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This meeting took place in 2011
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Meeting Details
AAA+ and Related ATP-Driven Protein Machines: Structure, Function and Mechanism (C6)
Organizer(s) Andreas Matouschek, Robert T. Sauer and Phyllis I. Hanson
March 20 - March 24, 2011
Granlibakken Resort • Tahoe City, California USA
Abstract Deadline: November 18, 2010
Late Abstract Deadline: December 21, 2010
Scholarship Deadline: November 18, 2010
Early Registration Deadline: January 20, 2011
Sponsored by Bayer USA Foundation
CME Information
Summary of Meeting:
AAA+ protein machines catalyze basic biological processes: they degrade proteins, remodel protein complexes and nucleic acids, transport macromolecules across membranes, and shape membranes. They are at the center of cellular processes such as cell cycle control, protein sorting, DNA replication, cytoskeleton dynamics, and membrane budding. Thus, AAA+ machines play roles in a wide range of disease including cancer, neurodegeneration and infection.
Despite the diversity of function, there appears to be a common operating mode of AAA+ proteins and we are at the cusp of acquiring a deep understanding of their molecular mechanism. However, different aspects of the mechanism are understood in different systems.
At this conference we bring together speakers who have elucidated critical aspects of different AAA+ proteins. The group transcends molecular scales and methodology. We add a smaller number of speakers who have made breakthroughs in the understanding of proteins that do not belong to the AAA+ family but are either functionally or structurally related. We aniticipate that this combination will lead to insights into the common mechanism of these proteins and inspire novel experimental approaches and discoveries.
CME Information
AAA+ protein machines catalyze basic biological processes: they degrade proteins, remodel protein complexes and nucleic acids, transport macromolecules across membranes, and shape membranes. They are at the center of cellular processes such as cell cycle control, protein sorting, DNA replication, cytoskeleton dynamics, and membrane budding. Thus, AAA+ machines play roles in a wide range of disease including cancer, neurodegeneration and infection. Despite the diversity of function, there appears to be a common operating mode of AAA+ proteins and we are at the cusp of acquiring a deep understanding of their molecular mechanism. However, different aspects of the mechanism are understood in different systems. At this conference we bring together speakers who have elucidated critical aspects of different AAA+ proteins. The group transcends molecular scales and methodology. We add a smaller number of speakers who have made breakthroughs in the understanding of proteins that do not belong to the AAA+ family but are either functionally or structurally related. We aniticipate that this combination will lead to insights into the common mechanism of these proteins and inspire novel experimental approaches and discoveries.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 20
19:15—20:30
Welcome and Keynote Address
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*
Andreas Matouschek,
Northwestern University, USA
*
Robert T. Sauer,
Massachusetts Institute of Technology, USA
*
Phyllis I. Hanson,
Washington University School of Medicine, USA
Tania A. Baker,
Massachusetts Institute of Technology, USA
AAA+ Proteases in Protein Quality Control
AAA+ Proteases in Protein Quality Control
08:00—11:00
AAA Proteases and Remodeling
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*
Robert T. Sauer,
Massachusetts Institute of Technology, USA
The ClpXP Protein-Unfolding Machine
The ClpXP Protein-Unfolding Machine
Aaron L. Lucius,
University of Alabama at Birmingham, USA
Short Talk: Examination of E. coli ClpA Catalyzed Polypeptide Translocation Using Single-Turnover Fluorescence Stopped-Flow Techniques
Short Talk: Examination of E. coli ClpA Catalyzed Polypeptide Translocation Using Single-Turnover Fluorescence Stopped-Flow Techniques
Michael Maurizi,
National Cancer Institute, USA
Short Talk: Molecular Architecture of Lon Protease: Gated Access to a Sequestered Degradation Chamber
Short Talk: Molecular Architecture of Lon Protease: Gated Access to a Sequestered Degradation Chamber
Francis T.F. Tsai,
Baylor College of Medicine, USA
Short Talk: Structure and Mechanism of the Hsp104 AAA+ ATPase
Short Talk: Structure and Mechanism of the Hsp104 AAA+ ATPase
James Shorter,
University of Pennsylvania School of Medicine, USA
Short Talk: Hsp104: Structure, Mechanism and Functional Applications
Short Talk: Hsp104: Structure, Mechanism and Functional Applications
Joel R. Hoskins,
National Cancer Institute, USA
Short Talk: Species-Specific Cooperation of Hsp104/ClpB and Hsp70/DnaK in Thermotolerance and Protein Disaggregation is Dictated by the M-Domain of Hsp104/ClpB
Short Talk: Species-Specific Cooperation of Hsp104/ClpB and Hsp70/DnaK in Thermotolerance and Protein Disaggregation is Dictated by the M-Domain of Hsp104/ClpB
Eilika Weber-Ban,
ETH Zürich, Switzerland
Short Talk: Roles of the AAA ATPase Mpa in the Pup Proteasome System
Short Talk: Roles of the AAA ATPase Mpa in the Pup Proteasome System
17:00—19:15
Proteasome and p97: Targeting Proteins to AAA Machines
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Nieng Yan,
Tsinghua University School of Medicine, China
Structure of the CED-4 Apoptosome: Insights into its Assembly and Function
Structure of the CED-4 Apoptosome: Insights into its Assembly and Function
Daniel J. Finley,
Harvard University, USA
Assembly and Function of the Hetero-Hexameric AAA Ring of the Proteasome
Assembly and Function of the Hetero-Hexameric AAA Ring of the Proteasome
Andreas Matouschek,
Northwestern University, USA
A Second Component to the Degradation Signal: The Proteasome Initiation Site
A Second Component to the Degradation Signal: The Proteasome Initiation Site
08:00—11:00
DNA Gymnastics
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*
James M. Berger,
University of California, Berkeley, USA
Structural Basis for Hexameric Helicase Translocation and Polarity
Structural Basis for Hexameric Helicase Translocation and Polarity
Michael Botchan,
University of California, Berkeley, USA
Adaptors Essential for the Activity of the MCM Helicase
Adaptors Essential for the Activity of the MCM Helicase
Stephen C. Kowalczykowski,
University of California, Davis, USA
Visualization of DNA Helicases and DNA Strand Exchange Proteins at the Single-Molecule Level
Visualization of DNA Helicases and DNA Strand Exchange Proteins at the Single-Molecule Level
Brian A. Kelch,
University of California Berkeley, USA
Short Talk: Crystal Structures Provide Snapshots of the Clamp Loading Mechanism
Short Talk: Crystal Structures Provide Snapshots of the Clamp Loading Mechanism
Taekjip Ha,
University of Illinois at Urbana Champaign, USA
Reverse-Chaperoning Activity of an AAA+ Protein
Reverse-Chaperoning Activity of an AAA+ Protein
17:00—19:00
DNA Gymnastics II and Moving Molecules Across Membranes
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Xiaodong Zhang,
Imperial College London, UK
Structures and Mechanism of AAA+ Transcriptional Activators
Structures and Mechanism of AAA+ Transcriptional Activators
Tatyana A. Sysoeva,
Pennsylvania State University, USA
Short Talk: Intricate Interactions among Subunits within the Ring of an AAA+ ATPase
Short Talk: Intricate Interactions among Subunits within the Ring of an AAA+ ATPase
Jorge E. Galán,
Yale University School of Medicine, USA
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Eukaryotic Cells
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Eukaryotic Cells
08:00—11:00
Building and Rebuilding the Cytoskeleton and Other Interesting ATPases
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*
Eva Nogales,
University of California Berkeley, USA
Visualizing the Regulated, Dynamic Interaction of Microtubules with Kinetochores
Visualizing the Regulated, Dynamic Interaction of Microtubules with Kinetochores
Antonina Roll-Mecak,
NINDS, National Institutes of Health, USA
Cytoskeleton Regulation by AAA+ Proteins: Molecular Dissection of Microtubule Severing
Cytoskeleton Regulation by AAA+ Proteins: Molecular Dissection of Microtubule Severing
Michal Sharon,
Weizmann Institute of Science, Israel
Short Talk: Characterizing the Cooperative Behavior of ATP Driven Machines
Short Talk: Characterizing the Cooperative Behavior of ATP Driven Machines
17:00—19:00
Shaping Membranes
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Wesley I. Sundquist,
University of Utah School of Medicine, USA
Structure and Function of the VPS4 ATPase
Structure and Function of the VPS4 ATPase
*
Phyllis I. Hanson,
Washington University School of Medicine, USA
VPS4, ESCRT-III, and Membrane Deformation
VPS4, ESCRT-III, and Membrane Deformation
James H. Hurley,
National Institutes of Health, USA
Its all in the Neck: How the ESCRTs Make Multivesicular Bodies
Its all in the Neck: How the ESCRTs Make Multivesicular Bodies
Harish N. Ramanathan,
NIDDK, National Institutes of Health, USA
Short Talk: The p97 ATPase Associates with EEA1 to Regulate the Size of Early Endosomes
Short Talk: The p97 ATPase Associates with EEA1 to Regulate the Size of Early Endosomes
19:00—19:15
Closing Remarks/Summary
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Andreas Matouschek,
Northwestern University, USA
Robert T. Sauer,
Massachusetts Institute of Technology, USA
Phyllis I. Hanson,
Washington University School of Medicine, USA
*Session Chair †Speaker invited, not yet responded.
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