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Hyatt Regency Austin Floorplan

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This meeting took place in 2014


Here are the related meetings in 2015:
Autophagy (E6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Autophagy: Fundamentals to Disease (E2)


Organizer(s) Christina H. Eng, Daniel J. Klionsky, Guido Kroemer and Li Yu
May 23—28, 2014
Hyatt Regency Austin • Austin, Texas USA
Discounted Abstract Deadline: Jan 23, 2014
Abstract Deadline: Feb 27, 2014
Scholarship Deadline: Jan 23, 2014
Discounted Registration Deadline: Mar 24, 2014

Sponsored by AbbVie Inc., Cell Research and Shire Human Genetic Therapies

Summary of Meeting:
Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn’s disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MAY 23

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


SATURDAY, MAY 24

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

08:30—19:30
Poster Viewing

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christina H. Eng, Pfizer, USA

Noboru Mizushima, University of Tokyo, Graduate School of Medicine, Japan
Novel Insights into Autophagy Function

09:30—11:45
Autophagosome Biogenesis and Trafficking
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Li Yu, Tsinghua University, China

Zvulun Elazar, Weizmann Institute of Science, Israel
Atg8 in Health and Disease

Fulvio Reggiori, University Medical Centre Utrecht, Netherlands
Roles of phosphatidylinositol-3-phosphate in autophagy

Sharon A. Tooze, London Research Institute, UK
The Role of PI3P and WIPI2 in Autophagy

Liang Ge, University of California, Berkeley, USA
Short Talk: A Functional Approach Identifies the ER-Golgi Intermediate Compartment as a Key Membrane Source for Autophagosome Biogenesis

10:10—10:30
Coffee Break

11:45—12:45
Lunch

12:45—15:00
Poster Session 1

15:00—17:00
Workshop 1: Autophagy at the Single Cell and Molecular Level

* David C. Rubinsztein, Cambridge Institute for Medical Research, UK

* Sharon A. Tooze, London Research Institute, UK

Ben Loos, Stellenbosch University, South Africa
Defining and Measuring Autophagic Flux at Single Cell Level

Jiajie Diao, Stanford University, USA
Single-Vesicle Analysis of SNARE-Mediated Membrane Fusion Involved in Autophagy

Sangita Sinha, North Dakota State University, USA
Intrinsically Disordered Regions in Autophagy Proteins

Takanori Otomo, The Scripps Research Institute, USA
Structural Basis of ATG3 Recognition by the Autophagic Ubiquitin-Like Protein ATG12

Daric J. Wible, University of Texas MD Anderson Science Park, USA
ATG16L1 Interaction with ATG5 Forms a Molecular Switch that Controls the Competing Conjugation Reactions of Ubiquitin and the Ubiquitin-Like (Ubl) Protein, ATG12

Calvin Yip, University of British Columbia, Canada
Molecular Architecture of the Saccharomyces cerevisiae Autophagy Regulatory Complex Atg17-Atg31-Atg29

17:00—17:30
Coffee Available

17:30—19:30
Mitochondrial Autophagy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy

Mondira Kundu, St. Jude Children's Hospital, USA
Mitochondrial (Dys)Function and Autophagy - A “Chicken or Egg?” Conundrum

Charleen T. Chu, University of Pittsburgh, USA
Mitophagy and Parkinson’s Disease: Hanging in the Balance

Iain Scott, NHLBI, National Institutes of Health, USA
Short Talk: GCN5L1 – Holding the Balance between Mitochondrial Biogenesis and Degradation

19:30—
On Own for Dinner


SUNDAY, MAY 25

07:30—08:30
Breakfast

08:30—11:45
Mechanisms of Autophagy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Fulvio Reggiori, University Medical Centre Utrecht, Netherlands

Meiyan Jin, University of Michigan, USA
Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation

Adi Kimchi, Weizmann Institute of Science, Israel
Discovering Novel Protein-Protein Interactions in Autophagy and in its Cross-Talk with Apoptosis

Li Yu, Tsinghua University, China
Regulation of Autophagy by Protein Acetylation

Beat Nyfeler, Novartis Institutes for BioMedical Research, Switzerland
Genetic and Pharmacological Tools to Modulate Autophagy

Virginie M. Betin, University of Bristol, UK
Short Talk: Investigating the Role of Sorting Nexin-4 (SNX4) in Autophagosome Biogenesis

Guang-Chao Chen, Academia Sinica, Taiwan
Short Talk; The Transmembrane Protein Atg9 Coordinates with dTRAF2/TRAF6 in the Regulation of JNK Signaling and Autophagy Under Oxidative Stress Conditions

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Role of Autophagy in Neurodegeneration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Charleen T. Chu, University of Pittsburgh, USA

Albert R. La Spada, University of California, San Diego, USA
Defining a Transcriptional Regulatory Network for Autophagy Activation

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Lysosome Dysfunction and Neurodegeneration

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
ATG16L1 Meets mATG9 in Recycling Endosomes - Additional Roles for the Plasma Membrane and Endocytosis in Autophagosome Biogenesis

Veronika Redmann, Washington University, USA
Short Talk: Clec16A Plays a Critical Role in Autophagy and the Survival of Purkinje Cells

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


MONDAY, MAY 26

07:30—08:30
Breakfast

08:30—11:45
Impact of Autophagy in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Beth Levine, University of Texas Southwestern Medical Center, USA

Guido Kroemer, Institut Gustave Roussy, France
Autophagy and Anticancer Immune Responses

Ravi K. Amaravadi, University of Pennsylvania, USA
Targeting Autophagy for Cancer Therapy

Jayanta Debnath, University of California, San Francisco, USA
Autophagy, Secretion and Cancer

Eileen P. White, Rutgers University, USA
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

Xian-De Liu, University of Texas MD Anderson Cancer Center, USA
Short Talk: Autophagy Mediates HIF2alpha Degradation and Suppresses Renal Tumorigenesis

David L. Boone, Indiana University School of Medicine, USA
Short Talk: The Thr300Ala Variant in ATG16L1 Is Associated with Improved Survival in Human Colorectal Cancer and Enhanced Production of Type I Interferon

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Pharmacological Manipulation of Autophagy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ravi K. Amaravadi, University of Pennsylvania, USA

Christina H. Eng, Pfizer, USA
Are Atgs Good Oncology Drug Targets?

Natalie D'Amore, Takeda Boston, USA
Targeting Autophagy for Cancer Therapy

Junying Yuan, Harvard Medical School, USA
Chaperone-Mediated Autophagy Degrades Mutant p5

Xiaojun Tan, University of Wisconsin-Madison, USA
Short Talk: A Kinase Independent Role for EGF Receptor in Autophagy Initiation

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


TUESDAY, MAY 27

07:30—08:30
Breakfast

08:30—11:45
Autophagy and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Junying Yuan, Harvard Medical School, USA

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy and Immunity

Andrea Ballabio, Telethon Institute of Genetics and Medicine, Italy
The Transcriptional Control of Autophagy in Health and Disease

Ken H. Cadwell, New York University School of Medicine, USA
Anti-Inflammatory Functions of Autophagy in Crohn’s Disease and Beyond

Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Autophagy and Cardiomyopathy

Qingjun Wang, University of Kentucky, USA
Short Talk: Novel Role of Juvenile Neuronal Ceroid Lipofuscinosis (Batten) Disease Gene CLN3 in Autophagy

Neng-Yu Lin, Friedrich Alexander University, Germany
Short Talk: Inhibition of Autophagy Ameliorates Inflammatory and Non-Inflammatory Bone Loss

09:50—10:10
Coffee Break

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Novel Functions of Autophagy

* Christina H. Eng, Pfizer, USA

* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Hong Dou, University of Texas MD Anderson Cancer Center, USA
SUMO-Driven Autophagy Regulates DNA Replication

Seungmin Hwang, University of Chicago, USA
Vesicle-Like Endomembrane Structures of Pathogens Are Targeted for Disruption by the Ubiquitin-Like Conjugation Systems of Macroautophagy Pathway

Wen-Xing Ding, University of Kansas Medical Center, USA
Excess Endoplasmic Reticulum Is Degraded by SQSTM1/p62-Mediated Selective Autophagy in Mammals

Taras Y. Nazarko, University of California, San Diego, USA
Atg37/ACBD5 Is a New Important Component of the Pexophagic Receptor Protein Complex

Jon Sin, Heart Institute, Cedars-Sinai Medical Center, USA
Coxsackievirus B3 Escapes the Host Cell via Ejected Autophagosomes

Chengyu Liang, University of Southern California, USA
A Coordinator of Golgi-ER Transport and Atg9-Mediated Autophagy Trafficking

Michelangelo Campanella, RVC and UCL Consortium for Mitochondrial Research, UK
The 18kDa Translocator Protein Triggers a ROS-Mediated Inhibition of Mitochondrial Autophagy

Zaiming Tang, University of Texas Southwestern Medical Center, USA
Autophagy Promotes Primary Ciliogenesis

16:30—17:00
Coffee Available

17:00—19:00
Interplay between Autophagy, Metabolism and Aging
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Guido Kroemer, Institut Gustave Roussy, France

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy and Metabolism in Aging

Frank Madeo, University of Graz, Austria
Spermidine Induced Autophagy for the Avoidance of Age-Associated Diseases

Myung-Shik Lee, Samsung Medical Center, South Korea
Role of Autophagy in Obesity and Diabetes

Louis R. Lapierre, Sanford-Burnham Medical Research Institute, USA
Short Talk: HLH-30/TFEB Is a Conserved Regulator of Autophagy and Modulates Longevity in C. elegans

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


WEDNESDAY, MAY 28

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. Cell Research
Shire Human Genetic Therapies
 

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Promega Corporation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA183034-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Pharma AG


Pfizer Oncology


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676