Granlibakken Tahoe Floorplan

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This meeting took place in 2012



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Sirtuins in Metabolism, Aging and Disease (B2)


Organizer(s) Aleksey G. Kazantsev, Antonello Mai and Tiago Fleming Outeiro
February 12—16, 2012
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Oct 12, 2011
Late Abstract Deadline: Nov 11, 2011
Scholarship Deadline: Oct 12, 2011
Early Registration Deadline: Dec 12, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Sirtuins comprise a unique class of NAD+-dependent enzymes that modify multiple protein substrates to execute diverse biological functions. Sirtuins are key regulators of clinically important cellular and organismal processes including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in the past decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has catapulted them to a prominent status as potential targets for nutritional and therapeutic development. The Keystone Symposia meeting on Sirtuins in Metabolism, Aging and Disease will address fundamental questions on the regulation, biochemical, molecular and cellular mechanisms and pathways of sirtuins. The significance of sirtuin-dependent regulation of homeostasis with respect to diverse biological organisms will be discussed. We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 12

15:00—19:30
Registration

Pre Function
18:15—19:15
Buffet Dinner

Granhall
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Aleksey G. Kazantsev, Harvard Medical School & Massachusetts General Hospital, USA
Welcoming Remarks and Introduction

Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins Aging and Diseases


MONDAY, FEBRUARY 13

07:00—08:00
Breakfast

Granhall
08:00—11:15
Sirtuin Biology
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Tiago Fleming Outeiro, University Medizin Gottingen, Germany

J. Lawrence Marsh, University of California, Irvine, USA
Acetylation Homeostasis and Neurodegeneration: A Delicate Balance

Eric M. Verdin, University of California, San Francisco, USA
Mitochondrial Sirtuins

Mario F. Fraga, National Center for Biotechnology, Spain
Role of Sirtuin 1 in Stem Cell Differentiation

Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins

Christian Neri, Inserm, France
Short Talk: SIRT1, FOXO and their Roles in Longevity and Neurodegenerative Disease

Wenzhen Duan, Johns Hopkins University School of Medicine, USA
Short Talk: Neuroprotective Role of Sirt1 in Mammalian Models of Huntington’s Disease through Activation of Multiple Sirt1 Targets

09:20—09:40
Coffee Break

Pre Function
11:15—13:00
Poster Setup

Bay
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Sirtuin Structure and Biochemistry
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Eric M. Verdin, University of California, San Francisco, USA

John M. Denu, University of Wisconsin-Madison, USA
Chemical and Biological Functions of Sirtuins

Antti Poso, University of Eastern Finland, Finland
Identification of Substrate Mimicking Regulators for Sirtuins

Marcia C. Haigis, Harvard Medical School, USA
Control of Mitochondrial Metabolism by SIRT4

Clemens Steegborn, University of Bayreuth, Germany
Short Talk: Identification and Characterization of Sirtuin Substrates and Modulators

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Granhall
08:00—11:15
Metabolism and Aging. Session Sponsored by The Ellison Medical Foundation
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Ruth Luthi-Carter, University of Leicester, UK

David A. Sinclair, Harvard Medical School, USA
New Insights into the Roles of Sirtuins in Aging and Age-Related Diseases

Shin-ichiro Imai, Washington University School of Medicine, USA
SIRT1, the Brain, and the NAD World: The Systemic Regulatory Network for Metabolism, Aging, and Longevity in Mammals

Emma De Fabiani, University of Milan, Italy
Energy Metabolism: Transcriptional and Epigenetic Control

Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School, USA
The Histone Deacetylase SIRT6, a Critical Regulator of Glycolytic Metabolism

John E. Dominy, Dana Farber Cancer Institute, USA
Short Talk: The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses PGC-1alpha-Mediated Hepatic Gluconeogenesis

Hening Lin, Cornell University, USA
Short Talk: The Enzymatic Activity of Sirtuins Uncovers Novel Protein Posttranslational Modifications

09:20—09:40
Coffee Break

Pre Function
11:15—13:00
Poster Setup

Bay
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mechanisms

Mountain/Lake
* Aleksey G. Kazantsev, Harvard Medical School & Massachusetts General Hospital, USA

* Tiago Fleming Outeiro, University Medizin Gottingen, Germany

Danica Chen, University of California, Berkeley, USA
Stem Cell Aging and Rejuvenation: the Plasticity of Mitochondrial Homeostasis

Li Gan, Gladstone Institutes and University of California, San Francisco, USA
SIRT1 in Aging and Neurodegeneration

Daniel Kaganovich, Hebrew University of Jerusalem, Israel
The IPOD Compartment Modulates Protein Aggregation during Stress and Aging

Heather Weir, Harvard T. H. Chan School of Public Health, USA
SIRT3 Expression in Alzheimer's Disease Pathology

Anne H. H. Tseng, Academia Sinica and National Yang Ming University, Taiwan
SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Promote Mitochondrial Homeostasis

Rita Machado de Oliveira, Instituto de Medicina Molecular, Portugal
Sirt2: Crossing the Bridge between Aging and Neurodegeneration

Gizem Donmez, Tufts University School of Medicine, USA
SIRT1 Protects against a-Synuclein Aggregation by Activating Molecular Chaperones

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Sirtuins in Human Diseases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Antonello Mai, Università degli Studi di Roma La Sapienza, Italy

Vittorio Sartorelli, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA
Skeletal Muscle Specific Deletion of SirT1 Impairs the Adaptive Metabolic Response to High Fat Feeding

Stefanie Dimmeler, University of Frankfurt, Germany
SIRT1-Regulating microRNAs in Cardiovascular Disease and Aging

Lucia Altucci, Seconda Università degli Studi di Napoli, Italy
Sirtuins as Targets of Anticancer Therapeutic Strategies

Alejandro Vaquero, Bellvitge Institute for Biomedical Research, Spain
Short Talk: SIRT2 is a Tumor Suppressor that Regulates DNA Replication through the Control of H4K16Ac Levels

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour

Bay

WEDNESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Granhall
08:00—11:15
Developing Sirtuin-Based Therapies
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* John M. Denu, University of Wisconsin-Madison, USA

Manfred Jung, University of Freiburg, Germany
Targeting the NADinome: Developing Inhibitors of NAD+-Dependent Histone Deacetylases and Related Enzymes

Antonello Mai, Università degli Studi di Roma La Sapienza, Italy
Assessing Sirtuins as Drug Targets in Human Illnesses

George P. Vlasuk, Navitor Pharmaceuticals, USA
Small Molecule SIRT1 Activation: Mechanism, Pharmacology and Experimental Medicine

Yana Cen, University of Texas Medical Branch, USA
Short Talk: Transition States of ADP-ribosylation Catalyzed by Plasmodium falciparum and Archaeoglobus fulgidus Sirtuins

Jay H. Chung, NHLBI, National Institutes of Health, USA
Short Talk: Demystifying the Mechanism of Action of Resveratrol and SRT1720 in vivo

Beatriz E. Bolivar, University at Albany, SUNY, USA
Short Talk: The Unanticipated Inhibition of Human SIRT6 by the Antituberculous Drug Pyrazinamide and Analogs of Pyrazinamide

Lindsey B. Gano, University of Colorado, Anschutz Medical Campus, USA
Short Talk: SRT1720 Ameliorates Age-Related Endothelial Dysfunction: Relation to Regulators of Mitochondrial Function and Antioxidant Enzymes

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Breaking News and Future Directions
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* David A. Sinclair, Harvard Medical School, USA

Andrew G. Dillin, University of California, Berkeley, USA
Humoral Control of Mitochondrial Form and Function

Ruth Luthi-Carter, University of Leicester, UK
SIRT2 Inhibition and Cholesterol Biosynthesis

Sergiy Libert, Massachusetts Institute of Technology, USA
Short Talk: SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

Rafael de Cabo, NIA, National Institutes of Health, USA
Future Perspectives on Targeting Sirtuins for Healthy Aging and Age-Related Diseases

Haim Cohen, Faculty of Life Science, Israel
Late Breaking Short Talk: SIRT 6 Extends the Life of Male Mice

19:15—20:15
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

THURSDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG040857-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

The Ellison Medical Foundation Landes Bioscience

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Sirtris, a GSK Company


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676