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Fairmont Banff Springs Floorplan

Fairmont Banff Springs Floorplan

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This meeting took place in 2013


Here are the related meetings in 2014:
Obesity: A Multisystems Perspective (J2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Neuronal Control of Appetite, Metabolism and Weight (C6)


Organizer(s) Tony K.T. Lam and Matthias H. Tschöp
March 17—22, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 14, 2012
Late Abstract Deadline: Dec 19, 2012
Scholarship Deadline: Nov 14, 2012
Early Registration Deadline: Jan 17, 2013

Sponsored by AVEO Oncology

Summary of Meeting:
Obesity and Type 2 diabetes are associated with a disruption in energy, glucose and lipid homeostasis. Exciting new developments indicate a key role for the central nervous system in the homeostatic control of systemic metabolic processes. A goal of the Keystone Symposia meeting on Neuronal Control of Appetite, Metabolism and Weight is to bring together basic and clinical scientists from academia and the pharmaceutical industry studying neuronal control of appetite, metabolism and body weight or related complementary fields (such as addiction/reward, cellular stress, and inflammation) to share novel and relevant insights with relevance for human obesity, diabetes and metabolic disease. The meeting seeks to integrate existing knowledge with novel discoveries on central nervous system mechanisms activated by hormones or nutrients that regulate systemic metabolism. Meeting participants will discuss the latest research in this field along with future directions and perspectives that are relevant for both basic science and clinical research.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 17

16:00—20:00
Arrival and Registration


MONDAY, MARCH 18

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Matthias H. Tschöp, HelmholtzZentrum München, Germany

Richard D. Palmiter, HHMI/University of Washington, USA
Deciphering Neural Circuits Controlling Appetite

09:00—12:00
Hypothalamic Inflammation, ER Stress and Mitochondrial Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tony K.T. Lam, University of Toronto, Canada

Dongsheng Cai, Albert Einstein College of Medicine, USA
Hypothalamic Autophagy, Inflammation and Neurodegeneration in Obesity and Diabetes

Umut Ozcan, Children's Hospital Boston, Harvard Medical School, USA
Hypothalamic Inflammation, ER Stress and Metabolic Control

Jens C. Brüning, Institute for Genetics, University of Cologne, Germany
Insulin Receptors in the Brain: Where Do They Matter?

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
Central Actions of FGF21

Eduardo A. Nillni, Brown University, Rhode Island Hospital, USA
Short Talk: Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-Translational Processing

09:40—10:00
Coffee Break

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:00—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Is the CNS Still a Relevant Pharmaceutical Target for Metabolic Disease?

* Mads Tang-Christensen, Novo Nordisk, Denmark

* Ruth E. Gimeno, Eli Lilly & Company, USA
Targeting TrkB/BDNF for the Treatment of Metabolic Disorders

Birgitte S. Wulff, Novo Nordisk, Denmark
Safety and Efficacy of a Long Acting alpha-MSH Analogue, MC4-NN2-0453, in Overweight to Obese But Otherwise Healthy Subjects

Giles Yeo, University of Cambridge, UK
Is the Obesity Related FTO a Viable Therapeutic Target?

Andrew C. Adams, Eli Lilly & Company, USA
FGF21: From the Brain to Adipose and Back Again

Lora K. Heisler, University of Aberdeen, UK
5-HT2C Receptor Agonist: a New Obesity Treatment

16:30—17:00
Coffee Available

17:00—19:00
Addiction and Reward in the CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kevin L. Grove, Oregon National Primate Research Center, USA

Harvey J. Grill, University of Pennsylvania, USA
Do Separate Sets of Neurons Control for the Satiation, the Motivational, and the Association-Based Preference Effects of Leptin?

Tamas L. Horvath, Yale University School of Medicine, USA
A Role for the Arcute Nucleus in Reward and Complex Behaviors

Dana M. Small, Yale University School of Medicine, USA
Metabolic Control of Neural Circuits Underlying Food Reward Learning in Humans

Sandeep Sharma, Montreal Diabetes Research Center, University de Montreal, Canada
Short Talk: Saturated High-Fat Diets Are Anxiogenic and Elicit Pro-Inflammatory Signaling in Brain Reward Circuitry

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 19

07:00—08:00
Breakfast

08:00—11:15
Nutrient Sensing and the Brain
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert H. Eckel, University of Colorado Denver, Anschutz Medical Campus, USA

Daniele Piomelli, University of California, Irvine, USA
The Role of Endocannabinoids in the Role of Food Intake

Tony K.T. Lam, University of Toronto, Canada
Nutrient Sensing in the Gut and the Brain

Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Neurocircuits Regulating Energy Balance

Sabrina Diano, Yale University School of Medicine, USA
Glucose Sensing and Hypothalamic Neuropeptide Processing

Eglantine Balland, INSERM, France
Short Talk: Tanycytes of the Median Eminence Gate Leptin Transport into the Hypothalamus

Raj Kamal Srivastava, Institute of Physiological Chemistry, Germany
Short Talk: Genetic Deletion of the CB1 Receptor from Dopamine-beta-Hydroxylase Expressing Cells Makes Mice Sensitive to Stress-Induced Obesity

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

15:00—16:30
Workshop 2: Challenges of the Publishing Process: How to Write a Scientific Masterpiece

* Ushma Savla Neill, Journal of Clinical Investigation & Molecular Metabolism, USA

Iain Patten, Scientific Writing Consultant, Spain

Randy S. Levinson, Nature Publishing Group, USA

Nikla Emambokus, Cell Press, USA

16:30—17:00
Coffee Available

17:00—19:00
Dissecting CNS Control of Metabolism I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gregory James Morton, University of Washington, USA

Kendra K. Bence, University of Pennsylvania, USA
The Role of Protein Tyrosine Phosphatases in Neuronal Control of Energy Balance

Christoph Buettner, Mount Sinai School of Medicine, USA
Novel Roles of Brain Insulin Signaling in Regulating Whole Body Nutrient Partitioning and Innate Immunity

Domenico Accili, Columbia University, USA
FoxO1 Targets Regulating Energy Balance in the Central Nervous System

Toshiya Kojima, University of Tokyo, Japan
Short Talk: SUMOylation of Krüppel-Like Factor 5 Controls Food Intake by Suppressing AgRP Expression on Contact with FoxO1 in Hypothalamic Neurons

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

08:00—11:15
Gut-Brain Interactions in the Control of Systemic Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Darleen A. Sandoval, University of Cincinnati, USA

Daniel J. Drucker, Samuel Lunenfeld Research Institute, Canada
The Biology of Incretins: Gut-Brain-Cardiovascular Connections

Remy G. Burcelin, Institute of Molecular Medicine, France
The Role of GLP-1 on the Gut-Brain Axis

Hans-Rudolf Berthoud, Pennington Biomedical Research Center, USA
Bariatric Surgery on CNS Control of Metabolism

Randy J. Seeley, University of Cincinnati, USA
Molecular Targets for Bariatric Surgery

Chen Liu, University of Texas Southwestern Medical Center, USA
Short Talk: PPARgamma Signaling in Vagal Sensory Neurons Regulates Energy Balance

Gary J. Schwartz, Albert Einstein College of Medicine, USA
Short Talk: Mediobasal Hypothalamic beta-3 Adrenergic Receptor Signaling Regulates Energy Intake and Utilization

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: CNS Control of Metabolism: Hot Topics

* Thierry Alquier, University of Montreal-Montreal Diabetes Research Center, Canada

* Diego Perez-Tilve, University of Cincinnati, USA

Pawan Gulati, University of Cambridge, UK
Novel Function for FTO in Cell Growth and Translational Control

Martin Heni, Eberhard Karls University Tübingen, Germany
Variation in the Obesity Risk Gene FTO Determines the Postprandial Cerebral Processing of Food Stimuli

Roger D. Cone, Vanderbilt University, USA
Developmental Control of the Pharmacological Function of the Melanocortin-4 Receptor by MRAP2 Proteins

Qingchun Tong, University of Texas, Houston, USA
Disruption of Glutamate Release from Leptin Receptor-Expressing Neurons Results in Torpor-Like Behavior

Lei Zhang, Garvan Institute of Medical Research, Australia
Gender Specific Role of Neuropeptide FF Receptor 2 in the Regulation of Energy Balance and Glucose Homeostasis

16:30—17:00
Coffee Available

17:00—19:00
Dissecting CNS Control of Metabolism II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Scott Waddell, University of Oxford, UK

Scott Sternson, HHMI/Janelia Farm Research Campus, USA
Neural Circuits and Motivational Processes Underlying Hunger

Lora K. Heisler, University of Aberdeen, UK
CNS Integration of Metabolic Signals

Vishwa Deep Dixit, Pennington Biomedical Research Center
Inflammasomes and Astrogliosis

Daniel D. Lam, Stanford University, USA
Short Talk: A Dual Enhancer Complex Controls Neuronal Pomc Expression and Body Weight

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:15
Neurocircuitry and Systemic Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* William F. Colmers, University of Alberta, Canada

Lori M. Zeltser, Columbia University, USA
Plasticity in Developing Circuits Regulating Energy Homeostasis

Martin G. Myers, Jr., University of Michigan, USA
Leptin Receptors in the Brain: Where Do They Matter?

Michael A. Cowley, Monash University, Australia
Leptin Modulation of DMH Circuits Controlling the Sympathetic Nervous System

Roberto Coppari, University of Genève, Switzerland
Metabolic Actions of Hypothalamic SIRT1

Stephanie M. Correa, University of California, San Francisco, USA
Short Talk: A Population of Estrogen-Responsive Nkx2-1 Neurons in the Ventromedial Hypothalamus (VMH) Mediates Sex-Specific Obesity in Mice

Barbora Doslikova, University of Cambridge, UK
Short Talk: 5-HT2C Receptor Agonist Anorectic Efficacy Potentiated by 5-HT1B Receptor Agonist Co-Application; an Effect Mediated via Augmented Pro-Opiomelanocortin Neuron Activation

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—18:30
Glia Cells and CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Serge Luquet, Université Paris Diderot, Sorbonne Paris Cité, France

Matthias H. Tschöp, HelmholtzZentrum München, Germany
Hypothalamic Inflammatory Processes in Diabetes and Obesity

Licio A. Velloso, University of Campinas, Brazil
A Role for Hypothalamic Microglia in Obesity and Diabetes

Darya Kryzskaya, McGill University, Canada
Short Talk: A Role for Hypothalamic NG2-glia in Energy Homeostasis

18:30—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Matthias H. Tschöp, HelmholtzZentrum München, Germany

Michael W. Schwartz, University of Washington, USA
Brain Mechanisms Governing Glucose Homeostasis: Implications for Diabetes Pathogenesis and Treatment

19:15—20:15
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 22

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

AVEO Oncology

We gratefully acknowledge additional support for this conference from:

Educational grant from Lilly USA, LLC

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK098956-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Molecular Metabolism (Elsevier GmbH)


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676