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This meeting took place in 2012



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Fungal Pathogens: From Basic Biology to Drug Discovery (J2)


Organizer(s) Joseph Heitman, John Taylor and Leah E. Cowen
January 15—20, 2012
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Sep 19, 2011
Late Abstract Deadline: Oct 19, 2011
Scholarship Deadline: Sep 19, 2011
Early Registration Deadline: Nov 15, 2011

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation.


Summary of Meeting:
The aim of this meeting is to bring together the academic, medical and pharmaceutical communities focused on fungal microbial pathogens of humans and other animals to illustrate common themes, and therapeutic, diagnostic and preventive opportunities. We seek to bridge both basic and physician-scientists working on the pathogenic microbe (via genetics, cell biology, genomics) and the host (immunology, including both innate and adaptive immunity). With respect to therapeutics, the emphasis is on developed as well as novel therapeutics, including both drugs and vaccines. A key aspect is to bridge the communities working on the diversity of fungi that infect humans and those working on the chytrid outbreak causing amphibian decline and extinctions. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Drug Discovery for Protozoan Parasites, which will share the keynote address and two plenary sessions with this meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 15

15:00—19:30
Registration

Sweeney Ballroom Foyer
18:15—19:15
Refreshments

Sweeney Ballroom F
19:15—19:30
Welcoming Remarks (Joint)

Sweeney Ballroom A-E
Norman C. Waters, United States Military Academy, USA

Frederick S. Buckner, University of Washington, USA

* Vicky M. Avery, Griffith University, Australia

Joseph Heitman, Duke University, USA

John Taylor, University of California, Berkeley, USA

Leah E. Cowen, University of Toronto, Canada

19:30—21:00
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Norman C. Waters, United States Military Academy, USA

Dennis E. Kyle, University of South Florida, USA
Managing Risk and Exploiting Success in Antiprotozoan Drug Development

* John Taylor, University of California, Berkeley, USA

Arturo Casadevall, Albert Einstein College of Medicine, USA
On Fungal Virulence


MONDAY, JANUARY 16

07:00—08:00
Breakfast

Sweeney Ballroom F
07:30—08:00
Poster Setup

Sweeney Ballroom F
08:00—17:00
Poster Viewing

Sweeney Ballroom F
08:00—11:15
Mechanisms of Virulence
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Arturo Casadevall, Albert Einstein College of Medicine, USA

Robin C. May, University of Birmingham, UK
Fungus-Phagocyte Interactions: Understanding Fungal Virulence in vitro, in vivo and in Fish-o

Kirsten Nielsen, University of Minnesota, USA
Short Talk: Cryptococcal Titan Cell Formation Affects Interactions with the Host and Subsequent Pathogenesis

William E. Goldman, University of North Carolina at Chapel Hill, USA
Intracellular Survival Strategies of Histoplasma capsulatum

Nuri Rodriguez Del Val, University of Puerto Rico, USA
An RNAi and Yeast Two-Hybrid Study of Calcium/Calmodulin Kinase1 and its Relationship to Thermotolerance and HSP90 in Sporothrix schencki

Melanie T. Cushion, University of Cincinnati College of Medicine, USA
Stealth and Opportunism: Strategies for Survival of Pneumocystis within the Mammalian Lung

Robert A. Cramer, Montana State University, USA
Short Talk: Defining the Hypoxia Response of Aspergillus fumigatus: Implications for Fungal Pathogenesis and Antifungal Drugs

08:00—11:15
Drug Resistance I
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Pradipsinh K. Rathod, University of Washington, USA

Philip J. Rosenthal, University of California, San Francisco, USA
Selection for Decreased Sensitivity to Artemisinin Partner Drugs

Qin Cheng, Australian Army Malaria Institute, Australia
Artemisinin Induced Dormancy and Resistance in Plasmodium falciparum in vitro

David A. Fidock, Columbia University Medical Center, USA
Balancing Drug Resistance and Fitness via Compensatory Mutations in the Plasmodium falciparum Chloroquine Resistance Transporter

Rentala Madhubala, Jawaharlal Nehru University, India
A Comparative Proteomics Approach to Understand the Mode of Action and Mechanism of Drug Resistance in Leishmania donovani

Leann M. Tilley, University of Melbourne, Australia
Short Talk: Potent Artemisinin Activity against Plasmodium falciparum Requires Hemoglobin Uptake and Digestion

Dylan R. Pillai, University of Calgary, Canada
Short Talk: Reversing Antimalarial Resistance by Targeting Plasmodium falciparum Heat Shock Protein (PfHsp)90

09:20—09:40
Coffee Break

Sweeney Ballroom F
11:15—12:00
Lunch

Sweeney Ballroom F
12:00—14:30
Poster Session 1

Sweeney Ballroom F
14:30—16:30
Workshop 1: NIH Funding Opportunities (Joint)

Sweeney Ballroom C-E
16:30—17:00
Coffee Available

Sweeney Ballroom F
17:00—19:00
Host Responses to Fungal Pathogens
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Annika E. Scheynius, Karolinska Institutet, Sweden

Aimee K. Zaas, Duke University Medical Center, USA
Host Gene Expression Response to Fungal Infection

Gordon D. Brown, University of Aberdeen, UK
Immunity to Fungal Infections, Innate and Adaptive?

Paul L. Fidel, Jr., Louisiana State University Health Science Center, USA
Host Defense Against Mucosal Candida Infections: Opportunities for New Immunotherapeutics

Kimberly Gerik, Washington University School of Medicine, USA
Short Talk: Chitinases – Pathogen Signaling and Host Response to C. neoformans

17:00—19:15
Drug Target Identification, Validation and Screening
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Don L. Gardiner, Queensland Institute of Medical Research, Australia

Geoffrey Ian McFadden, University of Melbourne, Australia
Life Cycle Studies to Identify When and Where Malaria Parasites are Vulnerable

Emily Derbyshire, Duke University, USA
Efforts to Target and Disrupt Liver Stage Development of the Malarial Parasite

William A. Petri, Jr., University of Virginia, USA
Transmembrane Kinases of Entamoeba histolytica

Norman C. Waters, United States Military Academy, USA
Short Talk: Targeting the Cell Cycle Machinery of Plasmodium falciparum

Audrey R. Odom, Washington University School of Medicine, USA
Short Talk: Targeting Methylerythritol Cytidyltransferase (IspD) for Antimalarial Drug Discovery

19:00
On Own for Dinner


TUESDAY, JANUARY 17

07:00—08:00
Breakfast

Sweeney Ballroom F
08:00—11:30
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Meg Phillips, University of Texas Southwestern Medical Center, USA

* Audrey R. Odom, Washington University School of Medicine, USA

Leah E. Cowen, University of Toronto, Canada
New Therapeutic Strategies for Fungal Disease Based on Combinatorial Control

Dickon Alley, Anacor Pharmaceuticals, Inc., USA
Boron-based Agents for Fungal and Protozoan Infections

Xuewen Pan, Baylor College of Medicine, USA
Short Talk: Novel Functional Genomics Approaches for Drug Target Identification and Validation

Frederick S. Buckner, University of Washington, USA
Sterol 14-Demethylase Inhibitors for Chagas Disease

Andrew P. Waters, University of Glasgow, UK
Commitment to sexual development – towards an understanding of a molecular mechanism.

Dominic Hoepfner, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Cladosporin, a Natural Product with Antifungal and Antimalarial Activity Targets lysyl-tRNA Synthetase

Doron C. Greenbaum, University of Pennsylvania, USA
Short Talk: Small Molecule Mimics of Antimicrobial Peptides as Antimalarials

09:20—09:40
Coffee Break

Sweeney Ballroom F
11:30—13:00
Poster Setup

Sweeney Ballroom F
11:30
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney Ballroom F
14:30—16:30
Workshop 2: Publishing (Joint)

Sweeney Ballroom A-E
Lakshmi Goyal, Cell Press, USA

Arturo Casadevall, Albert Einstein College of Medicine, USA

Aaron P. Mitchell, Carnegie Mellon University, USA

Meg Phillips, University of Texas Southwestern Medical Center, USA

Kevin J. Saliba, Australian National University, Australia

Joseph Heitman, Duke University, USA

Alexander D. Johnson, University of California, San Francisco, USA

Tamara L. Doering, Washington University Medical School, USA

Judith G. Berman, University of Minnesota, USA

Tom Edlind, Drexel University College of Medicine, USA

Leah E. Cowen, University of Toronto, Canada

16:30—17:00
Coffee Available

Sweeney Ballroom F
17:00—19:00
Evolution and Comparative Genomics of Fungal Pathogens
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Charles W. Saunders, Procter & Gamble Co., USA

Jim Kronstad, University of British Columbia, Canada
Pathogenic Basidiomycetes: Metabolic Adaptation and Virulence Factor Expression

Emily Troemel, University of California, San Diego, USA
Non-lytic Escape of Microsporidia from C. elegans Intestinal Cells

Axel A. Brakhage, Friedrich Schiller University Jena, Germany
Dermatophyte Genomics and Secondary Metabolites Involved in Fungal Pathogenicity

Annika E. Scheynius, Karolinska Institutet, Sweden
Short Talk: The Basidiomycete Malassezia Species Complex – A Genomic Platform to Elucidate Host-Fungal Interactions Involved in Common Skin Disorders

17:00—19:15
Hit to Lead Identification
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Paul G. Wyatt, University of Dundee, UK

Michael Riscoe, Oregon Health & Science University, USA
Revisiting Historical Leads for Clues to the Design of Future Antimalarial Drugs.

Bakela Nare, SCYNEXIS, Inc., USA
Development of Oxaborole Compounds for Human African Trypanosomiasis

Richard Glynne, Genomics Institute of the Novartis Research Foundation, USA
High-Throughput Whole-Cell Screening against Trypanosomatids

Richard W. Heidebrecht, Jr., Broad Institute, USA
Short Talk: Identification of a Novel Lead for the Treatment of Malaria via Diversity Oriented Synthesis

Mark E. Drew, Ohio State University College of Medicine, USA
Short Talk: Potent Antiprotozoal Activity of a Novel Semi-Synthetic Berberine Derivative

19:00—20:00
Social Hour with Lite Bites

Sweeney Ballroom F
19:30—22:00
Poster Session 2

Sweeney Ballroom F

WEDNESDAY, JANUARY 18

07:00—08:00
Breakfast

Sweeney Ballroom F
08:00—11:15
Cell Circuitry and Adaptive Responses
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
Alexander D. Johnson, University of California, San Francisco, USA
Evolution of Gene Regulation in Fungi

Aaron P. Mitchell, Carnegie Mellon University, USA
Portrait of Candida albicans Adherence Regulators

Hiten D. Madhani, University of California, San Francisco, USA
Using a Gene Deletion Collection to Understand how Cryptococcus neoformans Causes Disease and Responds to Chemicals

Maurizio Del Poeta, Medical University of South Carolina, USA
Short Talk: Identification of New Compounds Targeting the Fungal Sphingolipid Pathway

* Tamara L. Doering, Washington University Medical School, USA
Short Talk: Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans

Anita Sil, University of California, San Francisco, USA
Regulation of Histoplasma Cell Shape and Virulence by Temperature

08:00—11:00
Pre-Clinical Development
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Thierry T. Diagana, Novartis Institute for Tropical Diseases, Singapore

Susan A. Charman, Monash University, Australia
Genesis of OZ439: From Preclinical Studies to Clinical Trials

Julio A. Urbina, Venezuelan Institute for Science Research, USA
Ergosterol Biosynthesis Inhibitors for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials

Michael Zhuo Wang, University of Kansas, USA
Evaluation of Novel Anti-Trypanosomal Benzofuran Derivatives: Pharmacokinetics, Toxicity, and Efficacy

Rosa M. Andrade, University of California, San Diego, USA
Short Talk: A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal

Maria Jose Lafuente, GlaxoSmithKline, Spain
Short Talk: Open Source to Drug Discovery for Malaria: Sharing TCAMS

09:20—09:40
Coffee Break

Sweeney Ballroom F
11:15—12:15
Workshop 3: Fungal Genome Databases

Sweeney Ballroom C-E
* Jason E. Stajich, University of California, Riverside, USA

11:15—13:00
Poster Setup

Sweeney Ballroom F
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney Ballroom F
16:30—17:00
Coffee Available

Sweeney Ballroom F
17:00—19:00
Population Genetics and Genomics of Fungal Pathogens
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Fred S. Dietrich, Duke University, USA

Matthew C. Fisher, Imperial College, London, UK
Why Fungi Cause Species Extinctions: Evolutionary Insights from Population Genetics and Genomics

Timothy Y. James, University of Michigan, USA
Pathogen Recombination during the Amphibian Chytridiomycosis Pandemic - Why Change What's Working?

Geraldine Butler, University College Dublin, Ireland
Beyond the Candida albicans Paradigm: Evolution of the Hypoxic Response in Fungal Species

Guilhem Janbon, Institut Pasteur, France
Short Talk: Regulation of Gene Expression by Intron in Cryptococcus Neoformans

17:00—19:00
Lead Optimization
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Susan A. Charman, Monash University, Australia

Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Malaria Dihydroorotate Dehydrogenase

Geoffrey S. Dow, United States Army Medical & Material Development Activity, USA
Lead Optimization and Development of Next Generation Quinoline Methanols for Malaria Treatment and Prevention

Paul G. Wyatt, University of Dundee, UK
Validation of N-Myristoyltransferase as a Drug Target

Michael P. Pollastri, Northeastern University, USA
Short Talk: Optimization of a Human Aurora Kinase Inhibitor Chemotype for Selective Anti-Trypanosomal Activity

19:00—20:00
Social Hour with Lite Bites

Sweeney Ballroom F
19:30—22:00
Poster Session 3

Sweeney Ballroom F

THURSDAY, JANUARY 19

07:00—08:00
Breakfast

Sweeney Ballroom F
08:00—11:15
Drug Resistance II/Antifungal Strategies and Resistance Mechanisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Michael T. Ferdig, University of Notre Dame, USA

* Mitchell Mutz, Amplyx Pharmaceuticals, Inc., USA

Judith G. Berman, University of Minnesota, USA
Aneuploidy and Drug Resistance in Pathogenic Fungi

Pradipsinh K. Rathod, University of Washington, USA
Accelerated Acquisition of Drug Resistance in Malaria: The Problem and a Possible New Solution

Thomas E. Wellems, NIAID, National Institutes of Health, USA
Drug-Resistant Malaria: Determinants of Treatment Outcome and Prospects for Control

Geoffrey H. Siwo, University of Notre Dame, USA
Short Talk: Rewired Gene Networks Predict Differential Chemosensitivities of Multi-Drug Resistant Malaria Parasites

Damian Krysan, University of Rochester, USA
Short Talk: Protein Kinase Inhibitors as Antifungal Molecules: HTS Identification, Evaluation and Mechanism of Action

Bruce Klein, University of Wisconsin-Madison, USA
Fungi Subvert Vaccine T-Cell Priming at the Respiratory Mucosa by Inducing MMP2 and Retarding CCL7-Mediated Influx of Inflammatory Monocytes

09:00—09:20
Coffee Break

Sweeney Ballroom F
11:15—12:15
Workshop 4: Career Development

Sweeney Ballroom A-E
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney Ballroom F
17:00—19:00
Sex, Cell Identity and Virulence
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Haoping Liu, University of California, Irvine, USA

Richard Bennett, Brown University, USA
Phenotypic Switching and Sexual Reproduction in Candida Species

Paul Dyer, University of Nottingham, UK
Cryptic Sex in Aspergillus

Christina M. Hull, University of Wisconsin, Madison, USA
When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores

Xiaorong Lin, Texas A&M University, USA
Short Talk: A Link in Disguise: Sex-Independent Fungal Morphogenesis and Virulence

17:00—19:00
Clinical Development
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Vicky M. Avery, Griffith University, Australia

J. Kevin Baird, Eijkman Institute for Molecular Biology, Indonesia
Severe Morbidity and Mortality in Vivax Malaria and Chemotherapeutics Challenges in Coping with that Threat

Anjan Debnath, University of California, San Francisco, USA
Short Talk: Drug Discovery for Naegleria

Alison Webster, GlaxoSmithKline, UK
Tafenoquine: Lessons Learned

Thierry T. Diagana, Novartis Institute for Tropical Diseases, Singapore
Discovery and Development of Novel Antimalarial Drugs for the Treatment of P. falciparum and P. vivax Malaria

19:00—20:00
Social Hour with Lite Bites

Sweeney Ballroom F
20:00—23:00
Entertainment

Sweeney Ballroom F

FRIDAY, JANUARY 20

 
Departure


*Session Chair †Invited, not yet responded.


Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge additional support for this conference from:


Amplyx Pharmaceuticals, Inc.


Department of Molecular Genetics and Microbiology, Duke University Medical Center


OneWorld Health


Procter & Gamble Company

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI098158-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Anacor Pharmaceuticals, Inc.


Scynexis, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676