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This meeting took place in 2013
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Meeting Details
DNA Replication and Recombination (X5)
Organizer(s) James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper
March 3 - March 8, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: November 7, 2012
Late Abstract Deadline: December 4, 2012
Scholarship Deadline: November 7, 2012
Early Registration Deadline: January 7, 2013
Supported by the Directors' Fund
CME Information
Joint Meeting:
Genomic Instability and DNA Repair (X6)
Summary of Meeting:
Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited.
This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting.
CME Information
Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited. This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 3
19:15—21:30
Welcome and Keynote Session (Joint)
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*
Stephen P. Jackson,
University of Cambridge, UK
*
James M. Berger,
University of California, Berkeley, USA
Frederick W. Alt,
Boston Children's Hospital, USA
Mechanisms of Programmed DNA Rearrangements and Chromosomal Translocations in the Immune System
Mechanisms of Programmed DNA Rearrangements and Chromosomal Translocations in the Immune System
Kenneth J. Marians,
Memorial Sloan-Kettering Cancer Center, USA
Multiple Pathways to Reactivate Replication Forks Stalled by Damage in the Leading-Strand Template
Multiple Pathways to Reactivate Replication Forks Stalled by Damage in the Leading-Strand Template
08:00—11:15
Mechanisms and Control of DNA Repair/Mechanisms of Homologous Recombination (Joint)
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*
Susan M. Gasser,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Stephen C. Kowalczykowski,
University of California, Davis, USA
Single-Molecule Analysis of DNA Recombination
Single-Molecule Analysis of DNA Recombination
Maria Jasin,
Memorial Sloan-Kettering Cancer Center, USA
Re-Considering the Role of BRCA1
Re-Considering the Role of BRCA1
Samuel F. Bunting,
Rutgers University, USA
Short Talk: BRCA1 Functions Independently in Excision of DNA Interstrand Crosslinks and in Homologous Recombination
Short Talk: BRCA1 Functions Independently in Excision of DNA Interstrand Crosslinks and in Homologous Recombination
Roland Kanaar,
Erasmus MC, Netherlands
Modulation of Homologous Recombination
Modulation of Homologous Recombination
Douglas K. Bishop,
University of Chicago, USA
Short Talk: Overlapping RAD51-DMC1 foci come in well Separated Pairs: Symmetric Model for Meiotic Recombination
Short Talk: Overlapping RAD51-DMC1 foci come in well Separated Pairs: Symmetric Model for Meiotic Recombination
14:30—16:30
Workshop 1: Regulation of DNA Superstructure
Erin A. Ronayne,
University of Wisconsin-Madison, USA
Structure and Function of the E. coli MgsA Protein
Structure and Function of the E. coli MgsA Protein
Manolis Papamichos-Chronakis,
Institut Curie, France
Integration of the INO80 Chromatin Remodeling Complex in the Ubiquitin-Mediated Protein Degradation Pathway Is Essential for Genome Stability
Integration of the INO80 Chromatin Remodeling Complex in the Ubiquitin-Mediated Protein Degradation Pathway Is Essential for Genome Stability
Margaret M. F. Renaud-Young,
University of Calgary, Canada
The NuA4 Complex Is a Novel Participant in the Translesion Synthesis Pathway of DNA Post Replication Repair
The NuA4 Complex Is a Novel Participant in the Translesion Synthesis Pathway of DNA Post Replication Repair
Liz Colby,
Cancer Research UK, London Research Institute
Creating Site-Specific DNA Damage in S. cerevisiae to Study Replication-Associated Lesion Bypass
Creating Site-Specific DNA Damage in S. cerevisiae to Study Replication-Associated Lesion Bypass
Mariana C. Gadaleta,
Drexel University College of Medicine, USA
Swi1 Prevents DNA Damage during Replication of Difficult-to-Replicate Sites
Swi1 Prevents DNA Damage during Replication of Difficult-to-Replicate Sites
Diana E. Libuda,
Stanford University, USA
Meiotic Chromosome Structures Constrain and Respond to Designation of Crossover Recombination Sites
Meiotic Chromosome Structures Constrain and Respond to Designation of Crossover Recombination Sites
Rebecca C. Burgess,
National Cancer Institute, USA
Activation of DNA Damage Response Signaling by Condensed Chromatin
Activation of DNA Damage Response Signaling by Condensed Chromatin
14:30—16:30
Workshop 1: DNA-Damage Checkpoint Signaling
*
Aaron A. Goodarzi,
Southern Alberta Cancer Research Institute, Canada
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Dephosphorylation of 53BP1 Is Necessary for its Function in the DNA Damage Response
Dephosphorylation of 53BP1 Is Necessary for its Function in the DNA Damage Response
Madalena Tarsounas,
University of Oxford, UK
EMBO Young Investigator Presenter: ARF Induces Senescence in Response to DNA Damage by Altering Expression of p53 Targets
EMBO Young Investigator Presenter: ARF Induces Senescence in Response to DNA Damage by Altering Expression of p53 Targets
Michela Di Virgilio,
Rockefeller University, USA
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
J. Ross Chapman,
London Research Institute, Clare Hall Laboratories, UK
Rif1: A Critical Regulator of DNA Double-Strand Break Repair Required for Genome Stability and Immune Responses in Mice
Rif1: A Critical Regulator of DNA Double-Strand Break Repair Required for Genome Stability and Immune Responses in Mice
Kyle M. Miller,
University of Texas at Austin, USA
Systematic Identification of Functional Residues in Mammalian Histone H2AX
Systematic Identification of Functional Residues in Mammalian Histone H2AX
Jean-Yves Masson,
Laval University Cancer Research Center, Canada
Function of PALB2 in DNA Double-Strand Break Repair and Recombination-Associated DNA Synthesis
Function of PALB2 in DNA Double-Strand Break Repair and Recombination-Associated DNA Synthesis
Simon Bekker-Jensen,
University of Copenhagen, Denmark
Human RNF111 Is a Novel SUMO-Targeted Ubiquitin Ligase Functioning in the DNA Damage Response
Human RNF111 Is a Novel SUMO-Targeted Ubiquitin Ligase Functioning in the DNA Damage Response
17:00—19:00
Postreplication Repair/Restart
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Johannes C. Walter,
Harvard Medical School, USA
Mechanisms of Replication-Coupled Crosslink Repair
Mechanisms of Replication-Coupled Crosslink Repair
James E. Haber,
Brandeis University, USA
Genome Stability and Instability: Repair of a Broken Chromosome
Genome Stability and Instability: Repair of a Broken Chromosome
*
Wei Yang,
NIDDK, National Institutes of Health, USA
Translesion DNA Synthesis: Chemistry and Cancer Biology
Translesion DNA Synthesis: Chemistry and Cancer Biology
Maria Spies,
University of Iowa, USA
Short Talk: Priming Heteroduplex Rejection: hMSH2-hMSH6 Recognizes Mismatches within Recombination Intermediates
Short Talk: Priming Heteroduplex Rejection: hMSH2-hMSH6 Recognizes Mismatches within Recombination Intermediates
17:00—19:00
Chromosomal Stability, Instability and Nuclear Architecture
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Alan D. D'Andrea,
Dana-Farber Cancer Institute, USA
Stephen P. Jackson,
University of Cambridge, UK
Post-Translational Modifications Controlling the Assembly and Functions of Protein Complexes at DNA Damage Sites
Post-Translational Modifications Controlling the Assembly and Functions of Protein Complexes at DNA Damage Sites
Evi Soutoglou,
Institute of Genetics and Molecular and Cellular Biology
Nuclear Compartmentalization and DNA Repair: Evidence for Reduced DDR at the Nuclear Periphery
Nuclear Compartmentalization and DNA Repair: Evidence for Reduced DDR at the Nuclear Periphery
Ciaran G. Morrison,
National University of Ireland, Galway, Ireland
Short Talk: The Pericentriolar Material as a Hub for DNA Damage Checkpoints: Pericentrin and Mcph1 Control Nuclear Chk1 Activation
Short Talk: The Pericentriolar Material as a Hub for DNA Damage Checkpoints: Pericentrin and Mcph1 Control Nuclear Chk1 Activation
08:00—11:15
Replication Initiation Strategies across Species
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Stephen P. Bell,
Massachusetts Institute of Technology, USA
Is Helicase Competence Required for Helicase Loading?
Is Helicase Competence Required for Helicase Loading?
Terry L. Orr-Weaver,
Massachusetts Institute of Technology, USA
Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model
Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model
Daniel L. Kaplan,
Florida State University College of Medicine, USA
Short Talk: Cdc45-ssDNA Interaction Is Important for Stalling the Helicase during Replication Stress
Short Talk: Cdc45-ssDNA Interaction Is Important for Stalling the Helicase during Replication Stress
James M. Berger,
University of California, Berkeley, USA
Loading and Activation of a Bacterial Hexameric Helicase
Loading and Activation of a Bacterial Hexameric Helicase
J. Julian Blow,
University of Dundee, Scotland
How the Distribution and Regulation of Replication Origins Ensures Precise Chromosome Duplication
How the Distribution and Regulation of Replication Origins Ensures Precise Chromosome Duplication
Philip Zegerman,
University of Cambridge, UK
Short Talk: DNA Replication Initiation Rates Control Cell Cycle Events at the Mid-Blastula Transition of Xenopus laevis
Short Talk: DNA Replication Initiation Rates Control Cell Cycle Events at the Mid-Blastula Transition of Xenopus laevis
08:00—11:15
Controlling DNA Damage Responses by Ubiquitylation and Sumoylation
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*
Daniel Durocher,
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
The Mystery of 53BP1 Recruitment
The Mystery of 53BP1 Recruitment
Dana Branzei,
FIRC Institute of Molecular Oncology, Italy
A SUMO-Dependent Chromatin Architectural Pathway Facilitates Error-Free DNA Damage Tolerance via Sister Chromatid Recombination
A SUMO-Dependent Chromatin Architectural Pathway Facilitates Error-Free DNA Damage Tolerance via Sister Chromatid Recombination
Kristijan Ramadan,
Institute of Pharmacology and Toxicology, Switzerland
Short Talk: Premature Aging Syndrome in Human Is Caused by Mutations in p97/VCP-Cofactor DVC1/Spartan
Short Talk: Premature Aging Syndrome in Human Is Caused by Mutations in p97/VCP-Cofactor DVC1/Spartan
Petra Beli,
Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: Systems-Wide Analysis of Ubiquitylation in Response to UV
Short Talk: Systems-Wide Analysis of Ubiquitylation in Response to UV
Titia K. Sixma,
Netherlands Cancer Institute, Netherlands
Short Talk: RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
Short Talk: RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
Jacqueline J. Jacobs,
Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Short Talk: New Factors Controlling Telomere-Driven Genomic Instability
EMBO Young Investigator Short Talk: New Factors Controlling Telomere-Driven Genomic Instability
14:30—16:30
Workshop 2: DNA Repair/Recombination Processes
*
Marc S. Wold,
University of Iowa, USA
New Insights into Repair-Specific Roles of Replication Protein A
New Insights into Repair-Specific Roles of Replication Protein A
Andrea Regier Voth,
NIDDK, National Institutes of Health, USA
Structural Characterization of the Molecular Mechanism of the DNA Transposase Hermes
Structural Characterization of the Molecular Mechanism of the DNA Transposase Hermes
Kayleigh Wardell,
University of Nottingham, UK
RcrA, a Novel Protein at the Crossroads of Replication and Recombination
RcrA, a Novel Protein at the Crossroads of Replication and Recombination
Jordan R. Becker,
University of Minnesota, USA
Ubiquitinated PCNA Monitors Okazaki Fragment Processing
Ubiquitinated PCNA Monitors Okazaki Fragment Processing
Sabine S. Lange,
University of Texas MD Anderson Cancer Center, USA
Dual Role for Mammalian DNA Polymerase Zeta in Supporting Proliferative Responses and Maintaining Genome Stability
Dual Role for Mammalian DNA Polymerase Zeta in Supporting Proliferative Responses and Maintaining Genome Stability
Robin N. Eichmiller,
State University of New York, Buffalo, USA
Mutations in RAD1 Reveal Altered Regulation of Rad1-Rad10 Activity
Mutations in RAD1 Reveal Altered Regulation of Rad1-Rad10 Activity
Georgios I. Karras,
Whitehead Institute for Biomedical Research, USA
Non-Canonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway
Non-Canonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway
14:30—16:30
Workshop 3: DNA Replication Processes
*
Michael A. Trakselis,
University of Pittsburgh, USA
Formation of an Archaeal Primosome Complex Controls DNA Priming and Unwinding
Formation of an Archaeal Primosome Complex Controls DNA Priming and Unwinding
Arek Kulczyk,
Harvard Medical School, USA
Single-Molecule Studies of the Replisome Structure and Dynamics
Single-Molecule Studies of the Replisome Structure and Dynamics
Ian M. Slaymaker,
University of Southern California, USA
Mini-Chromosome Maintenance Complexes Form a Filament to Remodel DNA Structure and Topology
Mini-Chromosome Maintenance Complexes Form a Filament to Remodel DNA Structure and Topology
Juan Méndez,
Spanish National Cancer Research Centre, Spain
PrimPol, a New Human DNA Primase/Polymerase, Is Involved in Translesion Synthesis and Recovery of Stalled Forks during Nuclear DNA Replication
PrimPol, a New Human DNA Primase/Polymerase, Is Involved in Translesion Synthesis and Recovery of Stalled Forks during Nuclear DNA Replication
Lindsey N. Williams,
University of Washington, USA
Checkpoint-Dependent Mutagenesis by Error-Prone DNA Polymerase epsilon Variants
Checkpoint-Dependent Mutagenesis by Error-Prone DNA Polymerase epsilon Variants
Kin Fan On,
London Research Institute, Clare Hall Laboratories, UK
A Cell-Free DNA Replication System Using Pre-RCs Reconstituted with Purified Proteins
A Cell-Free DNA Replication System Using Pre-RCs Reconstituted with Purified Proteins
Viola Nähse-Kumpf,
Institute for Cancer Research, Norwegian Radium Hospital, Norway
Checkpoint Kinase WEE1 Protects Against Replication-Associated DNA Damage
Checkpoint Kinase WEE1 Protects Against Replication-Associated DNA Damage
17:00—19:15
Replication, Chromatin and Genome Instability (Joint)
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Geneviève Almouzni,
Centre National de la Recherche Scientifique, France
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage and Genome Instability
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage and Genome Instability
Ian D. Hickson,
University of Copenhagen, Denmark
Resolution of Stalled Replication Forks and Late Replication Intermediates
Resolution of Stalled Replication Forks and Late Replication Intermediates
Susan M. Gasser,
Friedrich Miescher Institute for Biomedical Research, Switzerland
The Spatial Dynamics of Repair
The Spatial Dynamics of Repair
Jennifer A. Cobb,
University of Calgary, Canada
Short Talk: Nej1 C-Terminus Is Critical for Efficient Nonhomologous End-Joining in S. cerevisiae
Short Talk: Nej1 C-Terminus Is Critical for Efficient Nonhomologous End-Joining in S. cerevisiae
Brendan D. Price,
Dana-Farber Cancer Institute, USA
Short Talk: Histone H2A.Z Regulates Chromatin Structure and End-Resection by CtIP at DSBs
Short Talk: Histone H2A.Z Regulates Chromatin Structure and End-Resection by CtIP at DSBs
08:00—11:15
Genome Structure and Maintenance
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*
Lorraine S. Symington,
Columbia University, USA
RPA Coordinates DNA End Resection and Prevents Formation of Hairpins
RPA Coordinates DNA End Resection and Prevents Formation of Hairpins
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Simon J. Boulton,
London Research Institute, Clare Hall Laboratories, UK
Replication Blocking Lesions. HelQ: Role in DNA Repair
Replication Blocking Lesions. HelQ: Role in DNA Repair
Massimo Lopes,
University of Zürich, Switzerland
EMBO Young Investigator Short Talk: Remodelling of Replication Intermediates upon DNA Replication Stress
EMBO Young Investigator Short Talk: Remodelling of Replication Intermediates upon DNA Replication Stress
Stephen C. West,
London Research Institute, UK
Alternative Pathways for Holliday Junction Resolution in Human Cells
Alternative Pathways for Holliday Junction Resolution in Human Cells
Akira Shinohara,
Osaka University, Japan
Control of Meiotic Recombination by Rad51 Mediators and DNA Helicases
Control of Meiotic Recombination by Rad51 Mediators and DNA Helicases
Gary Karpen,
Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Short Talk: Heterochromatin and Nuclear Pore Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs
Short Talk: Heterochromatin and Nuclear Pore Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs
08:00—11:15
Genome Instability, Telomeres, Disease and Aging. Session sponsored by The Ellison Medical Foundation.
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NOTE: Support for these organizer-selected speakers generously provided by this foundation.
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Susan P. Lees-Miller,
University of Calgary, Canada
Titia de Lange,
Rockefeller University, USA
TRF2 Promotes T-Loop Formation to Block ATM Signaling and NHEJ at Chromosome Ends
TRF2 Promotes T-Loop Formation to Block ATM Signaling and NHEJ at Chromosome Ends
André Nussenzweig,
NCI, National Institutes of Health, USA
Identification of a Novel Class of Early Replicating Fragile Sites that Contribute to Genomic Instability in B Cell Lymphomas
Identification of a Novel Class of Early Replicating Fragile Sites that Contribute to Genomic Instability in B Cell Lymphomas
Catherine H. Freudenreich,
Tufts University, USA
Short Talk: Regulation of Acetylation on the Histone H4 Tail Maintains Fidelity of Homologous Recombination and Prevents CAG Expansions
Short Talk: Regulation of Acetylation on the Histone H4 Tail Maintains Fidelity of Homologous Recombination and Prevents CAG Expansions
Laura J. Niedernhofer,
The Scripps Research Institute, USA
The Mechanism by which DNA Repair Protects Against Aging
The Mechanism by which DNA Repair Protects Against Aging
Keith W. Caldecott,
University of Sussex, UK
Topoisomerase-Induced DNA Double Strand Breakage and Repair in Human Disease
Topoisomerase-Induced DNA Double Strand Breakage and Repair in Human Disease
Carl L. Schildkraut,
Albert Einstein College of Medicine, USA
Short Talk: DNA Replication Fork Progression through the Fragile X and Telomere Repeats
Short Talk: DNA Replication Fork Progression through the Fragile X and Telomere Repeats
17:00—19:00
Topological Transformations in DNA
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*
Phoebe A. Rice,
University of Chicago, USA
The How, When and Where of Site-Specific DNA Recombination
The How, When and Where of Site-Specific DNA Recombination
Camilla Sjögren,
Karolinska Institutet, Sweden
Sister Chromatid Intertwinings and the SMC Complexes
Sister Chromatid Intertwinings and the SMC Complexes
Claire Wyman,
Erasmus Medical Center, Netherlands
The "See Me, Feel Me" Approach to Understand Key Steps in Homologous Recombination
The "See Me, Feel Me" Approach to Understand Key Steps in Homologous Recombination
Jon Baxter,
University of Sussex, UK
Short Talk: The Yeast Pif1 Family Helicase RRM3 Promotes DNA Unwinding during Replication Fork Swiveling
Short Talk: The Yeast Pif1 Family Helicase RRM3 Promotes DNA Unwinding during Replication Fork Swiveling
17:00—19:00
DNA Damage and Links to Transcription, RNA Metabolism and Other Processes
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*
David Cortez,
Vanderbilt University Medical Center, USA
Andrés Aguilera,
Andalusian Molecular Biology and Regenerative Medicine Centre - CABIMER, Spain
Mechanisms of Transcription- and RNA-Induced DNA Damage and Genome Instability
Mechanisms of Transcription- and RNA-Induced DNA Damage and Genome Instability
Scott R. Floyd,
Massachusetts Institute of Technology, USA
Short Talk: Linking Chromatin State to Signaling Networks in the DDR
Short Talk: Linking Chromatin State to Signaling Networks in the DDR
Uttiya Basu,
Columbia University, USA
Short Talk: B Cell Genome Mutator AID Is Regulated in the RNA Polymerase II Associated Transcriptional Complex by E3-Ubiquitin Ligase NEDD4
Short Talk: B Cell Genome Mutator AID Is Regulated in the RNA Polymerase II Associated Transcriptional Complex by E3-Ubiquitin Ligase NEDD4
Manuel Stucki,
Universität Zürich, Switzerland
Short Talk: NBS1 and the Nucleolar Response to DNA Double-Strand Breaks
Short Talk: NBS1 and the Nucleolar Response to DNA Double-Strand Breaks
08:00—11:15
Replication Elongation Machineries
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David J. Sherratt,
University of Oxford, UK
High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination
High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination
*
Peter M. Burgers,
Washington University School of Medicine, USA
Connecting DNA Damage to Checkpoint Initiation
Connecting DNA Damage to Checkpoint Initiation
John A. Tainer,
The Scripps Research Institute, USA
Short Talk: MRE11 Complex Regulates Repair Pathway Choice as Shown by Chemical Knockdown of Specific Activities
Short Talk: MRE11 Complex Regulates Repair Pathway Choice as Shown by Chemical Knockdown of Specific Activities
Nicholas E. Dixon,
University of Wollongong, Australia
Short Talk: An epsilon-beta Interaction in E. coli DNA Polymerase III Stabilizes the Replicase in the Polymerization Mode
Short Talk: An epsilon-beta Interaction in E. coli DNA Polymerase III Stabilizes the Replicase in the Polymerization Mode
08:00—11:00
Genomic and Genome-Wide Studies
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*
Karlene A. Cimprich,
Stanford University, USA
Michael Stratton,
Wellcome Trust Sanger Institute, UK
Signatures of Mutational Processes Operative in Human Cancers
Signatures of Mutational Processes Operative in Human Cancers
David Cortez,
Vanderbilt University Medical Center, USA
Identification and Characterization of Mammalian Genome Maintenance Proteins
Identification and Characterization of Mammalian Genome Maintenance Proteins
Ryan L. Ragland,
Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Genome-Wide Identification of Replication-Associated Breakpoints
Short Talk: Genome-Wide Identification of Replication-Associated Breakpoints
Marcel Tijsterman,
Leiden University Medical Center, Netherlands
Pol theta Mediated end Joining of DNA Breaks Induced by Replication Fork Barriers
Pol theta Mediated end Joining of DNA Breaks Induced by Replication Fork Barriers
Peter C. Stirling,
University of British Columbia, Canada
Short Talk: Systematic Genetic and Cytological Analysis of Genome Integrity Pathways in Yeast
Short Talk: Systematic Genetic and Cytological Analysis of Genome Integrity Pathways in Yeast
Gaelle Legube,
CNRS - Toulouse University, France
Short Talk: Transcription Channels DNA Double Strand Breaks to a RAD51-Dependent Repair Pathway
Short Talk: Transcription Channels DNA Double Strand Breaks to a RAD51-Dependent Repair Pathway
14:30—16:30
Workshop 4: Enzymes Acting on Nucleic Acids
*
John L. Nitiss,
University of Illinois, USA
A Mutation in Eukaryotic Topoisomerase II that Mimics the Action of Topoisomerase Poisons: Role of the C-Terminal Dimerization Domain in Regulation of DNA Cleavage
A Mutation in Eukaryotic Topoisomerase II that Mimics the Action of Topoisomerase Poisons: Role of the C-Terminal Dimerization Domain in Regulation of DNA Cleavage
Ilya Finkelstein,
University of Texas at Austin, USA
Single Molecule Imaging Reveals the Mechanisms of Roadblock Clearance by DNA-Binding Motor Enzymes
Single Molecule Imaging Reveals the Mechanisms of Roadblock Clearance by DNA-Binding Motor Enzymes
Aaron C. Mason,
Vanderbilt University, USA
Structural Insight into the Mechanism of the DNA Damage Response Protein Smarcal1
Structural Insight into the Mechanism of the DNA Damage Response Protein Smarcal1
Hannah E. Mischo,
Clare Hall Laboratories, London Research Institute, UK
Connections between Transcription Termination and Genome Integrity: Dissecting the Function of the Superfamily I Helicase Sen1
Connections between Transcription Termination and Genome Integrity: Dissecting the Function of the Superfamily I Helicase Sen1
Alessandro Vindigni,
St. Louis University, USA
Mechanistic Insight into Replication Fork Reversal and Restart Under Genotoxic Stress
Mechanistic Insight into Replication Fork Reversal and Restart Under Genotoxic Stress
Alessandro Costa,
London Research Institute, UK
Structure of the Bloom's Complex: Insights into the Mechanism of Double Holliday Junction Dissolution
Structure of the Bloom's Complex: Insights into the Mechanism of Double Holliday Junction Dissolution
Sarah Wessel,
University of Wisconsin, USA
Molecular Interactions in PriC-Mediated DNA Replication Restart
Molecular Interactions in PriC-Mediated DNA Replication Restart
14:30—16:30
Workshop 2: DNA DSB Repair and Associated Processes
*
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Katheryn D. Meek,
Michigan State University, USA
Unraveling the Complexities of DNA-PK Autophosphorylation
Unraveling the Complexities of DNA-PK Autophosphorylation
Alessandro A. Sartori,
Institute of Molecular Cancer Research, Switzerland
The Human PIN1 Isomerase Regulates DSB Repair
The Human PIN1 Isomerase Regulates DSB Repair
Jacques Côté,
Laval University Cancer Research Center, Canada
Phospho-Dependent Recruitment of NuA4 by MRX at DNA Breaks Regulates RPA Dynamics during Resection
Phospho-Dependent Recruitment of NuA4 by MRX at DNA Breaks Regulates RPA Dynamics during Resection
Lei Li,
University of Alberta, Canada
DEAD Box 1 Interacts with Rif1 and Promotes Homologous DNA Repair
DEAD Box 1 Interacts with Rif1 and Promotes Homologous DNA Repair
Martin A. M. Reijns,
MRC Institute for Genetics and Molecular Medicine
Ribonuclease H2 Is Essential for the Removal of Misincorporated Ribonucleotides and for Mammalian Genome Integrity
Ribonuclease H2 Is Essential for the Removal of Misincorporated Ribonucleotides and for Mammalian Genome Integrity
David O. Ferguson,
University of Michigan Medical School, USA
Mre11 Interacts with Cyclin-Dependent Kinase 2 to Regulate Double Strand Break Repair
Mre11 Interacts with Cyclin-Dependent Kinase 2 to Regulate Double Strand Break Repair
Nidhi Nair,
University of Dundee, UK
Slx1 and Mus81 Nucleases Cooperate in Holliday Junction Resolution
Slx1 and Mus81 Nucleases Cooperate in Holliday Junction Resolution
Priscilla K. Cooper,
Lawrence Berkeley National Laboratory, USA
XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability
XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability
17:00—19:00
Replicating Challenging Regions
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Joachim Lingner,
École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
The THO Complex Counteracts Telomeric R-Loops and Telomere Instability
The THO Complex Counteracts Telomeric R-Loops and Telomere Instability
Maria Teresa Teixeira,
CNRS - Institut de Biologie Physico-Chimique, France
Short Talk: The DNA End Replication Problem and the Establishment of Replicative Senescence in Saccharomyces cerevisiae
Short Talk: The DNA End Replication Problem and the Establishment of Replicative Senescence in Saccharomyces cerevisiae
Julia Promisel Cooper,
London Research Institute, UK
Solving the End Replication and Protection Problems without Telomerase or Telomere Repeats
Solving the End Replication and Protection Problems without Telomerase or Telomere Repeats
17:00—19:15
Diagnostic and Therapeutic Applications
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*
Stephen P. Jackson,
University of Cambridge, UK
Thomas Helleday,
Karolinska Institutet, Sweden
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition
Jos Jonkers,
Netherlands Cancer Institute, Netherlands
DDR-Based Therapeutic Strategies and Resistance Mechanisms
DDR-Based Therapeutic Strategies and Resistance Mechanisms
Óscar Fernández-Capetillo,
Spanish National Cancer Research Centre, Spain
Exploring the Role of Replicative Stress in Cancer and Aging
Exploring the Role of Replicative Stress in Cancer and Aging
Yves G. Pommier,
NCI, National Institutes of Health, USA
Short Talk: PARP1-TDP1 Partnership for DNA Repair and Processing of Top1-DNA Complexes
Short Talk: PARP1-TDP1 Partnership for DNA Repair and Processing of Top1-DNA Complexes
Michael Weinfeld,
University of Alberta, Canada
Short Talk: Synthetic Lethality through Targeted Disruption of Polynucleotide Kinase/Phosphatase
Short Talk: Synthetic Lethality through Targeted Disruption of Polynucleotide Kinase/Phosphatase
*Session Chair †Speaker invited, not yet responded.
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