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This meeting took place in 2013



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Frontiers of NMR in Biology (A3)


Organizer(s) Gerhard Wagner, Angela M. Gronenborn and Marc Baldus
January 13—18, 2013
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 13, 2012
Late Abstract Deadline: Oct 15, 2012
Scholarship Deadline: Sep 13, 2012
Early Registration Deadline: Nov 13, 2012

Supported by the Directors' Fund

Summary of Meeting:
Nuclear magnetic resonance (NMR) spectroscopy has become an important technology in molecular biology and is widely used for elucidating biological mechanisms. It can provide structural information similar and complementary to X-ray crystallography, electron microscopy, mass spectroscopy and small-angle scattering methods. However, NMR can also provide unique insights not obtainable otherwise, such as ones involving weak interactions, enzyme reactions or dynamic states. Thus, the focus of the field is expanding from structure determination to macromolecular interactions, post-translational modifications, functional studies and drug discovery. Unexpected new technologies are constantly emerging suitable to provide new biological insights. Thus, this meeting will include sessions on new enabling technologies and applications to large and challenging systems. Topics will also include membrane protein structures, protein/nucleotide complexes and systems of high biological significance. The symposium will also include presentations on structure-derived function, post-translational modifications studied in whole cells or cell extracts, and drug discovery. The overall goal of the meeting will be to examine recent technological developments and to demonstrate state-of-the-art applications that yield new understanding of biological mechanisms.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 13

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerhard Wagner, Harvard Medical School, USA

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
NMR Methods for Large RNAs: Structure of the HIV-1 5'-Leader

09:00—12:15
New Methods in Solid State NMR
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Marc Baldus, Utrecht University, Netherlands

Beat H. Meier, ETH Zürich, Switzerland
Amyloid Structures by Solid State NMR

Lynette Cegelski, Stanford University, USA
Short Talk: Structure and Function of Bacterial Amyloid Fibers and Biofilms

Tatyana Polenova, University of Delaware, USA
Magic Angle Spinning Solid-State NMR Studies of HIV-1 Protein Assemblies

Cody L. Hoop, University of Pittsburgh, USA
Short Talk: Structural and Motional Investigations of Polyglutamine-Containing Amyloid Fibrils by Magic-Angle-Spinning Solid-State NMR

Bernd Reif, Technische Universität München, Germany
Amyloid Aggregates and Large Soluble Protein Complexes

Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
High-Resolution Protein Structures by Magic-Angle Spinning NMR

09:40—10:00
Coffee Break

12:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
NMR in Cells and Cell Extracts
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mitsuhiko Ikura, University of Toronto, Canada

Philipp Selenko, Leibniz-Institut für Molekulare Pharmakologie (FMP-Berlin), Germany
In-Cell NMR of Post-Translational Protein Modifications

Masahiro Shirakawa, Kyoto University, Japan
In-Cell NMR Spectroscopy of Proteins inside Living Cells

Christopher B. Marshall, University Health Network, Canada
Short Talk: Probing the GTPase Cycle with Real-Time NMR: GAP and GEF Activities in Whole Cell Extracts

Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA
Stable Isotope-Resolved Metabolomic (SIRM) Approach to Measuring Metabolic Dynamics in Cells and Whole Organisms

19:00—19:15
Lightning Talks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerhard Wagner, Harvard Medical School, USA

19:15—20:15
Social Hour with Lite Bites

19:45—22:00
Poster Session 1


TUESDAY, JANUARY 15

07:00—08:00
Breakfast

08:00—11:15
Elucidating Protein Structure and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John L. Markley, University of Wisconsin-Madison, USA

Kevin H. Gardner, CUNY Advanced Science Research Center, USA
Natural and Artificial Control of the Mammalian Hypoxia Response

Mitsuhiko Ikura, University of Toronto, Canada
Dissecting Cancer Cell Signalling and Ion Channel Gating Mechanisms by NMR

Angela M. Gronenborn, University of Pittsburgh, USA
Interactions between HIV Accessory Proteins and Their Cellular Targets

Katherine A. Henzler-Wildman, Washington University, USA
Asymmetry and Exchange in the Mechanism of Multidrug Efflux by EmrE

Sharon L. Campbell, University of North Carolina at Chapel Hill, USA
Short Talk: Ras Activity Regulation by Monoubiquitination

David Fushman, University of Maryland, USA
Short Talk: Deciphering the “Ubiquitin Code”

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop: Methods for Sample Production, Labeling and Measuring

* Gerhard Wagner, Harvard Medical School, USA

Scott A. McCallum, Rensselaer Polytechnic Institute, USA
Investigating the Role of Heparin in the Cooperative Assembly of the VEGF Signaling Complex using Novel 13C/15N Enrichment and Spin-Labeling Approaches

Russell Spencer-Smith, University of Illinois at Chicago, USA
Utilizing Reductive Lysine Methylations in NMR Structural Studies of G-Protein Coupled Receptors

Franz Hagn, Harvard Medical School, USA
Size-Optimized Phospholipid Bilayer Nanodiscs for the NMR Structure Determination of Membrane Proteins

Sarah Ann Monti, University of Maryland, Baltimore County, USA
Characterization of the Monomeric Conformation of the HIV-1 RNA 5’-Untranslated Region

Erik R. P. Zuiderweg, University of Michigan, USA
EZ-ASSIGN: An Algorithm for the Evaluation of Partial Protein Backbone Assignments from Incomplete Triple-Resonance Data

Brian E. Coggins, Duke University Medical Center, USA
Getting Structures Faster: Putting Sparse Sampling and New Processing Methods to Work in Determining Protein Global Folds

16:30—17:00
Coffee Available

17:00—19:00
Nucleotides and Nucleotide/Protein Complexes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Angela M. Gronenborn, University of Pittsburgh, USA

Juli Feigon, University of California, Los Angeles, USA
The Architecture of Telomerase

Walter J. Chazin, Vanderbilt University, USA
Architecture and Remodeling of Modular Multi-Domain Proteins in Genome Maintenance Machines

Michael A. Durney, Harvard University, USA
Short Talk: Equilibrium-Dependent Ribosomal Recoding Mechanisms in RNA Viruses

Michael J. Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Regulation of Spliceosome Assembly and Peroxisomal Biogenesis by Posttranslational Modification

19:00—19:15
Lightning Talks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Marc Baldus, Utrecht University, Netherlands

19:15—20:15
Social Hour with Lite Bites

19:45—22:00
Poster Session 2


WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

08:00—11:00
Membrane Proteins
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ichio Shimada, University of Tokyo, Japan

Marc Baldus, Utrecht University, Netherlands
NMR Studies at the Interface of Cellular and Structural Biology

Linda Columbus, University of Virginia, USA
Structure, Folding and Functional Studies of Opacity-Associated (Opa) Proteins from Neisseria gonorrhoeae

James Jeiwen Chou, Harvard Medical School, USA
An NMR View of Membrane Transporters and Channels

Mohammad T. Mazhab-Jafari, University of Toronto, Canada
Short Talk: Structure and Function of Lipidated, Membrane-Tethered Rheb: NMR Studies of a GTPase on Nanodiscs

Senyon Choe, The Salk Institute, USA
Facile NMR Structure Determination of Human Membrane Proteins

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Drug Targets, NMR in Industry
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Erik R. P. Zuiderweg, University of Michigan, USA

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Drug Discovery Using Fragment-Based Methods

Teresa Carlomagno, European Molecular Biology Laboratory, Heidelberg, Germany
Structural Mechanisms of Drugs Studied by INPHARMA-NMR: Methodology and Applications

Maurizio Pellecchia, Sanford-Burnham Medical Research Institute, USA
Short Talk: HTS by NMR for the Design of Inhibitors of Protein-Protein Interactions

Daniel F. Wyss, Merck Research Laboratories, USA
FBDD on a Tough Target Starts to Yield – Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors

19:00—19:15
Lightning Talks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Angela M. Gronenborn, University of Pittsburgh, USA

19:15—20:15
Social Hour with Lite Bites

19:45—22:00
Poster Session 3


THURSDAY, JANUARY 17

07:00—08:00
Breakfast

08:00—11:15
Solution NMR Methods
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert Kaptein, University of Utrecht, Netherlands

Ad Bax, NIDDK, National Institutes of Health, USA
Extending the Empirical Limits of Chemical Shifts

Gottfried Otting, Australian National University, Australia
Paramagnetic Probes for NMR Studies

Gerhard Wagner, Harvard Medical School, USA
New NMR Experiments for Challenging Proteins

Bernhard Brutscher, Institut de Biologie Structurale, France
Fast-Pulsing NMR Techniques: Applications to the Study of Protein Folding and Structural Disorder

Clemens G. Anklin, Bruker BioSpin Corporation, USA
Short Talk: Continuous Temperature Measurement Inside NMR Samples, the NMR-Thermometer

G. Marius Clore, NIDDK, National Institutes of Health, USA
Short Talk: Atomic Resolution Dynamics on the Surface of Amyloid beta Protofibrils Probed by Dark State Exchange Saturation Transfer (DEST) Spectroscopy

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Folding and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kevin H. Gardner, CUNY Advanced Science Research Center, USA

Ichio Shimada, University of Tokyo, Japan
Functional Equilibrium of Membrane Proteins

Robert Tycko, NIDDK, National Institutes of Health, USA
Amyloid Fibril Structures, in vitro and ex vivo

Anja Böckmann, CNRS, France
Short Talk: The Whole Is Different from the Sum of the Pieces: Full-Length Prions vs. Isolated Domains

Kurt Wüthrich, ETH Zürich / The Scripps Research Institute, Switzerland
Solution NMR with G Protein-Coupled Receptors (GPCRs)

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 18

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


Cambridge Isotope Laboratories


New Era Enterprises, Inc.


NMR-Bio

Agilent Technologies Bruker BioSpin Corporation
ISOTEC, a member of the Sigma-Aldrich Group
Suraj Manrao Student Travel Fund

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck & Co., Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676