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Granlibakken Resort Floorplan

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This meeting took place in 2011



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AAA+ and Related ATP-Driven Protein Machines: Structure, Function and Mechanism (C6)


Organizer(s) Andreas Matouschek, Robert T. Sauer and Phyllis I. Hanson
March 20—24, 2011
Granlibakken Resort • Tahoe City, California USA
Abstract Deadline: Nov 18, 2010
Late Abstract Deadline: Dec 21, 2010
Scholarship Deadline: Nov 18, 2010
Early Registration Deadline: Jan 20, 2011

Sponsored by Bayer USA Foundation

Summary of Meeting:
AAA+ protein machines catalyze basic biological processes: they degrade proteins, remodel protein complexes and nucleic acids, transport macromolecules across membranes, and shape membranes. They are at the center of cellular processes such as cell cycle control, protein sorting, DNA replication, cytoskeleton dynamics, and membrane budding. Thus, AAA+ machines play roles in a wide range of disease including cancer, neurodegeneration and infection. Despite the diversity of function, there appears to be a common operating mode of AAA+ proteins and we are at the cusp of acquiring a deep understanding of their molecular mechanism. However, different aspects of the mechanism are understood in different systems. At this conference we bring together speakers who have elucidated critical aspects of different AAA+ proteins. The group transcends molecular scales and methodology. We add a smaller number of speakers who have made breakthroughs in the understanding of proteins that do not belong to the AAA+ family but are either functionally or structurally related. We aniticipate that this combination will lead to insights into the common mechanism of these proteins and inspire novel experimental approaches and discoveries.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 20

15:00—19:30
Registration

19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Andreas Matouschek, Northwestern University, USA

* Robert T. Sauer, Massachusetts Institute of Technology, USA

* Phyllis I. Hanson, Washington University School of Medicine, USA

Tania A. Baker, Massachusetts Institute of Technology, USA
AAA+ Proteases in Protein Quality Control


MONDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:00
AAA Proteases and Remodeling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert T. Sauer, Massachusetts Institute of Technology, USA
The ClpXP Protein-Unfolding Machine

Aaron L. Lucius, University of Alabama at Birmingham, USA
Short Talk: Examination of E. coli ClpA Catalyzed Polypeptide Translocation Using Single-Turnover Fluorescence Stopped-Flow Techniques

Michael Maurizi, National Cancer Institute, USA
Short Talk: Molecular Architecture of Lon Protease: Gated Access to a Sequestered Degradation Chamber

Francis T.F. Tsai, Baylor College of Medicine, USA
Short Talk: Structure and Mechanism of the Hsp104 AAA+ ATPase

James Shorter, University of Pennsylvania School of Medicine, USA
Short Talk: Hsp104: Structure, Mechanism and Functional Applications

Joel R. Hoskins, National Cancer Institute, USA
Short Talk: Species-Specific Cooperation of Hsp104/ClpB and Hsp70/DnaK in Thermotolerance and Protein Disaggregation is Dictated by the M-Domain of Hsp104/ClpB

Eilika Weber-Ban, ETH Zürich, Switzerland
Short Talk: Roles of the AAA ATPase Mpa in the Pup Proteasome System

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
11:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Proteasome and p97: Targeting Proteins to AAA Machines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Nieng Yan, Tsinghua University School of Medicine, China
Structure of the CED-4 Apoptosome: Insights into its Assembly and Function

Daniel J. Finley, Harvard University, USA
Assembly and Function of the Hetero-Hexameric AAA Ring of the Proteasome

* Raymond J. Deshaies, California Institute of Technology, USA
p97 as a Protein Targeting Platform

Andreas Matouschek, Northwestern University, USA
A Second Component to the Degradation Signal: The Proteasome Initiation Site

19:15—20:15
Dinner

20:00—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, MARCH 22

07:00—08:00
Breakfast

08:00—11:00
DNA Gymnastics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* James M. Berger, Johns Hopkins School of Medicine, USA
Structural Basis for Hexameric Helicase Translocation and Polarity

Michael Botchan, University of California, Berkeley, USA
Adaptors Essential for the Activity of the MCM Helicase

Stephen C. Kowalczykowski, University of California, Davis, USA
Visualization of DNA Helicases and DNA Strand Exchange Proteins at the Single-Molecule Level

Brian A. Kelch, University of California Berkeley, USA
Short Talk: Crystal Structures Provide Snapshots of the Clamp Loading Mechanism

Taekjip Ha, University of Illinois at Urbana Champaign, USA
Reverse-Chaperoning Activity of an AAA+ Protein

09:20—09:40
Coffee Break

13:00—22:00
Poster Viewing

Bay
11:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
DNA Gymnastics II and Moving Molecules Across Membranes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Xiaodong Zhang, Imperial College London, UK
Structures and Mechanism of AAA+ Transcriptional Activators

Tatyana A. Sysoeva, Pennsylvania State University, USA
Short Talk: Intricate Interactions among Subunits within the Ring of an AAA+ ATPase

Jorge E. Galán, Yale University School of Medicine, USA
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Eukaryotic Cells

* Briana M. Burton, Harvard University, USA
Importing DNA and Exporting Proteins

19:00—20:00
Dinner

20:00—22:00
Poster Viewing

Bay
20:00—21:00
Social Hour

Bay

WEDNESDAY, MARCH 23

07:00—08:00
Breakfast

08:00—11:00
Building and Rebuilding the Cytoskeleton and Other Interesting ATPases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ronald D. Vale, University of California, San Francisco, USA
The Structure of the Dynein Motor

* Eva Nogales, University of California, Berkeley, USA
Visualizing the Regulated, Dynamic Interaction of Microtubules with Kinetochores

Antonina Roll-Mecak, NINDS, National Institutes of Health, USA
Cytoskeleton Regulation by AAA+ Proteins: Molecular Dissection of Microtubule Severing

Michal Sharon, Weizmann Institute of Science, Israel
Short Talk: Characterizing the Cooperative Behavior of ATP Driven Machines

09:20—09:40
Coffee Break

11:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Shaping Membranes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Wesley I. Sundquist, University of Utah School of Medicine, USA
Structure and Function of the VPS4 ATPase

* Phyllis I. Hanson, Washington University School of Medicine, USA
VPS4, ESCRT-III, and Membrane Deformation

James H. Hurley, University of California, Berkeley, USA
Its all in the Neck: How the ESCRTs Make Multivesicular Bodies

Harish N. Ramanathan, NIDDK, National Institutes of Health, USA
Short Talk: The p97 ATPase Associates with EEA1 to Regulate the Size of Early Endosomes

19:00—19:15
Closing Remarks/Summary
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Andreas Matouschek, Northwestern University, USA

Robert T. Sauer, Massachusetts Institute of Technology, USA

Phyllis I. Hanson, Washington University School of Medicine, USA

19:15—20:15
Dinner

20:00—23:00
Entertainment


THURSDAY, MARCH 24

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Bayer USA Foundation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Science Foundation (NSF)

Grant No. MCB-1112682




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