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JW Marriott New Orleans Floorplan
This meeting took place in 2013
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Meeting Details
Malaria (A8)
Organizer(s) Fidel P. Zavala, Andrew P. Waters, Kevin Marsh and Carolina V. Barillas-Mury
January 20 - January 25, 2013
JW Marriott New Orleans • New Orleans, Louisiana USA
Abstract Deadline: September 20, 2012
Late Abstract Deadline: October 23, 2012
Scholarship Deadline: September 20, 2012
Early Registration Deadline: November 15, 2012
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation, with additional support from Medicines for Malaria Venture — Ian Bathurst Global Health Travel Awards
CME Information
Summary of Meeting:
Malaria affects hundreds of millions of people and causes nearly 1 million deaths per year. The control and eventual eradication of malaria will require a concerted, multi-disciplinary effort to decrease parasite infectivity through vaccines and anti-parasitic drugs, and by preventing transmission to the vertebrate host. In this meeting we will promote discussion of: 1) Innate and adaptive immune responses to Plasmodium infection and how the parasite interferes with these responses; 2) Development of new adjuvants and anti-malaria vaccine strategies; 3) Basic aspects of Plasmodium cellular and population biology that affect infection and the development of drug resistance; 4) Plasmodium transmission, including gametocytogenesis and Plasmodium biology in the mosquito vector, including cellular and molecular aspects of parasite-mosquito interactions, field studies, functional genomics and the development of potential control strategies; and 5) Severe malaria in endemic areas, recent advances in our understanding of the physiopathology of disease in humans and in animal models, and genome-based strategies to identify biomarkers of susceptibility to severe disease.
Since basic and translational malaria research is eminently multi-disciplinary, the 2013 Keystone Symposia meeting on Malaria will bring together researchers working in disciplines ranging from basic molecular studies to population biology. This encounter will promote the exchange of ideas to both deepen our understanding of malaria and to develop novel control measures. Furthermore, we anticipate that this meeting will enable us to identify and prioritize the next generation of challenges faced by the field.
CME Information
Malaria affects hundreds of millions of people and causes nearly 1 million deaths per year. The control and eventual eradication of malaria will require a concerted, multi-disciplinary effort to decrease parasite infectivity through vaccines and anti-parasitic drugs, and by preventing transmission to the vertebrate host. In this meeting we will promote discussion of: 1) Innate and adaptive immune responses to Plasmodium infection and how the parasite interferes with these responses; 2) Development of new adjuvants and anti-malaria vaccine strategies; 3) Basic aspects of Plasmodium cellular and population biology that affect infection and the development of drug resistance; 4) Plasmodium transmission, including gametocytogenesis and Plasmodium biology in the mosquito vector, including cellular and molecular aspects of parasite-mosquito interactions, field studies, functional genomics and the development of potential control strategies; and 5) Severe malaria in endemic areas, recent advances in our understanding of the physiopathology of disease in humans and in animal models, and genome-based strategies to identify biomarkers of susceptibility to severe disease. Since basic and translational malaria research is eminently multi-disciplinary, the 2013 Keystone Symposia meeting on Malaria will bring together researchers working in disciplines ranging from basic molecular studies to population biology. This encounter will promote the exchange of ideas to both deepen our understanding of malaria and to develop novel control measures. Furthermore, we anticipate that this meeting will enable us to identify and prioritize the next generation of challenges faced by the field.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 20
16:00—20:00
Arrival and Registration
IDF Foyer
07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
Alan F. Cowman,
Walter and Eliza Hall Institute of Medical Research, Australia
Merozoite Invasion and Remodeling of Erythrocytes by Malaria Parasites
Merozoite Invasion and Remodeling of Erythrocytes by Malaria Parasites
09:30—12:45
Understanding Protective Immunity Against Plasmodium
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Mats Wahlgren,
Karolinska Institutet, Sweden
Kevin Marsh,
Kenya Medical Research Institute, Wellcome Trust Research Program, Kenya
Immune Responses to Malaria in Endemic Areas
Immune Responses to Malaria in Endemic Areas
Susan K. Pierce,
NIAID, National Institutes of Health, USA
Tipping the Scale in Severe Malaria: The Interplay of Host Genes and the Environment
Tipping the Scale in Severe Malaria: The Interplay of Host Genes and the Environment
Jean Langhorne,
National Institute for Medical Research, UK
Induction and Maintenance of IgG Responses during Blood-Stage Plasmodium chabaudi Malaria
Induction and Maintenance of IgG Responses during Blood-Stage Plasmodium chabaudi Malaria
Fidel P. Zavala,
Johns Hopkins Bloomberg School of Public Health, USA
Effector Liver-Resident Memory CD8+ T Cells
Effector Liver-Resident Memory CD8+ T Cells
10:50—11:10
Coffee Break
IDF Foyer
12:45—13:45
Poster Setup
Orleans/Rosalie/St. Claude
13:45—22:00
Poster Viewing
Orleans/Rosalie/St. Claude
12:45—16:30
On Own for Lunch and Recreation
Ile de France III
16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
New Approaches to Vaccination
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Fidel P. Zavala,
Johns Hopkins Bloomberg School of Public Health, USA
Robert Sauerwein,
Radboud University, Netherlands
Experimental Vaccination of Humans with Sporozoites
Experimental Vaccination of Humans with Sporozoites
Sarah E. Reece,
University of Edinburgh, UK
The Private Life of Parasites: Implications for Blocking Transmission
The Private Life of Parasites: Implications for Blocking Transmission
Arturo Reyes-Sandoval,
University of Oxford, UK
Short Talk: A Highly Immunogenic and Protective Plasmodium vivax Vaccine Using MVA and Chimpanzee Adenovirus Expressing TRAP: Potential for Clinical Use
Short Talk: A Highly Immunogenic and Protective Plasmodium vivax Vaccine Using MVA and Chimpanzee Adenovirus Expressing TRAP: Potential for Clinical Use
19:00—20:00
Social Hour w/ Lite Bites
Orleans/Rosalie/St. Claude
19:30—22:00
Poster Session 1
Orleans/Rosalie/St. Claude
07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—11:45
Cellular and Molecular Biology of Plasmodium
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Andrew P. Waters,
University of Glasgow, UK
Robert Ménard,
Institut Pasteur, France
Molecular Basis of Plasmodium zoite Invasion into Host Cells
Molecular Basis of Plasmodium zoite Invasion into Host Cells
Volker T. Heussler,
Institute of Cell Biology, Switzerland
Host Cell Autophagy Supports Growth of Plasmodium Liver Stage Parasites
Host Cell Autophagy Supports Growth of Plasmodium Liver Stage Parasites
Manoj T. Duraisingh,
Harvard School of Public Health, USA
In vitro Functional Analysis of Erythrocyte Variation and Plasmodium Infection
In vitro Functional Analysis of Erythrocyte Variation and Plasmodium Infection
Lea Barfod,
University of Copenhagen, Denmark
Short Talk: The Density of Knobs on Plasmodium falciparum-Infected Erythrocytes Depends on Developmental Age and Varies among Isolates
Short Talk: The Density of Knobs on Plasmodium falciparum-Infected Erythrocytes Depends on Developmental Age and Varies among Isolates
Markus Meissner,
University of Glasgow, UK
Short Talk: Actin, Myosin A and MIC2 Independent Invasion of the Host Cell by Toxoplasma gondii
Short Talk: Actin, Myosin A and MIC2 Independent Invasion of the Host Cell by Toxoplasma gondii
09:50—10:10
Coffee Break
IDF Foyer
11:45—13:00
Poster Setup
Orleans/Rosalie/St. Claude
13:00—22:00
Poster Viewing
Orleans/Rosalie/St. Claude
On Own for Lunch and Recreation
14:30—16:30
Workshop 1: Biology of Pre-Erythrocytic Forms
Ile de France Ballroom
*
Maria M. Mota,
Instituto de Medicina Molecular, Portugal
Maurice A. Itoe,
Instituto de Medicina Molecular, Portugal
Plasmodium Hijacks Host Phospholipid Biosynthesis Machinery to Establish Liver Stage Infection
Plasmodium Hijacks Host Phospholipid Biosynthesis Machinery to Establish Liver Stage Infection
Ashley M. Vaughan,
Seattle Biomedical Research Institute, USA
Apicoplast-Targeted Phosphatidic Acid Synthesis Is Essential for Plasmodium yoelii Liver Stage Development
Apicoplast-Targeted Phosphatidic Acid Synthesis Is Essential for Plasmodium yoelii Liver Stage Development
Alexis Kaushansky,
Seattle Biomedical Research Institute, USA
Profiling Host Apoptosis in Plasmodium-Infected Hepatocytes Reveals a Key Point of Susceptibility in the Mitochondrial Apoptotic Cascade
Profiling Host Apoptosis in Plasmodium-Infected Hepatocytes Reveals a Key Point of Susceptibility in the Mitochondrial Apoptotic Cascade
Lander Foquet,
Ghent University, Belgium
Anti-Circumsporozoite Antibodies Induced by the RTS,S Vaccine Block Hepatocyte Invasion of Plasmodium falciparum Sporozoites in a Humanized Mouse Model
Anti-Circumsporozoite Antibodies Induced by the RTS,S Vaccine Block Hepatocyte Invasion of Plasmodium falciparum Sporozoites in a Humanized Mouse Model
Katharine A. Collins,
University of Oxford, UK
R21, a Particle-Based Vaccine for a Combination Approach to Malaria Vaccination
R21, a Particle-Based Vaccine for a Combination Approach to Malaria Vaccination
Julius C. R. Hafalla,
London School of Hygiene and Tropical Medicine, UK
Targets of CD8+ T Cell Responses Against Malaria Liver Stages
Targets of CD8+ T Cell Responses Against Malaria Liver Stages
Sebastian A. Mikolajczak,
Seattle Biomedical Research Institute, USA
Plasmodium vivax Liver Stage Development and Hypnozoite Formation in a Human Liver Chimeric Mouse Model
Plasmodium vivax Liver Stage Development and Hypnozoite Formation in a Human Liver Chimeric Mouse Model
Shengyong Ng,
Massachusetts Institute of Technology, USA
Hypoxia Promotes Liver-Stage Malaria Infection in Primary Human Hepatocytes in Vitro
Hypoxia Promotes Liver-Stage Malaria Infection in Primary Human Hepatocytes in Vitro
16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
Integrating Genomic Science and Population Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Dyann F. Wirth,
Harvard School of Public Health, USA
David J. Conway,
London School of Hygiene and Tropical Medicine, UK
Parasite Population Genomics Identifies Targets of Immunity
Parasite Population Genomics Identifies Targets of Immunity
Michael T. Ferdig,
University of Notre Dame, USA
The Parasite Fights Back: Co-Expression Networks Distinguish Phenotypic States
The Parasite Fights Back: Co-Expression Networks Distinguish Phenotypic States
Mario Recker,
University of Oxford, UK
Short Talk: Evolutionary Determinants of the Var Gene Domain and Repertoire Architecture of Plasmodium falciparum
Short Talk: Evolutionary Determinants of the Var Gene Domain and Repertoire Architecture of Plasmodium falciparum
Yael Artzy-Randrup,
HHMI/University of Michigan, USA
Short Talk: Population Structuring of Multi-Copy, Antigen-Encoding Genes in Plasmodium falciparum
Short Talk: Population Structuring of Multi-Copy, Antigen-Encoding Genes in Plasmodium falciparum
19:00—20:00
Social Hour w/ Lite Bites
Orleans/Rosalie/St. Claude
19:30—22:00
Poster Session 2
Orleans/Rosalie/St. Claude
07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:00—08:30
Poster Setup
Orleans/Rosalie/St. Claude
08:30—11:45
Vector Biology and Malaria Transmission
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Oliver Billker,
Wellcome Trust Sanger Institute, UK
Carolina V. Barillas-Mury,
NIAID, National Institutes of Health, USA
Plasmodium falciparum Evasion of the Mosquito Immune System
Plasmodium falciparum Evasion of the Mosquito Immune System
Flaminia Catteruccia,
Harvard School of Public Health, USA
Molecular Mechanisms of Fecundity and Fertility in Anopheles gambiae Mosquitoes
Molecular Mechanisms of Fecundity and Fertility in Anopheles gambiae Mosquitoes
Luciano A. Moreira,
Instituto de Pesquisas René Rachou-Fiocruz, Brazil
Using Wolbachia to Control Vector-Borne Diseases
Using Wolbachia to Control Vector-Borne Diseases
Grant L. Hughes,
Pennsylvania State University, USA
Short Talk: Native Microbiota Impede Vertical Transmission of Wolbachia in the Major Malaria Vector Anopheles gambiae
Short Talk: Native Microbiota Impede Vertical Transmission of Wolbachia in the Major Malaria Vector Anopheles gambiae
Ryan C. Smith,
Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Multiple Mechanisms of Late-Phase Immunity Limit Plasmodium Development in the Mosquito Anopheles gambiae
Short Talk: Multiple Mechanisms of Late-Phase Immunity Limit Plasmodium Development in the Mosquito Anopheles gambiae
09:50—10:10
Coffee Break
IDF Foyer
08:30—17:00
Poster Viewing
Orleans/Rosalie/St. Claude
11:45—12:30
Lunch
Ile de France III
12:30—15:00
Poster Session 3
Orleans/Rosalie/St. Claude
15:00—15:30
Coffee Available
IDF Foyer
15:30—17:30
Biology of Plasmodium Transmission Stages
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Carolina V. Barillas-Mury,
NIAID, National Institutes of Health, USA
Andrew P. Waters,
University of Glasgow, UK
Commitment to Sexual Development in Plasmodium – Identification of a Conserved Transcription Factor that Is Essential to Gametocytogenesis
Commitment to Sexual Development in Plasmodium – Identification of a Conserved Transcription Factor that Is Essential to Gametocytogenesis
Friedrich Frischknecht,
University of Heidelberg, Germany
Mechanisms of Plasmodium Sporozoite Motility
Mechanisms of Plasmodium Sporozoite Motility
Jun Miao,
Pennsylvania State University, USA
Short Talk: Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites
Short Talk: Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites
17:30—
On Own for Dinner
07:30—08:30
Breakfast
Orleans/Rosalie/St. Claude/Ile de France
08:30—11:45
Epidemiology and Pathogenesis of Severe Malaria
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Kevin Marsh,
Kenya Medical Research Institute, Wellcome Trust Research Program, Kenya
Emelda A. Okiro,
Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
The Epidemiology of Severe Malaria in Africa
The Epidemiology of Severe Malaria in Africa
Terrie E. Taylor,
Michigan State University, USA
The Pathogenesis of Cerebral Malaria: Recent Clinical Insights
The Pathogenesis of Cerebral Malaria: Recent Clinical Insights
Christian R. Engwerda,
Queensland Institute of Medical Research, Australia
Early Suppression of Malaria-Specific T Cells Responses: Implications for Immunity and Disease Pathogenesis
Early Suppression of Malaria-Specific T Cells Responses: Implications for Immunity and Disease Pathogenesis
Dominic Kwiatkowski,
Wellcome Trust Centre for Human Genetics, UK
New Genetic Findings from Studying Diverse Populations
New Genetic Findings from Studying Diverse Populations
Linda M. Murungi,
Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
Short Talk: Antibody Responses Against Merozoite Antigens and Risk of Severe Malaria
Short Talk: Antibody Responses Against Merozoite Antigens and Risk of Severe Malaria
Laurent Rénia,
Singapore Immunology Network, (SIgN), A*STAR, Singapore
Short Talk: Brain Microvessel Cross-Presentation Is a Hallmark of Experimental Cerebral Malaria
Short Talk: Brain Microvessel Cross-Presentation Is a Hallmark of Experimental Cerebral Malaria
09:50—10:10
Coffee Break
IDF Foyer
On Own for Lunch and Recreation
14:30—16:30
Workshop 2: Immune Dysfunctions in Vaccines and Pathogenesis
Ile de France Ballroom
*
Jean Langhorne,
National Institute for Medical Research, UK
Michelle N. Wykes,
Queensland Institute of Medical Research, Australia
Restoration of Long-Term Protection Against Malaria in Mice without PD-1
Restoration of Long-Term Protection Against Malaria in Mice without PD-1
Johanna (Gianna) M. G. Triller,
Max Planck Institute for Infection Biology, Germany
Atypical and Classical Memory B Cells Produce Plasmodium falciparum Neutralizing Antibodies
Atypical and Classical Memory B Cells Produce Plasmodium falciparum Neutralizing Antibodies
Simone Abel,
University Hospital Essen, Germany
Regulatory T Cells Substantially Impair Plasmodium yoelii-Directed Immune Response
Regulatory T Cells Substantially Impair Plasmodium yoelii-Directed Immune Response
Philippe E. Van den Steen,
Rega Institute, Catholic University of Leuven, Belgium
Hemozoin Is a Prominent Inflammatory Virulence Factor in Malaria-Associated Acute Respiratory Distress Syndrome
Hemozoin Is a Prominent Inflammatory Virulence Factor in Malaria-Associated Acute Respiratory Distress Syndrome
Carolyne M. Kifude,
Kenya Medical Research Institute, Wellcome Trust Research Programme, Kenya
Identification of PfEMP1 Variant Associated with Rosetting in a Field Isolate and Functional Characterization of the Antibodies
Identification of PfEMP1 Variant Associated with Rosetting in a Field Isolate and Functional Characterization of the Antibodies
Silvia Portugal,
NIAID, National Institutes of Health, USA
A Molecular Signature of Inflammation-Attenuation and Tolerance following Febrile Malaria
A Molecular Signature of Inflammation-Attenuation and Tolerance following Febrile Malaria
16:30—17:00
Coffee Available
IDF Foyer
17:00—19:00
Mechanisms of Drug Resistance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ile de France Ballroom
*
Dominic Kwiatkowski,
Wellcome Trust Centre for Human Genetics, UK
David A. Fidock,
Columbia University Medical Center, USA
Molecular and Cellular Basis of Antimalarial Drug Resistance
Molecular and Cellular Basis of Antimalarial Drug Resistance
Xin-zhuan Su,
NIAID, National Institutes of Health, USA
Chemical Genomics Approaches to Study Mechanism(s) of Drug Action and Drug Resistance
Chemical Genomics Approaches to Study Mechanism(s) of Drug Action and Drug Resistance
Pradipsinh K. Rathod,
University of Washington, USA
Short Talk: A Two-Step Evolutionary Strategy to Acquire Beneficial DNA Amplifications in Asexual Populations of Plasmodium falciparum, with Minimum Collateral Damage in Surviving Parasites
Short Talk: A Two-Step Evolutionary Strategy to Acquire Beneficial DNA Amplifications in Asexual Populations of Plasmodium falciparum, with Minimum Collateral Damage in Surviving Parasites
20:00—21:00
Social Hour w/ Lite Bites
Ile de France Ballroom
20:00—23:00
Entertainment
Ile de France Ballroom
Departure
*Session Chair †Speaker invited, not yet responded.
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