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Santa Fe Community Convention Center Floorplan
This meeting took place in 2012
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Meeting Details
Fungal Pathogens: From Basic Biology to Drug Discovery (J2)
Organizer(s) Joseph Heitman, John Taylor and Leah E. Cowen
January 15 - January 20, 2012
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: September 19, 2011
Late Abstract Deadline: October 19, 2011
Scholarship Deadline: September 19, 2011
Early Registration Deadline: November 15, 2011
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation.
CME Information
Joint Meeting:
Drug Discovery for Protozoan Parasites (J1)
Summary of Meeting:
The aim of this meeting is to bring together the academic, medical and pharmaceutical communities focused on fungal microbial pathogens of humans and other animals to illustrate common themes, and therapeutic, diagnostic and preventive opportunities. We seek to bridge both basic and physician-scientists working on the pathogenic microbe (via genetics, cell biology, genomics) and the host (immunology, including both innate and adaptive immunity). With respect to therapeutics, the emphasis is on developed as well as novel therapeutics, including both drugs and vaccines. A key aspect is to bridge the communities working on the diversity of fungi that infect humans and those working on the chytrid outbreak causing amphibian decline and extinctions. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Drug Discovery for Protozoan Parasites, which will share the keynote address and two plenary sessions with this meeting.
CME Information
The aim of this meeting is to bring together the academic, medical and pharmaceutical communities focused on fungal microbial pathogens of humans and other animals to illustrate common themes, and therapeutic, diagnostic and preventive opportunities. We seek to bridge both basic and physician-scientists working on the pathogenic microbe (via genetics, cell biology, genomics) and the host (immunology, including both innate and adaptive immunity). With respect to therapeutics, the emphasis is on developed as well as novel therapeutics, including both drugs and vaccines. A key aspect is to bridge the communities working on the diversity of fungi that infect humans and those working on the chytrid outbreak causing amphibian decline and extinctions. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Drug Discovery for Protozoan Parasites, which will share the keynote address and two plenary sessions with this meeting.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 15
19:15—19:30
Welcoming Remarks (Joint)
Norman C. Waters,
United States Military Academy, USA
Frederick S. Buckner,
University of Washington, USA
*
Vicky M. Avery,
Griffith University, Australia
Joseph Heitman,
Duke University, USA
John Taylor,
University of California, Berkeley, USA
19:30—21:00
Keynote Session (Joint)
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*
Norman C. Waters,
United States Military Academy, USA
Dennis E. Kyle,
University of South Florida, USA
Managing Risk and Exploiting Success in Antiprotozoan Drug Development
Managing Risk and Exploiting Success in Antiprotozoan Drug Development
*
John Taylor,
University of California, Berkeley, USA
Arturo Casadevall,
Albert Einstein College of Medicine, USA
On Fungal Virulence
On Fungal Virulence
08:00—11:15
Mechanisms of Virulence
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*
Arturo Casadevall,
Albert Einstein College of Medicine, USA
Robin C. May,
University of Birmingham, UK
Fungus-Phagocyte Interactions: Understanding Fungal Virulence in vitro, in vivo and in Fish-o
Fungus-Phagocyte Interactions: Understanding Fungal Virulence in vitro, in vivo and in Fish-o
Kirsten Nielsen,
University of Minnesota, USA
Short Talk: Cryptococcal Titan Cell Formation Affects Interactions with the Host and Subsequent Pathogenesis
Short Talk: Cryptococcal Titan Cell Formation Affects Interactions with the Host and Subsequent Pathogenesis
William E. Goldman,
University of North Carolina at Chapel Hill, USA
Intracellular Survival Strategies of Histoplasma capsulatum
Intracellular Survival Strategies of Histoplasma capsulatum
Nuri Rodriguez Del Val,
University of Puerto Rico, USA
An RNAi and Yeast Two-Hybrid Study of Calcium/Calmodulin Kinase1 and its Relationship to Thermotolerance and HSP90 in Sporothrix schencki
An RNAi and Yeast Two-Hybrid Study of Calcium/Calmodulin Kinase1 and its Relationship to Thermotolerance and HSP90 in Sporothrix schencki
Melanie T. Cushion,
University of Cincinnati College of Medicine, USA
Stealth and Opportunism: Strategies for Survival of Pneumocystis within the Mammalian Lung
Stealth and Opportunism: Strategies for Survival of Pneumocystis within the Mammalian Lung
Robert A. Cramer,
Montana State University, USA
Short Talk: Defining the Hypoxia Response of Aspergillus fumigatus: Implications for Fungal Pathogenesis and Antifungal Drugs
Short Talk: Defining the Hypoxia Response of Aspergillus fumigatus: Implications for Fungal Pathogenesis and Antifungal Drugs
08:00—11:15
Drug Resistance I
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Philip J. Rosenthal,
University of California, San Francisco, USA
Selection for Decreased Sensitivity to Artemisinin Partner Drugs
Selection for Decreased Sensitivity to Artemisinin Partner Drugs
Qin Cheng,
Australian Army Malaria Institute, Australia
Artemisinin Induced Dormancy and Resistance in Plasmodium falciparum in vitro
Artemisinin Induced Dormancy and Resistance in Plasmodium falciparum in vitro
David A. Fidock,
Columbia University Medical Center, USA
Balancing Drug Resistance and Fitness via Compensatory Mutations in the Plasmodium falciparum Chloroquine Resistance Transporter
Balancing Drug Resistance and Fitness via Compensatory Mutations in the Plasmodium falciparum Chloroquine Resistance Transporter
Rentala Madhubala,
Jawaharlal Nehru University, India
A Comparative Proteomics Approach to Understand the Mode of Action and Mechanism of Drug Resistance in Leishmania donovani
A Comparative Proteomics Approach to Understand the Mode of Action and Mechanism of Drug Resistance in Leishmania donovani
Leann M. Tilley,
University of Melbourne, Australia
Short Talk: Potent Artemisinin Activity against Plasmodium falciparum Requires Hemoglobin Uptake and Digestion
Short Talk: Potent Artemisinin Activity against Plasmodium falciparum Requires Hemoglobin Uptake and Digestion
Dylan R. Pillai,
University of Calgary, Canada
Short Talk: Reversing Antimalarial Resistance by Targeting Plasmodium falciparum Heat Shock Protein (PfHsp)90
Short Talk: Reversing Antimalarial Resistance by Targeting Plasmodium falciparum Heat Shock Protein (PfHsp)90
17:00—19:00
Host Responses to Fungal Pathogens
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*
Annika E. Scheynius,
Karolinska Institutet, Sweden
Aimee K. Zaas,
Duke University Medical Center, USA
Host Gene Expression Response to Fungal Infection
Host Gene Expression Response to Fungal Infection
Gordon D. Brown,
University of Aberdeen, UK
Immunity to Fungal Infections, Innate and Adaptive?
Immunity to Fungal Infections, Innate and Adaptive?
Paul L. Fidel, Jr.,
Louisiana State University Health Science Center, USA
Host Defense Against Mucosal Candida Infections: Opportunities for New Immunotherapeutics
Host Defense Against Mucosal Candida Infections: Opportunities for New Immunotherapeutics
Kimberly Gerik,
Washington University School of Medicine, USA
Short Talk: Chitinases – Pathogen Signaling and Host Response to C. neoformans
Short Talk: Chitinases – Pathogen Signaling and Host Response to C. neoformans
17:00—19:15
Drug Target Identification, Validation and Screening
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*
Don L. Gardiner,
Queensland Institute of Medical Research, Australia
Geoffrey Ian McFadden,
University of Melbourne, Australia
Life Cycle Studies to Identify When and Where Malaria Parasites are Vulnerable
Life Cycle Studies to Identify When and Where Malaria Parasites are Vulnerable
Emily Derbyshire,
Harvard Medical School, USA
Efforts to Target and Disrupt Liver Stage Development of the Malarial Parasite
Efforts to Target and Disrupt Liver Stage Development of the Malarial Parasite
William A. Petri, Jr.,
University of Virginia, USA
Transmembrane Kinases of Entamoeba histolytica
Transmembrane Kinases of Entamoeba histolytica
Norman C. Waters,
United States Military Academy, USA
Short Talk: Targeting the Cell Cycle Machinery of Plasmodium falciparum
Short Talk: Targeting the Cell Cycle Machinery of Plasmodium falciparum
Audrey R. Odom,
Washington University School of Medicine, USA
Short Talk: Targeting Methylerythritol Cytidyltransferase (IspD) for Antimalarial Drug Discovery
Short Talk: Targeting Methylerythritol Cytidyltransferase (IspD) for Antimalarial Drug Discovery
08:00—11:30
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint)
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*
Margaret A. Phillips,
University of Texas Southwestern Medical Center, USA
Leah E. Cowen,
University of Toronto, Canada
New Therapeutic Strategies for Fungal Disease Based on Combinatorial Control
New Therapeutic Strategies for Fungal Disease Based on Combinatorial Control
Dickon Alley,
Anacor Pharmaceuticals, Inc., USA
Boron-based Agents for Fungal and Protozoan Infections
Boron-based Agents for Fungal and Protozoan Infections
Xuewen Pan,
Baylor College of Medicine, USA
Short Talk: Novel Functional Genomics Approaches for Drug Target Identification and Validation
Short Talk: Novel Functional Genomics Approaches for Drug Target Identification and Validation
Frederick S. Buckner,
University of Washington, USA
Sterol 14-Demethylase Inhibitors for Chagas Disease
Sterol 14-Demethylase Inhibitors for Chagas Disease
Andrew P. Waters,
University of Glasgow, UK
Commitment to sexual development – towards an understanding of a molecular mechanism.
Commitment to sexual development – towards an understanding of a molecular mechanism.
Dominic Hoepfner,
Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Cladosporin, a Natural Product with Antifungal and Antimalarial Activity Targets lysyl-tRNA Synthetase
Short Talk: Cladosporin, a Natural Product with Antifungal and Antimalarial Activity Targets lysyl-tRNA Synthetase
Doron C. Greenbaum,
University of Pennsylvania, USA
Short Talk: Small Molecule Mimics of Antimicrobial Peptides as Antimalarials
Short Talk: Small Molecule Mimics of Antimicrobial Peptides as Antimalarials
14:30—16:30
Workshop 2: Publishing (Joint)
Lakshmi Goyal,
Cell Press, USA
Arturo Casadevall,
Albert Einstein College of Medicine, USA
Margaret A. Phillips,
University of Texas Southwestern Medical Center, USA
Kevin J. Saliba,
Australian National University, Australia
Joseph Heitman,
Duke University, USA
Tamara L. Doering,
Washington University Medical School, USA
Tom Edlind,
Drexel University College of Medicine, USA
17:00—19:00
Evolution and Comparative Genomics of Fungal Pathogens
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*
Charles W. Saunders,
Procter & Gamble Co., USA
Jim Kronstad,
University of British Columbia, Canada
Pathogenic Basidiomycetes: Metabolic Adaptation and Virulence Factor Expression
Pathogenic Basidiomycetes: Metabolic Adaptation and Virulence Factor Expression
Emily Troemel,
University of California, San Diego, USA
Non-lytic Escape of Microsporidia from C. elegans Intestinal Cells
Non-lytic Escape of Microsporidia from C. elegans Intestinal Cells
Axel A. Brakhage,
Friedrich Schiller University Jena, Germany
Dermatophyte Genomics and Secondary Metabolites Involved in Fungal Pathogenicity
Dermatophyte Genomics and Secondary Metabolites Involved in Fungal Pathogenicity
Annika E. Scheynius,
Karolinska Institutet, Sweden
Short Talk: The Basidiomycete Malassezia Species Complex – A Genomic Platform to Elucidate Host-Fungal Interactions Involved in Common Skin Disorders
Short Talk: The Basidiomycete Malassezia Species Complex – A Genomic Platform to Elucidate Host-Fungal Interactions Involved in Common Skin Disorders
17:00—19:15
Hit to Lead Identification
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Michael K. Riscoe,
Veterans Affairs Medical Center, USA
Revisiting Historical Leads for Clues to the Design of Future Antimalarial Drugs.
Revisiting Historical Leads for Clues to the Design of Future Antimalarial Drugs.
Bakela Nare,
Scynexis Inc., USA
Development of Oxaborole Compounds for Human African Trypanosomiasis
Development of Oxaborole Compounds for Human African Trypanosomiasis
Richard Glynne,
Genomics Institute of the Novartis Research Foundation, USA
High-Throughput Whole-Cell Screening against Trypanosomatids
High-Throughput Whole-Cell Screening against Trypanosomatids
Richard W. Heidebrecht, Jr.,
Broad Institute, USA
Short Talk: Identification of a Novel Lead for the Treatment of Malaria via Diversity Oriented Synthesis
Short Talk: Identification of a Novel Lead for the Treatment of Malaria via Diversity Oriented Synthesis
Mark E. Drew,
Ohio State University College of Medicine, USA
Short Talk: Potent Antiprotozoal Activity of a Novel Semi-Synthetic Berberine Derivative
Short Talk: Potent Antiprotozoal Activity of a Novel Semi-Synthetic Berberine Derivative
08:00—11:15
Cell Circuitry and Adaptive Responses
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Alexander D. Johnson,
University of California, San Francisco, USA
Evolution of Gene Regulation in Fungi
Evolution of Gene Regulation in Fungi
Aaron P. Mitchell,
Carnegie Mellon University, USA
Portrait of Candida albicans Adherence Regulators
Portrait of Candida albicans Adherence Regulators
Hiten D. Madhani,
University of California, San Francisco, USA
Using a Gene Deletion Collection to Understand how Cryptococcus neoformans Causes Disease and Responds to Chemicals
Using a Gene Deletion Collection to Understand how Cryptococcus neoformans Causes Disease and Responds to Chemicals
Maurizio Del Poeta,
Medical University of South Carolina, USA
Short Talk: Identification of New Compounds Targeting the Fungal Sphingolipid Pathway
Short Talk: Identification of New Compounds Targeting the Fungal Sphingolipid Pathway
*
Tamara L. Doering,
Washington University Medical School, USA
Short Talk: Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans
Short Talk: Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans
Anita Sil,
University of California, San Francisco, USA
Regulation of Histoplasma Cell Shape and Virulence by Temperature
Regulation of Histoplasma Cell Shape and Virulence by Temperature
08:00—11:00
Pre-Clinical Development
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Susan A. Charman,
Monash University, Australia
Genesis of OZ439: From Preclinical Studies to Clinical Trials
Genesis of OZ439: From Preclinical Studies to Clinical Trials
Julio A. Urbina,
Venezuelan Institute for Science Research, USA
Ergosterol Biosynthesis Inhibitors for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials
Ergosterol Biosynthesis Inhibitors for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials
Michael Zhuo Wang,
University of Kansas, USA
Evaluation of Novel Anti-Trypanosomal Benzofuran Derivatives: Pharmacokinetics, Toxicity, and Efficacy
Evaluation of Novel Anti-Trypanosomal Benzofuran Derivatives: Pharmacokinetics, Toxicity, and Efficacy
Rosa M. Andrade,
University of California, San Diego, USA
Short Talk: A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal
Short Talk: A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal
Maria Jose Lafuente,
GlaxoSmithKline, Spain
Short Talk: Open Source to Drug Discovery for Malaria: Sharing TCAMS
Short Talk: Open Source to Drug Discovery for Malaria: Sharing TCAMS
11:15—12:15
Workshop 3: Fungal Genome Databases
*
Jason E. Stajich,
University of California, Riverside, USA
17:00—19:00
Population Genetics and Genomics of Fungal Pathogens
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*
Fred S. Dietrich,
Duke University, USA
Matthew C. Fisher,
Imperial College, London, UK
Why Fungi Cause Species Extinctions: Evolutionary Insights from Population Genetics and Genomics
Why Fungi Cause Species Extinctions: Evolutionary Insights from Population Genetics and Genomics
Timothy Y. James,
University of Michigan, USA
Pathogen Recombination during the Amphibian Chytridiomycosis Pandemic - Why Change What's Working?
Pathogen Recombination during the Amphibian Chytridiomycosis Pandemic - Why Change What's Working?
Geraldine Butler,
University College Dublin, Ireland
Beyond the Candida albicans Paradigm: Evolution of the Hypoxic Response in Fungal Species
Beyond the Candida albicans Paradigm: Evolution of the Hypoxic Response in Fungal Species
Guilhem Janbon,
Institut Pasteur, France
Short Talk: Regulation of Gene Expression by Intron in Cryptococcus Neoformans
Short Talk: Regulation of Gene Expression by Intron in Cryptococcus Neoformans
17:00—19:00
Lead Optimization
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*
Susan A. Charman,
Monash University, Australia
Margaret A. Phillips,
University of Texas Southwestern Medical Center, USA
Targeting Malaria Dihydroorotate Dehydrogenase
Targeting Malaria Dihydroorotate Dehydrogenase
Geoffrey S. Dow,
United States Army Medical & Material Development Activity, USA
Lead Optimization and Development of Next Generation Quinoline Methanols for Malaria Treatment and Prevention
Lead Optimization and Development of Next Generation Quinoline Methanols for Malaria Treatment and Prevention
Michael P. Pollastri,
Northeastern University, USA
Short Talk: Optimization of a Human Aurora Kinase Inhibitor Chemotype for Selective Anti-Trypanosomal Activity
Short Talk: Optimization of a Human Aurora Kinase Inhibitor Chemotype for Selective Anti-Trypanosomal Activity
08:00—11:15
Drug Resistance II/Antifungal Strategies and Resistance Mechanisms (Joint)
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*
Michael T. Ferdig,
University of Notre Dame, USA
*
Mitchell Mutz,
Amplyx Pharmaceuticals, Inc., USA
Pradipsinh K. Rathod,
University of Washington, USA
Accelerated Acquisition of Drug Resistance in Malaria: The Problem and a Possible New Solution
Accelerated Acquisition of Drug Resistance in Malaria: The Problem and a Possible New Solution
Thomas E. Wellems,
NIAID, National Institutes of Health, USA
Drug-Resistant Malaria: Determinants of Treatment Outcome and Prospects for Control
Drug-Resistant Malaria: Determinants of Treatment Outcome and Prospects for Control
Geoffrey H. Siwo,
University of Notre Dame, USA
Short Talk: Rewired Gene Networks Predict Differential Chemosensitivities of Multi-Drug Resistant Malaria Parasites
Short Talk: Rewired Gene Networks Predict Differential Chemosensitivities of Multi-Drug Resistant Malaria Parasites
Damian Krysan,
University of Rochester, USA
Short Talk: Protein Kinase Inhibitors as Antifungal Molecules: HTS Identification, Evaluation and Mechanism of Action
Short Talk: Protein Kinase Inhibitors as Antifungal Molecules: HTS Identification, Evaluation and Mechanism of Action
Bruce Klein,
University of Wisconsin-Madison, USA
Fungi Subvert Vaccine T-Cell Priming at the Respiratory Mucosa by Inducing MMP2 and Retarding CCL7-Mediated Influx of Inflammatory Monocytes
Fungi Subvert Vaccine T-Cell Priming at the Respiratory Mucosa by Inducing MMP2 and Retarding CCL7-Mediated Influx of Inflammatory Monocytes
17:00—19:00
Sex, Cell Identity and Virulence
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*
Haoping Liu,
University of California, Irvine, USA
Richard Bennett,
Brown University, USA
Phenotypic Switching and Sexual Reproduction in Candida Species
Phenotypic Switching and Sexual Reproduction in Candida Species
Christina M. Hull,
University of Wisconsin, Madison, USA
When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores
When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores
Xiaorong Lin,
Texas A&M University, USA
Short Talk: A Link in Disguise: Sex-Independent Fungal Morphogenesis and Virulence
Short Talk: A Link in Disguise: Sex-Independent Fungal Morphogenesis and Virulence
17:00—19:00
Clinical Development
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*
Vicky M. Avery,
Griffith University, Australia
J. Kevin Baird,
Eijkman Institute for Molecular Biology, Indonesia
Severe Morbidity and Mortality in Vivax Malaria and Chemotherapeutics Challenges in Coping with that Threat
Severe Morbidity and Mortality in Vivax Malaria and Chemotherapeutics Challenges in Coping with that Threat
Anjan Debnath,
University of California, San Francisco, USA
Short Talk: Drug Discovery for Naegleria
Short Talk: Drug Discovery for Naegleria
Alison Webster,
GlaxoSmithKline, UK
Tafenoquine: Lessons Learned
Tafenoquine: Lessons Learned
Thierry T. Diagana,
Novartis Institute for Tropical Diseases, Singapore
Discovery and Development of Novel Antimalarial Drugs for the Treatment of P. falciparum and P. vivax Malaria
Discovery and Development of Novel Antimalarial Drugs for the Treatment of P. falciparum and P. vivax Malaria
*Session Chair †Speaker invited, not yet responded.
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