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Beaver Run Resort Floorplan

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This meeting took place in 2012



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Complex Traits: Genomics and Computational Approaches (B5)


Organizer(s) Eric Schadt, Stephen H. Friend and Iya G. Khalil
February 20—25, 2012
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 20, 2011
Late Abstract Deadline: Dec 1, 2011
Scholarship Deadline: Oct 20, 2011
Early Registration Deadline: Jan 4, 2012

Supported by the Directors’ Fund

Summary of Meeting:
Complex traits are driven by constellations of genetic and environmental factors interacting in complex ways. Genetic and environmental perturbations do not directly lead to disease but, rather, impact molecular processes that underlie physiological states associated with disease. Therefore, in order to develop a complete understanding of complex traits like disease, biological systems must be queried in a comprehensive fashion in multiple dimensions. Different data dimensions like genotype, gene expression, proteomic and metabolomic offer complementary views that are useful individually and exceptionally valuable collectively. Without mastering the large-scale molecular data that underlies pathophysiological states, without sophisticated mathematical algorithms capable of data integration, and without an appropriate informatics infrastructure to apply these algorithms and translate the results into manageable bites of information that can be consumed by physicians and patients, efforts to realize the dream of personalized medicine will be difficult to achieve. Towards this end of realizing the promise of personalized medicine, the Keystone Symposia meeting on Complex Traits: Genomics and Computational Approaches will focus on three different areas: 1) methods for integrating diverse, large-scale, high-dimensional data with clinical phenotypes to construct predictive models (e.g., networks) of disease; 2) application of integrative biology approaches that combine large-scale molecular and clinical phenotype information to elucidate the underlying causes of disease and to prioritize drug targets and biomarkers; and 3) technological advances that will drive a dramatic explosion in data that will enable better models of disease and solutions to address the problem of how to enable others to share big data, interact with complex models and refine those models to improve our understanding of disease and associated biological processes.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 20

15:00—19:30
Registration

18:15—19:15
Refreshments

19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen H. Friend, Sage Bionetworks, USA

* Iya G. Khalil, GNS Healthcare, USA

Leroy E. Hood, Institute for Systems Biology, USA
Systems Approaches to Complex Diseases and the Emergence of Proactive P4 Medicine


TUESDAY, FEBRUARY 21

07:00—08:00
Breakfast

08:00—11:00
The Genetics of Complex Human Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Johan Lars Markus Björkegren, Karolinska Institutet, Sweden

Mark I. McCarthy, Churchill Hospital, UK
Diamonds in the Dirt: Defining the Genetic Basis of T2D Susceptibility through Large-Scale Sequencing Studies

Elizabeth K. Speliotes, University of Michigan, USA
Genetic Studies of Obesity and Nonalcoholic Fatty Liver Disease

Sekar Kathiresan, Massachusetts General Hospital, USA
A Mendelian Randomization Study for Plasma High-Density Lipoprotein Cholesterol and Risk for Myocardial Infarction

Manolis Kellis, Massachusetts Institute of Technology, USA
Thousands of Regulatory Variants Contribute to Complex Disease in Alzheimer's and Type 1 Diabetes

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

11:00—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

14:30—16:30
Workshop: Health Disparities. Supported by Novartis Institutes for BioMedical Research

Joshua M. Akey, University of Washington, USA
Personal and Population Genomics of Protein-Coding and Regulatory Variation in Humans

* M. Eileen Dolan, University of Chicago, USA
Pharmacogenomics of Anticancer Agents in Different World Populations

Elad Ziv, University of California, San Francisco, USA
Leveraging Genetic Ancestry to Map Complex Traits: Applications to Cancer Susceptibility

16:30—17:00
Coffee Available

17:00—19:00
Network and Pathway-Based Genome-Wide Association Studies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen H. Friend, Sage Bionetworks, USA

Barbara E. Stranger, Harvard Medical School/Brigham and Women's Hospital, USA
Cis-Regulatory Regions Influencing Immune-Mediated Disease Are a Target of Recent Positive Selection in Humans

Judy Zhong, New York University Medical School, USA
Networks of Expression Associated SNPs in Liver and Adipose

Andrew G. Clark, Cornell University, USA
Attributes of Metabolic Regulatory Networks Inferred from Natural Polymorphisms in a Reference Panel of Lines of Drosophila melanogaster

Sarah A. Pendergrass, Pennsylvania State University, USA
Short Talk: A Phenome-Wide Exploration of Genotype-Phenotype Associations and Pleiotropy Using MetaboChip in the PAGE Study

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


WEDNESDAY, FEBRUARY 22

07:00—08:00
Breakfast

08:00—11:00
Integrative Genomics Methods for Elucidating the Complexity of Living Systems
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Iya G. Khalil, GNS Healthcare, USA

Atul J. Butte, Stanford University, USA
Integrating Genome-Wide and Environmental-Wide Association Studies for Data-Driven Personalized Medicine

Eric Schadt, Mount Sinai School of Medicine, USA
Reverse Engineering Biological Systems to Construct Disease Networks

Leonid Kruglyak, Princeton University, USA
Genetic Dissection of Complex Traits in Simple Model Organisms

Dana Pe'er, Columbia University, USA
On the Road to Personalized Therapy, a Systems Approach

Jennifer Listgarten, Microsoft Research, USA
Short Talk: FaST Linear Mixed Models for Genome-Wide Association Studies

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

11:00—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
Applications of Integrative Genomics Strategies to Match Patients to Treatments of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen H. Friend, Sage Bionetworks, USA

Joseph Lehár, Novartis Institutes for BioMedical Research, USA
Approaching Selective Cancer Therapy via a Genomic, Phenotypic and Combination Campaign

Andrea Califano, Columbia University, USA
Using Predictive Regulatory Models to Identify Genes That Integrate the Aberrant Signal Spectrum of a Cancer Subtype

Euan A. Ashley, Stanford University, USA
Genome Interpretation to Identify Actionable Events That Will Impact Disease Diagnosis and Treatment Strategy

Laura Saba, University of Colorado Denver, USA
Short Talk: A “Modular” Approach to Elucidating Genetic Susceptibility to Ventricular Malfunction

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


THURSDAY, FEBRUARY 23

07:00—08:00
Breakfast

08:00—11:40
Technological Innovation Driving More Highly Accurate Models of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Johan Lars Markus Björkegren, Karolinska Institutet, Sweden

Stephen W. Turner, Pacific Biosciences, USA
Single-Molecule Real-Time Biology

Garry P. Nolan, Stanford University, USA
Mass Flow Cytometry to Construct Cellular Networks That Predict Disease Outcome

Jeff Hammerbacher, Cloudera Inc., USA
Experiences Evolving an Analytical Platform, with Applications to Health Care and the Life Sciences

Joel Dudley, NuMedii/Stanford University, USA
Systems Based Approaches for Connecting Therapeutic Mechanisms to the Molecular Pathophysiology of Disease

Maya M. Kasowski, Yale University, USA
Short Talk: Variation in Transcription Factor Binding Among Humans

Trey Ideker, University of California, San Diego, USA
From Networks to Predicting Response to Cancer Treatments

09:20—09:40
Coffee Break

11:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Data Sharing, Representing Models of Disease and Enabling Communities of Researchers to Interact
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Iya G. Khalil, GNS Healthcare, USA

Stephen H. Friend, Sage Bionetworks, USA
Use of Bionetworks to Build Maps of Diseases - Moving Beyond the Linear

Jason Bobe, PersonalGenomes.org, USA
Open Consent Framework for Public Genomics

Vicki L. Seyfert-Margolis, Food and Drug Administration, USA
Facilitating Data Sharing to Enhance Drug Effectiveness and Safety

Joel P. Wagner, Massachusetts Institute of Technology, USA
Short Talk: Network Simulation versus Network Inference: Contrasting ‘Omics Modeling Approaches

19:00—20:00
Social Hour w/ Lite Bites


FRIDAY, FEBRUARY 24

07:00—08:00
Breakfast

08:00—11:00
Reconstructing Biological Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Alexis Battle, Stanford University, USA
Using Prior Knowledge to Unravel the Genetic Factors Underlying Complex Traits

Iya G. Khalil, GNS Healthcare, USA
Constructing Ensembles of Networks to Predict Disease Phenotype

Jun Zhu, Mount Sinai School of Medicine, USA
An Integrative Bayesian Network Approach to Construct Disease Models

Marylyn D. Ritchie, Pennsylvania State University, USA
Meta-Dimensional Analysis of Phenotypes to Dissect the Architecture of Complex Traits

Jonathan R. Karr, Stanford University, USA
Short Talk: A Whole Cell Model of Mycoplasma genitalium Elucidates Mechanisms of Bacterial Growth and Replication

09:00—09:20
Coffee Break

11:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Application of Predictive Gene Networks to Identify the Drivers of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eric Schadt, Mount Sinai School of Medicine, USA

Johan Lars Markus Björkegren, Karolinska Institutet, Sweden
Construction and Mining of Cross-Tissue and Tissue Networks in Coronary Artery Disease

Alan D. Attie, University of Wisconsin-Madison, USA
Genetic Deconstruction of Type 2 Diabetes

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


SATURDAY, FEBRUARY 25

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


Pacific Biosciences


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger A.G. - Human Heredity

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676