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Fairmont Banff Springs Floorplan

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This meeting took place in 2013


Here are the related meetings in 2014:
Stem Cells and Reprogramming (Z4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Stem Cell Regulation in Homeostasis and Disease (B7)


Organizer(s) Sean J. Morrison, Iannis Aifantis and Yukiko M. Yamashita
February 24—March 1, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 24, 2012
Late Abstract Deadline: Nov 27, 2012
Scholarship Deadline: Oct 24, 2012
Early Registration Deadline: Dec 18, 2012

Sponsored by Cell Research, EMD Millipore and Life Technologies Corporation

Summary of Meeting:
Stem cell regulation is critical for tissue development and maintenance. Defects in stem cell regulatory mechanisms are thought to contribute to many diseases, including congenital diseases, cancer and diseases of aging; therefore, these mechanisms are of interest to a diverse audience. Recent stem cell meetings have tended to focus on the interface of stem cells and cancer, or on reprogramming. This has left the majority of stem cell biologists with fewer forums that focus on the basic mechanisms that regulate stem cell function. And yet critical advances are occurring that give glimpses of new molecular mechanisms that regulate stem cell and tissue homeostasis. The goal of this Keystone Symposia meeting is to identify new and common mechanisms governing stem cell function and differentiation across tissues and across species. To address this, the meeting is organized into sessions according to distinct modes of stem cell regulation, without regard to species, in a way that might highlight novel paradigms of regulation. Speakers were chosen, first and foremost, based on research quality, and then to cover broad areas of stem cell research. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on stem cell regulation in general provides an umbrella under which speakers from different areas of research (e.g., developmental biology, tissue growth and homeostasis, regeneration, cancer and aging) are being brought together in an environment that is highly conducive to cross-talk.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 24

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA

George Q. Daley, HHMI/Children's Hospital Boston, USA
Disease Modeling with iPS Cells

09:00—11:45
Pluripotency and Disease Modeling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Alysson R. Muotri, University of California, San Diego, USA
Modeling Autism Spectrum Disorders Using Human Neurons

Evangelos Kiskinis, Harvard Stem Cell Institute, USA
Short Talk: Motor Neurons Generated from ALS Patient-Specific iPS Cells Recapitulate Key Aspects of the Disease

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Direct Reprogamming of Fibroblasts to Cardiomyocyte-Like Cells

Danwei Huangfu, Memorial Sloan-Kettering Cancer Institute, USA
Short Talk: Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

Kathrin Plath, University of California, Los Angeles, USA
Understanding Mechanisms of Reprogramming

Thea D. Tlsty, University of California, San Francisco, USA
Extensive Plasticity in Rare Somatic Cells Found in Adult Human Tissue

09:40—10:00
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells and Regeneration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Allan C. Spradling, HHMI/Carnegie Institute, USA

Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
The Developmental Biology of a Totipotent, Adult Stem Cell Population

Trista E. North, Beth Israel Deaconess Medical Center, USA
Metabolic Regulation of Hematopoietic Stem Cell Formation and Function

Bruce M. Wang, Stanford University, USA
Short Talk: Wnt Signaling and the Stem Cell Niche in Progenitor Cell Mediated Liver Regeneration

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
The Pysiological Function of Mesenchymal Stem Cells

19:00—20:00
Social Hour w/ Lite Bites


TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

08:00—11:15
Niche Regulation of Stem Cell Function. Session sponsored by Development.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Support for these organized-selected speakers generously provided by this journal.

* David T. Scadden, Massachusetts General Hospital and Harvard University, USA

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow

Myriam Grunewald, Hebrew University, Israel
Short Talk: The Vascular Endothelial Growth Factor Generates a Fully Functional Hematopoietic Stem Cells Niche in the Spleen

Fiona Doetsch, Columbia University, USA
Stem Cells and their Niche in the Adult Mammalian Brain

Brett Shook, Yale University, USA
Extrinsic Regulation of Skin Stem Cells

Peter Andersen, Johns Hopkins University School of Medicine, USA
Short Talk: Lineage-Specific Mosaicism Identifies Renewing Cardiac Progenitor Cells and their Niche

Allan C. Spradling, HHMI/Carnegie Institute, USA
Stem Cells and Tissue Homeostasis

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Emerging Regulatory Mechanisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA

Iannis Aifantis, HHMI/New York University School of Medicine, USA
Regulation of Stem Cell Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

K. J. Patel, MRC Laboratory of Molecular Biology, UK
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells

Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Asymmetric Chromosome Segregation during Stem Cell Division in Drosophila Male Germline

Jean-Pierre Etchegaray, Massachusetts General Hospital Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Plays a Critical Role in Mouse Embryonic Stem Cell Differentiation

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

08:00—11:15
RNA Regulation and Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA

Haifan Lin, Yale University, USA
The Yb Body, a Novel Organelle Involved in Niche Signaling of Germline Stem Cell Self-Renewal

Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Pluripotency

Richard I. Gregory, Harvard Medical School, USA
Lin28, Let-7 and Stem Cells

Robert A.J. Signer, University of Texas Southwestern Medical Center, USA
Short Talk: The Rate of Protein Translation Regulates Hematopoietic Stem Cell Self-Renewal

Noelia Urban, MPI for Neurological Research, Germany
Short Talk: Degradation of Ascl1 by Huwe1 Is Essential for Stem Cells Maintenance and Neurogenesis in the Adult Hippocampus

Judith E. Kimble, University of Wisconsin, Madison, USA
Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Iannis Aifantis, HHMI/New York University School of Medicine, USA

Richard J. Gilbertson, St. Jude Children's Research Hospital, USA
Organism-Wide Mapping of Stem Cells and Cancer Origins

Austin Gurney, OncoMed Pharmaceuticals, Inc., USA
Targeting Stem Cell Pathways in Cancer

Luis F. Parada, University of Texas Southwestern Medical Center, USA
A Defined Subpopulation of Glioblastoma Cells Is Responsible for Tumor Recurrence following Chemotherapy

Hans-Guido Wendel, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Differential MYC Requirement in Healthy and Malignant Tissues Derived from Induced-Pluripotent Stem (iPS) Cells

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

08:00—11:15
The Aging of Mitotic Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alexandra Joyner, Memorial Sloan-Kettering Cancer Center, USA

Andrew G. Dillin, University of California, Berkeley, USA
Protein Quality Control in Stem Cells and Aging

Anne Brunet, Stanford University, USA
The Regulation of Stem Cell Aging

Jan M. van Deursen, Mayo Clinic, USA
Stem and Progenitor Cell Senescence in Aging

Norman E. Sharpless, University of North Carolina School of Medicine, USA
Expression of Markers of Senescence, Aging and Self-Renewal

Elizabeth A. Pollina, Stanford University, USA
Short Talk: Discovering Novel Regulators of Adult Neural Stem Cell Aging Using a Chromatin Signature

Tohru Itoh, IMCB, University of Tokyo, Japan
Short Talk: FGF7 Is a Functional Niche Signal Required for Stimulation of Adult Liver Progenitor Cells that Support Liver Regeneration

09:20—09:40
Coffee Break

 
On Own for Lunch and Recreation

15:00—16:30
Workshop: Emerging Insights into Stem Cells and Niches

* Iannis Aifantis, HHMI/New York University School of Medicine, USA

Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Modeling Myelodysplasia Using Human Pluripotent Stem Cells

Gabrielle Kardon, University of Utah, USA
Wnt/beta-Catenin Signaling Is Active, But Not Required for Stem Cell Function during Muscle Regeneration

E. Camilla Forsberg, University of California, Santa Cruz, USA
Robo4-Mediated Vascular Integrity Promotes Hematopoietic Stem Cell Engraftment

Valentina Greco, Yale School of Medicine, USA
Cellular and Signaling Mechanisms that Regulate Hair Follicle Stem Cells by Live Imaging

16:30—17:00
Coffee Available

17:00—19:00
Self-Renewal Pathways and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Norman E. Sharpless, University of North Carolina School of Medicine, USA

Alexandra Joyner, Memorial Sloan-Kettering Cancer Center, USA
Differential Regulation of Adult Stem Cells by Sonic Hedgehog Signaling

Fernando D. Camargo, Children's Hospital Boston, USA
Hippo/YAP Signaling in Stem Cells, Regeneration and Cancer

Kai Kessenbrock, University of California, San Francisco, USA
Short Talk: A Novel Role for Matrix Metalloproteinases In Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

Ulrich Steidl, Albert Einstein College of Medicine, USA
Short Talk: Special AT-Rich Sequence-Binding Protein 1 (Satb1) Regulates Hematopoietic Stem Cell Fate

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 1

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research EMD Millipore
Life Technologies Corporation
 

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. The Company of Biologists Ltd
March of Dimes Foundation Grant No. 4-FY12-556 Thermo Fisher Scientific, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD075474-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676