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This meeting took place in 2013
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Meeting Details
Frontiers of NMR in Biology (A3)
Organizer(s) Gerhard Wagner, Angela M. Gronenborn and Marc Baldus
January 13 - January 18, 2013
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: September 13, 2012
Late Abstract Deadline: October 15, 2012
Scholarship Deadline: September 13, 2012
Early Registration Deadline: November 13, 2012
Supported by the Directors' Fund
CME Information
Summary of Meeting:
Nuclear magnetic resonance (NMR) spectroscopy has become an important technology in molecular biology and is widely used for elucidating biological mechanisms. It can provide structural information similar and complementary to X-ray crystallography, electron microscopy, mass spectroscopy and small-angle scattering methods. However, NMR can also provide unique insights not obtainable otherwise, such as ones involving weak interactions, enzyme reactions or dynamic states. Thus, the focus of the field is expanding from structure determination to macromolecular interactions, post-translational modifications, functional studies and drug discovery. Unexpected new technologies are constantly emerging suitable to provide new biological insights. Thus, this meeting will include sessions on new enabling technologies and applications to large and challenging systems. Topics will also include membrane protein structures, protein/nucleotide complexes and systems of high biological significance. The symposium will also include presentations on structure-derived function, post-translational modifications studied in whole cells or cell extracts, and drug discovery. The overall goal of the meeting will be to examine recent technological developments and to demonstrate state-of-the-art applications that yield new understanding of biological mechanisms.
CME Information
Nuclear magnetic resonance (NMR) spectroscopy has become an important technology in molecular biology and is widely used for elucidating biological mechanisms. It can provide structural information similar and complementary to X-ray crystallography, electron microscopy, mass spectroscopy and small-angle scattering methods. However, NMR can also provide unique insights not obtainable otherwise, such as ones involving weak interactions, enzyme reactions or dynamic states. Thus, the focus of the field is expanding from structure determination to macromolecular interactions, post-translational modifications, functional studies and drug discovery. Unexpected new technologies are constantly emerging suitable to provide new biological insights. Thus, this meeting will include sessions on new enabling technologies and applications to large and challenging systems. Topics will also include membrane protein structures, protein/nucleotide complexes and systems of high biological significance. The symposium will also include presentations on structure-derived function, post-translational modifications studied in whole cells or cell extracts, and drug discovery. The overall goal of the meeting will be to examine recent technological developments and to demonstrate state-of-the-art applications that yield new understanding of biological mechanisms.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 13
08:00—09:00
Welcome and Keynote Address
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*
Gerhard Wagner,
Harvard Medical School, USA
Michael F. Summers,
HHMI/University of Maryland, Baltimore County, USA
NMR Methods for Large RNAs: Structure of the HIV-1 5'-Leader
NMR Methods for Large RNAs: Structure of the HIV-1 5'-Leader
09:00—12:15
New Methods in Solid State NMR
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*
Marc Baldus,
Utrecht University, Netherlands
Beat H. Meier,
ETH Zürich, Switzerland
Amyloid Structures by Solid State NMR
Amyloid Structures by Solid State NMR
Lynette Cegelski,
Stanford University, USA
Short Talk: Structure and Function of Bacterial Amyloid Fibers and Biofilms
Short Talk: Structure and Function of Bacterial Amyloid Fibers and Biofilms
Tatyana Polenova,
University of Delaware, USA
Magic Angle Spinning Solid-State NMR Studies of HIV-1 Protein Assemblies
Magic Angle Spinning Solid-State NMR Studies of HIV-1 Protein Assemblies
Cody L. Hoop,
University of Pittsburgh, USA
Short Talk: Structural and Motional Investigations of Polyglutamine-Containing Amyloid Fibrils by Magic-Angle-Spinning Solid-State NMR
Short Talk: Structural and Motional Investigations of Polyglutamine-Containing Amyloid Fibrils by Magic-Angle-Spinning Solid-State NMR
Bernd Reif,
Technische Universität München, Germany
Amyloid Aggregates and Large Soluble Protein Complexes
Amyloid Aggregates and Large Soluble Protein Complexes
17:00—19:00
NMR in Cells and Cell Extracts
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*
Mitsuhiko Ikura,
University of Toronto, Canada
Philipp Selenko,
Leibniz-Institut für Molekulare Pharmakologie (FMP-Berlin), Germany
In-Cell NMR of Post-Translational Protein Modifications
In-Cell NMR of Post-Translational Protein Modifications
Masahiro Shirakawa,
Kyoto University, Japan
In-Cell NMR Spectroscopy of Proteins inside Living Cells
In-Cell NMR Spectroscopy of Proteins inside Living Cells
Christopher B. Marshall,
University Health Network, Canada
Short Talk: Probing the GTPase Cycle with Real-Time NMR: GAP and GEF Activities in Whole Cell Extracts
Short Talk: Probing the GTPase Cycle with Real-Time NMR: GAP and GEF Activities in Whole Cell Extracts
Teresa W. M. Fan,
University of Louisville, USA
Stable Isotope-Resolved Metabolomic (SIRM) Approach to Measuring Metabolic Dynamics in Cells and Whole Organisms
Stable Isotope-Resolved Metabolomic (SIRM) Approach to Measuring Metabolic Dynamics in Cells and Whole Organisms
19:00—19:15
Lightning Talks
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*
Gerhard Wagner,
Harvard Medical School, USA
08:00—11:15
Elucidating Protein Structure and Function
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*
John L. Markley,
University of Wisconsin-Madison, USA
Kevin H. Gardner,
University of Texas Southwestern Medical Center, USA
Natural and Artificial Control of the Mammalian Hypoxia Response
Natural and Artificial Control of the Mammalian Hypoxia Response
Mitsuhiko Ikura,
University of Toronto, Canada
Dissecting Cancer Cell Signalling and Ion Channel Gating Mechanisms by NMR
Dissecting Cancer Cell Signalling and Ion Channel Gating Mechanisms by NMR
Angela M. Gronenborn,
University of Pittsburgh, USA
Interactions between HIV Accessory Proteins and Their Cellular Targets
Interactions between HIV Accessory Proteins and Their Cellular Targets
Katherine A. Henzler-Wildman,
Washington University, USA
Asymmetry and Exchange in the Mechanism of Multidrug Efflux by EmrE
Asymmetry and Exchange in the Mechanism of Multidrug Efflux by EmrE
Sharon L. Campbell,
University of North Carolina at Chapel Hill, USA
Short Talk: Ras Activity Regulation by Monoubiquitination
Short Talk: Ras Activity Regulation by Monoubiquitination
David Fushman,
University of Maryland, USA
Short Talk: Deciphering the “Ubiquitin Code”
Short Talk: Deciphering the “Ubiquitin Code”
14:30—16:30
Workshop: Methods for Sample Production, Labeling and Measuring
*
Gerhard Wagner,
Harvard Medical School, USA
Scott A. McCallum,
Rensselaer Polytechnic Institute, USA
Investigating the Role of Heparin in the Cooperative Assembly of the VEGF Signaling Complex using Novel 13C/15N Enrichment and Spin-Labeling Approaches
Investigating the Role of Heparin in the Cooperative Assembly of the VEGF Signaling Complex using Novel 13C/15N Enrichment and Spin-Labeling Approaches
Russell Spencer-Smith,
University of Illinois at Chicago, USA
Utilizing Reductive Lysine Methylations in NMR Structural Studies of G-Protein Coupled Receptors
Utilizing Reductive Lysine Methylations in NMR Structural Studies of G-Protein Coupled Receptors
Franz Hagn,
Harvard Medical School, USA
Size-Optimized Phospholipid Bilayer Nanodiscs for the NMR Structure Determination of Membrane Proteins
Size-Optimized Phospholipid Bilayer Nanodiscs for the NMR Structure Determination of Membrane Proteins
Sarah Ann Monti,
University of Maryland, Baltimore County, USA
Characterization of the Monomeric Conformation of the HIV-1 RNA 5’-Untranslated Region
Characterization of the Monomeric Conformation of the HIV-1 RNA 5’-Untranslated Region
Erik R. P. Zuiderweg,
University of Michigan, USA
EZ-ASSIGN: An Algorithm for the Evaluation of Partial Protein Backbone Assignments from Incomplete Triple-Resonance Data
EZ-ASSIGN: An Algorithm for the Evaluation of Partial Protein Backbone Assignments from Incomplete Triple-Resonance Data
Brian E. Coggins,
Duke University Medical Center, USA
Getting Structures Faster: Putting Sparse Sampling and New Processing Methods to Work in Determining Protein Global Folds
Getting Structures Faster: Putting Sparse Sampling and New Processing Methods to Work in Determining Protein Global Folds
17:00—19:00
Nucleotides and Nucleotide/Protein Complexes
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*
Angela M. Gronenborn,
University of Pittsburgh, USA
Walter J. Chazin,
Vanderbilt University, USA
Architecture and Remodeling of Modular Multi-Domain Proteins in Genome Maintenance Machines
Architecture and Remodeling of Modular Multi-Domain Proteins in Genome Maintenance Machines
Michael A. Durney,
Harvard University, USA
Short Talk: Equilibrium-Dependent Ribosomal Recoding Mechanisms in RNA Viruses
Short Talk: Equilibrium-Dependent Ribosomal Recoding Mechanisms in RNA Viruses
Michael J. Sattler,
Helmholtz Zentrum München & Technische Universität München, Germany
Regulation of Spliceosome Assembly and Peroxisomal Biogenesis by Posttranslational Modification
Regulation of Spliceosome Assembly and Peroxisomal Biogenesis by Posttranslational Modification
19:00—19:15
Lightning Talks
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*
Marc Baldus,
Utrecht University, Netherlands
08:00—11:00
Membrane Proteins
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*
Ichio Shimada,
University of Tokyo, Japan
Marc Baldus,
Utrecht University, Netherlands
NMR Studies at the Interface of Cellular and Structural Biology
NMR Studies at the Interface of Cellular and Structural Biology
Linda Columbus,
, USA
Structure, Folding and Functional Studies of Opacity-Associated (Opa) Proteins from Neisseria gonorrhoeae
Structure, Folding and Functional Studies of Opacity-Associated (Opa) Proteins from Neisseria gonorrhoeae
Mohammad T. Mazhab-Jafari,
University of Toronto, Canada
Short Talk: Structure and Function of Lipidated, Membrane-Tethered Rheb: NMR Studies of a GTPase on Nanodiscs
Short Talk: Structure and Function of Lipidated, Membrane-Tethered Rheb: NMR Studies of a GTPase on Nanodiscs
17:00—19:00
Drug Targets, NMR in Industry
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*
Erik R. P. Zuiderweg,
University of Michigan, USA
Stephen W. Fesik,
Vanderbilt University School of Medicine, USA
Cancer Drug Discovery Using Fragment-Based Methods
Cancer Drug Discovery Using Fragment-Based Methods
Teresa Carlomagno,
European Molecular Biology Laboratory, Heidelberg, Germany
Structural Mechanisms of Drugs Studied by INPHARMA-NMR: Methodology and Applications
Structural Mechanisms of Drugs Studied by INPHARMA-NMR: Methodology and Applications
Maurizio Pellecchia,
Sanford-Burnham Medical Research Institute, USA
Short Talk: HTS by NMR for the Design of Inhibitors of Protein-Protein Interactions
Short Talk: HTS by NMR for the Design of Inhibitors of Protein-Protein Interactions
Daniel F. Wyss,
Merck Research Laboratories, USA
FBDD on a Tough Target Starts to Yield – Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors
FBDD on a Tough Target Starts to Yield – Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors
19:00—19:15
Lightning Talks
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*
Angela M. Gronenborn,
University of Pittsburgh, USA
08:00—11:15
Solution NMR Methods
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*
Robert Kaptein,
University of Utrecht, Netherlands
Bernhard Brutscher,
Institut de Biologie Structurale, France
Fast-Pulsing NMR Techniques: Applications to the Study of Protein Folding and Structural Disorder
Fast-Pulsing NMR Techniques: Applications to the Study of Protein Folding and Structural Disorder
Clemens G. Anklin,
Bruker BioSpin Corporation, USA
Short Talk: Continuous Temperature Measurement Inside NMR Samples, the NMR-Thermometer
Short Talk: Continuous Temperature Measurement Inside NMR Samples, the NMR-Thermometer
G. Marius Clore,
NIDDK, National Institutes of Health, USA
Short Talk: Atomic Resolution Dynamics on the Surface of Amyloid beta Protofibrils Probed by Dark State Exchange Saturation Transfer (DEST) Spectroscopy
Short Talk: Atomic Resolution Dynamics on the Surface of Amyloid beta Protofibrils Probed by Dark State Exchange Saturation Transfer (DEST) Spectroscopy
17:00—19:00
Folding and Disease
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*
Kevin H. Gardner,
University of Texas Southwestern Medical Center, USA
Ichio Shimada,
University of Tokyo, Japan
Functional Equilibrium of Membrane Proteins
Functional Equilibrium of Membrane Proteins
Robert Tycko,
NIDDK, National Institutes of Health, USA
Amyloid Fibril Structures, in vitro and ex vivo
Amyloid Fibril Structures, in vitro and ex vivo
Anja Böckmann,
CNRS, France
Short Talk: The Whole Is Different from the Sum of the Pieces: Full-Length Prions vs. Isolated Domains
Short Talk: The Whole Is Different from the Sum of the Pieces: Full-Length Prions vs. Isolated Domains
Kurt Wüthrich,
ETH Zürich / The Scripps Research Institute, Switzerland
Solution NMR with G Protein-Coupled Receptors (GPCRs)
Solution NMR with G Protein-Coupled Receptors (GPCRs)
*Session Chair †Speaker invited, not yet responded.
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