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Sagebrush Inn and Conference Center Floorplan

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This meeting took place in 2013


Here are the related meetings in 2015:
Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Gut Microbiome: The Effector/Regulatory Immune Network (B3)


Organizer(s) Lloyd H. Kasper, Javier Ochoa-Repáraz and Sarkis K. Mazmanian
February 10—15, 2013
Sagebrush Inn and Conference Center • Taos, New Mexico USA
Abstract Deadline: Oct 9, 2012
Late Abstract Deadline: Nov 8, 2012
Scholarship Deadline: Oct 9, 2012
Early Registration Deadline: Dec 5, 2012

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
The mammalian GI track harbors a complex assemblage of microbial organisms that are essential for the development of the immune system. Alterations of the gut microbiota may lead to immune dysregulation both in the gut and in distal effector sites leading to the development of autoimmune disease. This meeting will focus on the role of the microbiota in balancing the effector and regulatory response leading to immune homeostasis. Recent findings suggest that altering certain bacterial populations present in the gut can lead to an inflammatory state associated with Th1/Th17 polarization. In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, are regulatory and protect against inflammation. Particular emphasis will be placed on the biologic dynamics of the microbiota, the interaction with APC, modulation of the regulatory network and the immunologic consequences on experimental and human autoimmune conditions such as IBD, CNS demyelination and RA. The practical application of these novel interactions between the host and gut microbiota may lead to the identification of new therapeutics and novel insights into the mechanisms of human autoimmunity. The opportunity to assemble basic scientists in bacteriology and mucosal immunology with clinicians to explore this rapidly expanding arena is unique as there have been no previous organized meetings to meet this need. How the gut microbiome guides effector and regulatory immune functions will provide new pathways for the development of novel therapeutic targets.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 10

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
The Gut Commensal Microbiota's Effects on Systemic Autoimmunity

09:00—11:45
The Gut Microbiome
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sarkis K. Mazmanian, California Institute of Technology, USA

David A. Relman, Stanford University, USA
Assembly, Stability and Resilience of the Human Microbiome

Javier Ochoa-Repáraz, Sanford-Burnham Medical Research Institute, USA
The Gut as a Source of Therapeutic Molecules Against Autoimmune Diseases

Gianfranco Grompone, Danone Research Center, France
Short Talk: A Crypt Specific Core Microbiota Resides in the Mouse Colon

Elaine Y. Hsiao, California Institute of Technology, USA
Short Talk: A Commensal Bacterium of the Gut Microbiome Modulates Serum Metabolites and Ameliorates Behavioral Abnormalities in a Mouse Model of an Autism Risk Factor

Duane R. Wesemann, Brigham and Women's Hospital, USA
Short Talk: Development and Education of Early B Lineage Cells in the Gut Lamina Propria

09:40—10:00
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Gut Microbiome and Immune Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dennis L. Kasper, Harvard Medical School, USA

Chyi-Song Hsieh, Washington University, USA
Education of the Immune System by Commensal Microbiota

Cathryn Nagler, University of Chicago, USA
Commensal Bacteria Induced Tregs and IgA Protect Against Allergic Responses to Food

Makoto Kinoshita, Osaka University, Japan
Short Talk: Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

Katherine Nutsch, Washington University in St. Louis, USA
Short Talk: Commensal Microbiota-Specific TCRs Regulate Differentiation to a Regulatory Phenotype in an Inflammatory Environment

Koji Atarashi, Research Center for Allergy & Immunology, RIKEN, Japan
Short Talk: Human Clostridium Species Promote Intestinal Accumulation of Treg Cells

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

08:00—11:00
Gut Microbiome-Innate Cell Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: To appreciate the interaction between the gut microbiome and antigen presention such as dendritic cells, immunocytes that lead to the development or regulation of autoimmunity.

* Dan R. Littman, HHMI/New York University School of Medicine, USA

Nadine Cerf-Bensussan, Université Paris Descartes, France
Interactions of Segmented Filamentous Bacterium with the Host Immune System: Lessons from Gnotobiotic Mice

Sarkis K. Mazmanian, California Institute of Technology, USA
A Microbial System Promotes Stable Colonization by Bacteroides of the Gut Microbiota

Brian L. Kelsall, NIAID, National Institutes of Health, USA
Definition and Function of Mononuclear Phagocytes in the Colon

Gérard Eberl, Institut Pasteur, France
Development and Regulation of Intestinal Innate Lymphoid Cells

Amiran Dzutsev, National Cancer Institute, USA
Short Talk: CD103+ Migratory Dendritic Cells Scout the Colon Luminal Space, Take Up Bacteria and Transport them to Colonic Lymphoid Patches

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Experimental Colitis/IBD: Regulatory Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: This session will focus on the role of the microbiome in the development or regulation of both human and experiemental inflammatory bowel disease.

* Brian L. Kelsall, NIAID, National Institutes of Health, USA

Richard S. Blumberg, Brigham and Women's Hospital, USA
CD1-NKT interactions in mucosal immunity

Dennis L. Kasper, Harvard Medical School, USA
Sphingolipids of Commensals Modulate Host Immunity through Regulation of iNKT Cells

David Artis, University of Pennsylvania School of Medicine, USA
Host-Microbial Interactions in Health and Disease

Dingding An, Harvard Medical School, USA
Short Talk: Symbiotic Bacterial Sphingolipids Modulate Host Adaptive Immune System and Host Resistance to Experimental Colitis Challenge

Suzanne Devkota, Harvard Medical School, USA
Short Talk: Omega-3 Supplementation Prevents Intestinal Inflammation by Inhibiting the Expansion of an Intestinal Pathobiont in IL10-/- Mice

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

08:00—11:15
Gut Bacteria Modulation of Effector Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: The objective of this session is to evaluate the interaction of the gut microbiome and its capacity to polarize the immune response to either an effector or regulatory phenotype.

* Javier Ochoa-Repáraz, Sanford-Burnham Medical Research Institute, USA

Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Microbiota-Mediated Resistance to Infection by Intestinal Pathogens

Susan V. Lynch, University of California, San Francisco, USA
Gastrointestinal Microbiome and Pediatric Asthma Development

Gabriel Nuñez, University of Michigan, USA
Control of Pathogen Colonization and Eradication by Virulence Factors and the Gut Microbiota

Fiona M. Powrie, University of Oxford, UK
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer

Nobuhiko Kamada, University of Michigan, USA
Short Talk: Controlling Virulence Factor Expression and Pathogen Eradication by Host Adaptive Immunity and the Gut Microbiota

Gregory F. Sonnenberg, University of Pennsylvania, USA
Short Talk: Innate Lymphoid Cell Regulation of Host-Microbiota Interactions and Intestinal Homeostasis

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Gut Modulation of Effector/Regulatory Networks in CNS Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard S. Blumberg, Brigham and Women's Hospital, USA

Gurumoorthy Krishnamoorthy, Max Planck Institute of Neurobiology, Germany
Commensal Microbiota as a Trigger of Spontaneous Autoimmune Demyelination

Yun Kyung Lee, California Institute of Technology, USA
The Microbiota Impacts Vitamin D Status and Experimental Autoimmune Encephalomyelitis

Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA
Role of Commensal Bacteria in the Regulation of Central Nervous System Disease Demyelination

Sin-Hyeog Im, POSTECH, South Korea
Short Talk: Immunomodulation of Neural Autoimmune Disorders with Probiotics

Howard L. Weiner, Brigham & Women’s Hospital, USA
Short Talk: Investigation of the Gut Microbiome in Multiple Sclerosis Patients

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

08:00—11:15
Modulation of Gut Microbiota
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA

Peter J. Turnbaugh, Harvard University, USA
An Active Subset of the Gut Microbiome Responsive to Xenobiotics

Curtis Huttenhower, Harvard School of Public Health, USA
From Microbial Surveys to Mechanisms of Interaction in the Gut Microbiome

Paul D. Cotter, Teagasc Food Research Centre, Ireland
Modulation of the Gut Microbiota; Impact of Antimicrobial Administration, Diet and other Factors

Fei Sjöberg, University of Gothenburg, Sweden
Short Talk: The Oral Microbiota in Infancy and its Relation to Allergy Development

Taylor J. Feehley, University of Chicago, USA
Short Talk: Oral Tolerance to Dietary Antigen Relies on TLR-Mediated Signals from the Enteric Microbiota

Georg K. Gerber, Brigham and Women's Hospital/Harvard Medical School, USA
Short Talk: Principled Probabilistic Machine Learning Models for Analyzing Microbiome Time-Series Data

Joël Doré, INRA, France
Short Talk

09:20—09:40
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Gut Bacteria Modulation of Autoimmunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: This is a continuation of the morning session regarding the interaction of the gut microbiome with other autoimmune conditions.

* Javier Ochoa-Repáraz, Sanford-Burnham Medical Research Institute, USA

Dennis Sandris Nielsen, University of Copenhagen, Denmark
The Role of Gut Microbiota in Diabetes Type I and II Development

Alexander V. Chervonsky, University of Chicago, USA
Glycosylation of Gut Epithelial Surfaces in Response to Systemic Infections

Christophe Benoist, Harvard Medical School, USA
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cell

Ivan Vujkovic-Cvijin, University of California, San Francisco, USA
Short Talk: Dysregulation of the Colonic Mucosally-Adherent Microbiota Is Associated with Inflammatory Markers of HIV Disease Progression

Mark Bazett, McGill University, Canada
Short Talk: The Intestinal Microbiome and Intestinal Disease in a deltaF508 Cystic Fibrosis Mouse Model

Sarkis K. Mazmanian, California Institute of Technology, USA
Closing Remarks

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 15

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc.

We gratefully acknowledge additional support for this conference from:

Crohn's & Colitis Foundation of America Cubist Pharmaceuticals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-04

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

The Journal of Rheumatology

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