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This meeting took place in 2013
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Meeting Details
Hematopoiesis (A4)
Organizer(s) Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck
January 14 - January 19, 2013
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: September 13, 2012
Late Abstract Deadline: October 16, 2012
Scholarship Deadline: September 13, 2012
Early Registration Deadline: November 13, 2012
Sponsored by Celgene Corporation
CME Information
Summary of Meeting:
Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self-renewal process, development of the hematopoietic system and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potential therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease.
CME Information
Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self-renewal process, development of the hematopoietic system and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potential therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease.
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, JANUARY 14
08:00—11:15
Developmental Hematopoiesis Including ES and iPS to Blood
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*
David Traver,
University of California, San Diego, USA
Catherine Porcher,
University of Oxford, UK
The SCL Complex in Haematopoiesis
The SCL Complex in Haematopoiesis
Elaine A. Dzierzak,
Erasmus University, Netherlands
Development of Adult HSCs and the Involvement of Gata2
Development of Adult HSCs and the Involvement of Gata2
Joanna M. Tober,
University of Pennsylvania, USA
Runx1 is Required through E11.5 for Hematopoietic Progenitor and HSC Formation
Runx1 is Required through E11.5 for Hematopoietic Progenitor and HSC Formation
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Thierry Jaffredo,
University Pierre and Marie Curie, CNRS UMR7622, France
Short Talk: In vivo Multilineage Hematopoietic Production by Bone Marrow-Derived Hemogenic Endothelium
Short Talk: In vivo Multilineage Hematopoietic Production by Bone Marrow-Derived Hemogenic Endothelium
Christopher M. Sturgeon,
McEwen Centre for Regenerative Medicine, Canada
Short Talk: Human Definitive and Primitive Hematopoiesis Are Specified Simultaneously from Human Pluripotent Stem Cells
Short Talk: Human Definitive and Primitive Hematopoiesis Are Specified Simultaneously from Human Pluripotent Stem Cells
14:30—16:30
Workshop 1: Stem Cell Self-Renewal
*
Thierry Jaffredo,
University Pierre and Marie Curie, CNRS UMR7622, France
Lev Silberstein,
Massachusetts General Hospital, USA
Single Cell RNA-Seq Analysis Identifies a Novel Embigin+ CD106+ Population of the Osteolineage Cells which Modulate HSPC Behavior
Single Cell RNA-Seq Analysis Identifies a Novel Embigin+ CD106+ Population of the Osteolineage Cells which Modulate HSPC Behavior
Dan Su,
NIEHS, National Institutes of Health, USA
Chromatin State Primes Stress Specific p53-Regulated Gene Responses in Human Lymphoblastoid Cells
Chromatin State Primes Stress Specific p53-Regulated Gene Responses in Human Lymphoblastoid Cells
Saghi Ghaffari,
Mount Sinai School of Medicine, USA
SIRT1 Deacetylase is Essential for Hematopoietic Stem Cell Activity via Regulation of Foxo3
SIRT1 Deacetylase is Essential for Hematopoietic Stem Cell Activity via Regulation of Foxo3
Anna E. Beaudin,
University of California, Santa Cruz, USA
Discovery of a Novel, Developmentally Restricted Hematopoietic Stem Cell
Discovery of a Novel, Developmentally Restricted Hematopoietic Stem Cell
Eric M. Pietras,
University of California, San Francisco, USA
Type I Interferons Induce Transient Proliferation and Antagonize HSC Function by Altering Interactions with the Bone Marrow Niche
Type I Interferons Induce Transient Proliferation and Antagonize HSC Function by Altering Interactions with the Bone Marrow Niche
Rong Lu,
Stanford University, USA
Systems-Level Clonal Tracking of Mouse Hematopoietic Stem Cells in Vivo
Systems-Level Clonal Tracking of Mouse Hematopoietic Stem Cells in Vivo
Shalin H. Naik,
Walter & Eliza Hall Institute, Australia
Distinct Lineage Production by Single Hematopoietic Progenitors in vivo, as Revealed by Cellular Barcoding
Distinct Lineage Production by Single Hematopoietic Progenitors in vivo, as Revealed by Cellular Barcoding
17:00—18:40
Novel Hematopoietic Regulators
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*
Margaret A. Goodell,
Baylor College of Medicine, USA
Leonard I. Zon,
HHMI/Children's Hospital Boston, USA
Pathways Regulating Engraftment of Blood Stem Cells
Pathways Regulating Engraftment of Blood Stem Cells
Sean J. Morrison,
HHMI/University of Texas Southwestern Medical Center, USA
Haematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow
Haematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow
18:40—19:30
Keynote Address
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George Q. Daley,
Children's Hospital Boston, USA
Milestones and Barriers in HSC Production from Pluripotent Stem Cells
Milestones and Barriers in HSC Production from Pluripotent Stem Cells
08:00—11:15
Adult Stem Cell Self-Renewal and Function
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*
Elaine A. Dzierzak,
Erasmus University, Netherlands
Emmanuelle Passegué,
University of California, San Francisco, USA
DNA Damage in Old Hematopoietic Stem Cells
DNA Damage in Old Hematopoietic Stem Cells
Amy J. Wagers,
Harvard University, USA
Local and Systemic Regulation of Blood Stem Cell Function throughout Life
Local and Systemic Regulation of Blood Stem Cell Function throughout Life
Margaret A. Goodell,
Baylor College of Medicine, USA
Regulation of Hematopoietic Stem Cells by de novo DNA Methyltransferases
Regulation of Hematopoietic Stem Cells by de novo DNA Methyltransferases
Daniel G. Tenen,
Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors and DNA Methylation by Noncoding RNAs
Regulation of Myeloid Transcription Factors and DNA Methylation by Noncoding RNAs
Catherine S. Spina,
Boston University & Wyss Institute, USA
Short Talk: A Bone Marrow-on-a-Chip that Maintains Hematopoietic Regenerative Capacity in vitro
Short Talk: A Bone Marrow-on-a-Chip that Maintains Hematopoietic Regenerative Capacity in vitro
Jian Huang,
University of Pennsylvania, USA
Short Talk: Maintenance of Hematopoietic Stem Cells through Regulation of Wnt and mTOR Pathways
Short Talk: Maintenance of Hematopoietic Stem Cells through Regulation of Wnt and mTOR Pathways
17:00—19:00
Microenvironment
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*
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
Bone Cells Govern T Lymphopoiesis by Regulating Thymic Emigrants from Bone Marrow
Bone Cells Govern T Lymphopoiesis by Regulating Thymic Emigrants from Bone Marrow
Toshio Suda,
Keio University, Japan
A Metabolic Guide to Stem Cell Homeostasis
A Metabolic Guide to Stem Cell Homeostasis
Michael P. Cooke,
Genomics Institute of the Novartis Research Foundation, USA
Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor
Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor
Michael D. Ginsberg,
Weill Cornell Medical College, USA
Short Talk: Efficient Transcriptional Reprogramming of Mature Amniotic Cells into Vascular Niche Cells that Support Hematopoiesis
Short Talk: Efficient Transcriptional Reprogramming of Mature Amniotic Cells into Vascular Niche Cells that Support Hematopoiesis
08:00—11:00
Erythroid and Megakaryocyte Development
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*
Berthold Gottgens,
Cambridge Institute for Medical Research, UK
Stuart H. Orkin,
Dana-Farber Cancer Institute, USA
Regulation of Erythroid Stage Transcription and Globin Gene Switching
Regulation of Erythroid Stage Transcription and Globin Gene Switching
Christopher Thom,
Children's Hospital of Philadelphia, USA
Short Talk: A Putative E3 Ubiquitin Ligase that Regulates Cytokinesis During Late Stage Erythropoiesis
Short Talk: A Putative E3 Ubiquitin Ligase that Regulates Cytokinesis During Late Stage Erythropoiesis
Harvey Lodish,
Whitehead Institute for Biomedical Research, USA
The Terminal Stages of Red Cell Development
The Terminal Stages of Red Cell Development
Hanna K. A. Mikkola,
University of California, Los Angeles, USA
Specification and Self-Renewal of Hematopoietic Stem Cells
Specification and Self-Renewal of Hematopoietic Stem Cells
Soraya Carrancio,
Celgene, USA
Short Talk: Sotatercept, an Activin Receptor IIA (ActRIIA) Ligand Trap, Promotes Late-Stage Erythropoiesis and a Rapid Induction of Red Blood Cell Number and Hemoglobin
Short Talk: Sotatercept, an Activin Receptor IIA (ActRIIA) Ligand Trap, Promotes Late-Stage Erythropoiesis and a Rapid Induction of Red Blood Cell Number and Hemoglobin
Jalal Ahmed,
Mount Sinai School of Medicine, USA
Short Talk: Characterization of the Fetal Liver Hematopoietic Stem Cell Niche
Short Talk: Characterization of the Fetal Liver Hematopoietic Stem Cell Niche
14:30—16:30
Workshop 2: Differentiation of Hematopoietic Cells
*
Hanna K. A. Mikkola,
University of California, Los Angeles, USA
Wilson K. Clements,
St. Jude Children's Research Hospital, USA
Atypical Wnt Receptor Involvement in Hematopoietic Stem Cell Specification and Leukemia
Atypical Wnt Receptor Involvement in Hematopoietic Stem Cell Specification and Leukemia
Yehudit Birger,
Sheba Medical Center, Israel
Perturbation of Fetal Mega-Erythropoiesis in a Mouse Model of Down Syndrome Transient Myeloproliferative Disorder
Perturbation of Fetal Mega-Erythropoiesis in a Mouse Model of Down Syndrome Transient Myeloproliferative Disorder
Tiago C. Luis,
Weatherall Institute of Molecular Medicine, UK
Embryonic Thymopoiesis Is Initiated by Immune-Restricted Lympho-Myeloid Progenitor Cells
Embryonic Thymopoiesis Is Initiated by Immune-Restricted Lympho-Myeloid Progenitor Cells
Victoria R. Moignard,
University of Cambridge, UK
Single Cell Gene Expression Analysis in Primary Blood Stem and Progenitor Cells Reveals Dynamic Transcriptional Network States and Identifies New Links between Key Regulators
Single Cell Gene Expression Analysis in Primary Blood Stem and Progenitor Cells Reveals Dynamic Transcriptional Network States and Identifies New Links between Key Regulators
Ryo Yamamoto,
University of Tokyo, Japan
In vivo Clonal Analysis of Hematopoietic Stem Cells Unveils Novel Non-Stepwise Differentiation Pathways
In vivo Clonal Analysis of Hematopoietic Stem Cells Unveils Novel Non-Stepwise Differentiation Pathways
Hsuan-Ting Huang,
Children's Hospital Boston, USA
Suppression of chd7 Enhances Hematopoietic Development
Suppression of chd7 Enhances Hematopoietic Development
17:00—19:00
Hematopoietic Cell Differentiation and Function
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*
Iannis Aifantis,
HHMI/New York University School of Medicine, USA
Berthold Gottgens,
Cambridge Institute for Medical Research, UK
Combinatorial Transcriptional Control of Blood Stem and Progenitor Cells
Combinatorial Transcriptional Control of Blood Stem and Progenitor Cells
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Control of Immunoglobulin Diversity through Spatial Regulation of V(D)J Recombination
Control of Immunoglobulin Diversity through Spatial Regulation of V(D)J Recombination
Irving L. Weissman,
Stanford University School of Medicine, USA
Normal and Neoplastic Stem Cell
Normal and Neoplastic Stem Cell
Emery H. Bresnick,
University of Wisconsin School of Medicine and Public Health, USA
Short Talk: Establishing the Definitive Hematopoietic Stem/Progenitor Cell Compartment
Short Talk: Establishing the Definitive Hematopoietic Stem/Progenitor Cell Compartment
08:00—11:15
Leukemogenesis
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*
Harvey Lodish,
Whitehead Institute for Biomedical Research, USA
Ross L. Levine,
Memorial Sloan-Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of Myeloid Malignancies
Role of Mutations in Epigenetic Regulators in Pathogenesis of Myeloid Malignancies
Scott A. Armstrong,
Memorial Sloan-Kettering Cancer Center, USA
Molecular Characterization of Leukemia Stem Cell Self-Renewal
Molecular Characterization of Leukemia Stem Cell Self-Renewal
Iannis Aifantis,
HHMI/New York University School of Medicine, USA
Short Talk: Ubiquitin-Mediated Protein Half-Life and its Impact on Leukemia-Initiating Cell Function
Short Talk: Ubiquitin-Mediated Protein Half-Life and its Impact on Leukemia-Initiating Cell Function
John E. Dick,
Princess Margaret Cancer Centre, University Health Network, Canada
Toward Unification of the Genetic and Cancer Stem Cell Models of Leukemia
Toward Unification of the Genetic and Cancer Stem Cell Models of Leukemia
Wei Tong,
Children's Hospital of Philadelphia, USA
Investigation of Novel Signaling Pathways in Hematopoietic Stem Cells
Investigation of Novel Signaling Pathways in Hematopoietic Stem Cells
Anwesha Dey,
Genentech Inc., USA
Short Talk: Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
Short Talk: Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
17:00—19:00
Lymphoid
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*
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Sten Eirik W. Jacobsen,
University of Oxford, UK
Emergence of Immune Restricted Lympho-Myeloid Progenitors Prior to Definitive Hematopoietic Stem Cells
Emergence of Immune Restricted Lympho-Myeloid Progenitors Prior to Definitive Hematopoietic Stem Cells
Ellen V. Rothenberg,
California Institute of Technology, USA
Sequential Operation of Gene Regulatory Networks in the Stem Cell to T Cell Commitment Process
Sequential Operation of Gene Regulatory Networks in the Stem Cell to T Cell Commitment Process
Louise M. Treanor,
St. Jude Children's Research Hospital, USA
Short Talk: Genetic Lesions that Drive Early T-Cell Precursor Leukemia in Multipotent Primitive Thymocytes
Short Talk: Genetic Lesions that Drive Early T-Cell Precursor Leukemia in Multipotent Primitive Thymocytes
*Session Chair †Speaker invited, not yet responded.
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