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JW Marriott New Orleans Floorplan

JW Marriott New Orleans Floorplan

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This meeting took place in 2013



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Malaria (A8)


Organizer(s) Fidel P. Zavala, Andrew P. Waters, Kevin Marsh and Carolina V. Barillas-Mury
January 20—25, 2013
JW Marriott New Orleans • New Orleans, Louisiana USA
Abstract Deadline: Sep 20, 2012
Late Abstract Deadline: Oct 23, 2012
Scholarship Deadline: Sep 20, 2012
Early Registration Deadline: Nov 15, 2012

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation, with additional support from Medicines for Malaria Venture — Ian Bathurst Global Health Travel Awards

Summary of Meeting:
Malaria affects hundreds of millions of people and causes nearly 1 million deaths per year. The control and eventual eradication of malaria will require a concerted, multi-disciplinary effort to decrease parasite infectivity through vaccines and anti-parasitic drugs, and by preventing transmission to the vertebrate host. In this meeting we will promote discussion of: 1) Innate and adaptive immune responses to Plasmodium infection and how the parasite interferes with these responses; 2) Development of new adjuvants and anti-malaria vaccine strategies; 3) Basic aspects of Plasmodium cellular and population biology that affect infection and the development of drug resistance; 4) Plasmodium transmission, including gametocytogenesis and Plasmodium biology in the mosquito vector, including cellular and molecular aspects of parasite-mosquito interactions, field studies, functional genomics and the development of potential control strategies; and 5) Severe malaria in endemic areas, recent advances in our understanding of the physiopathology of disease in humans and in animal models, and genome-based strategies to identify biomarkers of susceptibility to severe disease. Since basic and translational malaria research is eminently multi-disciplinary, the 2013 Keystone Symposia meeting on Malaria will bring together researchers working in disciplines ranging from basic molecular studies to population biology. This encounter will promote the exchange of ideas to both deepen our understanding of malaria and to develop novel control measures. Furthermore, we anticipate that this meeting will enable us to identify and prioritize the next generation of challenges faced by the field.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 20

16:00—20:00
Arrival and Registration
IDF Foyer

MONDAY, JANUARY 21

07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia
Cell-cell Communication between Malaria Parasites Promotes Sexual Differentiation via Exosome-like Vesicles

09:30—12:45
Understanding Protective Immunity Against Plasmodium
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Mats Wahlgren, Karolinska Institutet, Sweden

Kevin Marsh, Kenya Medical Research Institute, Wellcome Trust Research Program, Kenya
Immune Responses to Malaria in Endemic Areas

Susan K. Pierce, NIAID, National Institutes of Health, USA
Tipping the Scale in Severe Malaria: The Link between Susceptibility to Autoimmunity and Resistance to Severe Disease

Jean Langhorne, National Institute for Medical Research, UK
Induction and Maintenance of IgG Responses during Blood-Stage Plasmodium chabaudi Malaria

William R. Heath, University of Melbourne, Australia
Antigen Presentation in Rodent Malaria

Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA
Effector Liver-Resident Memory CD8+ T Cells

10:50—11:10
Coffee Break
IDF Foyer
12:45—13:45
Poster Setup
Orleans/Rosalie/St. Claude
13:45—22:00
Poster Viewing
Orleans/Rosalie/St. Claude
12:45—16:30
On Own for Lunch and Recreation
Ile de France III
16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
New Approaches to Vaccination
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA

Robert Sauerwein, Radboud University, Netherlands
Experimental Vaccination of Humans with Sporozoites

Simon J. Draper, University of Oxford, UK
Combinatorial Vaccines Against Blood-Stages

Sarah E. Reece, University of Edinburgh, UK
The Private Life of Parasites: Implications for Blocking Transmission

Arturo Reyes-Sandoval, University of Oxford, UK
Short Talk: A Highly Immunogenic and Protective Plasmodium vivax Vaccine Using MVA and Chimpanzee Adenovirus Expressing TRAP: Potential for Clinical Use

19:00—20:00
Social Hour with Lite Bites
Orleans/Rosalie/St. Claude
19:30—22:00
Poster Session 1
Orleans/Rosalie/St. Claude

TUESDAY, JANUARY 22

07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—11:45
Cellular and Molecular Biology of Plasmodium
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Andrew P. Waters, University of Glasgow, UK

Robert Ménard, Institut Pasteur, France
Host Cell Invasion by Apicomplexa

Volker T. Heussler, Institute of Cell Biology, Switzerland
Host Cell Autophagy Supports Growth of Plasmodium Liver Stage Parasites

Maria M. Mota, Instituto de Medicina Molecular, Portugal
PVM- The Interface between Plasmodium and the Host Cell

Manoj T. Duraisingh, Harvard School of Public Health, USA
In vitro Functional Analysis of Erythrocyte Variation and Plasmodium Infection

Lea Barfod, University of Copenhagen, Denmark
Short Talk: The Density of Knobs on Plasmodium falciparum-Infected Erythrocytes Depends on Developmental Age and Varies among Isolates

Markus Meissner, University of Glasgow, UK
Short Talk: Actin, Myosin A and MIC2 Independent Invasion of the Host Cell by Toxoplasma gondii

09:50—10:10
Coffee Break
IDF Foyer
11:45—13:00
Poster Setup
Orleans/Rosalie/St. Claude
13:00—22:00
Poster Viewing
Orleans/Rosalie/St. Claude
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 1: Biology of Pre-Erythrocytic Forms
Ile de France Ballroom
* Maria M. Mota, Instituto de Medicina Molecular, Portugal

Maurice A. Itoe, Instituto de Medicina Molecular, Portugal
Plasmodium Hijacks Host Phospholipid Biosynthesis Machinery to Establish Liver Stage Infection

Ashley M. Vaughan, Seattle Biomedical Research Institute, USA
Apicoplast-Targeted Phosphatidic Acid Synthesis Is Essential for Plasmodium yoelii Liver Stage Development

Alexis Kaushansky, Seattle Biomedical Research Institute, USA
Profiling Host Apoptosis in Plasmodium-Infected Hepatocytes Reveals a Key Point of Susceptibility in the Mitochondrial Apoptotic Cascade

Lander Foquet, Ghent University, Belgium
Anti-Circumsporozoite Antibodies Induced by the RTS,S Vaccine Block Hepatocyte Invasion of Plasmodium falciparum Sporozoites in a Humanized Mouse Model

Katharine A. Collins, University of Oxford, UK
R21, a Particle-Based Vaccine for a Combination Approach to Malaria Vaccination

Julius C. R. Hafalla, London School of Hygiene and Tropical Medicine, UK
Targets of CD8+ T Cell Responses Against Malaria Liver Stages

Sebastian A. Mikolajczak, Seattle Biomedical Research Institute, USA
Plasmodium vivax Liver Stage Development and Hypnozoite Formation in a Human Liver Chimeric Mouse Model

Shengyong Ng, Massachusetts Institute of Technology, USA
Hypoxia Promotes Liver-Stage Malaria Infection in Primary Human Hepatocytes in Vitro

16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
Integrating Genomic Science and Population Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Dyann F. Wirth, Harvard School of Public Health, USA

David J. Conway, London School of Hygiene and Tropical Medicine, UK
Parasite Population Genomics Identifies Targets of Immunity

Michael T. Ferdig, University of Notre Dame, USA
The Parasite Fights Back: Co-Expression Networks Distinguish Phenotypic States

Mario Recker, University of Oxford, UK
Short Talk: Evolutionary Determinants of the Var Gene Domain and Repertoire Architecture of Plasmodium falciparum

Yael Artzy-Randrup, HHMI/University of Michigan, USA
Short Talk: Population Structuring of Multi-Copy, Antigen-Encoding Genes in Plasmodium falciparum

19:00—20:00
Social Hour with Lite Bites
Orleans/Rosalie/St. Claude
19:30—22:00
Poster Session 2
Orleans/Rosalie/St. Claude

WEDNESDAY, JANUARY 23

07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:00—08:30
Poster Setup
Orleans/Rosalie/St. Claude
08:30—11:45
Vector Biology and Malaria Transmission
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Oliver Billker, Wellcome Trust Sanger Institute, UK

Carolina V. Barillas-Mury, NIAID, National Institutes of Health, USA
Plasmodium falciparum Evasion of the Mosquito Immune System

George Dimopoulos, Johns Hopkins University, USA
Targeting Plasmodium in the Mosquito Gut

Flaminia Catteruccia, Harvard School of Public Health, USA
Molecular Mechanisms of Fecundity and Fertility in Anopheles gambiae Mosquitoes

Luciano A. Moreira, Instituto de Pesquisas René Rachou-Fiocruz, Brazil
Using Wolbachia to Control Vector-Borne Diseases

Grant L. Hughes, Pennsylvania State University, USA
Short Talk: Native Microbiota Impede Vertical Transmission of Wolbachia in the Major Malaria Vector Anopheles gambiae

Ryan C. Smith, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Multiple Mechanisms of Late-Phase Immunity Limit Plasmodium Development in the Mosquito Anopheles gambiae

09:50—10:10
Coffee Break
IDF Foyer
08:30—17:00
Poster Viewing
Orleans/Rosalie/St. Claude
11:45—12:30
Lunch
Ile de France III
12:30—15:00
Poster Session 3
Orleans/Rosalie/St. Claude
15:00—15:30
Coffee Available
IDF Foyer
15:30—17:30
Biology of Plasmodium Transmission Stages
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Carolina V. Barillas-Mury, NIAID, National Institutes of Health, USA

Andrew P. Waters, University of Glasgow, UK
Commitment to Sexual Development in Plasmodium – Identification of a Conserved Transcription Factor that Is Essential to Gametocytogenesis

Oliver Billker, Wellcome Trust Sanger Institute, UK
Signaling and Zygote Development

Friedrich Frischknecht, University of Heidelberg, Germany
Mechanisms of Plasmodium Sporozoite Motility

Jun Miao, Pennsylvania State University, USA
Short Talk: Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites

17:30—
On Own for Dinner

THURSDAY, JANUARY 24

07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—11:45
Epidemiology and Pathogenesis of Severe Malaria
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Kevin Marsh, Kenya Medical Research Institute, Wellcome Trust Research Program, Kenya

Emelda A. Okiro, Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
The Epidemiology of Severe Malaria in Africa

Terrie E. Taylor, Michigan State University, USA
The Pathogenesis of Cerebral Malaria: Recent Clinical Insights

Christian R. Engwerda, Queensland Institute of Medical Research, Australia
Early Suppression of Malaria-Specific T Cells Responses: Implications for Immunity and Disease Pathogenesis

Dominic Kwiatkowski, Wellcome Trust Centre for Human Genetics, UK
New Genetic Findings from Studying Diverse Populations

Linda M. Murungi, Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
Short Talk: Antibody Responses Against Merozoite Antigens and Risk of Severe Malaria

Laurent Rénia, Singapore Immunology Network, (SIgN), A*STAR, Singapore
Short Talk: Brain Microvessel Cross-Presentation Is a Hallmark of Experimental Cerebral Malaria

09:50—10:10
Coffee Break
IDF Foyer
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 2: Immune Dysfunctions in Vaccines and Pathogenesis
Ile de France Ballroom
* Jean Langhorne, National Institute for Medical Research, UK

Michelle N. Wykes, Queensland Institute of Medical Research, Australia
Restoration of Long-Term Protection Against Malaria in Mice without PD-1

Johanna (Gianna) M. G. Triller, Max Planck Institute for Infection Biology, Germany
Atypical and Classical Memory B Cells Produce Plasmodium falciparum Neutralizing Antibodies

Simone Abel, University Hospital Essen, Germany
Regulatory T Cells Substantially Impair Plasmodium yoelii-Directed Immune Response

Philippe E. Van den Steen, Rega Institute, Catholic University of Leuven, Belgium
Hemozoin Is a Prominent Inflammatory Virulence Factor in Malaria-Associated Acute Respiratory Distress Syndrome

Carolyne M. Kifude, Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
Identification of PfEMP1 Variant Associated with Rosetting in a Field Isolate and Functional Characterization of the Antibodies

Silvia Portugal, NIAID, National Institutes of Health, USA
A Molecular Signature of Inflammation-Attenuation and Tolerance following Febrile Malaria

16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
Mechanisms of Drug Resistance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ile de France Ballroom
* Dominic Kwiatkowski, Wellcome Trust Centre for Human Genetics, UK

David A. Fidock, Columbia University Medical Center, USA
Molecular and Cellular Basis of Antimalarial Drug Resistance

Dyann F. Wirth, Harvard School of Public Health, USA
Genetics Analysis of Drug Resistance

Xin-zhuan Su, NIAID, National Institutes of Health, USA
Chemical Genomics Approaches to Study Mechanism(s) of Drug Action and Drug Resistance

Pradipsinh K. Rathod, University of Washington, USA
Short Talk: A Two-Step Evolutionary Strategy to Acquire Beneficial DNA Amplifications in Asexual Populations of Plasmodium falciparum, with Minimum Collateral Damage in Surviving Parasites

20:00—21:00
Social Hour with Lite Bites
Ile de France Ballroom
20:00—23:00
Entertainment
Ile de France Ballroom

FRIDAY, JANUARY 25

 
Departure

*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation Medicines for Malaria Venture — Ian Bathurst Global Health Travel Awards

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI102425-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Malaria Nexus Malaria World

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676