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This meeting took place in 2012


Here are the related meetings in 2014:
Exploiting and Understanding Chemical Biotransformations in the Human Microbiome (D1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Microbiome (Q8)


Organizer(s) Andrew T. Gewirtz, Fergus Shanahan and Ruth E. Ley
March 4—9, 2012
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 3, 2011
Late Abstract Deadline: Dec 8, 2011
Scholarship Deadline: Nov 3, 2011
Early Registration Deadline: Jan 5, 2012

Supported by the Directors’ Fund


Summary of Meeting:
Emerging themes from several traditionally disparate areas of research have begun to coalesce around the concept that the complex microbial communities that inhabit most external human surfaces play a key role in health and disease. Specifically, processes including basic immune system development, host-pathogen interactions, metabolic disease and cancer are all greatly influenced by the composition and bioactivity of the microbiota that live within us. Understanding how mammalian hosts regulate their microbiota and the myriad of ways by which the microbiota can alter susceptibility to a wide range of diseases is a key opportunity to better understand numerous diseases and, subsequently, provide strategies to promote human health. Thus, the goal of the Keystone Symposia meeting on The Microbiome is to facilitate the understanding of mechanisms that maintain a healthy host-microbiota relationship and explore how perturbations in this relationship increase susceptibility to a variety of diseases, especially those associated with chronic inflammation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Innate Immunity: Sensing the Microbes and Damage Signals, which will share a keynote address and three plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 4

15:00—19:30
Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Damage Control in Host-Pathogen Interactions

Jeffrey I. Gordon, Washington University School of Medicine, USA
Dining in with Trillions of Friends: Exploring the Human Gut Microbiome


MONDAY, MARCH 5

07:00—08:00
Breakfast

08:00—11:15
Defining the Normal and Aberrant Microbiotas
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Joseph F. Petrosino, Baylor College of Medicine, USA

Ruth E. Ley, Cornell University, USA
Host Genetic Control of the Gut Microbiome

Rob Knight, University of Colorado, USA
Defining an Aberrant Microbiota

Forest Rohwer, San Diego State University, USA
The Human Virome

Erwin G. Zoetendal, Wageningen University, Netherlands
Functional Metagenomics in the Gut

Loreto Andrea Abusleme, University of Chile, Faculty of Dentistry, Chile
Short Talk: The Relationship between Clinical Signs of Periodontal Destruction and Inflammation and the Subgingival Microbiome

Kenny De Meirleir, University of Brussels, Belgium
Short Talk: Alterations of Intestinal Microflora in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

08:00—11:00
Inflammasome Activation by DAMPs and PAMPs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Akiko Iwasaki, Yale University School of Medicine, USA

Kate A. Fitzgerald, University of Massachusetts Medical School Lab Rm 308, USA
A Novel Inflammasome Pathway by Gram-Negative Bacteria

Gabriel Nuñez, University of Michigan, USA
Sensing Microbes by the Inflammasome

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Immune Pathways by the NLRs

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs in Infection,Inflammation and Signaling

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: A Novel NLR Critical in the Initiation of Adaptive Immunity

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

11:15—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

14:30—16:30
Workshop: Microbiota and Your Research: A How-to Guide to Designing and Executing Studies of the Microbiota in Your Favorite Niche

* Ruth E. Ley, Cornell University, USA

16:30—17:00
Coffee Available

17:00—19:00
Viral Sensors and Defense Mechanisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK

Akiko Iwasaki, Yale University School of Medicine, USA
Antiviral Immunity at the Mucosal Surface

Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Sensing Viral RNA in Cytoplasm and Activation of Antiviral Innate Immunity

Michael S. Diamond, Washington University School of Medicine, USA
2'O Methylation of Viral RNA and Antagonism of an Interferon-Induced Antiviral Response

Yorgo Modis, Yale University, USA
Short Talk: MDA5 Cooperatively Forms Dimers and ATP-Sensitive Filaments upon Binding Double-Stranded RNA

17:00—19:00
Pathogen Microbiota Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jorge A. Giron, Emerging Pathogens Institute, University of Florida, USA

Wendy S. Garrett, Harvard School of Public Health, USA
Disease-Associated and Beneficial Gut Microbiota in Colitis and Colorectal Cancer

Colin Hill, University College Cork, Ireland
Controlling Clostridium difficile without 'Collateral' Damage to the Microbiota

Natalia Shulzhenko, Oregon State University, USA
Microbiota and IgA: Keeping the Metabolism Up

Nobuhiko Kamada, University of Michigan, USA
Short Talk: Virulence Factor Expression Regulates the Interaction Between Enteric Pathogen and the Microbiota and Pathogen Eradication

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 6

07:00—08:00
Breakfast

08:00—11:15
Complexity in Microbiota Host Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Matam Vijay-Kumar, Georgia State University, USA

Jeremy K. Nicholson, Imperial College, London University, UK
Systems Approaches to Investigate Host-Microbiota Metabolic Interactions

Jens Walter, University of Nebraska, Lincoln, USA
Evolutionary Mechanisms That Shape Host-Microbiota Interactions and Their Consequences

Thaddeus S. Stappenbeck, Washington University School of Medicine, USA
Host-Microbe Interactions that Play a Role in the Pathogenesis of Inflammatory Bowel Disease

Andrew T. Gewirtz, Georgia State University, USA
TLR5: Protecting the Gut from its BFF

Christopher Power, University of Alberta, Canada
Short Talk: Human Brain Microbiome Diversity and Expression: alpha-Proteobacteria Predominate Independent of Host Immune Status

Lara M. Bull-Otterson, Baylor College of Medicine, USA
Short Talk: A Preliminary Comparison of the Distal Gut Microbiome from HIV Infected before and after HAART

08:00—11:15
Pattern Recognition Receptor Trafficking and Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kate A. Fitzgerald, University of Massachusetts Medical School Lab Rm 308, USA

Gregory M. Barton, University of California Berkeley, USA
Regulation of Intracellular Toll-Like Receptors

Jonathan C. Kagan, Children's Hospital Boston, USA
Cell Biology Aspect of Innate Immunity

Michael Gale, Jr., University of Washington, USA
Control of RIG-I Signaling in RNA Virus Infection and Immunity

Zhijian 'James' Chen, HHMI/University of Texas Southwestern Medical Center, USA
MAVS – A Marvelous Mitochondrial Anti-Viral Signaling Protein

Carolyn B. Coyne, University of Pittsburgh, USA
Short Talk: Focal Adhesion Kinase is a Component of RIG-I-like Receptor Antiviral Signaling

Tsan Xiao, NIAID, National Institutes of Health, USA
Short Talk: Mechanisms of DNA Recognition by the AIM2 and IFI16 Inflammasomes

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

11:15—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

14:30—16:30
Workshop 1: Inflammasomes Activation by Pathogens and Stress

* Koichi S. Kobayashi, Texas A&M Health Science Center, USA

Fabianno F. Dutra, Institute of Microbiology, Brazil
Heme (Iron Protoporphyrin IX) Activates the NLRP3 Inflammasome

Jakob H. von Moltke, University of California, San Francisco, USA
A Novel Effector Function of the Inflammasome in vivo

Naeha Subramanian, NIAID / National Institutes of Health, USA
Mitochondria Play a Central Role in NLRP3 Inflammasome Activation

Kenichi Shimada, Cedars Sinai Medical Center, USA
Activation of the NLRP3 Inflammasome by Oxidized Mitochondrial DNA during Apoptosis

Saguna Verma, University of Hawaii at Manoa, USA
Inflammasome Sensor Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) Restricts West Nile Virus (WNV) Infection and Spread to the Central Nervous System

Petr Broz, Biozentrum, University of Basel, Switzerland
Canonical and Non-Canonical Inflammasomes Coordinate Host Response to Intracellular Salmonella typhimurium

Sammy Bedoui, University of Melbourne, Australia
NLRC4 Inflammasome Activation in Splenic Dendritic Cells Regulates Anti-Bacterial Effector Function by Memory CD8 T Cells

16:30—17:00
Coffee Available

17:00—19:00
Innate Immune Protection against Microbiota (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dan R. Littman, HHMI/New York University School of Medicine, USA

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Immune Defense of the Intestinal Epithelial Surface

Gunnar C. Hansson, University of Gothenburg, Sweden
Good Barriers Encourage Appropriate Microbiota

Dana Philpott, University of Toronto, Canada
Sensing Bacterial Pathogens by NOD Proteins

Embriette Alicki, Baylor College of Medicine, USA
Short Talk: The Impact of IgA on the Intestinal Microbiome

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 7

07:00—08:00
Breakfast

08:00—11:15
Microbiota Regulation of Innate Immunity (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

Andrew J. Macpherson, University of Bern, Switzerland
Immune Compartmentalisation in Mutualism with the Intestinal Microbiota

Maria Rescigno, European Institute of Oncology, Italy
Dendritic Cells in Host-Microbe Interactions in the Intestine

Kiyoshi Takeda, Osaka University, Japan
Regulatory Mechanisms of Immune Responses to Intestinal Bacteria

Sarkis K. Mazmanian, California Institute of Technology, USA
Learning to Tolerate our Microbial Self

Gretchen E. Diehl, New York University, USA
Short Talk: Commensals Limit Trafficking of Antigens from the Lamina Propria to the Mesenteric Lymph Nodes by CX3CR1+ Cells

Janelle S. Ayres, The Salk Institute, USA
Short Talk: Lethal Inflammasome Activation by a Multi-Drug Resistant Pathobiont upon Antibiotic Disruption of the Microbiota

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

11:15—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

14:30—16:30
Workshop 2: Innate Viral Recognition and IFN Responses

* Chris C. Norbury, Pennsylvania State University Medical School, USA

Elina I. Zuniga, University of California, San Diego, USA
Regulation of Type I Interferon Production by Plasmacytoid Dendritic Cell

Dmitry M. Shayakhmetov, University of Washington, USA
Virus-Misplaced Host Protein Activates Innate Immunity

Aaron R. Everitt, Wellcome Trust Sanger Institute, UK
IFITM3 Restricts the Morbidity and Mortality Associated with Influenza

Gerard E. Kaiko, University of Newcastle, Australia
Early-Life Viral Infection and TLR7 Susceptibility Gene Interaction Predispose Toward the Development of Asthma in Later-Life

Maulik Patel, Fred Hutchinson Cancer Research Center, USA
Functional Dissection of MAVS Evolution

Yayoi Izu, Pennsylvania State University, Milton S. Hershey College of Medicine, USA
Non-Classical Endocytosis Bypasses Early Endosomes To Deliver Mousepox Virions Directly to TLR9-Containing Lysosomes in Dendritic Cells, a Requisite Step in Protection from Lethal Infection

16:30—17:00
Coffee Available

17:00—19:00
Lymphocyte-Microbiota Interactions (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ifor Williams, Emory University, USA

David Artis, University of Pennsylvania School of Medicine, USA
Microbial Regulation of Immune Cell Homeostasis

Dan R. Littman, HHMI/New York University School of Medicine, USA
Microbiota Regulation of Intestinal Lymphocytes

Kenya Honda, RIKEN Research Center for Allergy and Immunology, Japan
Intestinal Commensal Bacteria-Mediated Treg Induction

Timothy W. Hand, NIAID, National Institutes of Health, USA
Short Talk: Gastrointestinal Infection Induces Microbiota-Specific B and T Cell Responses

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 8

07:00—08:00
Breakfast

08:00—11:00
Microbiota and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jens Walter, University of Nebraska, Lincoln, USA

Fredrik Bäckhed, University of Gothenburg, Sweden
The Gut Microbiota as a Novel Modulator of Host Metabolism and Obesity

Patrice D. Cani, Université Catholique de Louvain, Belgium
Metabolic Endotoxemia Links Low-Grade Inflammation to Metabolic Diseases

Martin J. Blaser, New York University School of Medicine, USA
Animal Models of Microbe-Induced Obesity

Frederic D. Bushman, University of Pennsylvania, USA
Microbiome Dynamics: Diet and Disease

Eran Elinav, Yale University School of Medicine, USA
Short Talk: Nod-Like Receptor Proteins Regulate the Steady State and Mucosal Damage Response

08:00—11:00
Pattern Recognition Receptors in Health and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gabriel Nuñez, University of Michigan, USA

Robert L. Coffman, Dynavax Technologies, USA
Translating Innate Signals to Clinical Use

Herbert W. Virgin, Washington University School of Medicine, USA
Role of the Virome and Autophagy Proteins in Host Defense and Disease Susceptibility

Alan Sher, NIAID, National Institutes of Health, USA
Critical Role for Mincle/Card9 Signaling in the IL-1beta Dependent Th17 Polarizing Activity of Mycobacterial Adjuvant

Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome: What Are the NOD Sensors Sensing?

Felix Yarovinsky, University of Texas Southwestern Medical Center, USA
Short Talk: B Cell-Intrinsic TLR Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

09:20—09:40
Coffee Break

11:00—
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Innate Control of Inflammation and Adaptive Immunity

* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia

Carla V. Rothlin, Yale University, USA
T Cell-Derived Protein S Negatively Regulates the Innate Immune Response

Alison N. Thorburn, Monash University, Australia
Bacterial Metabolite, Acetate, Suppresses Allergic Airways Disease

Adriana R. Mantegazza, University of Pennsylvania School of Medicine, USA
AP-3 is Required for Phagosome-Intrinsic TLR Signaling and Subsequent MHC-II Presentation in Dendritic Cells

Ty Dale Troutman, University of Texas Southwestern Medical Center, USA
BCAP is a TIR-Domain Containing Signaling Adaptor Linking TLRs to PI3K/AKT

Malin E. V. Johansson, University of Gothenburg, Sweden
Mucus Barrier Defects are Associated with Intestinal Inflammation both in Murine Spontaneous Colitis Models and Patients with Ulcerative Colitis

Iliyan D. Iliev, Cedars-Sinai Medical Center, USA
Dectin-1 Mediated Mucosal Immunity to Commensal Fungi Influences Colitis

16:30—17:00
Coffee Available

17:00—19:00
Therapeutic Manipulation of Microbiota
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alexander Khoruts, University of Minnesota, USA

Fergus Shanahan, National University of Ireland, Ireland
Making Peace: Altering Host-Microbiota Relationship in Chronic Gut Inflammation

Philip M. Sherman, Hospital for Sick Children, University of Toronto, Canada
Altering the Pediatric Intestinal Microbiota

James Versalovic, Texas Children's Hospital, USA
Defining Microbial Disease Signatures in Pediatric Gut Microbiomes – and Microbial Modification Strategies as Therapies

Marie-Christine Simon, Institute for Clinical Diabetology, Germany
Short Talk: Probiotics as a Novel Approach to Modulate Gut Hormone Secretion and Insulin Sensitivity and Secretion

17:00—19:00
Recognition of Cell Death and Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gregory M. Barton, University of California Berkeley, USA

Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK
Recognition of Cell Death and Adaptive Immunity

Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA

Julie Magarian Blander, Mount Sinai School of Medicine, USA
Infection and Apoptosis as a Combined Inflammatory Trigger

Thomas F. Gajewski, University of Chicago, USA
Short Talk: Innate Immune Sensing of Tumors is Driven by a Cytosolic DNA Sensing/STING Pathway that Induces Host IFN-beta Production and DC Activation

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 9

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Biogen Idec Cubist Pharmaceuticals, Inc.
JDRF
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI098352-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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