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Fairmont Banff Springs Floorplan

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This meeting took place in 2013



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Genomic Instability and DNA Repair (X6)


Organizer(s) Stephen P. Jackson, Alan D. D'Andrea and Susan M. Gasser
March 3—8, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 7, 2012
Late Abstract Deadline: Dec 4, 2012
Scholarship Deadline: Nov 7, 2012
Early Registration Deadline: Jan 7, 2013

Supported by the Directors' Fund


Summary of Meeting:
Because DNA is constantly being attacked by endogenous and environmental agents, life has evolved systems to detect DNA damage, signal its presence and mediate its repair. Defects in these systems cause many human pathologies, including cancer, neurodegenerative diseases, immune-deficiencies, infertility, developmental defects and premature ageing. Understanding how DNA damage arises and how it is dealt with by cells and organisms is therefore of high academic and medical importance. Recent discoveries have indicated that DNA-damage responses are more complex, and impact on a wider range of cellular functions, than had been hitherto anticipated. Unlike other “DNA damage oriented” conferences, which tend to focus heavily on specific areas of the field, this conference will bring together researchers investigating how DNA damage is dealt with at the molecular, cellular and whole-organism levels. Furthermore, in addition to addressing already well-studied – but as yet incompletely understood – links between DNA-damage responses and events such as cell cycle progression, DNA replication and the control of telomere structure, the meeting will forge new scientific links by also featuring researchers studying complementary areas of science such as the Ubiquitin system, chromatin, transcription and RNA metabolism. Thus, the program will nurture cutting-edge research and exciting new collaborations between junior and more established scientists in diverse fields. Finally, by also featuring researchers working in clinical and drug discovery settings, the conference will foster research aimed at translating new knowledge of DNA-damage responses towards understanding and better diagnosing and treating human disease, particularly cancer and other age-related medical conditions.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 3

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen P. Jackson, University of Cambridge, UK

* James M. Berger, Johns Hopkins School of Medicine, USA

Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms of Programmed DNA Rearrangements and Chromosomal Translocations in the Immune System

Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA
Multiple Pathways to Reactivate Replication Forks Stalled by Damage in the Leading-Strand Template


MONDAY, MARCH 4

06:45—08:00
Breakfast

08:00—11:15
Mechanisms and Control of DNA Repair/Mechanisms of Homologous Recombination (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Analysis of DNA Recombination

Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA
Re-Considering the Role of BRCA1

Samuel F. Bunting, Rutgers University, USA
Short Talk: BRCA1 Functions Independently in Excision of DNA Interstrand Crosslinks and in Homologous Recombination

Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Regulating Recombination

Roland Kanaar, Erasmus MC, Netherlands
Modulation of Homologous Recombination

Douglas K. Bishop, University of Chicago, USA
Short Talk: Overlapping RAD51-DMC1 foci come in well Separated Pairs: Symmetric Model for Meiotic Recombination

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: DNA-Damage Checkpoint Signaling

* Aaron A. Goodarzi, Southern Alberta Cancer Research Institute, Canada

Ralph Scully, Beth Israel Deaconess Medical Center, USA
Dephosphorylation of 53BP1 Is Necessary for its Function in the DNA Damage Response

Madalena Tarsounas, University of Oxford, UK
EMBO Young Investigator Presenter: ARF Induces Senescence in Response to DNA Damage by Altering Expression of p53 Targets

Michela Di Virgilio, Rockefeller University, USA
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

J. Ross Chapman, London Research Institute, Clare Hall Laboratories, UK
Rif1: A Critical Regulator of DNA Double-Strand Break Repair Required for Genome Stability and Immune Responses in Mice

Kyle M. Miller, University of Texas at Austin, USA
Systematic Identification of Functional Residues in Mammalian Histone H2AX

Jean-Yves Masson, Laval University Cancer Research Center, Canada
Function of PALB2 in DNA Double-Strand Break Repair and Recombination-Associated DNA Synthesis

Simon Bekker-Jensen, University of Copenhagen, Denmark
Human RNF111 Is a Novel SUMO-Targeted Ubiquitin Ligase Functioning in the DNA Damage Response


Following Session is for DNA Replication and Recombination (X5)

14:30—16:30
Workshop 1: Regulation of DNA Superstructure

* Michael M. Cox, University of Wisconsin-Madison, USA

Erin A. Ronayne, University of Wisconsin, Madison, USA
Structure and Function of the E. coli MgsA Protein

Manolis Papamichos-Chronakis, Institut Curie, France
Integration of the INO80 Chromatin Remodeling Complex in the Ubiquitin-Mediated Protein Degradation Pathway Is Essential for Genome Stability

Margaret M. F. Renaud-Young, University of Calgary, Canada
The NuA4 Complex Is a Novel Participant in the Translesion Synthesis Pathway of DNA Post Replication Repair

Liz Colby, Cancer Research UK, London Research Institute
Creating Site-Specific DNA Damage in S. cerevisiae to Study Replication-Associated Lesion Bypass

Mariana C. Gadaleta, Drexel University College of Medicine, USA
Swi1 Prevents DNA Damage during Replication of Difficult-to-Replicate Sites

Diana E. Libuda, Stanford University, USA
Meiotic Chromosome Structures Constrain and Respond to Designation of Crossover Recombination Sites

Rebecca C. Burgess, National Cancer Institute, USA
Activation of DNA Damage Response Signaling by Condensed Chromatin

16:30—17:00
Coffee Available

17:00—19:00
Chromosomal Stability, Instability and Nuclear Architecture
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Stephen P. Jackson, University of Cambridge, UK
Post-Translational Modifications Controlling the Assembly and Functions of Protein Complexes at DNA Damage Sites

Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology
Nuclear Compartmentalization and DNA Repair: Evidence for Reduced DDR at the Nuclear Periphery

Ciaran G. Morrison, National University of Ireland, Galway, Ireland
Short Talk: The Pericentriolar Material as a Hub for DNA Damage Checkpoints: Pericentrin and Mcph1 Control Nuclear Chk1 Activation


Following Session is for DNA Replication and Recombination (X5)

17:00—19:00
Postreplication Repair/Restart
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Johannes C. Walter, Harvard Medical School, USA
Mechanisms of Replication-Coupled Crosslink Repair

James E. Haber, Brandeis University, USA
Genome Stability and Instability: Repair of a Broken Chromosome

* Wei Yang, NIDDK, National Institutes of Health, USA
Translesion DNA Synthesis: Chemistry and Cancer Biology

Maria Spies, University of Iowa, USA
Short Talk: Priming Heteroduplex Rejection: hMSH2-hMSH6 Recognizes Mismatches within Recombination Intermediates

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 5

06:45—08:00
Breakfast

08:00—11:15
Controlling DNA Damage Responses by Ubiquitylation and Sumoylation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Daniel Durocher, Samuel Lunenfeld-Tanenbaum Research Institute, Canada
The Mystery of 53BP1 Recruitment

Dana Branzei, FIRC Institute of Molecular Oncology, Italy
A SUMO-Dependent Chromatin Architectural Pathway Facilitates Error-Free DNA Damage Tolerance via Sister Chromatid Recombination

Kristijan Ramadan, Institute of Pharmacology and Toxicology, Switzerland
Short Talk: Premature Aging Syndrome in Human Is Caused by Mutations in p97/VCP-Cofactor DVC1/Spartan

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
The Importance of UBCZ Domains

Petra Beli, Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: Systems-Wide Analysis of Ubiquitylation in Response to UV

Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Short Talk: RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

Jacqueline J. Jacobs, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Short Talk: New Factors Controlling Telomere-Driven Genomic Instability


Following Session is for DNA Replication and Recombination (X5)

08:00—11:15
Replication Initiation Strategies across Species
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen P. Bell, Massachusetts Institute of Technology, USA
Is Helicase Competence Required for Helicase Loading?

Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA
Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model

Daniel L. Kaplan, Florida State University College of Medicine, USA
Short Talk: Cdc45-ssDNA Interaction Is Important for Stalling the Helicase during Replication Stress

James M. Berger, Johns Hopkins School of Medicine, USA
Loading and Activation of a Bacterial Hexameric Helicase

J. Julian Blow, University of Dundee, Scotland
How the Distribution and Regulation of Replication Origins Ensures Precise Chromosome Duplication

Philip Zegerman, University of Cambridge, UK
Short Talk: DNA Replication Initiation Rates Control Cell Cycle Events at the Mid-Blastula Transition of Xenopus laevis

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation


Following Session is for DNA Replication and Recombination (X5)

14:30—16:30
Workshop 2: DNA Repair/Recombination Processes

* Marc S. Wold, University of Iowa, USA
New Insights into Repair-Specific Roles of Replication Protein A

Andrea Regier Voth, NIDDK, National Institutes of Health, USA
Structural Characterization of the Molecular Mechanism of the DNA Transposase Hermes

Kayleigh Wardell, University of Nottingham, UK
RcrA, a Novel Protein at the Crossroads of Replication and Recombination

Jordan R. Becker, University of Minnesota, USA
Ubiquitinated PCNA Monitors Okazaki Fragment Processing

Sabine S. Lange, University of Texas MD Anderson Cancer Center, USA
Dual Role for Mammalian DNA Polymerase Zeta in Supporting Proliferative Responses and Maintaining Genome Stability

Robin N. Eichmiller, State University of New York, Buffalo, USA
Mutations in RAD1 Reveal Altered Regulation of Rad1-Rad10 Activity

Georgios I. Karras, Whitehead Institute for Biomedical Research, USA
Non-Canonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway


Following Session is for DNA Replication and Recombination (X5)

14:30—16:30
Workshop 3: DNA Replication Processes

* Michael A. Trakselis, University of Pittsburgh, USA
Formation of an Archaeal Primosome Complex Controls DNA Priming and Unwinding

Arek Kulczyk, Harvard Medical School, USA
Single-Molecule Studies of the Replisome Structure and Dynamics

Ian M. Slaymaker, University of Southern California, USA
Mini-Chromosome Maintenance Complexes Form a Filament to Remodel DNA Structure and Topology

Juan Méndez, Spanish National Cancer Research Centre, Spain
PrimPol, a New Human DNA Primase/Polymerase, Is Involved in Translesion Synthesis and Recovery of Stalled Forks during Nuclear DNA Replication

Lindsey N. Williams, University of Washington, USA
Checkpoint-Dependent Mutagenesis by Error-Prone DNA Polymerase epsilon Variants

Kin Fan On, London Research Institute, Clare Hall Laboratories, UK
A Cell-Free DNA Replication System Using Pre-RCs Reconstituted with Purified Proteins

Viola Nähse-Kumpf, Institute for Cancer Research, Norwegian Radium Hospital, Norway
Checkpoint Kinase WEE1 Protects Against Replication-Associated DNA Damage

16:30—17:00
Coffee Available

17:00—19:15
Replication, Chromatin and Genome Instability (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sophie Polo, UMR7216 CNRS Université Paris Diderot, France

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage and Genome Instability

Ian D. Hickson, University of Copenhagen, Denmark
Resolution of Stalled Replication Forks and Late Replication Intermediates

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Spatial Dynamics of Repair

Jennifer A. Cobb, University of Calgary, Canada
Short Talk: Nej1 C-Terminus Is Critical for Efficient Nonhomologous End-Joining in S. cerevisiae

Brendan D. Price, Dana-Farber Cancer Institute, USA
Short Talk: Histone H2A.Z Regulates Chromatin Structure and End-Resection by CtIP at DSBs

19:15—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 6

06:45—08:00
Breakfast

08:00—11:15
Genome Instability, Telomeres, Disease and Aging. Session sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Support for these organizer-selected speakers generously provided by this foundation.

* Susan P. Lees-Miller, University of Calgary, Canada

Titia de Lange, Rockefeller University, USA
TRF2 Promotes T-Loop Formation to Block ATM Signaling and NHEJ at Chromosome Ends

André Nussenzweig, NCI, National Institutes of Health, USA
Identification of a Novel Class of Early Replicating Fragile Sites that Contribute to Genomic Instability in B Cell Lymphomas

Catherine H. Freudenreich, Tufts University, USA
Short Talk: Regulation of Acetylation on the Histone H4 Tail Maintains Fidelity of Homologous Recombination and Prevents CAG Expansions

Laura J. Niedernhofer, The Scripps Research Institute, USA
The Mechanism by which DNA Repair Protects Against Aging

Keith W. Caldecott, University of Sussex, UK
Topoisomerase-Induced DNA Double Strand Breakage and Repair in Human Disease

Carl L. Schildkraut, Albert Einstein College of Medicine, USA
Short Talk: DNA Replication Fork Progression through the Fragile X and Telomere Repeats


Following Session is for DNA Replication and Recombination (X5)

08:00—11:15
Genome Structure and Maintenance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lorraine S. Symington, Columbia University, USA
RPA Coordinates DNA End Resection and Prevents Formation of Hairpins

* Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
Replication Blocking Lesions. HelQ: Role in DNA Repair

Massimo Lopes, University of Zürich, Switzerland
EMBO Young Investigator Short Talk: Remodelling of Replication Intermediates upon DNA Replication Stress

Stephen C. West, London Research Institute, UK
Alternative Pathways for Holliday Junction Resolution in Human Cells

Akira Shinohara, Osaka University, Japan
Control of Meiotic Recombination by Rad51 Mediators and DNA Helicases

Gary Karpen, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Short Talk: Heterochromatin and Nuclear Pore Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
DNA Damage and Links to Transcription, RNA Metabolism and Other Processes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David Cortez, Vanderbilt University Medical Center, USA

Andrés Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre - CABIMER, Spain
Mechanisms of Transcription- and RNA-Induced DNA Damage and Genome Instability

Karlene A. Cimprich, Stanford University, USA
Novel Mechanisms for Maintaining Genome Stability

Scott R. Floyd, Massachusetts Institute of Technology, USA
Short Talk: Linking Chromatin State to Signaling Networks in the DDR

Uttiya Basu, Columbia University, USA
Short Talk: B Cell Genome Mutator AID Is Regulated in the RNA Polymerase II Associated Transcriptional Complex by E3-Ubiquitin Ligase NEDD4

Manuel Stucki, Universität Zürich, Switzerland
Short Talk: NBS1 and the Nucleolar Response to DNA Double-Strand Breaks


Following Session is for DNA Replication and Recombination (X5)

17:00—19:00
Topological Transformations in DNA
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Phoebe A. Rice, University of Chicago, USA
The How, When and Where of Site-Specific DNA Recombination

Camilla Sjögren, Karolinska Institutet, Sweden
Sister Chromatid Intertwinings and the SMC Complexes

Claire Wyman, Erasmus Medical Center, Netherlands
The "See Me, Feel Me" Approach to Understand Key Steps in Homologous Recombination

Jon Baxter, University of Sussex, UK
Short Talk: The Yeast Pif1 Family Helicase RRM3 Promotes DNA Unwinding during Replication Fork Swiveling

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 7

06:45—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:00
Genomic and Genome-Wide Studies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karlene A. Cimprich, Stanford University, USA

Michael Stratton, Wellcome Trust Sanger Institute, UK
Signatures of Mutational Processes Operative in Human Cancers

David Cortez, Vanderbilt University Medical Center, USA
Identification and Characterization of Mammalian Genome Maintenance Proteins

Ryan L. Ragland, Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Genome-Wide Identification of Replication-Associated Breakpoints

Marcel Tijsterman, Leiden University Medical Center, Netherlands
Pol theta Mediated end Joining of DNA Breaks Induced by Replication Fork Barriers

Peter C. Stirling, University of British Columbia, Canada
Short Talk: Systematic Genetic and Cytological Analysis of Genome Integrity Pathways in Yeast

Gaelle Legube, CNRS - Toulouse University, France
Short Talk: Transcription Channels DNA Double Strand Breaks to a RAD51-Dependent Repair Pathway


Following Session is for DNA Replication and Recombination (X5)

08:00—11:15
Replication Elongation Machineries
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

David J. Sherratt, University of Oxford, UK
High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination

* Peter M. Burgers, Washington University School of Medicine, USA
Connecting DNA Damage to Checkpoint Initiation

John A. Tainer, The Scripps Research Institute, USA
Short Talk: MRE11 Complex Regulates Repair Pathway Choice as Shown by Chemical Knockdown of Specific Activities

Stephen D. Bell, Indiana University, USA
The Okazakisome

Linda B. Bloom, University of Florida, USA
Clamp Loading Mechanisms

Nicholas E. Dixon, University of Wollongong, Australia
Short Talk: An epsilon-beta Interaction in E. coli DNA Polymerase III Stabilizes the Replicase in the Polymerization Mode

09:20—09:40
Coffee Break

11:00—12:00
Lunch

12:00—14:30
Poster Session 4

14:30—16:30
Workshop 2: DNA DSB Repair and Associated Processes

* Ralph Scully, Beth Israel Deaconess Medical Center, USA

Katheryn D. Meek, Michigan State University, USA
Unraveling the Complexities of DNA-PK Autophosphorylation

Alessandro A. Sartori, Institute of Molecular Cancer Research, Switzerland
The Human PIN1 Isomerase Regulates DSB Repair

Jacques Côté, Laval University Cancer Research Center, Canada
Phospho-Dependent Recruitment of NuA4 by MRX at DNA Breaks Regulates RPA Dynamics during Resection

Lei Li, University of Alberta, Canada
DEAD Box 1 Interacts with Rif1 and Promotes Homologous DNA Repair

Martin A. M. Reijns, MRC Institute for Genetics and Molecular Medicine
Ribonuclease H2 Is Essential for the Removal of Misincorporated Ribonucleotides and for Mammalian Genome Integrity

David O. Ferguson, University of Michigan Medical School, USA
Mre11 Interacts with Cyclin-Dependent Kinase 2 to Regulate Double Strand Break Repair

Nidhi Nair, University of Dundee, UK
Slx1 and Mus81 Nucleases Cooperate in Holliday Junction Resolution

Priscilla K. Cooper, Environment Mutagen Society, USA
XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability


Following Session is for DNA Replication and Recombination (X5)

14:30—16:30
Workshop 4: Enzymes Acting on Nucleic Acids

* John L. Nitiss, University of Illinois, USA
A Mutation in Eukaryotic Topoisomerase II that Mimics the Action of Topoisomerase Poisons: Role of the C-Terminal Dimerization Domain in Regulation of DNA Cleavage

Ilya Finkelstein, University of Texas at Austin, USA
Single Molecule Imaging Reveals the Mechanisms of Roadblock Clearance by DNA-Binding Motor Enzymes

Aaron C. Mason, Vanderbilt University, USA
Structural Insight into the Mechanism of the DNA Damage Response Protein Smarcal1

Hannah E. Mischo, Clare Hall Laboratories, London Research Institute, UK
Connections between Transcription Termination and Genome Integrity: Dissecting the Function of the Superfamily I Helicase Sen1

Alessandro Vindigni, St. Louis University, USA
Mechanistic Insight into Replication Fork Reversal and Restart Under Genotoxic Stress

Alessandro Costa, London Research Institute, UK
Structure of the Bloom's Complex: Insights into the Mechanism of Double Holliday Junction Dissolution

Sarah Wessel, University of Wisconsin, USA
Molecular Interactions in PriC-Mediated DNA Replication Restart

16:30—17:00
Coffee Available

17:00—19:15
Diagnostic and Therapeutic Applications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen P. Jackson, University of Cambridge, UK

Thomas Helleday, Karolinska Institutet, Sweden
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition

Jos Jonkers, Netherlands Cancer Institute, Netherlands
DDR-Based Therapeutic Strategies and Resistance Mechanisms

Óscar Fernández-Capetillo, Spanish National Cancer Research Centre, Spain
Exploring the Role of Replicative Stress in Cancer and Aging

Yves G. Pommier, NCI, National Institutes of Health, USA
Short Talk: PARP1-TDP1 Partnership for DNA Repair and Processing of Top1-DNA Complexes

Michael Weinfeld, University of Alberta, Canada
Short Talk: Synthetic Lethality through Targeted Disruption of Polynucleotide Kinase/Phosphatase


Following Session is for DNA Replication and Recombination (X5)

17:00—19:00
Replicating Challenging Regions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Virginia A. Zakian, Princeton University, USA
Conservation of Functions in Pif1 Family Helicases

Joachim Lingner, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
The THO Complex Counteracts Telomeric R-Loops and Telomere Instability

Maria Teresa Teixeira, CNRS - Institut de Biologie Physico-Chimique, France
Short Talk: The DNA End Replication Problem and the Establishment of Replicative Senescence in Saccharomyces cerevisiae

Julia Promisel Cooper, London Research Institute, UK
Solving the End Replication and Protection Problems without Telomerase or Telomere Repeats

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 8

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. The Ellison Medical Foundation
MISSION Therapeutics Limited
 

We gratefully acknowledge support for this conference from:


Directors' Fund


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