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This meeting took place in 2013


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Meeting Details

Multiple Sclerosis (A1)


Organizer(s) Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle
January 11 - January 16, 2013
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: September 12, 2012
Late Abstract Deadline: October 11, 2012
Scholarship Deadline: September 12, 2012
Early Registration Deadline: November 12, 2012

Sponsored by Biogen Idec and the National Multiple Sclerosis Society

CME Information
Summary of Meeting:
Multiple sclerosis (MS) is a complex disease in which genetic, environmental and stochastic factors all play a part to induce aberrant interactions between the immune system and neural cells, ultimately transforming into progressive neurological disability. Our understanding of MS is rapidly evolving, and multiple areas of research are showing great promise of future treatment or cure. However, further progress will depend on establishing a deep understanding of the underlying disease mechanisms. With this in mind, this meeting aims to: 1) Define integrated approaches by which to study disease pathogenesis, which represents a critical barrier to progress in the field; 2) Provide an up-to-date perspective on molecular pathogenesis and how this might be used to optimize patient management; 3) Define state-of-the-art technologies by which to quantitate disease burden; 4) Discuss key elements concerning the concept of disease heterogeneity and how emergent approaches to disease stratification can optimize management strategies; and 5) Provide perspectives concerning the potential therapeutic applications of neuroprotective, regenerative and bioengineering-based strategies, and how these might complement immunotherapy. Speakers have been carefully selected on the basis that, independent of whether they are basic scientists or clinician researchers, they each have a track record in adopting a multi-disciplinary approach that has enabled the application of discoveries in one area of endeavor to seed advances in another. We anticipate that participants will gain an understanding of how a systems biology-based approach can accelerate our knowledge base of multiple sclerosis and how that knowledge base can be successfully applied to novel clinical research and development, as well as potentiated patient care.

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 11

16:00—20:00
Arrival and Registration


SATURDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Trevor J. Kilpatrick, University of Melbourne, Australia

Lawrence Steinman, Stanford University, USA
When Bad is Good: Amyloid Molecules as Guardians Against Neuroinflammation

09:00—11:15
Nature and Nurture: Insights Beyond GWAS and Epidemiological Studies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Patrizia Casaccia, Mount Sinai School of Medicine, USA
Genome-Wide Study of DNA Methylation Reveals Epigenetic Alterations in Brains of Multiple Sclerosis Patients

Justin P. Rubio, GlaxoSmithKline R&D, UK
Realizing the Promise of Pharmacogenomics

Tomas Olsson, Karolinska Institutet, Sweden
Genes and Lifestyle/Environmental Factors in Multiple Sclerosis and their Interactions

Judith Field, University of Melbourne, Australia
Short Talk: Gene Expression in Immune Cell Subsets: A Risk Gene Study for Multiple Sclerosis

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Cellular and Molecular Profiling: The Road to an Integrated Approach
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Hartmut Wekerle, Max Planck Institut, Germany
From Gut to Brain: The Complex Build-Up of Experimental Autoimmune Encephalomyelitis

William H. Robinson, Stanford University School of Medicine, USA
From Tissue to Proteomics and Lipidomics

Ronald N. Germain, NIAID, National Institutes of Health, USA
Using Highly Multiplexed Data Collection and Computational Biology to Probe the Human Immune System

Simone C. Wuest, NINDS, National Institutes of Health, USA
Short Talk: Investigation of Cellular Intrathecal and Peripheral Immune Responses in Patients with Multiple Sclerosis

Peter Kosa, NINDS, National Institutes of Health, USA
Short Talk: Exosomes – A Potential Source of Biomarkers in Multiple Sclerosis

19:15—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


SUNDAY, JANUARY 13

07:00—08:00
Breakfast

08:00—11:00
Paraclinical Measures of Structural and Functional Change
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France

Elliot M. Frohman, University of Texas Southwestern Medical Center, USA
Eye-ing a Window of Neuroprotection in the Visual System for MS

John C. Gore, Vanderbilt University, USA
Recent Developments in MRI

Adrienne N. Dula, Vanderbilt University, USA
Short Talk: Molecular MRI of Multiple Sclerosis Using 7 Tesla Chemical Exchange Saturation Transfer (CEST)

Paul M. Matthews, GSK/Imperial College London, UK
Short Talk: Interpreting Molecular Imaging Measures of Inflammation in MS

Frauke Zipp, Johannes-Gutenberg-Universität Mainz, Germany
Crosstalk of the Immune and Nervous Systems

Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany
Harnessing the Potential of Cellular and Molecular in vivo Imaging Techniques

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Immunopathogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lawrence Steinman, Stanford University, USA

Stephen M. Anderton, University of Edinburgh, UK
Immune-Mediated Auto-Aggression and Regulation

Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
Integrating Innate Immunity and Key Environmental Interactions

Bahareh Ajami, Stanford University School of Medicine, USA
Short Talk: Pathological Differences in Th1 and Th17 Mediated Experimental Autoimmune Encephalomyelitis (EAE)

Stephen D. Miller, Northwestern University Medical School, USA
Tolerance Induction Using Antigen-Coupled Apoptotic Cells and Biodegradable Nanoparticles for MS Therapy – Mechanisms and Clinical Prospects

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


MONDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—11:00
Clinical Controversies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Helen Tremlett, University of British Columbia, Canada
Emerging Concepts of Disease Heterogeneity

Jun-ichi Kira, Kyushu University, Japan
Cutting Edges of Multiple Sclerosis and Neuromyelitis Optica

* Brenda Banwell, University of Pennsylvania, USA
Negotiating Between ADEM, CIS and MS: An Age-Specific Roadmap

Judith M. Greer, University of Queenland, Australia
Short Talk: HLA Alleles Carried by Patients with Multiple Sclerosis Play a Role in Determining the Disease Course and Distribution of Lesions

Timothy Coetzee, National Multiple Sclerosis Society, USA
CCSVI – Lessons for Funders and the Research Community

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Clinical Developments
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

* Richard A. Rudick, Cleveland Clinic Foundation, USA
Design Issues for Progressive MS Clinical Trials

Paul M. Matthews, GSK/Imperial College London, UK
Treatment Stratification for MS: Opportunities and Challenges

Zongqi Xia, Brigham and Women's Hospital and Harvard Medical School, USA
Short Talk: Leveraging Electronic Health Records for Research in Multiple Sclerosis

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


TUESDAY, JANUARY 15

07:00—08:00
Breakfast

08:00—11:00
Neurobiology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Peter K. Stys, University of Calgary, Canada
Axon-Myelin Interactions

* Trevor J. Kilpatrick, University of Melbourne, Australia
Targeting the Oligodendrocyte Lineage in Demyelinative Disease

Patrick Kuery, University of Duesseldorf, Germany
Short Talk: Nucleocytoplasmic Translocation of p57kip2 Promotes Oligodendroglial Differentiation

Hedwich F. Kuipers, Stanford University, USA
Short Talk: Differential Roles for the Small Heat Shock Protein Alpha B-Crystallin in Cuprizone-Induced De- and Remyelination

Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France
Translational Approaches to Remyelination

Peter I. Jukkola, Ohio State University, USA
Short Talk: K+ Channel Alterations in the Progression of Experimental Autoimmune Encephalomyelitis

09:20—09:40
Coffee Break

11:30—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Cellular Dynamics Underpinning Pathogenesis and Repair
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Amit Bar-Or, Montreal Neurological Institute, Canada
Immune:Glial Interactions in MS: Implication during CNS Injury and Repair

Shannon Dunn, University of Toronto, Canada
Sex Differences in Multiple Sclerosis: Role for Male and Female Pubertal Factors

Gianvito Martino, San Raffaele Scientific Institute, Italy
The Role of Neural Stem Cells in Brain Regeneration

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


WEDNESDAY, JANUARY 16

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Biogen Idec National Multiple Sclerosis Society

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS080288-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline R&D China


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