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This meeting took place in 2011



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Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines (T1)


Organizer(s) Cecil Czerkinsky, William Petri Jr., Yasmine Belkaid, Gagandeep Kang and Maharaj Kishan Bhan
November 7—11, 2011
Le Meridien New Delhi • New Delhi, India
Abstract Deadline: Jul 11, 2011
Late Abstract Deadline: Aug 10, 2011
Scholarship Deadline: Jul 11, 2011
Early Registration Deadline: Sep 23, 2011

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:
Malnutrition is among the most devastating health conditions worldwide, affecting one of three children in developing countries and contributing more than ten million deaths annually. The relationship between nutrition and immunity has been a topic of study for more than five decades. Seminal developments in our understanding of the organization and regulation of the immune system have indicated a close relationship between host nutritional status and systemic immunity. However, surprisingly little is known regarding the impact of nutrition on the mucosal immune system of the digestive tract, a system that functions almost independently from the systemic immune apparatus. Recent research also suggests that the composition and metabolic activity of the gut microbiota modulates intestinal barrier function and immune responsiveness (and vice-versa), and can be affected by specific nutrients or lack of these. This meeting will focus on understanding the role of nutrition in modulating gut immunity to vaccines in order to formulate strategies for improving the performance of enteric vaccines in malnourished children. The objective of this symposium is to formulate innovative hypotheses regarding specific mechanisms by which nutrients and defined microbiota affect gut immunity. A better understanding of the links between nutrients, the gut microbiome and the intestinal immune system is likely to pave the way to the development of innovative approaches that target activation of specific immunological pathways for promoting host’s gut defense. Such knowledge should impact on the development of vaccine formulations and intervention strategies for improved control of enteric infections in developing countries. The Keystone Symposia meeting on Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines will benefit from a partnership with the Bill & Melinda Gates Foundation (BMGF), whereby the 2011 business meeting of the BMGF Grand Challenges in Global Health awardees will be held in conjunction with the Keystone Symposia meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, NOVEMBER 7

12:00—16:00
Registration

Sovereign Foyer
16:30—16:35
Welcoming Remarks (Joint Session with Grand Challenges in Global Health)

Taj Palace Hotel
Chris Wilson, Bill & Melinda Gates Foundation, USA
Innovation and Partnership in India

16:35—17:20
Round Table Discussion on Family Health Research Agenda, Challenges and Funding Opportunities (Joint Session with Grand Challenges in Global Health)

Andrew C. Serazin, Bill & Melinda Gates Foundation, USA
GC Healthy Growth

Yiwu He, Bill & Melinda Gates Foundation, USA
Gut Function and Health Biomarkers

17:20—18:00
Opening Remarks (Joint Session with Grand Challenges in Global Health)

Gagandeep Kang, Christian Medical College, India
Introduction to Keystone Meeting Goals

Chris Wilson, Bill & Melinda Gates Foundation, USA
Innovation and Partnership in Family Health and Vaccine Science

Maharaj Kishan Bhan, Ministry of Science and Technology, Government of India, India
Family Health Innovation and Innovation in India, Sam Pitroda Introduction

18:00—18:30
Keynote Address (Joint Session with Grand Challenges in Global Health)
Meeting has ended...abstracts no longer viewable online.

The Taj Palace Hotel, Shahjehan Hall
18:30—19:30
Joint Reception with GCGH

Raja Bagh Lawn
19:30—21:00
Informal Informational Sessions: Grant Opportunities (Joint Session with Grand Challenges in Global Health)

B 1-2

TUESDAY, NOVEMBER 8

07:30—08:30
Breakfast

Sovereign
08:30—11:45
Epidemiology of Malnutrition
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
Cecil Czerkinsky, International Vaccine Institute, South Korea
Introductory Remarks

* Robert E. Black, Johns Hopkins University, Bloomberg School of Public Health, USA
The Global Burden of Malnutrition

Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK
Nutrition-Disease Interactions in the Developing World

Mark Manary, Medical College of Malawi, Malawi
The Role of Gut Function and Inflammation in Growth Faltering in Rural Sub-Saharan Africa

William A. Petri, Jr., University of Virginia, USA
Genetic Basis of Malnutrition

James A. Berkley, KEMRI/Wellcome Trust, Kenya
Short Talk: Severe Acute Malnutrition in Infants Less Than Six Months Old

Dilruba Nasrin, University of Maryland, USA
Short Talk: Effect of Moderate to Severe Diarrhea on Linear Growth of Children in Developing Countries

09:40—10:00
Coffee Break

Sovereign 1
09:40—10:00
Poster Setup

Sovereign 1
11:45—12:30
Lunch

Sovereign 1
12:00—15:00
Poster Session 1

Sovereign 1
14:30—15:00
Coffee Available

Sovereign 1
15:00—17:00
Intestinal Barriers
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Gail Hecht, University of Illinois at Chicago, USA

Jerrold R. Turner, University of Chicago, USA
Molecular Basis of Intestinal Barrier Function: Implications for Immune-Mediated Disease

Gunnar C. Hansson, University of Gothenburg, Sweden
Intestinal Mucus and Host-Microbial Interactions

Kim E. Barrett, University of California, San Diego, USA
Modulation of Epithelial Barrier and Transport Functions by "Good" and "Bad" Bacteria

17:00
On Own for Dinner


WEDNESDAY, NOVEMBER 9

07:30—08:30
Breakfast

Sovereign
07:30—08:30
Poster Setup

Sovereign 1
08:30—11:45
Nutrition and the Gut Microbiota
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* William A. Petri, Jr., University of Virginia, USA

G. Balakrish Nair, National Institute of Cholera and Enteric Diseases (NICED), India
The Inside Story of the Impoverished Gut

Elizabeth K. Costello, Stanford University, USA
Assembly of the Human Microbiome during the First Two Years of Life

Tanya Yatsunenko, Kaleido Biosciences, USA
Short Talk: Human Gut Microbiome in Children with Severe Malnutrition: A Comparative Metagenomic Study of Malawian Twins

Honorine D. Ward, Tufts Medical Center, USA
Short Talk: The Intestinal Microbiota of Children from Urban and Rural Sites in Pakistan

Shinji Fukuda, Keio University, Japan
Short Talk: Bifidobacteria can Protect from Enteropathogenic Infection through Production of Acetate

Ajay Kumar, Colorado State University, USA
Short Talk: Dietary Supplementation with Rice Bran Reduces Susceptibility to Salmonella enterica Typhimurium Infection in Mice via Changes in Gut Microbiota

Michelle I. Smith, Washington University, St. Louis, USA
Short Talk: Metagenomic Studies of Humanized Gnotobiotic Mice Harboring the Gut Microbiomes of Malawian Twins Discordant for Kwashiorkor

Beth D. Kirkpatrick, University of Vermont College of Medicine, USA
Short Talk: Exploration of the Biologic Basis for Underperformance of Enteric Vaccines

09:40—10:00
Coffee Break

Sovereign 1
11:45—12:30
Lunch

Sovereign 1
12:00—15:00
Poster Session 2

Sovereign 1
14:30—15:00
Coffee Available

Sovereign 1
15:00—17:00
Host-Microbial Interactions and Gut Immunity
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Gail Hecht, University of Illinois at Chicago, USA
Intestinal Epithelial Responses to Pathogens

Wendy S. Garrett, Harvard School of Public Health, USA
Interplay between the Immune System and the Gut Microbiota

17:00
On Own for Dinner


THURSDAY, NOVEMBER 10

07:30—08:30
Breakfast

Sovereign
07:30—08:30
Poster Setup

Sovereign 1
08:30—11:30
Gut Immunobiology
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Cecil Czerkinsky, International Vaccine Institute, South Korea

Per Brandtzaeg, University of Oslo, Norway
Structure and Function of the Human Intestinal Immune System

Martine Heyman, INSERM U989, France
Antigen Handling by the Gut Epithelium for Interaction with the Immune System

Odilia Wijburg, University of Melbourne, Australia
Role of Secretory IgA in Protection and Herd Immunity

Swantje Hammerschmidt, Medical School Hannover, Germany
Short Talk: Retinoic Acid as Adjuvant Induces Homing of Protective T and B Cells to the Gut After Subcutaneous Immunization in Mice

David Haym Schwartz, Hackensack University Medical Center, USA
Short Talk: Induction of Gut IgA after Peripheral Immunization by Manipulation of Vitamins A and D at Sites of Injection

Sean Spencer, University of Pennsylvania, USA
Short Talk: Gastrointestinal Eosinophils Regulate Mucosal CD4+ T Cell Responses and are Controlled by the Dietary Metabolite Retinoic Acid

09:40—10:00
Coffee Break

Sovereign 1
11:30—12:30
Lunch

Sovereign 1
12:00—15:00
Poster Session 3

Sovereign 1
14:30—15:00
Coffee Available

Sovereign 1
15:00—17:00
Nutrients, Infectious Diseases and Gut Immunity
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Pearay L. Ogra, University of Buffalo, USA

Charles B. Stephensen, US Department of Agriculture, USA
Nutrition, Infection and Immunity

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Roles of Vitamin A in Mucosal Immune Responses

Erika Isolauri, University of Turku, Finland
Modulation of Gut Immunity by Probiotics

17:00
On Own for Dinner


FRIDAY, NOVEMBER 11

07:30—08:30
Breakfast

Sovereign
08:30—11:30
Underperformance of Enteric Vaccines in Developing Countries
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Maharaj Kishan Bhan, Ministry of Science and Technology, Government of India, India
Improving the Performance of Vaccines in the Developing World

T. Jacob John, Christian Medical College, India
Improving the Performance of Enteric Vaccines in Developing Countries: Oral Polio Vaccine

Gagandeep Kang, Christian Medical College, India
Rotavirus Vaccines

Richard Walker, PATH, USA
Developing ETEC and Shigella Vaccines for Children in Developing Countries

09:40—10:00
Coffee Break

Sovereign 1
11:30—14:30
On Own for Lunch and Recreation

14:30—15:00
Coffee Available

Sovereign 1
15:00—17:00
Strategies for Improving the Immunogenicity of Enteric Vaccines
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Richard Walker, PATH, USA

Gregory M. Glenn, Novavax, USA
Transcutaneous Immunization

Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh
Supplementation with Micronutrients and Withdrawal from Breast Feeding: Effects on the Immunogenicity of Enteric Vaccines

Cecil Czerkinsky, International Vaccine Institute, South Korea
Alternative Routes of Vaccine Delivery

17:00—18:30
Social Hour with Lite Bites

Allure/Pre Function
 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI096802-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Landes Bioscience

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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