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This meeting took place in 2014



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

RNA Silencing (A9)


Organizer(s) V. Narry Kim, David P. Bartel and Julius Brennecke
January 31—February 5, 2014
Sheraton Seattle Hotel • Seattle, Washington USA
Discounted Abstract Deadline: Oct 10, 2013
Abstract Deadline: Nov 5, 2013
Scholarship Deadline: Oct 10, 2013
Discounted Registration Deadline: Dec 2, 2013

Supported by the Directors' Fund

Summary of Meeting:
Small regulatory RNAs have been implicated in virtually every developmental process and have key impacts on pathological pathways. Over the last 15 years, the field has rapidly discovered novel types of small RNAs and their associated silencing machineries in diverse species. Major gaps remain, however, in our understanding of the function and the molecular mechanisms of the diverse array of RNA silencing pathways. This meeting has been playing a central role in the field of small RNA silencing by mixing and synergizing expertise from diverse academic backgrounds. Since the beginning, it serves as an annual forum for researchers working on many different biological systems ranging from bacteria to plants and humans. The 2014 meeting will adhere to this tradition and puts an additional emphasis on translational research and therapeutics development, as well as emerging resources and technologies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 31

16:00—20:00
Arrival and Registration


SATURDAY, FEBRUARY 1

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* V. Narry Kim, Seoul National University, South Korea

Phillip D. Zamore, University of Massachusetts Medical School, USA
Germline and Somatic Small Silencing RNAs

09:30—11:45
Small RNAs in Microorganisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
RNA-Programmed Genome Defense by Bacterial CRISPRs

Linfeng Huang, Boston Children's Hospital, USA
Short Talk: siRNA-Like RNAs in Bacteria

Yi Liu, University of Texas Southwestern Medical Center, USA
Mechanisms of Small and Long Noncoding RNA Pathways in Fungi

Elisabetta Ullu, Yale University, USA
Small RNA Machinery in Trypanosoma

10:10—10:30
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Regulation of miRNA

* Antonio J. Giraldez, Yale University School of Medicine, USA

Haoquan Wu, Texas Tech University Health Sciences Center, USA
The Lower and Upper Stem–ssRNA Junctions Together Determine the Drosha Cleavage Site

Kristina M. Herbert, Yale University, USA
Phosphorylation of DGCR8 Increases its Intracellular Stability and Induces a Pro-Growth miRNA Profile

Eran Hornstein, Weizmann Institute of Science, Israel
Dicer Activity and microRNA Maturation Are Regulated by Stress Signaling in Neurodegeneration

Dimitris Lagos, University of York, UK
The Cytoplasmic microRNA Biogenesis Assembly as a Determinant of Primary Cell Activation and Survival

Xuhang Liu, University of Pennsylvania, USA
A Precursor MicroRNA Surveillance System in Quality Control of MicroRNA Synthesis

Corinna Speth, University of Tübingen, Germany
RACK1 Scaffold Proteins Influence miRNA Abundance in Arabidopsis

Martin J. Simard, Laval University Cancer Research Centre, Canada
Identification of a New Modulator of microRNA Function

Manuel de la Mata, Friedrich Miescher Institute for Biomedical Research, Switzerland
Target-Mediated microRNA Decay in Neurons

16:30—17:00
Coffee Available

17:00—19:00
Structure and Mechanism I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria

Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA
Structural Insights into Silencing Machineries

Leemor Joshua-Tor, HHMI/Cold Spring Harbor Laboratory, USA
Slicer and the Argonautes

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Structural Insight into the Interaction of GW182 Proteins with Deadenylase Complexes

Jinbiao Ma, Fudan University, China
Short Talk: Structural and Functional Insights into NRPD4/7 Subcomplex of Plant Specific RNA Polymerase IV

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


SUNDAY, FEBRUARY 2

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

08:30—19:00
Poster Viewing

08:30—11:45
Structure and Mechanism II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Ian MacRae, The Scripps Research Institute, USA
Structure of Dicer and Argonaute

Antonio J. Giraldez, Yale University School of Medicine, USA
Silencing Mechanism in Zebrafish

Takashi Fukaya, , Japan
Short Talk: microRNAs Block eIF4F Assembly during Translation Initiation in Drosophila

V. Narry Kim, Seoul National University, South Korea
MicroRNA Regulation via 3' End Modifications

Xuemei Chen, University of California, Riverside, USA
Mechanisms of MicroRNA Turnover in Plants

Ivan Martinez, West Virginia University, USA
Short Talk: TMG-Capped Primary MicroRNAs are XPO1 Dependent and XPO5 Independent during Cellular Quiescence

09:50—10:10
Coffee Break

11:45—12:30
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop 2: Biology of Small RNAs

* Julie M. Claycomb, University of Toronto, Canada

Amelia F. Alessi, University of Michigan, USA
CEY-1 Attenuates let-7 MicroRNA-Mediated gene Silencing in C. elegans

Hervé Seitz, CNRS, France
MicroRNA Titration by Pseudo-Targets: An Alternative Explanation to Seed Match Conservation

Hyun Yong Jin, The Scripps Research Institute, USA
MiR-17~92 and Lymphomagenesis: Functions and Mechanistic Insights into MiRNA-Mediated Gene Regulation

Alex S. So, California Institute of Technology, USA
Dual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B Cell Leukemias

Rui Zhou, Sanford-Burnham Medical Research Institute, USA
Core snRNP Splicing Factor SmD1 Modulates RNAi in Drosophila

Anastasios Vourekas, University of Pennsylvania, USA
Direct Roles of MOV10L1 in Primary piRNA Precursor Processing Revealed by Transcriptome-Wide Target RNA Identification

Colin Dean Malone, New York University Medical Center, USA
The Exon Junction Complex Controls Transposon Mobilization in Drosophila Gonads by Ensuring Faithful Splicing of Piwi Transcripts

16:30—17:00
Coffee Available

17:00—19:00
Small RNAs in Disease and Therapeutics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David P. Bartel, HHMI/MIT/Whitehead Institute, USA

Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Mammalian MicroRNA Functions in Normal Physiology and Cancer

Sonya D. Zabludoff, Regulus Therapeutics, USA
Targeting the Pathways of Human Disease with MicroRNA Therapeutics

Christopher L. Daige, Mirna Therapeutics, USA
Short Talk: Development of a miR34-Based Cancer Therapy

Rachel E. Meyers, Alnylam Pharmaceuticals Inc., USA
Developing RNAi Therapeutics for the Treatment of Rare Diseases

19:00—
On Own for Dinner


MONDAY, FEBRUARY 3

07:30—08:30
Breakfast

08:30—11:45
Function of MicroRNA
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gregory J. Hannon, Cold Spring Harbor Laboratory, USA

David P. Bartel, HHMI/MIT/Whitehead Institute, USA
MicroRNAs and their Regulatory Effects

Eric C. Lai, Sloan-Kettering Institute, USA
Genetic Analysis of Neural miRNA Functions

Katherine McJunkin, University of Massachusetts Medical School, USA
Short Talk: An Essential MicroRNA Family Prevents Precocious Expression of the Sex Determination Program in C. elegans

Markus Stoffel, ETH Zürich, Switzerland
MicroRNA Function in Metabolism

Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Destabilization and Stabilization of Cell Fates

Jia L. Song, University of Delaware, USA
Short Talk: Functional Analysis of MicroRNAs in Cell Specification and Morphogenesis

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Small Interfering RNAs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Xuemei Chen, University of California, Riverside, USA

Andrew Fire, Stanford University, USA
Triggers and Limits to Amplification in RNAi

Kazufumi Mochizuki, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Transgenerational Epigenetic Inheritance of DNA Elimination in Tetrahymena

David C. Baulcombe, University of Cambridge, UK
RNA Silencing and Epigenetics in Plants

Blake C. Meyers, University of Delaware, USA
Short Talk: Plant PhasiRNAs in Male Reproductive Tissues, as Analogs of Mammalian piRNAs

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


TUESDAY, FEBRUARY 4

07:30—08:30
Breakfast

08:30—11:45
Piwi-Interacting RNAs and Genome Control
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Phillip D. Zamore, University of Massachusetts Medical School, USA

Gregory J. Hannon, Cold Spring Harbor Laboratory, USA
Small RNAs in Mammalian Germline

Haruhiko Siomi, Keio University School of Medicine, Japan
Small RNAs in the Adult Testes of the Common Marmoset, a Model Primate

Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
The Involvement of Chromatin in the Drosophila piRNA Pathway

Zhao Zhang, University of Massachusetts Medical School, USA
Short Talk: Organization of a Transposon Silencing Machine

Alexei A. Aravin, California Institute of Technology, USA
Short Talk: The Role of Chromatin and Trans-Generational Inheritance in piRNA Biogenesis

Julie M. Claycomb, University of Toronto, Canada
Short Talk: The C. elegans Argonaute CSR-1 Licenses Germline Gene Expression

Colin C. Conine, University of Massachusetts Medical School, USA
Short Talk: Argonautes Promote Transcription in the Male Germline and Provide a Paternal Memory of Germline Gene Expression in C. elegans

09:50—10:10
Coffee Break

11:45—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Technology, Disease and Therapeutics

* Eric C. Lai, Sloan-Kettering Institute, USA

Jerome E. Lee, University of Colorado, USA
High-Efficiency RNA Cloning Enables Accurate Quantification of miRNA Expression by Deep Sequencing

Sung Wook Chi, SAIHST, Sungkyunkwan University, South Korea
Modification of Seed Regions Harness Target Specificity of RNA Interference

Christof Fellmann, Mirimus Inc., USA
An Optimized microRNA Backbone for Effective Single-Copy RNAi

Christopher J. Cheng, Yale University, USA
AntimiRs Targeted to the Tumor Microenvironment to Exploit OncomiR Addiction in Lymphoma

Soon-Tae Lee, Seoul National University Hospital, South Korea
Development of Antagomir-Based Drug for Alzheimer's Disease

Dongli Pan, Harvard Medical School, USA
A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Establishment of Latency

Eva H. Gottwein, Northwestern University, USA
Role of a Partial Viral Mimic of Cellular miR-142-3p in Transformation by the Kaposin Locus

16:30—17:00
Coffee Available

17:00—19:00
Resources and Emerging Technologies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Feng Zhang, Broad Institute of MIT and Harvard University, USA
Genome Engineering: Technologies and Applications

Peyton Greenside, Stanford University, USA
Short Talk: Consequences and Solutions for Widespread RNAi Off-Target Effects Detected at Genome Scale

Michael T. McManus, University of California, San Francisco Diabetes Center, USA
A Resource for the Conditional Ablation of miRNAs

Sam Griffiths-Jones, University of Manchester, UK
miRBase, High Quality MicroRNAs and Community Annotation

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


WEDNESDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Dow AgroSciences Exiqon A/S
Landes Bioscience
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Alnylam Pharmaceuticals, Inc.


Regulus Therapeutics Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676