Resort at Squaw Creek Floorplan

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This meeting took place in 2012



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The Life of a Stem Cell: From Birth to Death (C3)


Organizer(s) Margaret A. Goodell, Ruth Lehmann and Thomas A. Rando
March 11—16, 2012
Resort at Squaw Creek • Olympic Valley, California USA
Abstract Deadline: Nov 9, 2011
Late Abstract Deadline: Dec 13, 2011
Scholarship Deadline: Nov 9, 2011
Early Registration Deadline: Jan 11, 2012

Supported by Stanford University via a California Institute for Regenerative Medicine (CIRM) Conference Grant

Summary of Meeting:
Stem cell studies have demonstrated unexpected plasticity of cellular differentiation programs and challenged the long-standing paradigm of progressive irreversibility of cell fate during development. The field of stem cell biology interfaces with many areas of basic biology including developmental biology, tissue growth and homeostasis, regeneration, cancer and aging. Unlike most meetings on stem cells, the Keystone Symposia meeting on The Life of a Stem Cell: From Birth to Death focuses on stem cells within the context of the organism. Stem cell systems are discussed with respect to the life cycle of whole organisms: gametogenesis and embryogenesis, where tissue types are established; maturity, where organ systems are maintained in homeostasis; and aging, where stem cells systems change physiologically or because of disease. Speakers have been chosen to broadly reflect lessons learned from a variety of model organisms, experimental approaches and organ systems.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 11

15:00—19:30
Registration

Lobby
18:15—19:15
Refreshments

Sierra Prefunction
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt Signaling, Lgr5 Stem Cells and Cancer


MONDAY, MARCH 12

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Embryo-Derived Stem and Progenitor Cells. Session Sponsored by Development
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Ruth Lehmann, New York University School of Medicine, USA

Claudio D. Stern, University College London, UK
Cell Diversity and Potential in Early Embryos and Stem Cells

Austin Smith, University of Cambridge, UK
Design Principles of Pluripotent Stem Cells

James A. Thomson, Morgridge Institute for Research, University of Wisconsin, USA
Phosphorylation of Pluripotency Factors in Human Pluripotent Stem Cells

Azim Surani, University of Cambridge, UK
Principles and Epigenetic Programming of the Mammalian Germ Line

Lilach Gilboa, Weizmann Institute of Science, Israel
Short Talk: Coordination of Niche and Germ Line Stem Cell Establishment through Broad Complex

Paul Gadue, Children's Hospital of Philadelphia, USA
Short Talk: Generation of Multipotent Endodermal Stem Cells from Human ES Cells and iPS Cells

09:20—09:40
Coffee Break

Sierra Prefunction
11:15—13:00
Poster Setup

Alpine Ballroom
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop: Reprogramming

Grand Sierra Ballroom
* Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA

Ian Chambers, University of Edinburgh, UK
The Origin and Functional Significance of Transcription Factor Heterogeneity in ES Cells

Daniel J. Paull, New York Stem Cell Foundation, USA
Reprogramming Somatic Cells to a Pluripotent State through the Use of Human Oocytes

Xiaoxiao Zhang, Harvard University, USA
beta-Catenin Substitutes Core Pluripotency Factors in Transcriptional Complexes Maintaining Mouse Embryonic Stem Cells

Shannon Buckley, University of Nebraska Medical Center, USA
Regulation of Pluripotency and Embryonic Stem Cell Differentiation by the Ubiquitin-Proteasome System

Thomas Vierbuchen, Stanford Medical School, USA
Integrative Genomic Analysis of Fibroblast to Neuron Conversion: Insights into the Mechanism of Lineage Reprogramming

Hye-Ju Eun, Gyeongsang National University, South Korea
Nuclear Reprogramming Induced by Activation-Induced Cytidine Deaminase

Peter Wernet, Institute for Transplantation Diagnostics and Cell Therapeutics, Germany
Epigenetic Reprogramming of the Differentiation Potential of Unrestricted Somatic Stem Cells (USSC) from Human Cord Blood

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:15
Germline Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Margaret A. Goodell, Baylor College of Medicine, USA

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
The Strange Phenomenon of Pluripotentiality: Embryonic Stem Cells, Germ Cells, and Genomic Conflicts

Ruth Lehmann, New York University School of Medicine, USA
Silencing the Germline

Shosei Yoshida, National Institute for Basic Biology, Japan
Behavior and Niche Regulation of Mouse Sperm Stem Cells

Horacio M. Frydman, Boston University, USA
Short Talk: Manipulation of Birth and Death of the Germline by an Intracellular Bacterium

Miho Asaoka, National Institute of Genetics, Japan
Short Talk: A Transient Niche for the Maintenance of Undifferentiated State of Germline-Stem-Cell Precursors in Drosophila Ovary

Erika A. Bach, New York University School of Medicine, USA
Poster Teaser: Hedgehog Regulates Self-Renewal and Niche Competition in the Drosophila Testis

You-Ying Chau, MRC Human Genetics Unit, UK
Poster Teaser: Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator, Wt1

Joe V. Chakkalakal, Massachusetts General Hospital, Harvard University, USA
Poster Teaser: Label Retention Character Specifies and Maintains Adult Skeletal Muscle Stem Cell Function

Robert W. Brooks, State University of New York Upstate Medical University, USA
Poster Teaser: The Stem Cell Specific SHIP Isoform, s-SHIP, is Required for Niche Retention and Control of Stem Cell Numbers in vivo

Tom H. Cheung, Stanford University School of Medicine, USA
Poster Teaser: Maintenance of Muscle Stem Cell Quiescence by MicroRNA-489

19:15—20:15
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 1

Alpine Ballroom

TUESDAY, MARCH 13

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Adult Stem and Progenitor Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Thomas A. Rando, Stanford University School of Medicine, USA

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Pathways Regulating Blood Stem Cell Self-Renewal and Engraftment

Anne Brunet, Stanford University, USA
Regulation of Neural Stem Cells by FoxO3

Fiona Doetsch, Columbia University, USA
Stem Cells and Their Niche in the Adult Mammalian Brain

Iannis Aifantis, New York University School of Medicine, USA
In vivo Mapping of Notch Pathway Expression and Activity in Adult Stem Cell Differentiation

Christa Muller-Sieburg, Sanford-Burnham Medical Research Institute, USA
Short Talk: The Life of a Hematopoietic Stem Cell

Shukry James Habib, HHMI/Stanford University, USA
Short Talk: Can External Cues Induce Asymmetric Division of Stem Cells?

09:20—09:40
Coffee Break

Sierra Prefunction
11:15—13:00
Poster Setup

Alpine Ballroom
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:15
Stem Cell and Niche Interactions
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Leonard I. Zon, HHMI/Boston Children's Hospital, USA

Benjamin Ohlstein, Columbia University Medical Center, USA
Precise Regulation of Stem Cell Number in the Drosophila Adult Midgut

Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Asymmetric Chromosome Segregation during Stem Cell Division in Drosophila Male Germline

Thomas A. Rando, Stanford University School of Medicine, USA
Rejuvenation of Aged Stem Cells

Valentina Greco, Yale School of Medicine, USA
Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle

Maneesha S. Inamdar, Jawaharlal Nehru Centre for Advanced Scientific Research, India
Poster Teaser: OCIA Domain Proteins Maintain Embryonic Stem Cell Pluripotency and the Hematopoietic Niche

Laura I. Hudish, University of Colorado Denver, USA
Poster Teaser: Regulation of Neural Precursor Division: Potential Intersection of Polarity and miRNAs

Kateryna Kyrylkova, Oregon State University, USA
Poster Teaser: Transcription Regulatory Protein BCL11B Regulates Asymmetric Development of Labial and Lingual Stem Cell Niches in the Mouse Incisor

Lingyu Li, Hospital for Sick Children, Canada
Poster Teaser: Identification of Ectodermal Cells during Early Mouse Embryonic Development and EpiSC Differentiation

Melissa Popowski, University of Texas at Austin, USA
Poster Teaser: Loss of the Transcription Factor Bright can Induce Pluripotency in Mouse Embryonic Fibroblasts

Micha Nethe, University of Virginia, USA
Poster Teaser: A 3D in vitro Study of the Human Mammary Gland

19:15—20:15
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 2

Alpine Ballroom

WEDNESDAY, MARCH 14

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Tissue Regeneration
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* M. Celeste Simon, University of Pennsylvania, USA

Peter W. Reddien, Whitehead Institute, USA
The Cellular and Molecular Basis for Planarian Regeneration

Fernando D. Camargo, Boston Children's Hospital, USA
Hippo Signaling in Somatic Stem Cells

Timm Schroeder, ETH Zürich, Switzerland
Long-Term Quantification of Transcription Factor Protein Levels in Living Stem Cells

Yoshiki Sasai, RIKEN Center for Developmental Biology, Japan
Self-Organization of Neural Patterns and Structures in 3D Culture of ES Cells

Janel Kopp, University of British Columbia, Canada
Short Talk: Multipotency of Pancreatic Ductal Cells is Associated with Expression of the Imprinted Gene Network

Jean-Yves M. Metais, NHLBI, National Institutes of Health, USA
Short Talk: In Vivo Clonal Tracking of Multi-Color Hematopoietic Stem and Progenitor Cells During Murine Bone Marrow Regeneration

09:20—09:40
Coffee Break

Sierra Prefunction
11:15—13:00
Poster Setup

Alpine Ballroom
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:15
Energy Utilization in Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Anne Brunet, Stanford University, USA

M. Celeste Simon, University of Pennsylvania, USA
The Role of Oxygen Availability in Embryonic Development and Stem Cell Function

Toshio Suda, Keio University, Japan
Hematopoietic Stem Cell Metabolism

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Adipose Stem Cells: Give Me a Pill and Not a Treadmill

Alana M. O'Reilly, Fox Chase Cancer Center, USA
Short Talk: Nutritional Changes Stimulate Hedgehog Release to Promote Follicle Stem Cell Proliferation

Julie B. Sneddon, Harvard University, USA
Poster Teaser: Renewal of ES-Derived Progenitors in vitro by Mesenchyme

Alexis Tapanes-Castillo, St. Thomas University, USA
Poster Teaser: Characterization of Putative Stem and Neural Progenitor Cell Populations from Adult Zebrafish Brainstem Tissue

G. Grant Welstead, Editas Medicine, USA
Poster Teaser: The H3K27me3 Demethylase Utx is Required for ES Cell Differentiation and Embryogenesis

Gozde Yucel, Stanford University, USA
Poster Teaser: The Role of Voltage-Gated Calcium Channels in Controlling Stem Cells in Non-Excitable Tissues

Margarida A. Santos, NCI, National Institutes of Health, USA
Poster Teaser: Regulation of Hematopoietic Stem Cell Aging by the MLL3/4 Histone Methyltransferase Complex

Cong Xu, Harvard Medical School, USA
Poster Teaser: Examining Skeletal Muscle Development in Zebrafish Blastomere Cell Culture using High-Throughput Image-Based Chemical Screening

19:15—20:15
Social Hour with Lite Bites

Alpine Ballroom
19:30—22:00
Poster Session 3

Alpine Ballroom

THURSDAY, MARCH 15

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Epigenetic Regulation of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
DNA Methylation Dynamics in Development

Margaret A. Goodell, Baylor College of Medicine, USA
Epigenetic Regulation of Hematopoietic Stem Cells

Steven E. Artandi, Stanford University, USA
Telomerase in Stem Cell Proliferation and Self-Renewal

Joanna Wysocka, Stanford University School of Medicine, USA
Making a Face: What Stem Cell Epigenomics can Teach Us about Human Development

Dona C. Love, National Institutes of Health, USA
Short Talk: O-GlcNAc Cycling Links Nutrient Flux to the Epigenetic Machinery

David Sassoon, Hopital Pitié Salpêtrière, Paris VI, France
Short Talk: Epigenetic Changes during Stem Cell Mobilization: A New Model for in vivo Analyses

09:20—09:40
Coffee Break

Sierra Prefunction
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Reprogramming and Pluripotency
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom
* Joanna Wysocka, Stanford University School of Medicine, USA

Robert H. Blelloch, University of California, San Francisco, USA
miRNA Regulation of Pluripotency

Konrad Hochedlinger, Massachusetts General Hospital, USA
Mechanisms of Cellular Reprogramming

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Dopamine Neurons from iPS Cells

Qiaoran Xi, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: A Poised Chromatin Platform for TGF-beta Access to Master Regulator

19:00—20:00
Social Hour with Lite Bites

Alpine Ballroom
20:00—23:00
Entertainment

Alpine Ballroom

FRIDAY, MARCH 16

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:


Stanford University via a California Institute for Regenerative Medicine (CIRM) Conference Grant

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Addgene Chroma Technology Corporation
Development, The Company of Biologists Ltd Labome
March of Dimes Foundation The Company of Biologists Ltd

ViaCyte, Inc.

 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD071676-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676