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This meeting took place in 2014
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Epigenetic Programming and Inheritance (D2)
Organizer(s) Joseph H. Nadeau, Marisa S. Bartolomei, Peter Gluckman and Wolf Reik
April 6—10, 2014
Boston Park Plaza • Boston, Massachusetts USA
Discounted Abstract Deadline: Dec 5, 2013
Abstract Deadline: Jan 14, 2014
Scholarship Deadline: Dec 5, 2013
Discounted Registration Deadline: Feb 4, 2014
Supported by the Directors' Fund
Summary of Meeting:
Epigenetics is emerging as a fundamentally important area of biological and medical research with implications for our understanding of developmental and physiological processes, for childhood and adult disease, as well as for an unexpected and important new mode of inheritance. Epigenetics deals with phenotypic changes that are independent of the underlying DNA sequence. These mechanisms modulate gene expression, RNA biology and protein function throughout development and adulthood and are strongly influenced by both genetic and environmental factors. Anomalies can lead to birth defects, metabolic disease, cancer and behavioral changes. Recent evidence shows that epigenetic features can be transmitted across generations, suggesting that molecular changes in addition to DNA sequence differences control phenotypic variation and disease risk and therefore that epigenetics might be as important as genetics in organismal biology. This meeting will bring together both established researchers and rising stars; for the first time individuals focusing on molecular mechanisms can interact with those studying population consequences, with the hope that these two communities will begin to work together to understand epigenetics in the context of health and disease.
View Scholarships/Awards
Epigenetics is emerging as a fundamentally important area of biological and medical research with implications for our understanding of developmental and physiological processes, for childhood and adult disease, as well as for an unexpected and important new mode of inheritance. Epigenetics deals with phenotypic changes that are independent of the underlying DNA sequence. These mechanisms modulate gene expression, RNA biology and protein function throughout development and adulthood and are strongly influenced by both genetic and environmental factors. Anomalies can lead to birth defects, metabolic disease, cancer and behavioral changes. Recent evidence shows that epigenetic features can be transmitted across generations, suggesting that molecular changes in addition to DNA sequence differences control phenotypic variation and disease risk and therefore that epigenetics might be as important as genetics in organismal biology. This meeting will bring together both established researchers and rising stars; for the first time individuals focusing on molecular mechanisms can interact with those studying population consequences, with the hope that these two communities will begin to work together to understand epigenetics in the context of health and disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 6
MONDAY, APRIL 7
TUESDAY, APRIL 8
WEDNESDAY, APRIL 9
THURSDAY, APRIL 10
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 6
08:30—11:45
Epigenetic and Epigenomic Mechanisms I.
Session sponsored by the journal, Development.
Meeting has ended...abstracts no longer viewable online.
Support for these organizer-selected speakers generously provided by this journal.
Joseph H. Nadeau,
Pacific Northwest Research Institute, USA
Introduction and Welcome Remarks
Introduction and Welcome Remarks
*
Bradley R. Cairns,
HHMI/University of Utah, USA
Wolf Reik,
Babraham Institute, UK
The Role of DNA Modifications in Epigenetic Reprogramming and Signaling
The Role of DNA Modifications in Epigenetic Reprogramming and Signaling
Alexander Meissner,
Max Planck Institute for Molecular Genetics, Germany
DNA Methylation Dynamics in Stem Cells and Development
DNA Methylation Dynamics in Stem Cells and Development
Antoine H.F.M. Peters,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Epigenetic Control of Mammalian Germ Line and Early Embryonic Development
Epigenetic Control of Mammalian Germ Line and Early Embryonic Development
Bluma J. Lesch,
Whitehead Institute for Biomedical Research, USA
Short Talk: Genes Central to Embryogenesis Retain a Poised Chromatin State during Mammalian Germ Cell Development
Short Talk: Genes Central to Embryogenesis Retain a Poised Chromatin State during Mammalian Germ Cell Development
Jerome Jullien,
CRUK Wellcome Trust Gurdon Institute, UK
Short Talk: Sperm Is Programmed to Support Transcription of Developmentally-Important Embryonic Genes
Short Talk: Sperm Is Programmed to Support Transcription of Developmentally-Important Embryonic Genes
17:00—19:00
Epigenetic and Epigenomic Mechanisms II
Meeting has ended...abstracts no longer viewable online.
*
Wolf Reik,
Babraham Institute, UK
Bradley R. Cairns,
HHMI/University of Utah, USA
Chromatin Strategies for Maintaining Pluripotency in Adult Germline Stem Cells and Mammalian Spermatogenesis
Chromatin Strategies for Maintaining Pluripotency in Adult Germline Stem Cells and Mammalian Spermatogenesis
Mitinori Saitou,
Graduate School of Medicine, Kyoto University, Japan
Mechanism and Reconstitution in vitro of Germ Cell Development in Mice
Mechanism and Reconstitution in vitro of Germ Cell Development in Mice
Eric L. Greer,
Harvard Medical School, Boston Children's Hospital, USA
Short Talk: A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans
Short Talk: A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans
08:30—11:45
Transgenerational Inheritance and Imprinting I
Meeting has ended...abstracts no longer viewable online.
*
Joseph H. Nadeau,
Pacific Northwest Research Institute, USA
Marisa S. Bartolomei,
University of Pennsylvania Perelman School of Medicine, USA
Endocrine Disrupting Chemicals Exposure in Mouse: Genomic Imprinting, Physiology and Transgenerational Inheritance
Endocrine Disrupting Chemicals Exposure in Mouse: Genomic Imprinting, Physiology and Transgenerational Inheritance
Anne C. Ferguson-Smith,
University of Cambridge, UK
Genomic Imprinting
Genomic Imprinting
John A. Stamatoyannopoulos,
Altius Institute for Biomedical Sciences, USA
Epigenetics and GWAS
Epigenetics and GWAS
Nicole L. Yohn,
University of Pennsylvania, Perelman School of Medicine, USA
Short Talk: The Multigenerational Interaction of Nicotine and Chronic Stress on Anxiety and Stress Sensitivity in Mice
Short Talk: The Multigenerational Interaction of Nicotine and Chronic Stress on Anxiety and Stress Sensitivity in Mice
Brian G. Dias,
Emory University, USA
Short Talk: Transgenerational Inheritance of Ancestral Olfactory Experience
Short Talk: Transgenerational Inheritance of Ancestral Olfactory Experience
11:45—12:45
Career Development Workshop - “How to Choose Your Next Lab or Workplace”
"Choose Your Next Lab or Workplace” Grad students and postdocs frequently don’t choose a lab as if it were a major career decision, yet they spend 4-7 years working for one person in a small group. Choosing a lab is definitely worth a little preparation to make sure it will be a good fit and get junior investigators close to where they want to go in the future. This presentation gives practical tips about what to look for and how to find it when choosing a new lab. While geared to junior scientists, this talk will also help advisors understand their lab culture. Presented by Joanne Kamens, Ph.D., Executive Director, Addgene.
17:00—19:00
Transgenerational Inheritance and Imprinting II
Meeting has ended...abstracts no longer viewable online.
*
Marisa S. Bartolomei,
University of Pennsylvania Perelman School of Medicine, USA
Oliver J. Rando,
University of Massachusetts Medical School, USA
Paternal Effects on Gene Regulation in Mammals
Paternal Effects on Gene Regulation in Mammals
Ueli Grossniklaus,
University of Zürich, Switzerland
Epigenetic Maternal Regulation of Seed Development
Epigenetic Maternal Regulation of Seed Development
Joseph H. Nadeau,
Pacific Northwest Research Institute, USA
The Genetics of Epigenetic Inheritance
The Genetics of Epigenetic Inheritance
Louise E. Docherty,
University of Southampton, UK
Short Talk: Using Genome-Wide DNA Methylation Analysis of Patients with Complex Imprinting Disorders to Identify Novel Candidate Imprinted Genes
Short Talk: Using Genome-Wide DNA Methylation Analysis of Patients with Complex Imprinting Disorders to Identify Novel Candidate Imprinted Genes
08:30—11:30
Developmental Origins and Epigenetic Epidemiology I
Meeting has ended...abstracts no longer viewable online.
*
Terrence Forrester,
University of the West Indies, Jamaica
Peter Gluckman,
University of Auckland, New Zealand
Epigenetic Epidemiology: Its Application to the Challenge of the Developmental Origins of Health and Disease Hypothesis
Epigenetic Epidemiology: Its Application to the Challenge of the Developmental Origins of Health and Disease Hypothesis
Caroline L. Relton,
Newcastle University, UK
Epigenetic Biomarkers and Causality in Complex Disease
Epigenetic Biomarkers and Causality in Complex Disease
Jonathan Mill,
University of Exeter Medical School and King's College London, UK
Epigenetic Trajectories to Neuropsychiatric Disease
Epigenetic Trajectories to Neuropsychiatric Disease
Bas T. Heijmans,
Leiden University Medical Centre, Netherlands
The Prenatal Epigenome and Studies into Long-Term Health
The Prenatal Epigenome and Studies into Long-Term Health
Soetkin Versteyhe,
Copenhagen University, Denmark
Short Talk: Obese Human have an Altered Spermatozoal Small RNA Expression Profile - Possible Contributors of Epigenetic Inheritance
Short Talk: Obese Human have an Altered Spermatozoal Small RNA Expression Profile - Possible Contributors of Epigenetic Inheritance
11:30—12:00
Workshop on Biological Applications of Epigenetics
Epigenetics methods and thinking are increasingly applied in many areas of exciting contemporary biology, such as developmental programming, neurosciences, and metabolic disorders. This discussion session explores links between the disciplines and how choice of methods and quality standards is important so that results can be widely compared, increasing confidence in the conclusions.
*
Marisa S. Bartolomei,
University of Pennsylvania Perelman School of Medicine, USA
*
Wolf Reik,
Babraham Institute, UK
17:00—19:00
Developmental Origins and Epigenetic Epidemiology II
Meeting has ended...abstracts no longer viewable online.
*
Peter Gluckman,
University of Auckland, New Zealand
Terrence Forrester,
University of the West Indies, Jamaica
Long-Term Consequences of Early-Life Malnutrition: Developmental Context
Long-Term Consequences of Early-Life Malnutrition: Developmental Context
Cheryl L. Walker,
Baylor College of Medicine, USA
Developmental (re)Programming by Endocrine Disruptors: Environmental Cross-Talk with the Epigenetic Machinery
Developmental (re)Programming by Endocrine Disruptors: Environmental Cross-Talk with the Epigenetic Machinery
Krishnendu Mukherjee,
Fraunhofer Institute for Molecular Biology and Applied Ecology, Germany
Short Talk: Epigenetic Changes during Pathogen Infections, Trans-Generational Immune Priming and Metamorphosis in the Insect Model Galleria Mellonella
Short Talk: Epigenetic Changes during Pathogen Infections, Trans-Generational Immune Priming and Metamorphosis in the Insect Model Galleria Mellonella
Marine Baptissart,
INSERM, France
Short Talk: Paternal Bile Acids Exposure: a Dark Messenger throughout Generations
Short Talk: Paternal Bile Acids Exposure: a Dark Messenger throughout Generations
Mara C. Inniss,
Obsidian Therapeutics, USA
Short Talk: Synthetic Cellular Memory for Tracking Human Cell Fate
Short Talk: Synthetic Cellular Memory for Tracking Human Cell Fate
*Session Chair †Invited, not yet responded.
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