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This meeting took place in 2011


Here are the related meetings in 2015:
HIV Vaccines (X5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Protection from HIV: Targeted Intervention Strategies (X8)


Organizer(s) Mario Roederer, Carolyn Williamson and Robin Shattock
March 20—25, 2011
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 22, 2010
Late Abstract Deadline: Dec 22, 2010
Scholarship Deadline: Nov 22, 2010
Early Registration Deadline: Jan 21, 2011

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Sangamo BioSciences, Inc.


Summary of Meeting:
Biological efforts to prevent HIV infection center on four independent approaches: inducing adaptive immune responses through vaccination, augmenting innate responses, using peri-exposure prophylactic drug therapy, and developing microbicides and/or recombinant antiviral microbial products. While all four of these approaches have promise, they still require significant optimization and further clinical trials. Indeed, successful prevention of HIV infection will likely require a combination of these approaches. Such development efforts require a better understanding of viral and immunological events at the site of transmission. This Keystone Symposia meeting will have a focus on mucosal immunology as well as the interplay between the virus and innate and adaptive immune responses, particularly during the acute phase of the infection. Leading experts in the fields will discuss recent scientific advances in these varied approaches to preventing infection and present data from recent clinical trials testing their efficacy.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 20

15:00—19:30
Registration

18:15—19:15
Refreshments

19:15—20:30
Welcome and Keynote Address: Viral Transmission Dynamics (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ashley T. Haase, University of Minnesota, USA
Founder Events at the Portal of Entry in Mucosal Transmission


MONDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:00
Virus-Specific Microbicides
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robin Shattock, St. George's, University of London, UK

Peter A. Anton, David Geffen School of Medicine at UCLA, USA
Rectal Microbicides: Mucosal Lessons in Developing New Therapies

Laurel A. Lagenaur, Osel Inc., USA
“Live” Microbial Prevention Strategies

Oliver Hartley, University of Geneva, Switzerland
Targeting CCR5 in HIV Prevention

Walid Heneine, Centers for Disease Control and Prevention, USA
Prevention of SHIV Infection in Macaques by Oral and Topical Antiretroviral Prophylaxis

Nathalie Dereuddre-Bosquet, Centre des Etudes Atomique, France
Short Talk: MiniCD4 Microbicide Gel Prevents Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

08:00—11:00
Lentiviral Diversity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Emerman, Fred Hutchinson Cancer Research Center, USA

Reuben S. Harris, University of Minnesota, USA
The Endogenous Origins of HIV G-to-A Hypermutations

Aris Katzourakis, University of Oxford, UK
Endogenous Retroviruses and the Evolution of the Lentiviruses

Michael Worobey, University of Arizona, USA
The Tempo and Mode of SIV and HIV Outbreaks

Frederic Bibollet-Ruche, University of Alabama, Birmingham, USA
Short Talk: A Chimpanzee CD4 Glycosylation Site Polymorphism Governs Susceptibility to SIVcpz Infection

Will Fischer, Los Alamos National Laboratory, USA
Short Talk: Whole-Genome Deep-Sequencing of HIV-1 in the First Weeks, Months, and Years of Infection

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

11:00—12:30
Hands-On Computer Workshop on Los Alamos Sequence Database

NOTE: Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

11:00—12:30
Hands On Computer Workshop on Los Alamos Sequence Database

NOTE: Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Vaccines & Immune Responses

* Georgia Doris Tomaras, Duke University Medical Center, USA

Shan Lu, University of Massachusetts Medical Center, USA
Identification of a Subset of Primary HIV-1 Env that can Elicit Broader Neutralizing Antibody Responses by a DNA Prime – Protein Boost Vaccination Strategy

David B. Weiner, University of Pennsylvania School of Medicine, USA
Enhanced DNA Vaccine +/-Protein Boost Delivered by EP Expands B and T Cell Responses and Neutralizing Phenotype in vivo

Penny L. Moore, National Institute for Communicable Diseases, South Africa
Development of Broadly Cross-Neutralizing Antibodies is Associated with Delayed HIV Viral Escape

Matthew Johnson, National Institutes of Health, USA
Determinants of Poor Immunogenicity of Alternative Adenoviruses

Jeffrey Teigler, Beth Israel Deaconess Medical Center, USA
Cytokine Secretion Profiles of Adenovirus and Poxvirus Vaccine Vectors in Rhesus Macaques

Michael K.P. Liu, University of Oxford, UK
The Role of The First/Early T Cells In Subjects With Acute HIV-1 Infection

14:30—16:30
Workshop 1: Innate Immune Sensing of Lentiviruses

* Olivier Schwartz, Institut Pasteur, France
Innate Sensing of HIV-Infected Cells

Richard M. Dunham, University of California, San Francisco, USA
TLR-Mediated IFNalpha and IDO Production in pDC is Altered in African Green Monkeys

Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
HIV-1 Tat Mimics the Activity of Interferons in Primary Human Immature Dendritic Cells and Macrophages

Susanna Marie Bächle, Karolinska Institutet, Sweden
Evolutionary Conservation of Lentiviral Interference with CD1d-Mediated Immunity

Edward Barker, Rush University Medical Center, USA
Vpu Prevents Natural Killer Cell Destruction of HIV-Infected Cells

Mario L. Santiago, University of Colorado Denver, USA
Mechanistic Dissection of the Apobec3/Rfv3 Phenotype: Implications for Improving Retroviral Humoral Immunity

16:30—17:00
Coffee Available

17:00—19:00
Clinical Trials Update
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Myron S. Cohen, University of North Carolina at Chapel Hill, USA
Antiretroviral Therapy to Prevent HIV-1: Before and After the(F)Act(s)

Nelson L. Michael, Walter Reed Army Institute of Research, USA
Beyond RV 144: Prime Boost Approaches

Salim S. Abdool Karim, University of KwaZulu-Natal, South Africa
Update on Microbicide and Pre-exposure Prophylaxis (PrEP) Trials

17:00—19:00
Non-Pathogenic Lentiviral Infections
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA

Theodora Hatziioannou, Aaron Diamond AIDS Research Center, USA
Towards an animal model for HIV/AIDS

Cristian Apetrei, University of Pittsburgh, USA
Pathogenesis of Cross-Species-Transmitted SIV Infection

Michaela Müller-Trutwin, Institut Pasteur, France
IFN-I related Responses in Non-pathogenic Versus Pathogenic SIV/HIV Infections

Jacob D. Estes, SAIC-Frederick, Inc., USA
Short Talk: Reduced Lymphatic Tissue Immunopathology and Altered Myeloid Lineage Cell Recruitment in SIV-Infected Rhesus Macaques Receiving Anti-TNFalpha Treatment

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 22

07:00—08:00
Breakfast

08:00—11:15
Correlates of Protection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eric Hunter†, Emory University, USA

Jo-Ann S. Passmore, University of Cape Town, South Africa
Correlates of Protection against HIV Infection in the Female Genital Tract

Susan W. Barnett, Novartis Vaccines and Diagnostics, Inc., USA
Protective Vaccine-Induced Humoral Responses

Anuradha Ganesan, Anuradha Ganesan, USA
Early Immunologic and Virologic Correlates of Protection

Ravi Tandon, University of California, San Francisco, USA
Short Talk: HERV Specific T Cell Responses in Vertically HIV-1 Infected Children are Inversely Correlated with HIV-1 Plasma Viral Load

Monica Vaccari, National Cancer Institute, National Institutes of Health, USA
Short Talk: Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure

M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Cellular Immune Responses Induced by HIV Vaccines

08:00—11:00
Evolution of Pathogenicity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Cristian Apetrei, University of Pittsburgh, USA

Guido Silvestri, Emory University School of Medicine, USA
Protection of Central Memory CD4+ T Cell Homeostasis in Natural SIV Hosts

Michael Emerman, Fred Hutchinson Cancer Research Center, USA
Paleovirology and the Evolution of Primate Antiviral Defenses

Sebastian L. Bonhoeffer, ETH-Zentrum, Switzerland
Tracing Epidemiological Patterns in Sequence Data: Transmission Structure, Basic Reproductive Rate, and Heritability of Virus Load

Nichole R. Klatt, University of Washington, USA
Short Talk: Mechanisms Underlying Damage to the Mucosal Barrier and Immune Activation after Pathogenic SIV Infection of Rhesus Macaques

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

11:15—12:30
Hands On Computer Workshop on Los Los Alamos Sequence Database

NOTE: Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

11:15—12:30
Hands On Computer Workshop on Los Alamos Sequence Database

NOTE: Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Mucosal Immunology and Microbicides

* Jo-Ann S. Passmore, University of Cape Town, South Africa

Carolina Herrera, Imperial College, UK
Combinations of Maraviroc and Reverse Transcriptase Inhibitors as Potential Microbicides

Peter D. Katsikis, Drexel University College of Medicine, USA
Anti-Viral and Anti-Inflammatory Dual Acting Microbicide for HIV-1 Infection

Ramesh K. Akkina, Colorado State University, USA
Oral Pre-Exposure Prophylaxis by Anti-Retrovirals Raltegravir and Maraviroc Protects against HIV-1 Vaginal Transmission in a Humanized Mouse Model

Jean-Charles J. B. Grivel, NICHHD, National Institutes of Health, USA
Infection of Cervical Tissue Explants with Transmitted/Founder HIV-1 Viruses

Steven L. Zeichner, Children's Research Institute, Children's National Medical Center, George Washington University, USA
HIV Human Vaginal Microbicide Effects on the Vaginal Microbial Community

Natasa Strbo, School of Medicine, University of Miami, USA
Profound Mucosal CD8+ T Cell Immunity Elicited by Intraperitoneal Immunization with Secreted Heat Shock Protein gp96-Ig

16:30—17:00
Coffee Available

17:00—19:00
Viral Variation from Transmission to Populations (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Worobey, University of Arizona, USA

Andrew Leigh-Brown, University of Edinburgh, Scotland
HIV Transmission Dynamics

Carolyn Williamson, University of Cape Town, South Africa
Early Viral Evolution and Escape in Subtype C Infected Individuals with Single- and Super-Infection

Jessica L. Prince, Emory University, USA
Short Talk: The Role of Transmitted HLA Associated Gag Polymorphisms in Defining HIV-1 Set-Point Viral Load and in vitro Replicative Fitness

Brandon F. Keele, Frederick National Laboratory, USA
Modeling HIV Transmission and Early Evolution in Nonhuman Primates

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 23

07:00—08:00
Breakfast

08:00—11:15
Humoral Responses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Nancy L. Haigwood, Oregon Health & Science University, USA

Peter D. Kwong, NIAID, National Institutes of Health, USA
Prospects for Generating VRC01-like Antibodies Revealed by Crystal Structures and 454 Pyrosequencing

John R. Mascola, NIAID, National Institutes of Health, USA
Isolation and Characterization of Broadly Neutralizing Monoclonal Antibodies to HIV-1

Nancy L. Haigwood, Oregon Health & Science University, USA
Short Talk: Passive Transfer of Physiologic Levels of Neutralizing IgG Results in Profound Control of Plasma Virus in Newborn Rhesus Macaques Orally Exposed to SHIV-SF162P3 and Protects B Cells in vivo

Shannon A. Allen, Northwestern University Feinberg School of Medicine, USA
Short Talk: Neutralizing and Non-Neutralizing HIV-Specific Antibodies Hinder the Movement of Virus in Fresh Human Cervical Mucus

Lynn Morris, National Institute for Communicable Diseases, South Africa
Interplay between Autologous and Broadly Cross-Reactive Neutralizing Antibodies in HIV-1 Infection

08:00—11:00
Host Genome I: The Variable Human Genome
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Frederic D. Bushman, University of Pennsylvania, USA

David B. Goldstein, Duke University, USA
Whole Genome Sequencing and the Host Genetics of HIV-1 Acquisition and Viral Control

Manolis Emmanouil T. Dermitzakis, University of Geneva Medical School, Switzerland
Human Cellular Quantitative Genetics

Monsef Benkirane, Institut de Genetique Humaine, France
Identification of an HIV Restriction Fsctor in DCs

Amalio Telenti, Centre Hospitalier Universitaire Vaudois, Switzerland
Host and Pathogen Evolution at Genome Scale

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: HIV/Host Interactions

* Vicente Planelles, University of Utah, USA
Homeostatic Proliferation of Central Memory T Cells and the Latent HIV-1 Reservoir

Mathias Lichterfeld, Massachusetts General Hospital, USA
An Intrinsic Inhibitor of CDK9-Mediated Transcriptional Elongation of HIV-1 in CD4 T Cells from Elite Controllers

Vincent Piguet, Cardiff University, UK
Quantitative Multicolour Super-Resolution Microscopy Reveals Tetherin HIV-1 Interaction

Suzanne Willey, Kings College London, UK
Analysis of Tetherin Antagonism by HIV-1 Vpu and HIV-2 Env Alleles Isolated from Infected Individuals

Rogier W. Sanders, Weill Medical College of Cornell University, USA
HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Degradation

Nuria Izquierdo-Useros, Irsicaixa, Spain
Live Cell Imaging of Cell-Associated Viral Capture by Mature Dendritic Cells

David R. Graham, Johns Hopkins School of Medicine, USA
An Update on HIV Proteomics: Comparisons between Macrophage and T Cell Derived HIV-1

14:30—16:30
Workshop: Data Sharing: A Priority of the Enterprise 2010 Scientific Strategic Plan

* Yegor Voronin, Global HIV Vaccine Enterprise, USA

* Lynn Morris, National Institute for Communicable Diseases, South Africa

* Douglas D. Richman, University of California, San Diego, USA

16:30—17:00
Coffee Available

17:00—19:00
The Earliest Responses and Host Genetics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
Innate Recognition: NK Cells

Christian L. Boutwell, General Hospital Corporation, USA
Short Talk: Ultra-Deep Whole Genome HIV Sequencing Reveals the Impact of Viral Adaptation on Immune Control During Acute Infection

Georgia Doris Tomaras, Duke University Medical Center, USA
Analysis of the Envelope B Cell Repertoire in the Thai RV144 Efficacy Trial

Andrew J. McMichael, John Radcliffe Hospital, UK
T Cell Responses, HLA B*57 and Control of Viremia in Acute HIV-1 Infection

17:00—19:00
Host Genome II: Host Genome and Retroviral Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Amalio Telenti, Centre Hospitalier Universitaire Vaudois, Switzerland

Frederic D. Bushman, University of Pennsylvania, USA
HIV DNA Integration and RNA Splicing Studied using Deep Sequencing

Angela Ciuffi, Institute of Microbiology (IMUL-CHUV), Switzerland
Host Transcriptional Reprogramming during the HIV Life Cycle

Paul de Bakker, Brigham and Women's Hospital, USA
Unravelling the Genetic Contributions of MHC Variation to Durable Host Control of HIV-1

Nick Schopman, University of Amsterdam, Netherlands
Short Talk: Deep Sequencing of Small RNAs from HIV-1 Infected Cells Reveals Possible HIV-Encoded miRNAs

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 24

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:15
Cellular Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard A. Koup†, NIAID, National Institutes of Health, USA

Robert Paul Johnson, Harvard Medical School, New England Primate Research Center, USA
Maturation of Protective Immunity Induced by Live Attenuated SIV

Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
Correlates of Protection following Vaccination against TB

Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
Genetic Determinants of Vaccine Protection in Rhesus Monkeys

Neil Almond, National Institute Biology Standards, UK
Short Talk: Conditional Live Attenuated SIVrtTA Protects Against Heterologous SIVsmE660

Maria H. Foley, Massachusetts Institute of Technology, USA
Short Talk: Time-Lapse Video Microscopy of HIV-Specific CTL: The Effects of Cell Motility and TCR Avidity on Target Engagement and Killing

Louis J. Picker, Oregon Health & Science University, USA
Live Vectors - CMV

08:00—11:00
HIV Host Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Theodora Hatziioannou, Aaron Diamond AIDS Research Center, USA

Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Genetics of HIV Entry into the Nucleus

Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the Capsid of HIV-1 and Other Retroviruses

Li Wu, Ohio State University, USA
HIV Interactions with Dendritic Cells

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Short Talk: Reverse Transcription Facilitates HIV Uncoating

Benjamin K. Chen, Mount Sinai School of Medicine, USA
Short Talk: Neutralization Resistance of HIV-1 Virological Synapse-Mediated Infection is Regulated by Env Cytoplasmic Tail

09:00—09:20
Coffee Break

11:15—12:15
Lunch

12:15—14:30
Poster Session 4

14:30—16:30
Workshop 3: The NHP Model - Limitations and Lessons

* Brandon F. Keele, Frederick National Laboratory, USA

Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
A Protective Allo-Immune Strategy Utilising Serum and Mucosal Antibodies and APOBEC3G

Matthew R. Reynolds, University of Wisconsin-Madison, USA
Testing the Efficacy of the STEP Trial Recombinant Ad5 gag/pol/nef Vaccine Regimen in Rhesus Macaques using a Limiting Dose Heterologous SIV Challenge

Barbara K. Felber, National Cancer Institute, National Institutes of Health, USA
SIVmac239 DNA and Virus Particle Vaccination Confers Protection Upon Mucosal Challenge With Heterologous SIVsmE660

Jorge Ramos de Almeida, NIAID, National Institutes of Health, USA
CD8+ T Cell Public Clonotype Usage in a Single Epitope-Specific Response in Acute SIV Infection of Mamu-B*08 Positive Rhesus Macaques may Determine Control of Viral Replication

Philip Mudd, University of Wisconsin - Madison, USA
Reduction of CD4+ T Cells in vivo does not affect Virus Load in Macaque Elite Controllers

Pamela J. Skinner, University of Minnesota, USA
Location, Abundance, and Activation/Proliferation Status of SIV-Specific CD8 T Cells in situ in SIVdeltanef Immunized SIVmac251 Challenged Rhesus Macaques

16:30—17:00
Coffee Available

17:00—19:00
Targeting Mucosal and T Cell Immunity (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter A. Anton, David Geffen School of Medicine at UCLA, USA

Elena Martinelli, Population Council, USA
Virus-Cell Interplay and Modulation of Immune Function

James B. Whitney, Beth Israel Deaconess Medical Center, Harvard University, USA
Short Talk: Reduction of Founder/Transmitted Virus in Vaccinated Monkeys after Mucosal SIV Challenge

Robin Shattock, St. George's, University of London, UK
Combining Prevention Technologies: Vaccines and Microbicides

Mario Roederer, NIAID, National Institutes of Health, USA
Identification and Characterization of T Memory Stem Cells in Humans and NHP: Implication for Vaccine Design

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 25

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Office of AIDS Research, NIH
Sangamo BioSciences, Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI093270-01




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