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This meeting took place in 2011
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Dendritic Cells and the Initiation of Adaptive Immunity (J7)
Organizer(s) Ira Mellman, Michel C. Nussenzweig, Virginia Pascual and Federica Sallusto
February 12—17, 2011
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Oct 13, 2010
Late Abstract Deadline: Nov 17, 2010
Scholarship Deadline: Oct 13, 2010
Early Registration Deadline: Dec 13, 2010
Sponsored by Amgen Inc., Genentech, Inc. and Novo Nordisk A/S
Summary of Meeting:
Current studies of Dendritic Cells (DCs) have confirmed not only their major role as antigen presenting cells in adaptive immunity but also their important functions in maintaining tolerance and in the initiation of the innate resistance and inflammatory responses. Thus, DCs function as an important bridge between innate resistance and adaptive immunity either through cellular interactions or secretion of pro-inflammatory and immunoregulatory cytokines. The origin and migration pattern of DCs, their cell biological mechanisms of action, their functional diversity, their specializations and activities in specific tissue contexts, as well as their sharing of hematopoietic lineages, functions, and receptors with other phagocytic cell types such as monocytes and macrophages are subjects of intense investigation. Increasingly, the role of dendritic cells in disease pathology and as potential therapeutic targets is being explored both in the laboratory and in the clinic. This is particularly true in human cancer, where both active and passive immunotherapies involving dendritic cells are finally being put to the test in a systematic fashion. In this symposium, each of these aspects of dendritic cell biology and immunological function will be explored in detail, including taking a number of “in depth” looks at functions (such as innate activation mechanisms) that are key to understanding how dendritic cells perform their many remarkable tasks. In addition, this symposium will combine and synergize with a second, jointly organized symposium entitled "Cancer Control by Tumor Suppressors and Immune Effectors", thereby emphasizing emerging concepts concerning the role of the immune response in cancer and cancer therapy.
View Scholarships/Awards
Current studies of Dendritic Cells (DCs) have confirmed not only their major role as antigen presenting cells in adaptive immunity but also their important functions in maintaining tolerance and in the initiation of the innate resistance and inflammatory responses. Thus, DCs function as an important bridge between innate resistance and adaptive immunity either through cellular interactions or secretion of pro-inflammatory and immunoregulatory cytokines. The origin and migration pattern of DCs, their cell biological mechanisms of action, their functional diversity, their specializations and activities in specific tissue contexts, as well as their sharing of hematopoietic lineages, functions, and receptors with other phagocytic cell types such as monocytes and macrophages are subjects of intense investigation. Increasingly, the role of dendritic cells in disease pathology and as potential therapeutic targets is being explored both in the laboratory and in the clinic. This is particularly true in human cancer, where both active and passive immunotherapies involving dendritic cells are finally being put to the test in a systematic fashion. In this symposium, each of these aspects of dendritic cell biology and immunological function will be explored in detail, including taking a number of “in depth” looks at functions (such as innate activation mechanisms) that are key to understanding how dendritic cells perform their many remarkable tasks. In addition, this symposium will combine and synergize with a second, jointly organized symposium entitled "Cancer Control by Tumor Suppressors and Immune Effectors", thereby emphasizing emerging concepts concerning the role of the immune response in cancer and cancer therapy.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, FEBRUARY 12
SUNDAY, FEBRUARY 13
MONDAY, FEBRUARY 14
TUESDAY, FEBRUARY 15
WEDNESDAY, FEBRUARY 16
THURSDAY, FEBRUARY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, FEBRUARY 12
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
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Laurence Zitvogel,
Institut Gustave Roussy, France
Michael Karin,
University of California, San Diego, USA
Inflammation, Immunity and Cancer
Inflammation, Immunity and Cancer
Jean-Laurent Casanova,
Rockefeller University, USA
A Genetic Dissection of Immunity to Infection in Natura
A Genetic Dissection of Immunity to Infection in Natura
08:00—11:00
Origins of Dendritic Cells
Meeting has ended...abstracts no longer viewable online.
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Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Title to be Determined
Title to be Determined
Boris Reizis,
New York University Langone Medical Center, USA
Signaling Pathways Regulating Dendritic Cell Development
Signaling Pathways Regulating Dendritic Cell Development
Steffen Jung,
Weizmann Institute of Science, Israel
Differential Functions of Intestinal Mononuclear Phagocytes
Differential Functions of Intestinal Mononuclear Phagocytes
Miriam Merad,
Mount Sinai School of Medicine, USA
Regulation of Development and Function of Non-Lymphoid Tissue Dendritic Cells
Regulation of Development and Function of Non-Lymphoid Tissue Dendritic Cells
Dimitris Skokos,
Regeneron Pharmaceuticals, USA
Short Talk: Notch Signaling in DC-Treg Cross-Talk and Autoimmunity
Short Talk: Notch Signaling in DC-Treg Cross-Talk and Autoimmunity
08:00—11:00
Pathogenesis: Cancer and Inflammation
Meeting has ended...abstracts no longer viewable online.
Wolf-Hervé Fridman,
Cordeliers Research Centre, France
Prognostic Significance of Tumor-Invading Immune Effectors and Regulators in Human Malignancies
Prognostic Significance of Tumor-Invading Immune Effectors and Regulators in Human Malignancies
*
Robert D. Schreiber,
Washington University School of Medicine, USA
Molecular Mechanisms Underlying Cancer Immunoediting
Molecular Mechanisms Underlying Cancer Immunoediting
Giorgio Trinchieri,
NCI, National Institutes of Health, USA
Innate Resistance and Inflammation in Cancer
Innate Resistance and Inflammation in Cancer
*
Drew M. Pardoll,
Johns Hopkins University School of Medicine, USA
STAT3, Th17 and Cancer Progression
STAT3, Th17 and Cancer Progression
Wael Al Zoughbi,
Medical University of Graz, Austria
Short Talk: Downregulation of ATGL Enhances Malignant Tumor Growth, ATGL as a Tumor Suppressor Protein
Short Talk: Downregulation of ATGL Enhances Malignant Tumor Growth, ATGL as a Tumor Suppressor Protein
14:30—16:30
Workshop 1: A DC by Any Other Name Would Still Smell as Sweet
*
Ken Shortman,
Walter and Eliza Hall Institute of Medical Research, Australia
Cheolho Cheong,
Institut de Recherches Cliniques de Montreal, Canada
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
Alicia Rodriguez-Pla,
Baylor Institute for Immunology Research, USA
SLE Serum Synergizes with CD14 Signaling in Generation of CCR-7-Expressing Monocyte-Derived DCs
SLE Serum Synergizes with CD14 Signaling in Generation of CCR-7-Expressing Monocyte-Derived DCs
Jay W. Heinecke,
University of Washington School of Medicine, USA
The Plasma Membrane Proteome Unravels Macrophage and Myeloid Dendritic Cell Heterogeneity
The Plasma Membrane Proteome Unravels Macrophage and Myeloid Dendritic Cell Heterogeneity
Florent Ginhoux,
Singapore Immunology Network, Singapore
Langerhans Cells Arise from Yolk Sac Primitive Macrophages during Early Embryonic Development
Langerhans Cells Arise from Yolk Sac Primitive Macrophages during Early Embryonic Development
Sandra Bajaña,
Oklahoma Medical Research Foundation, USA
Interferon Regulatory Factor 4 Regulates Tissue Dendritic Cell Migration from the Skin during Homeostasis and upon Inflammation in vivo
Interferon Regulatory Factor 4 Regulates Tissue Dendritic Cell Migration from the Skin during Homeostasis and upon Inflammation in vivo
Molly Ingersoll,
Institut Pasteur, France
Analysis of Antigen-Presenting Cell Trafficking from the Bladder to Lymph Nodes
Analysis of Antigen-Presenting Cell Trafficking from the Bladder to Lymph Nodes
Kang Liu,
Columbia University Medical Center, USA
The Steady State Mouse Brain Contains Dendritic Cells that are Functionally Distinct from Microglia
The Steady State Mouse Brain Contains Dendritic Cells that are Functionally Distinct from Microglia
Milena Bogunovic,
Pennsylvania State University College of Medicine, USA
Homeostasis and Function of Intestinal Muscularis Dendritic Cells
Homeostasis and Function of Intestinal Muscularis Dendritic Cells
14:30—16:30
Workshop 1
Ana Stojanovic,
German Cancer Research Center, Germany
Analysis of Tumor Infiltrating Natural Killer Cells
Analysis of Tumor Infiltrating Natural Killer Cells
Philippe D. Pierre,
Centre d'Immunologie Marseille-Luminy, CIML, France
Regulated eIF2alpha Dephosphorylation Impairs Translational Stress Responses in Poly I:C -Activated Dendritic Cells
Regulated eIF2alpha Dephosphorylation Impairs Translational Stress Responses in Poly I:C -Activated Dendritic Cells
Lionel J. Apetoh,
Centre Georges Francois Leclerc, France
Restoration of Anticancer Immune Responses through Selective Inhibition of Myeloid Derived Suppressor Cells
Restoration of Anticancer Immune Responses through Selective Inhibition of Myeloid Derived Suppressor Cells
Uciane Kimble Scarlett,
Dartmouth College, USA
Progressive Abrogation of Early Anti-Tumor Immunity by Dendritic Cells Provides New Opportunities for Novel Diagnostic Interventions
Progressive Abrogation of Early Anti-Tumor Immunity by Dendritic Cells Provides New Opportunities for Novel Diagnostic Interventions
Jennifer C. Byrne,
Royal College of Surgeons in Ireland, Ireland
Knock-Out of BTK May Promote a Tumor Tolerogenic State through Alteration of TLR Signalling
Knock-Out of BTK May Promote a Tumor Tolerogenic State through Alteration of TLR Signalling
Liat Izhak,
National Cancer Institute, National Institutes of Health, USA
The Relative Role of Two Types of Regulatory T Cells in Tumor Immunity : Tregs and Type II NKT Cells
The Relative Role of Two Types of Regulatory T Cells in Tumor Immunity : Tregs and Type II NKT Cells
George Coukos,
University Hospital of Lausanne - CHUV, Switzerland
CCR10+ Regulatory T Cells are Recruited by Hypoxic Tumor Cells via the CCL28 Chemokine to Promote Immune Tolerance and Angiogenesis in Cancer
CCR10+ Regulatory T Cells are Recruited by Hypoxic Tumor Cells via the CCL28 Chemokine to Promote Immune Tolerance and Angiogenesis in Cancer
17:00—19:15
Mechanisms of Antigen Processing by Dendritic Cells
Meeting has ended...abstracts no longer viewable online.
*
Ira Mellman,
Genentech, Inc., USA
Endosomes and Antigen Presentation by Dendritic Cells
Endosomes and Antigen Presentation by Dendritic Cells
Hidde L. Ploegh,
Boston Children's Hospital, USA
Title to be Determined
Title to be Determined
Sebastian Amigorena,
Institut Curie, France
Antigen Cross Presentation in DCs
Antigen Cross Presentation in DCs
Pierre Guermonprez,
Kings College London, UK
Short Talk
Short Talk
17:00—19:00
Innate Immunity Against Cancer
Meeting has ended...abstracts no longer viewable online.
Vassili Soumelis,
Institut Curie, France
Plasmacytoid DC-Tumor Interactions in Humans
Plasmacytoid DC-Tumor Interactions in Humans
Carl G. Figdor,
Radboud University Medical Center, Netherlands
Human Plasmacytoid DC in Cancer and Cancer Immunotherapy
Human Plasmacytoid DC in Cancer and Cancer Immunotherapy
*
Mark J. Smyth,
QIMR Berghofer Medical Research Institute, Australia
NK/NKT Cell Receptor-Mediated Immunosurveillance
NK/NKT Cell Receptor-Mediated Immunosurveillance
Stephen B. Willingham,
Corvus Pharmaceuticals, USA
Short Talk: Efficacy of Anti-CD47 Antibody Therapy for Human Solid Tumors
Short Talk: Efficacy of Anti-CD47 Antibody Therapy for Human Solid Tumors
08:00—11:15
Harnessing the Cell Biology of Dendritic Cells against Cancer (Joint)
Meeting has ended...abstracts no longer viewable online.
Yong-Jun Liu,
Sanofi, USA
Identification of DNA/RNA Sensors in DCs
Identification of DNA/RNA Sensors in DCs
Madhav V. Dhodapkar,
Yale School of Medicine, USA
Dual Face of DCs in Cancer
Dual Face of DCs in Cancer
Jolanda de Vries,
NCMLS, Radboud University Medical Center, Netherlands
Short Talk: Imaging Early Immune Responses in Cancer Patients after DC Vaccination
Short Talk: Imaging Early Immune Responses in Cancer Patients after DC Vaccination
Kangling Xu,
Baylor Institute for Immunology Research, USA
Short Talk: TSLP Driven Inflammation Fosters Breast Tumor Development
Short Talk: TSLP Driven Inflammation Fosters Breast Tumor Development
Christopher E. Rudd,
University of Montreal, Canada
Short Talk: CTLA-4 Modulation of T-Cell-DC Interactions
Short Talk: CTLA-4 Modulation of T-Cell-DC Interactions
Hideki Ueno,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Generation of T Follicular Helper Cells by DCs in Humans
Short Talk: Generation of T Follicular Helper Cells by DCs in Humans
14:30—16:30
Workshop 2: Antigen Processing and Presentation
Amanda L. Blasius,
Novo Nordisk Research Center, USA
Slc15a4, AP-3 and Hermansky-Pudlak Syndrome Proteins are Required for TLR Signaling in Plasmacytoid Dendritic Cells
Slc15a4, AP-3 and Hermansky-Pudlak Syndrome Proteins are Required for TLR Signaling in Plasmacytoid Dendritic Cells
Misako Matsumoto,
Hokkaido University Graduate School of Medicine, Japan
Raftlin is Essential for Poly(I:C) Cellular Uptake in Human Myeloid Dendritic Cells
Raftlin is Essential for Poly(I:C) Cellular Uptake in Human Myeloid Dendritic Cells
Diana Matheoud,
Université de Montréal, Canada
Dendritic Cells Acquire Antigens Through a New Mechanism of Endocytosis Involving Gap Junctions
Dendritic Cells Acquire Antigens Through a New Mechanism of Endocytosis Involving Gap Junctions
Adriana R. Mantegazza,
University of Pennsylvania School of Medicine, USA
Adaptor Protein 3 (AP-3) Regulates Processing of Phagocytosed Antigen for Presentation by MHC Class II Molecules
Adaptor Protein 3 (AP-3) Regulates Processing of Phagocytosed Antigen for Presentation by MHC Class II Molecules
Berta Bosch,
National Cancer Institute, National Institutes of Health, USA
Clustering Enhances the Quality of MHC-II-Peptide Complex-Stimulation of CD4 T Lymphocytes by Dendritic Cells
Clustering Enhances the Quality of MHC-II-Peptide Complex-Stimulation of CD4 T Lymphocytes by Dendritic Cells
Erika Darrah,
Johns Hopkins University, USA
Cleavage of Peptidyl Arginine Deiminase IV by Granzyme B Induces Discrete Structural Changes and Influences Epitope Selection
Cleavage of Peptidyl Arginine Deiminase IV by Granzyme B Induces Discrete Structural Changes and Influences Epitope Selection
Guenther Baravalle,
University of California, San Francisco, USA
MARCH1-Mediated Ubiquitination Regulates CD86 Expression in Dendritic Cells in the Steady and Inflammatory States
MARCH1-Mediated Ubiquitination Regulates CD86 Expression in Dendritic Cells in the Steady and Inflammatory States
Jessica Ma,
Genentech, USA
Ubiquitination Regulates MHC-II Transport in Antigen Presenting Cells
Ubiquitination Regulates MHC-II Transport in Antigen Presenting Cells
14:30—16:30
Workshop 2: Immune Status Response at Different Stages of Tumor Development and Progression
Kenneth Nally,
University College Cork, Ireland
Regulation of a Putative Tumor Suppressor Gene BCL-G by Pro Inflammatory Cytokines in Intestinal Epithelial Cells
Regulation of a Putative Tumor Suppressor Gene BCL-G by Pro Inflammatory Cytokines in Intestinal Epithelial Cells
Stefanie Regine Dannenmann,
University Hospital Zürich, Switzerland
Immunoregulation of Tumor-Specific T Cell Responses in Clear Cell Renal Cell Carcinoma (ccRCC)
Immunoregulation of Tumor-Specific T Cell Responses in Clear Cell Renal Cell Carcinoma (ccRCC)
Joseph Edward Qualls,
Cincinnati Children's Hospital Medical Center, USA
Tumor Infiltrating Macrophages Acquire Similar Traits Independent of Tumor Type and Location
Tumor Infiltrating Macrophages Acquire Similar Traits Independent of Tumor Type and Location
Dinesh Chandra,
Albert Einstein College of Medicine, USA
Listeria Takes Control Over MDSC in the Tumor Microenvironment and Improves Anti-Tumor Immunity
Listeria Takes Control Over MDSC in the Tumor Microenvironment and Improves Anti-Tumor Immunity
Brent A. Hanks,
Duke University Medical Center, USA
Loss of the Type III TGF-beta Receptor Tumor Suppressor during Breast Cancer Progression Generates an Immunotolerant Tumor Microenvironment
Loss of the Type III TGF-beta Receptor Tumor Suppressor during Breast Cancer Progression Generates an Immunotolerant Tumor Microenvironment
Eric R. Lutz,
Johns Hopkins University, USA
Higher Avidity Mesothelin-Specific CD8+ T Cell Repertoires are Associated with Longer Disease-Free Survival and Tumor-Trafficking in Patients Treated with a GM-CSF-Secreting Pancreatic Tumor Vaccine
Higher Avidity Mesothelin-Specific CD8+ T Cell Repertoires are Associated with Longer Disease-Free Survival and Tumor-Trafficking in Patients Treated with a GM-CSF-Secreting Pancreatic Tumor Vaccine
17:00—19:00
Mechanisms and Consequences of Antigen Presentation by Dendritic Cells
Meeting has ended...abstracts no longer viewable online.
*
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Gillian Griffiths,
Cambridge Institute for Medical Research, UK
Innate to Adaptive: How to Deliver the Lethal Hit
Innate to Adaptive: How to Deliver the Lethal Hit
Bali Pulendran,
Stanford University School of Medicine, USA
Learning Immunology from Successful Vaccines
Learning Immunology from Successful Vaccines
Anna Smed Sörensen,
Karolinska Institutet, Sweden
Short Talk: Influenza A Virus Infection of Human Primary Dendritic Cells Impairs their Ability to Cross-Present Antigen to CD8 T Cells
Short Talk: Influenza A Virus Infection of Human Primary Dendritic Cells Impairs their Ability to Cross-Present Antigen to CD8 T Cells
Gerben Bouma,
Institute of Child Health, UK
Short Talk: Cytoskeletal Remodelling Mediated by WASp in DC is Required for Formation and Function of the Immunological Synapse
Short Talk: Cytoskeletal Remodelling Mediated by WASp in DC is Required for Formation and Function of the Immunological Synapse
17:00—19:00
Adaptive Immunity against Cancer?
Meeting has ended...abstracts no longer viewable online.
Richard A. Flavell,
HHMI/Yale University School of Medicine, USA
The Role of Inflammasome in Cancer
The Role of Inflammasome in Cancer
*
Glenn Dranoff,
Novartis Institutes for BioMedical Research, USA
Mechanisms of Protective Tumor Immunity
Mechanisms of Protective Tumor Immunity
Nicholas P. Restifo,
NCI, National Institutes of Health, USA
Adoptive Transfer of “Stem Cell-Like” Anti-Tumor T Cells can Eradicate Tumors
Adoptive Transfer of “Stem Cell-Like” Anti-Tumor T Cells can Eradicate Tumors
Li Wang,
Medical College of Wisconsin, USA
Short Talk: VISTA, a Novel Ig-Superfamily Ligand that Negatively Regulates T Cell Responses
Short Talk: VISTA, a Novel Ig-Superfamily Ligand that Negatively Regulates T Cell Responses
08:00—11:15
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
Meeting has ended...abstracts no longer viewable online.
*
Virginia Pascual,
Cornell University, USA
Neutrophil-Induced pDC Activation in SLE
Neutrophil-Induced pDC Activation in SLE
Fiona M. Powrie,
University of Oxford, UK
Gut Reactions: Dendritic Cells in the Intestine in Health and Disease
Gut Reactions: Dendritic Cells in the Intestine in Health and Disease
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
Monocytes as Antigen Presenting Cells for Induction of T Cell Response to Microbes
Monocytes as Antigen Presenting Cells for Induction of T Cell Response to Microbes
Julie Magarian Blander,
Weill Cornell Medicine, Cornell University, USA
Infection and Apoptosis as a Combined Inflammatory Trigger
Infection and Apoptosis as a Combined Inflammatory Trigger
Mirjam Kool,
Erasmus MC, Netherlands
Short Talk: The Ubiquitin Modifying Enzyme A20 is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity
Short Talk: The Ubiquitin Modifying Enzyme A20 is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity
08:00—11:00
Clearance of Dying Cells
Meeting has ended...abstracts no longer viewable online.
Kodi S. Ravichandran,
University of Virginia, USA
Signaling to Engulfment: The Beginnings of a Good Apoptotic Meal
Signaling to Engulfment: The Beginnings of a Good Apoptotic Meal
*
Douglas R. Green,
St. Jude Children's Research Hospital, USA
How Caspase-8 Keeps Cells and Mice Alive
How Caspase-8 Keeps Cells and Mice Alive
Yi Feng,
University of Bristol, UK
Short Talk: Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Initiation of a “Trophic” Inflammatory Response
Short Talk: Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Initiation of a “Trophic” Inflammatory Response
17:00—19:00
Sensing Innate Signals by Dendritic Cells and Other Cells
Meeting has ended...abstracts no longer viewable online.
Matthew Collin,
Newcastle University, UK
Dendritic Cell Immunodeficiency in Humans
Dendritic Cell Immunodeficiency in Humans
Christian Münz,
University of Zurich, Switzerland
Short Talk: Macroautophagy in Antigen Processing for MHC Presentation
Short Talk: Macroautophagy in Antigen Processing for MHC Presentation
Kenya Honda,
School of Medicine, Keio University, Japan
Short Talk: Commensal Bacteria-Mediated Treg Induction
Short Talk: Commensal Bacteria-Mediated Treg Induction
Nicolas Chevrier,
Harvard University, USA
Short Talk: Systematic Discovery of Signaling Components Identifies New Branches in Mammalian Viral-Sensing Pathways
Short Talk: Systematic Discovery of Signaling Components Identifies New Branches in Mammalian Viral-Sensing Pathways
17:00—19:15
Immunosuppressive Components
Meeting has ended...abstracts no longer viewable online.
Laurence Zitvogel,
Institut Gustave Roussy, France
Unraveling the Key-Lock Paradigm of the Immunogenicity of Cell Death
Unraveling the Key-Lock Paradigm of the Immunogenicity of Cell Death
Mario P. Colombo,
Fondazione IRCCS Istituto Nazionale Tumori, Italy
Cells and Matricellular Proteins Accomplices in Tumor Development
Cells and Matricellular Proteins Accomplices in Tumor Development
Ursula Grohmann,
University of Perugia, Italy
Spotlight on IDO: Tryptophan Catabolism and Beyond
Spotlight on IDO: Tryptophan Catabolism and Beyond
John Stagg,
University of Montréal, Canada
Short Talk: Host-Derived and Tumor-Derived CD73 Promotes Immune Escape and Metastasis
Short Talk: Host-Derived and Tumor-Derived CD73 Promotes Immune Escape and Metastasis
Lionel J. Apetoh,
Centre Georges Francois Leclerc, France
Short Talk: CD39 and CD73 Expression on Th17 Cells Suppress Antitumor Immunity
Short Talk: CD39 and CD73 Expression on Th17 Cells Suppress Antitumor Immunity
08:00—11:15
Dendritic Cells in situ: Function and Biology
Meeting has ended...abstracts no longer viewable online.
*
Ira Mellman,
Genentech, Inc., USA
Maria Rescigno,
European Institute of Oncology, Italy
DCs in Intestinal Disease and in Cancer Immunotherapy
DCs in Intestinal Disease and in Cancer Immunotherapy
Bart N. Lambrecht,
VIB, Ghent University, Belgium
Airway Dendritic Cell Biology
Airway Dendritic Cell Biology
Hiroshi Ohno,
RIKEN Research Center for Allergy and Immunology, Japan
Short Talk: M Cells and Antigen Delivery to DCs in the Gut
Short Talk: M Cells and Antigen Delivery to DCs in the Gut
Shannon J. Turley,
Genentech, Inc., USA
Regulation of DC Motility by Podoplanin Activation of Clec2
Regulation of DC Motility by Podoplanin Activation of Clec2
Jun Lu,
Brigham and Women's Hospital, USA
Short Talk: Dynamic Regulation of E-Cadherin on Myeloid DC Induces Ras and Potent T Cell Activation
Short Talk: Dynamic Regulation of E-Cadherin on Myeloid DC Induces Ras and Potent T Cell Activation
08:00—11:15
Cancer Vaccines: Prophylaxy or Therapy
Meeting has ended...abstracts no longer viewable online.
Vincent G. Brichard,
GlaxoSmithKline Biologicals, Belgium
Development of the MAGE-A3 ASCI: From Tumor Specificity to Predictive Biomarkers
Development of the MAGE-A3 ASCI: From Tumor Specificity to Predictive Biomarkers
Tibor P. Keler,
Celldex Therapeutics, Inc., USA
DC Targeting in Humans
DC Targeting in Humans
Asís Palazón,
CIMA, Spain
Short Talk: Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes
Short Talk: Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes
Lotte Pyfferoen,
Ghent University, Belgium
Short Talk: Multilevel Immunomodulation in an Orthotopic Mouse Model of Lung Cancer with Emphasis on Dendritic Cells
Short Talk: Multilevel Immunomodulation in an Orthotopic Mouse Model of Lung Cancer with Emphasis on Dendritic Cells
14:30—16:30
Workshop 3: Perspectives on Breaking Tolerance in Cancer Immunotherapy
*
Laurence Zitvogel,
Institut Gustave Roussy, France
Alison Clare West,
Peter MacCallum Cancer Centre, Australia
Anti-Cancer Therapy Mediated by a Histone Deacytelase Inhibitor Engages the Immune System
Anti-Cancer Therapy Mediated by a Histone Deacytelase Inhibitor Engages the Immune System
Saskia J.A.M. Santegoets,
VU University Medical Center, Netherlands
The Induction of Autoantibodies to PSMA, PNPO and NRP2 Correlates with Clinical Outcome in Patients Treated with Prostate GVAX/Anti-CTLA-4 Immunotherapy
The Induction of Autoantibodies to PSMA, PNPO and NRP2 Correlates with Clinical Outcome in Patients Treated with Prostate GVAX/Anti-CTLA-4 Immunotherapy
Anita Stam,
VU University Medical Center, Netherlands
Increased Type-2/Th17 T Cell Rates are Associated with Favorable Clinical Outcome in Prostate Cancer Patients Treated with Prostate GVAX/anti-CTLA-4 Immunotherapy
Increased Type-2/Th17 T Cell Rates are Associated with Favorable Clinical Outcome in Prostate Cancer Patients Treated with Prostate GVAX/anti-CTLA-4 Immunotherapy
Jose A. Villadangos,
University of Melbourne, Australia
Antigen Presentation by Tumor Cells, not by DC nor GR1+CD11b+ Cells, Rapidly Impairs Adoptive Anti-Lymphoma CTL Therapy
Antigen Presentation by Tumor Cells, not by DC nor GR1+CD11b+ Cells, Rapidly Impairs Adoptive Anti-Lymphoma CTL Therapy
Rikke Sick Andersen,
University of Southern Denmark, Denmark
T-Cell Specificities of Tumor-Infiltrating Lymphocytes from Patients with Malignant Melanoma
T-Cell Specificities of Tumor-Infiltrating Lymphocytes from Patients with Malignant Melanoma
Alexandre Johannsen,
CHUV, Switzerland
Definition of Key Variables for the Induction of Optimal NY-ESO-1-Specific T Cells in HLA Transgene Mice
Definition of Key Variables for the Induction of Optimal NY-ESO-1-Specific T Cells in HLA Transgene Mice
Toby Lawrence,
INSERM, France
IkappaB Kinase (IKK)beta Activation in Macrophages Maintains Tumor-Induced Immune Tolerance
IkappaB Kinase (IKK)beta Activation in Macrophages Maintains Tumor-Induced Immune Tolerance
Monique H. M. Melis,
Netherlands Cancer Institute, Netherlands
Development of a Doxycycline-Dependent Caspase 3 Death Switch Model to Assess the Host Immune Response to Rapid and Synchronous Tumor Cell Apoptosis in vivo
Development of a Doxycycline-Dependent Caspase 3 Death Switch Model to Assess the Host Immune Response to Rapid and Synchronous Tumor Cell Apoptosis in vivo
17:00—19:00
Translating Immune Responses Toward and Into the Clinic (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Virginia Pascual,
Cornell University, USA
Gerold Schuler,
University Hospital of Erlangen, Germany
Monocyte-Derived Dendritic Cells in Cancer Immunotherapy
Monocyte-Derived Dendritic Cells in Cancer Immunotherapy
Lei Zheng,
Johns Hopkins University School of Medicine, USA
Regulatory T Cells and their Role in the Tumor Micro-Environment
Regulatory T Cells and their Role in the Tumor Micro-Environment
19:00—20:00
Closing Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Ira Mellman,
Genentech, Inc., USA
Ralph M. Steinman,
Rockefeller University, USA
In vivo Veritas in Humans
In vivo Veritas in Humans
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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Genentech, Inc. |
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Genentech, Inc. |
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org, Phone:+1 970-262-2676 |
