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This meeting took place in 2014



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New Frontiers in the Discovery and Treatment of Thrombosis (A6)


Organizer(s) Jane E. Freedman, Bruce Furie and Dietmar Seiffert
January 26—30, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 9, 2013
Abstract Deadline: Oct 31, 2013
Scholarship Deadline: Oct 9, 2013
Discounted Registration Deadline: Nov 25, 2013

Sponsored by Bayer HealthCare Pharmaceuticals

Summary of Meeting:
During the last several decades, there has been unprecedented growth in the fundamental understanding of coagulation and platelet function. The logical evolution of these discoveries has been the development of a wide array of therapies targeting platelet receptors and pathways within coagulation to treat thrombotic diseases. Although clearly successful, the evolution of these agents is at a crossroads due to limitations and questions including hemorrhage and pleiotropic effects. The goal of this symposium is to explore new discoveries in thrombosis and consider their potential for translation relative to existing/developing therapies. This symposium will focus on: 1) Understanding how fundamental mechanisms regulating vascular disease risk factors and genetics modulate coagulation; 2) Investigating how these processes influence platelet-dependent thrombosis and vessel wall interactions; and 3) Determining how the evolution of treatments for thrombosis has led to a new appreciation of the complex interactions between coagulation and thrombosis, and how this may guide the use of new and existing therapies. This meeting will bridge clinical and basic investigators to discuss a rapidly evolving field. The goal is to gain a greater appreciation of the novel discoveries in the areas of vascular occlusion, the treatment of thrombosis and the minimization of risk.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 26

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 27

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jane E. Freedman, University of Massachusetts Medical School, USA

Andrew S. Weyrich, University of Utah School of Medicine, USA
Platelets: More Than We Ever Expected

09:00—11:15
Genomics and Transcriptomics in Thrombosis and Coagulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Bruce Furie, Beth Israel Deaconess Medical Center, USA

Jane E. Freedman, University of Massachusetts Medical School, USA
Platelet Transcripts, Genetics and Function

Marc Sabatine, Brigham and Women's Hospital, USA
Pharmacogenetics of Antithrombotic Therapy

Willem H. Ouwehand, University of Cambridge, UK
Genetic Regulation of Megakaryopoiesis and Platelet Formation

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop: Thrombosis, Inflammation and Infection

* Leslie V. Parise, University of North Carolina School of Medicine, USA

Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Inducing Anti-Thrombotic Host Protection in Pneumococcal Sepsis by Pre-Activation of the Ashwell-Morell Receptor

Sang Hee Min, University of Pennsylvania, USA
Loss of PIKfyve in Platelets Causes a Lysosomal Disease Leading to Inflammation and Thrombosis in Mice

Craig Morrell, University of Rochester School of Medicine, USA
Platelet Factor 4 Limits T-Helper 17 Differentiation and Responses to Cardiac Transplantation

Travis R. Sexton, University of Kentucky, USA
The Effect of Rosuvastatin on Platelet-Leukocyte Interactions in the Setting of Acute Myocardial Infarction

Norah Green Verbout, Oregon Health & Science University, USA
Pharmacological Protein C Activation Improves the Neurological Outcome of Experimental Autoimmune Encephalomyelitis in Mice

Fusun Kilic, University of Arkansas Medical School, USA
A Serotonin-Induced N-Glycan Switch Regulates Platelet Aggregation

16:30—17:00
Coffee Available

17:00—19:00
Breakthroughs in Coagulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gianluca Interlandi, University of Washington, USA

Nigel Mackman, University of North Carolina at Chapel Hill, USA
Novel Mechanisms Regulating Coagulation and Thrombosis

Wolfgang Bergmeier, University of North Carolina at Chapel Hill, USA
Short Talk: The Rap-GAP Rasa3 Is a Critical Negative Regulator of Platelet Activation

Bruce Furie, Beth Israel Deaconess Medical Center, USA
Protein Disulfide Isomerases: Novel Targets for Novel Antithrombotics

Jeffrey Weitz, McMaster University, Canada
Evolving Use and Limitations of New Oral Anticoagulants

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 28

07:00—08:00
Breakfast

08:00—11:00
Thrombotic Interactions with the Vessel Wall
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dong-Eog Kim, Dongguk University Ilsan Hospital, South Korea

Mortimer Poncz, Children's Hospital of Philadelphia, USA
Platelet-Targeted Thromboprophylactic: Lessons from Quebec Platelet Disorder

Shirin Feghhi, University of Washington, USA
Short Talk: GPIb-IX-V Complex Transmits Platelet Contractile Forces

Kohji Kasahara, Tokyo Metropolitan Institute of Medical Science, Japan
Short Talk: Clot Retraction Is Mediated by Factor XIII-Dependent Fibrin-alphaIIbbeta3-Myosin Axis in Platelet Sphingomyelin-Rich Membrane Rafts

Steven R. Lentz, University of Iowa, USA
Antithrombotic Gene Regulation in the Vessel Wall

Lawrence F. Brass, University of Pennsylvania, USA
Spatial and Structural Determinants of Thrombus Growth and Stability

09:20—09:40
Coffee Break

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
New, Evolving Use of Antithrombotic and Antiplatelet Therapies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dietmar Seiffert, Merck, USA

Joseph Italiano, Brigham and Women's Hospital, USA
Platelet Production On-a-Chip

Alan D. Michelson, Harvard Medical School, USA
Clopidogrel Pharmacokinetics and Pharmacodynamics

Erik Tucker, Aronora, Inc, USA
Short Talk: The Protein C Activator Enzyme EWE-Thrombin Rapidly Interrupts Occlusive Thrombus Formation in Primates

Francesco Violi, Università di Roma, Italy
Oxidative Stress, Platelets and Thrombosis

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 29

07:00—08:00
Breakfast

08:00—11:15
Antithrombotics: Balancing Hemorrhage, Off-Target Effects and Utility
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Debra D. Pittman, Pfizer, USA

Tilo Grosser, University of Pennsylvania, USA
Prostanoids and Thrombosis

Joachim Fruebis, Pfizer, USA
Novel Therapeutic Approaches in Hemophilia and Hematology

Scott L. Diamond, University of Pennsylvania, USA
Short Talk: Microfluidic Phenotyping of in vivo Aspirin Response of Normal Donors or Clotting Response of Blood from Hemophiliacs

Timothy J. Stalker, University of Pennsylvania, USA
Short Talk: Alpha2b-beta3 Outside-In Signaling Regulates Thrombus Formation in vivo via Effects on Intrathrombus Architecture and Solute Transport

Kenneth W. Mahaffey, Stanford University, USA
Antithrombotic Development Challenges for Acute Coronary Syndromes

Richard C. Becker, University of Cincinnati, USA
Antithrombotics: Balancing Hemorrhage, Off-Target Effects and Utility Beyond Aggregation-New Areas to Understand Efficacy and Bleeding

09:20—09:40
Coffee Break

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Thrombosis and Inflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lea M. Beaulieu, University of Massachusetts Medical School, USA

Susan S. Smyth, University of Kentucky Chandler Medical Center, USA
Thrombosis and Inflammation

Christian Gachet, University of Strasbourg, EFS-Alsace, France
Purinergic Signalling, Thrombosis and inflammation

Laura D. Healy, Oregon Health & Science University, USA
Short Talk: Contact Activation Supports the Prothrombotic Effect of Neutrophil Extracellular Traps (NETs)

Leslie V. Parise, University of North Carolina School of Medicine, USA
Systems Approach to Platelet Biology

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jane E. Freedman, University of Massachusetts Medical School, USA

19:15—20:15
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


THURSDAY, JANUARY 30

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL120495-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

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Phone:+1 970-262-2676