic Angle Spinning Solid State NMR Structural Studies of Proteins Modified with Paramagnetic Tags

Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution NMR Spectroscopy

Marcellus Ubbink, Leiden University, Netherlands
Paramagnetic Probes for Studying Macromolecular Structure and Interactions

Kaushik Dutta, New York Structural Biology Center, USA
Short Talk: Molecular Basis for FGF Receptor Autoinhibition by Alternative Splicing of Acid Box Region

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Exciting New Results
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Arthur G. Palmer, III, Columbia University, USA

Sharon L. Campbell, University of North Carolina at Chapel Hill, USA
Alternative Model of Vinculin/Actin Interactions and Regulation by Phosphorylation

Gabriele L. Varani, University of Washington, USA
RNA Dynamics in Real Time and Assembly of Ribonucleoproteins

A. Joshua Wand, University of Pennsylvania, USA
The Dark Energy of Proteins Comes to Light

Daniel A. Fox, University of Virginia, USA
Poster Preview: NMR Backbone Assignment of Opa I: A Mediator of Host: Neisseria Interactions

Thomas C. Edrington, University of Virginia, USA
Poster Preview: Solution Structure of the Outer Membrane Protein OprH from Pseudomonas Aeruginosa in Lipid Micelles and Bicelles

Ranabir Das, National Institutes of Health, USA
Poster Preview: Studies on the Molecular Mechanism of Allosteric Activation in Ubiquitin Conjugating Enzyme Ube2g2

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1

NOTE: Poster Rounds with Distinguished Scientists (by sign-up at check-in)


MONDAY, JANUARY 10

07:00—08:00
Breakfast

08:00—11:00
New Insights into RNA Structure and Dynamics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mark P. Foster, Ohio State University, USA

Frédéric H.T. Allain, ETH Zurich, Switzerland
Insight into RNA Splicing and Editing Mechanisms from the NMR Structures of Protein-RNA Complexes

Victoria Manuel D'Souza, Harvard University, USA
Genetic Recoding in Retroviruses: Structure and Function of a Readthrough Pseudoknot

Arthur G. Palmer, III, Columbia University, USA
Protein Dynamics from Experiment and Simulation and pulse Sequence

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structure of the 156 Nucleotide HIV-1 RNA Packaging Signal

Lili Mao, Center for Advanced Biotechnology and Medicine (CABM), USA
Poster Preview: Specific Amino Acid Labeling of Proteins with High Molecular Weight in E. coli for NMR Studies

Pétur O. Heidarsson, University of Copenhagen, Denmark
Poster Preview: Insights into the CRISPR Viral Defense System from the Solution Structure and DNA Binding Properties of a Crenarchaeal CRISPR Binding Protein

Helene M. M. Launay, University of Lille 1, UMR 8576, France
Poster Preview: NMR Studies of the Co-Translational Folding of an Immunoglobulin Domain

Gaya Amarasinghe, Washington University School of Medicine, USA
Poster Preview: Mechanisms of Innate Immune Evasion by the Multifunctional Ebolavirus VP35: Implications for Target Identification and Validation of Panfiloviral Inhibitors

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Advances in Protein and RNA Labeling

* Blanton S. Tolbert, Case Western Reserve University, USA

Jonathan M. Brown, ProSpect Pharma, Inc., USA
Methods and Materials for Specific Isotope Labeling of Biomolecules

Kwaku Dayie, University of Maryland, USA
Chemo-Enzymatic Selective Labeling Methods to Study RNAs

James R. Williamson, The Scripps Research Institute, USA
Methods for Selective Isotope Labeling of RNA

Bernhard H. Geierstanger, Genomics Institute of the Novartis Research Foundation, USA
Site-Specific Protein Labeling with Unnatural Amino Acids

16:30—17:00
Coffee Available

17:00—19:00
Protein Folding and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jane Dyson, The Scripps Research Institute, USA

Peter E. Wright, The Scripps Research Institute, USA
Promiscuous Liaisons: Functional Interactions of Intrinsically Disordered Proteins in Biological Signaling

Roberto Nguyen De Guzman, University of Kansas, USA
Structure and Assembly of Bacterial Needles

David E. Wemmer, University of California, Berkeley, USA
Conformations of Abeta Peptides/EGFR

Peter J. Lukavsky, Central European institute of Technology, Czech Republic
Poster Preview: NMR Structures of RNA Transport Signals Reveal Unexpected A’-Form RNA Helices Required for mRNA Transport in Drosophila

Michael A. Massiah, George Washington University, USA
Poster Preview: Human MID1 is a TRIM Protein that Targets PP2A for Ubiquitination: Probing the Structure and Function of MID1 Three Consecutive E3 Ligase Domains

Brett M. Kroncke, University of Virginia, USA
Poster Preview: Investigations Toward Improving Solution NMR Paramagnetic Relaxation Enhancement Distance Restraints for MTSSL Labeled alpha-helical Membrane Proteins

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2

NOTE: Poster Rounds with Distinguished Scientists (by sign-up at check-in)


TUESDAY, JANUARY 11

07:00—08:00
Breakfast

08:00—11:00
Interactions at Membranes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Linda Columbus, University of Virginia, USA

Tatiana G. Kutateladze, University of Colorado School of Medicine, USA
Structural Insights into Histone Code Recognition by PHD Fingers

Katherine A. Henzler-Wildman, Washington University, USA
Mechanistic Studies of Drug Transporter Systems

Charles R. Sanders, Vanderbilt University School of Medicine, USA
Debutante Ball for Peripheral Myelin Protein 22

Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA
Structural Studies of Bacterial Cell Envelope Proteins

Andreas Schlundt, , Germany
Poster Preview: Bidirectional Binding of a Self-Antigen to an MHC Class II Molecule

Thomas Spirig, University of California, Los Angeles, USA
Poster Preview: Visualizing Transient Protein-Protein Complexes that Transfer Heme Across the Cell Wall of Staphylococcus aureus

Blanton S. Tolbert, Case Western Reserve University, USA
Poster Preview: Probing the Molecular Determinants of HIV Alternative Splicing Regulation: NMR and Thermodynamic Studies of UP1/ESS3

Jonathan W. Werner-Allen, Duke University Medical Center, USA
Poster Preview: Application of Sparse Sampling and FFT-CLEAN to 4-D NOESY for Global Fold Calculations of Large Proteins

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Drug Targets
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Melissa A. Starovasnik, Genentech, Inc., USA

David J. Weber, University of Maryland, USA
S100 Protein Dynamics and Implications for Drug Design

Wolfgang S. Peti, Brown University, USA
Structural Biology of Large Intracellular Signaling Complexes

Alessio Ciulli, University of Cambridge, UK
Fragment-based Approaches to Chemically Interrogate Drug Targets: NMR and Other Methods

Casey O'Connor, Medical College of Wisconsin, USA
Poster Preview: Dynamics and Ligand Binding in Ras

Gabriela C. Pérez-Alvarado, Southern Illinois University, USA
Poster Preview: Structural Determinants of Molecular Recognition by the Adaptor Protein LMO7

Yonggang Chang, University of California, Merced, USA
Poster Preview: Timekeeping Mechanism of a Circadian Oscillator

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3

NOTE: Poster Rounds with Distinguished Scientists (by sign-up at check-in)


WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—11:00
Macromolecular Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Valerie Copié, Montana State University, USA

Kurt Wüthrich, ETH Zürich / The Scripps Research Institute, Switzerland
Conformational Polymorphism in Cellular Prion Proteins and Transmissible Spongiform Encephalopathies

Kylie J. Walters, University of Minnesota, USA
Mechanistic Insights into Ubiquitin-Dependent Proteolysis

Tatyana I. Igumenova, Texas A&M University, USA
Structure and Dynamics of Lipid-Binding Modules of PKCalpha by NMR

Mitsuhiko Ikura, University of Toronto, Canada
Probing Cancer Cell Signaling by NMR: Structure, Interaction, and Kinetics of the Small GTPase Cycle

G. Marius Clore, NIDDK, National Institutes of Health, USA
Short Talk: Solution Structure of the 128 kDa Enzyme I Dimer from Escherichia coli and its 146 kDa Complex With HPr Using Residual Dipolar Couplings and Small and Wide Angle X-Ray Scattering

09:20—09:40
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
New Methods for Studying Structure and Dynamics II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* R. Andrew Byrd, NCI, National Institutes of Health, USA

Marc Baldus, Utrecht University, Netherlands
Solid-State NMR on Complex Biomolecules

Dorothee Kern, Brandeis University/HHMI, USA
View at the Summit – Transition States in a Kinase

Yun-Xing Wang, NCI, National Institutes of Health, USA
Short Talk: A New Approach to Structure Determination of RNAs in Solution

Ad Bax, NIDDK, National Institutes of Health, USA
Chemical Shifts, Dipolar Couplings and SAXS: How Can They Help?

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


THURSDAY, JANUARY 13

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


New Era Enterprises, Inc.

Agilent Technologies Bruker BioSpin Corp.
Cambridge Isotope Laboratories CEDARLANE
ISOTEC, a member of the Sigma-Aldrich Group
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM095021-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676