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This meeting took place in 2013



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Multiple Sclerosis (A1)


Organizer(s) Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle
January 11—16, 2013
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 12, 2012
Late Abstract Deadline: Oct 11, 2012
Scholarship Deadline: Sep 12, 2012
Early Registration Deadline: Nov 12, 2012

Sponsored by Biogen Idec and the National Multiple Sclerosis Society

Summary of Meeting:
Multiple sclerosis (MS) is a complex disease in which genetic, environmental and stochastic factors all play a part to induce aberrant interactions between the immune system and neural cells, ultimately transforming into progressive neurological disability. Our understanding of MS is rapidly evolving, and multiple areas of research are showing great promise of future treatment or cure. However, further progress will depend on establishing a deep understanding of the underlying disease mechanisms. With this in mind, this meeting aims to: 1) Define integrated approaches by which to study disease pathogenesis, which represents a critical barrier to progress in the field; 2) Provide an up-to-date perspective on molecular pathogenesis and how this might be used to optimize patient management; 3) Define state-of-the-art technologies by which to quantitate disease burden; 4) Discuss key elements concerning the concept of disease heterogeneity and how emergent approaches to disease stratification can optimize management strategies; and 5) Provide perspectives concerning the potential therapeutic applications of neuroprotective, regenerative and bioengineering-based strategies, and how these might complement immunotherapy. Speakers have been carefully selected on the basis that, independent of whether they are basic scientists or clinician researchers, they each have a track record in adopting a multi-disciplinary approach that has enabled the application of discoveries in one area of endeavor to seed advances in another. We anticipate that participants will gain an understanding of how a systems biology-based approach can accelerate our knowledge base of multiple sclerosis and how that knowledge base can be successfully applied to novel clinical research and development, as well as potentiated patient care.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 11

16:00—20:00
Arrival and Registration

SATURDAY, JANUARY 12

07:00—08:00
Breakfast
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Trevor J. Kilpatrick, University of Melbourne, Australia

Lawrence Steinman, Stanford University, USA
When Bad is Good: Amyloid Molecules as Guardians of the Brain. An Unexpected Role of Amloidogenic Molecules in Multiple Sclerosis and Ischemic Diseases: aB Crystalline, Amyloid-beta, tau, Prion Protein and other Amyloids

09:00—11:15
Nature and Nurture: Insights Beyond GWAS and Epidemiological Studies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Patrizia Casaccia, Mount Sinai School of Medicine, USA
Genome-Wide Study of DNA Methylation Reveals Epigenetic Alterations in Normal Appearing White Matter of MS Brains

Justin P. Rubio, GlaxoSmithKline R&D, UK
Realizing the Promise of Pharmacogenomics

Tomas Olsson, Karolinska Institutet, Sweden
Genes and Lifestyle/Environmental Factors in Multiple Sclerosis

Judith Field, University of Melbourne, Australia
Short Talk: Gene Expression in Immune Cell Subsets: A Risk Gene Study for Multiple Sclerosis

09:40—10:00
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:15—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:15
Cellular and Molecular Profiling: The Road to an Integrated Approach
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Hartmut Wekerle, Max Planck Institut, Germany
From Gut to Brain: The Complex Build-Up of Experimental Autoimmune Encephalomyelitis

William H. Robinson, Stanford University School of Medicine, USA
From Tissue to Proteomics and Lipidomics

Ronald N. Germain, NIAID, National Institutes of Health, USA
Using Highly Multiplexed Data Collection and Computational Biology to Probe the Human Immune System

Simone C. Wuest, NINDS, National Institutes of Health, USA
Short Talk: Investigation of Cellular Intrathecal and Peripheral Immune Responses in Patients with Multiple Sclerosis

Peter Kosa, NINDS, National Institutes of Health, USA
Short Talk: Exosomes – A Potential Source of Biomarkers in Multiple Sclerosis

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

SUNDAY, JANUARY 13

07:00—08:00
Breakfast
08:00—11:00
Paraclinical Measures of Structural and Functional Change
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France

Elliot M. Frohman, University of Texas Southwestern Medical Center, USA
Eye-ing a Window of Neuroprotection in the Visual System for MS

John C. Gore, Vanderbilt University, USA
Recent Developments in MRI

Adrienne N. Dula, Vanderbilt University, USA
Short Talk: Molecular MRI of Multiple Sclerosis Using 7 Tesla Chemical Exchange Saturation Transfer (CEST)

Paul M. Matthews, GSK/Imperial College London, UK
Short Talk: Towards Imaging Dynamics of the Innate Immune Response in Multiple Sclerosis

Frauke Zipp, Johannes-Gutenberg-Universität Mainz, Germany
Crosstalk of the Immune and Nervous Systems

Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany
Harnessing the Potential of Cellular and Molecular in vivo Imaging Techniques

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Immunopathogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lawrence Steinman, Stanford University, USA

Stephen M. Anderton, University of Edinburgh, UK
Immune-Mediated Autoaggression and Regulation

Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
Integrating Innate Immunity and Key Environmental Interactions

Bahareh Ajami, Stanford University School of Medicine, USA
Short Talk: Pathological Differences in Th1 and Th17 Mediated Experimental Autoimmune Encephalomyelitis (EAE)

Stephen D. Miller, Northwestern University Medical School, USA
Tolerance Induction Using Myeline Peptide Coupled Apoptotic Cells and Biodegradable Nanparticles for MS Therapy

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

MONDAY, JANUARY 14

07:00—08:00
Breakfast
08:00—11:00
Clinical Controversies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Helen Tremlett, University of British Columbia, Canada
Disease Heterogeneity: Emerging Concepts in MS

Jun-ichi Kira, Kyushu University, Japan
Cutting Edges of Multiple Sclerosis and Neuromyelitis Optica

* Brenda Banwell, University of Pennsylvania, USA
Negotiating Between ADEM, CIS and MS: An Age-Specific Roadmap

Judith M. Greer, University of Queenland, Australia
Short Talk: HLA Alleles Play a Role in Determining the Disease Course and Distribution of Lesions in MS

Timothy Coetzee, National Multiple Sclerosis Society, USA
CCSVI – Lessons for Funders and the Research Community

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Clinical Developments
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

* Richard A. Rudick, Cleveland Clinic Foundation, USA
Design Issues for Clinical Trials in Progressive MS

Paul M. Matthews, GSK/Imperial College London, UK
Treatment Stratification for MS: Opportunities and Challenges

Zongqi Xia, Brigham and Women's Hospital and Harvard Medical School, USA
Short Talk: Leveraging Electronic Health Records for Research in Multiple Sclerosis

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

TUESDAY, JANUARY 15

07:00—08:00
Breakfast
08:00—11:00
Neurobiology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Peter K. Stys, University of Calgary, Canada
Axon-Glial Interactions in MS and AD

* Trevor J. Kilpatrick, University of Melbourne, Australia
Targeting the Oligodendrocyte Lineage in Demyelinative Disease

Patrick Kuery, University of Duesseldorf, Germany
Short Talk: Nucleocytoplasmic Translocation of p57kip2 Promotes Oligodendroglial Differentiation

Hedwich F. Kuipers, Stanford University, USA
Short Talk: Differential Roles for the Small Heat Shock Protein Alpha B-Crystallin in Cuprizone-Induced De- and Remyelination

Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France
Remyelination in MS: The New Frontier?

Peter I. Jukkola, Ohio State University, USA
Short Talk: K+ Channel Alterations in the Progression of Experimental Autoimmune Encephalomyelitis

09:20—09:40
Coffee Break
11:30—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Cellular Dynamics Underpinning Pathogenesis and Repair
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Amit Bar-Or, Montreal Neurological Institute, Canada
Immune:Glial Interactions in MS: Implication during CNS Injury and Repair

Shannon Dunn, University of Toronto, Canada
Sex Differences in Multiple Sclerosis: Role for Male and Female Pubertal Factors

Gianvito Martino, San Raffaele Scientific Institute, Italy
The Role of Neural Stem Cells in Brain Regeneration: Where we are and Where we go in Multiple Sclerosis

19:00—20:00
Social Hour with Lite Bites
20:00—23:00
Entertainment

WEDNESDAY, JANUARY 16

 
Departure

*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Biogen Idec National Multiple Sclerosis Society

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS080288-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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