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This meeting took place in 2013



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New Frontiers in Neurodegenerative Disease Research (J8)


Organizer(s) Li-Huei Tsai, Steven M. Paul and Michael Hutton
February 3—8, 2013
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Oct 4, 2012
Late Abstract Deadline: Nov 1, 2012
Scholarship Deadline: Oct 4, 2012
Early Registration Deadline: Dec 4, 2012

Sponsored by Janssen R&D, Pharmaceutical Companies of Johnson & Johnson, Takeda Pharmaceutical Company Limited and Vertex Pharmaceuticals Incorporated. Supported by an educational donation provided by Amgen.

Joint Meeting: Neurogenesis (J7)

Summary of Meeting:
It has been more than two decades since genes causing familial Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, motor neuron disease and other neurodegenerative disorders were identified. While numerous molecular and cellular events contributing to these devastating illnesses have been revealed, key pathological events and feasible targets for therapeutic intervention still elude us. Increasing evidence supports that mechanisms underlying neuronal demise may be shared amongst multiple neurodegenerative disorders. For example, compromised mitochondria function, although prominent in Parkinson’s disease, is also shared in Alzheimer’s and amyotrophic lateral sclerosis. Emerging evidence also indicates a negative influence of neurotoxic stress upon the epigenome, and that the restoration of the epigenome can be beneficial for cognition. Recent insights into the relationship between genome integrity and the aging brain have emphasized the role of DNA damage and repair in neuronal function. Particularly intriguing are the recent observations that protein misfolding can have either beneficial or detrimental effects and that misfolded proteins implicated in several neurodegenerative disease can propagate themselves. New tools for the study of neurodegenerative disorders include the use of human neurons derived from induced pluripotent stem cells (iPSCs) in addition to advances in the field of biomarkers and functional imaging. This meeting aims to address emerging areas in neurodegenerative disease research that may reveal novel mechanisms and targets for therapeutic intervention. It bring together experts studying various degenerative diseases using diverse approaches to provide reviews of up-and-coming areas in these fields and inspire new insights and approaches to the battle against neurodegenerative disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Neurogenesis, which will share two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 3

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Modeling Pathology in Simpler Cells


Following Session is for Neurogenesis (J7)

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Hongjun Song, Johns Hopkins University School of Medicine, USA

Fred H. Gage, The Salk Institute for Biological Studies, USA
Neurogenesis and Neurological Disorders: Lessons from Studies of Adult Neurogenesis and Patient-Derived iPSCs

09:00—11:00
Protein Aggregation and Propagation of Misfolded Proteins in the Brain
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Virginia M.-Y. Lee, University of Pennsylvania School of Medicine, USA
Alpha-Synuclein Transmission in Parkinson’s Disease

Mathias Jucker, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany
Prion-Like Aspects of Cerebral beta-amyloidosis

Jeffery W. Kelly, The Scripps Research Institute, USA
Adapting the Chemical and or Biology of Protein Homeostasis to Ameliorate Aggregation-Associated Diseases


Following Session is for Neurogenesis (J7)

09:00—11:15
Neurogenesis and Gliogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jonas Frisén, Karolinska Institutet, Sweden
Neurogenesis and Gliogenesis in the Adult CNS

Dwight E. Bergles, Johns Hopkins University School of Medicine, USA
NG2+ OPCs and their Role in ALS

Patrik Ernfors, Karolinska Institutet, Sweden
Neurogenesis and Cell-Type Diversification in the Sympathetic Lineage

Federico Calegari, Dresden University of Technology, CRTD, Germany
Short Talk: Transcriptomes of Proliferating Neural Stem Cells

Edmund Au, New York University Medical Center, USA
Short Talk: Directed Differentiation of ES Cells to Cortical Interneurons Demonstrates that LMO3 Biases Subtype Identity

Rebecca D. Hodge, University of Washington, USA
Short Talk: Tbr2 Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

09:40—10:00
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Mechanisms of Early Disease Intervention and Biomarkers
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Hutton, Eli Lilly Research Center, UK

John Q. Trojanowski, University of Pennsylvania, USA
Tau Biomarkers, Transmission and Therapies

Rosa Rademakers, Mayo Clinic, USA
Non-Coding Repeat Expansions in C9ORF72 as a Novel Cause of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Cristian A. Lasagna-Reeves, Baylor College of Medicine, USA
Short Talk: Ataxin-1 Amyloid Oligomers Form in a Mouse Model of Spinocerebellar Ataxia Type 1 and Correlate with Disease Pathogenesis

Kelly T. Dineley, University of Texas Medical Branch, USA
Short Talk: pERK-PPARgamma Protein Complexes In AD Cognitive Enhancement

Jessica L. Larson, Genentech, Inc., USA
Short Talk: A Meta-Analysis of Inflammation Gene Sets in Neurodegenerative Disease


Following Session is for Neurogenesis (J7)

17:00—19:00
Model Systems
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christopher A. Walsh, Children's Hospital Boston, USA

Andrea H. Brand, University of Cambridge, UK
Nutrient Control of Neural Stem Cells

Arnold R. Kriegstein, University of California, San Francisco, USA
OSVZ Neurogenesis in the Developing Human Neocortex

Su-Chun Zhang, University of Wisconsin-Madison, USA
Neural Subtype Specification from Human Pluripotent Stem Cells

Simon Hippenmeyer, Institute of Science and Technology Austria, Austria
Short Talk: Tracing Neurogenesis in Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Ryan P. Stadel, Johns Hopkins University School of Medicine, USA
Short Talk: Coexistence of Quiescent and Active Radial Neural Stem Cell Populations in the Adult Hippocampus

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:00
Molecular Mechanisms of Neuronal Vulnerability
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rosa Rademakers, Mayo Clinic, USA

* Ronald B. DeMattos, Lilly Research Laboratories, USA

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Mechanisms of Cell Death in Neurodegeneration

Amber L. Southwell, University of British Columbia, Canada
Selective Mutant Huntingtin Gene Silencing

Sarah E. Dougherty, University of Alabama at Birmingham, USA
Short Talk: Restricted Expression of Mutant Huntingtin to Parvalbumin-Positive Cell Populations Causes Hyperactivity and Altered Synaptic Function in the Motor Cortex

Eric J. Huang, University of California, San Francisco, USA
Role of RNA/DNA Binding Protein FUS in Neurodegeneration

Keith W. Crosby, University of Florida, USA
Short Talk: Immunophenotyping of Transgenic Mouse Models of CNS Proteinopathies


Following Session is for Neurogenesis (J7)

08:00—11:00
Neurogenesis and Development: Molecular Mechanisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yi Eve Sun, University of California, Los Angeles, USA

Yukiko Gotoh, University of Tokyo, Japan
Regulation of Neural Precursor Cell Fate in the Developing Mouse Neocortex

Soo-Kyung Lee, Oregon Health & Science University, USA
Gene Regulatory Networks in Spinal Cord Neurogenesis

Francois Guillemot, National Institute for Medical Research, UK
Regulation of Stem Cell Divisions in the Adult Brain

Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA
Activity-Dependent Gene Transcription in Adult Neurogenesis

Sven Falk, Helmholtz Center Munich, Germany
Short Talk: Smad4 and Trim33 Redundantly Regulate Neural Stem Cells in the Developing Cortex

Felipe Mora-Bermúdez, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Short Talk: Distinct Populations of Mitotic Microtubules Regulate Mammalian Neurogenesis

09:20—09:40
Coffee Break

11:00—12:00
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop (Joint): iPSC Technologies and their Application

* Fred H. Gage, The Salk Institute for Biological Studies, USA
Introduction

* Su-Chun Zhang, University of Wisconsin-Madison, USA
Introduction

Anita Bhattacharyya, University of Wisconsin-Madison, USA
Deficits in Human Trisomy 21 iPSCs and Neurons: A Model for Down Syndrome Intellectual Disability

Beatriz C. Freitas, University of California, San Diego, USA
Contribution of Human Astrocytes to Rett Syndrome

Marisa Karow, Ludwig Maximilian University of Munich, Germany
Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

Yves Maury, ISTEM-CECS, France
High Throughput iPS Characterization

16:30—17:00
Coffee Available

17:00—19:00
Novel Approaches for the Therapeutic Intervention of Neurodegenerative Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* André Fischer, German Center for Neurodegenerative Diseases, Germany

Michael Hutton, Eli Lilly Research Center, UK
Towards an Understanding of tau Pathology Propagation and Spreading

Anders Björklund, Lund University, Sweden
Nurr1 as Target for Neuroprotection and Therapeutic Intervention in Parkinson's Disease

Ronald B. DeMattos, Lilly Research Laboratories, USA
The Development of Abeta Target Specific Immunotherapies for AD

Pierre Drapeau, University of Montréal, Canada
Short Talk: Chemical Genetic Screens of TARDBP and FUS Modifiers in C. elegans and Zebrafish Models of ALS

Rebecca Canter, Massachusetts Institute of Technology, USA
Short Talk: Increased Cholinergic Activity Restores Memory Function in a Mouse Model of AD


Following Session is for Neurogenesis (J7)

17:00—19:00
Stem Cell Niches in the Developing and Adult Brain
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yukiko Gotoh, University of Tokyo, Japan

Christopher A. Walsh, Children's Hospital Boston, USA
Intrinsic and Extrinsic Control of Neurogenesis in the Cerebral Cortex

Chay T. Kuo, Duke University School of Medicine, USA
Sustaining New Neuron Production in the SVZ Niche

Sebastian Jessberger, University of Zürich, Switzerland
EMBO Young Investigator Programme Lecture: Metabolic Control of Adult Neural Stem/Progenitor Cell Activity

Sohyun Ahn, NICHD, National Institutes of Health, USA
Short Talk: Gli3 Repressor Interacts with the Numb and gp130/STAT3 Pathways to Promote the Establishment of the Postnatal Neural Stem Cell Niche

Stephen C. Noctor, University of California, Davis, USA
Short Talk: Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

 
On Own for Dinner


WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

08:00—11:00
Epigenetics and Genomics (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Bruce A. Yankner, Harvard Medical School, USA

Yi Eve Sun, University of California, Los Angeles, USA
Single Cell Transcriptome Analyses Reveal Secrets of the Adult Neurogenic Zone

André Fischer, German Center for Neurodegenerative Diseases, Germany
Epigenetic Mechanisms in Dementia

Daniel H. Geschwind, University of California, Los Angeles, USA
Functional Genomic Analyses of Pathways Dysregulated in Frontal Temporal Dementia

Hongjun Song, Johns Hopkins University School of Medicine, USA
Neuronal Activity-Induced Changes of DNA Methylome in Neurons

Johan Holmberg, Karolinska Institutet, Sweden
Short Talk: A Key Role for the Chromatin Remodeler CHD5 for Neuronal Differentiation and Tumor Suppression in the Nervous System

Matthew L. Eaton, Massachusetts Institute of Technology, USA
Short Talk: Genome-Wide Analysis of DNA Methylation and Genotype in 750 Individuals Reveals Global Regulatory Changes in Brain Enhancers Associated with Alzheimer’s Disease

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Aging and Genome Integrity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Li Gan, Gladstone Institutes, USA

Bruce A. Yankner, Harvard Medical School, USA
Modeling the Role of Genomic Instability in Aging and Alzheimer’s Disease

Peter J. McKinnon, St. Jude Children's Research Hospital, USA
DNA Damage Signaling and Neurogenesis

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Genome Integrity, Chromatin Remodeling and Neurodegenerative Disorders


Following Session is for Neurogenesis (J7)

17:00—19:00
Adult Neurogenesis: Regulation and Functions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Fred H. Gage, The Salk Institute for Biological Studies, USA

Matthew T. Valley, Pasteur Institute, France
Adult-Born Neurons Integrate Behavioral States

Gerd Kempermann, Technische Universität Dresden, Germany
Benefits from Newborn Neurons in the Adult Hippocampus

Shaoyu Ge, SUNY Stony Brook, USA
Optogenetic Probing for the Development and Function of Adult-Born Neurons

Cristina V. Dieni, University of Alabama at Birmingham, USA
Short Talk: Sparse Excitatory Innervation Provides High Input Specificity to Adult-Born Neurons

Mazen A. Kheirbek, Columbia University, USA
Short Talk: Control of Learning and Anxiety by Mature and Immature Granule Cells of the Dentate Gyrus

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

08:00—11:00
Neurobiology of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Valina L. Dawson, Johns Hopkins University School of Medicine, USA

David M. Holtzman, Washington University, USA
Sleep and Alzheimer’s Disease: Potential Cellular, Molecular, and Network Connections

Ted M. Dawson, Johns Hopkins University School of Medicine, USA
Understanding Molecular Mechanisms of Neurodegeneration in Parkinson’s Disease

Paula D. Ladd, University of Washington, USA
Short Talk: Expanding the Transcriptomes at Unstable Tandem Repeat Loci

Aimee W. Kao, University of California, San Francisco, USA
Short Talk: Progranulin and Granulin: Reciprocal Modulators of Organismal Stress Response

Li Gan, Gladstone Institutes, USA
Pathogenic Events Triggered by Tau Acetylation in Neurodegeneration

Ryan J. Watts, Genentech, Inc., USA
Targeting Neurodegeneration by Boosting Antibody Uptake in Brain


Following Session is for Neurogenesis (J7)

08:00—11:00
Adult Neurogenesis under Pathological Conditions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerd Kempermann, Technische Universität Dresden, Germany

Xinyu Zhao, University of Wisconsin-Madison, USA
Adult Neurogenesis and Neurodevelopmental Disorders

Heather A. Cameron, NIMH, National Institutes of Health, USA
Adult Neurogenesis, Stress and Depression

Randall R. Reed, Johns Hopkins University, USA
Maintenance and Regeneration of Olfactory Neurons

Jack M. Parent, University of Michigan, USA
Adult Neurogenesis and Epilepsy

Beate Winner, FAU Erlangen-Nurnberg, Germany and The Salk Institute, USA
Short Talk: Alpha-Synuclein in Neuronal Maturation and Adult Neurogenesis in the Dentate Gyrus

Caroline R. McKeown, The Scripps Research Institute, USA
Short Talk: Neurogenesis is Required for Behavioral Recovery after Injury in the Visual System of Xenopus laevis

09:00—09:20
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
iPSC Modeling of Developmental and Degenerative Neurological Diseases (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Li-Huei Tsai, Massachusetts Institute of Technology, USA

* Hongjun Song, Johns Hopkins University School of Medicine, USA

Guo-li Ming, Johns Hopkins University, USA
Understanding Functions of Schizophrenia Susceptibility Genes using Pluripotent Human Stem Cells

Gabsang Lee, Johns Hopkins University School of Medicine, USA
Discovery of Potential Therapeutic Compounds with Patient-Specific and Symptom-Relevant Neural Crest Derived from Familial Dysautonomia-iPSC

Stephen J. Haggarty, Harvard Medical School, Massachusetts General Hospital, USA
Probing Neuroplasticity Pathways in Neuropsychiatric Disorders with Patient Specific Stem Cell Models & Small Molecules

Helen Fong, University of California, San Francisco, USA
Short Talk: Modeling Tauopathies Using Isogenic Human Induced Pluripotent Stem Cells

Sandra Almeida, University of Massachusetts Medical School, USA
Short Talk: Induced Pluripotent Stem Cell Models of Frontotemporal Dementia

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen Janssen R&D, Pharmaceutical Companies of Johnson & Johnson
Takeda Pharmaceutical Company Limited Vertex Pharmaceuticals Incorporated

We gratefully acknowledge additional support for this conference from:

Alzheimer's Drug Discovery Foundation CEDARLANE
Cell Signaling Technology, Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS081943-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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