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This meeting took place in 2014



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Emerging Cytokine Networks (J3)


Organizer(s) Daniel J. Cua, Hergen Spits and Federica Sallusto
January 17—22, 2014
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Oct 8, 2013
Abstract Deadline: Oct 30, 2013
Scholarship Deadline: Oct 8, 2013
Discounted Registration Deadline: Nov 18, 2013

Sponsored by AstraZeneca, BioLegend, Inc., Takeda Pharmaceutical Company Limited and Theravance, Inc. Supported by an educational donation provided by Amgen.


Summary of Meeting:
There has been a great deal of enthusiasm in the cytokine field, with the discovery of powerful new cytokine networks that govern both T cells and innate lymphocytes (e.g., ILC, NK, gammadelta T, and iNKT cells), maintain tissue homeostasis, and promote inflammation/tissue repair during stress and injury responses. Increasing knowledge of cytokine network checkpoints has promoted the design of antibodies and inhibitors that show clinical efficacy for autoimmune disorders such as psoriasis, Crohn's disease and rheumatoid arthritis. However, there is still a wide gap between “early” basic scientific knowledge and “late” development of novel therapeutic agents. One of the goals of the meeting is to bring together scientists performing basic research on molecular and cellular mechanisms of immune cell activation and function with those working to develop this knowledge into novel therapies. It is our hope that attendees will gain a deeper understanding of how cytokines network together to maintain health, and gain an appreciation for the many potential strategies for targeting the network to create better drugs.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 17

16:00—20:00
Arrival and Registration

SATURDAY, JANUARY 18

07:30—08:30
Breakfast
08:30—10:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Daniel J. Cua, Merck Research Laboratories, USA

* Chen Dong, Tsinghua University, China

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Inflammation

Fiona M. Powrie, University of Oxford, UK
Cytokine Network Regulating Adaptive and Innate Immunity

10:30—10:50
Coffee Break
10:50—12:15
Cytokine Regulation of Inflammation (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tadamitsu Kishimoto, Osaka University, Japan

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
The NLR Gene Family and Cytokines

David Artis, University of Pennsylvania School of Medicine, USA
Regulation of Barrier Immunity

Christoph Wilhelm, NIAID, National Institutes of Health, USA
Short Talk: Adaptation of Innate Lymphoid Cells to Nutrient Deprivation Promotes Type 2 Barrier Immunity

12:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
12:15—14:30
On Own for Lunch and Recreation
14:30—16:30
Workshop 1
* Rene de Waal Malefyt, Merck Research Labs, USA

Yosuke Kumamoto, Yale University School of Medicine, USA
CD301b+ Dermal DCs Are Required for Th2 Cell Immunity

Marina Babic Cac, German Rheumatism Research Centre, Germany
The Activating Receptor NKG2D Regulates IL-10 Expression in Th1 Cells

Mei Li, Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC), France
Skin Thymic Stromal Lymphopoietin Initiates Th2 Responses through an Orchestrated Immune Cascade

Julien J. Karrich, Erasmus University Medical Center, Netherlands
Characterization of Plet1-Expressing DCs in the Intestine and Their Role in Controlling IL22-Driven Mucosal Innate Immunity

Jochem H.J. Bernink, Tytgat Institute, Netherlands
Mononuclear Phagocytes Regulate the Balance between Group 1 and Group 3 Innate Lymphoid Cells in Mucosal Tissues

Christina Chang, The Salk Institute, USA
REV-ERBs as Negative Regulators of the Th17 Immune Response

Sergei P. Atamas, University of Maryland School of Medicine, USA
Functionally Distinct Cytokine Patterns Evoked by Precursor and Mature IL-33

Brian T. Edelson, Washington University School of Medicine, USA
Bhlhe40 Regulates T Cell Cytokine Production and Is Essential for Autoimmune Neuroinflammation

16:30—17:00
Coffee Available
17:00—19:00
Regulation of Tissue-Resident ILC and T Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard M. Locksley, HHMI/University of California, San Francisco, USA

Hergen Spits, University of Amsterdam, Netherlands
Regulation of Development and Function of Human ILC

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Compartmentalized and Systemic Control of Tissue Immunity by Commensals

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
New Emerging Transcription Factor- and Cytokine Networks at the Mucosal Interface of the Intestine

Michael G. Constantinides, University of Chicago, USA
Short Talk: A Committed Precursor to Innate Lymphoid Cells

17:00—19:15
New Targets and Treatment in Allergic Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Yong-Jun Liu, MedImmune, USA
Regulators of Th2 Immunity

Rene de Waal Malefyt, Merck Research Labs, USA
Talk Title to be Announced

John G. Matthews, Genentech, Inc., USA
Lebrikizumab (Anti-IL-13) Treatment for Asthma

Hongbo Chi, St. Jude Children's Research Hospital, USA
Short Talk: mTORC1-Dependent Metabolic Programming of Exit from Quiescence Underlies T Cell Fate Decisions and Inflammation

Emily Hams, Trinity College Dublin, Ireland
Short Talk: Type 2 Innate Lymphoid Cells Regulate Obesity in Mice

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

SUNDAY, JANUARY 19

07:30—08:30
Breakfast
08:00—08:30
Poster Setup
08:30—19:00
Poster Viewing
08:30—11:30
Initial Cellular Sensors of Stress and Injury
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Hergen Spits, University of Amsterdam, Netherlands

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Cytokine Networks in Type 2 Immunity

Gabriel Nuñez, University of Michigan, USA
Pathogen Colonization and Allergic Skin Disease

Andreas Diefenbach, University of Mainz, Germany
Transcriptional Regulation of ILC Subsets

Marco Colonna, Washington University School of Medicine, USA
Regulation of ILC and NK Subsets

08:30—12:00
T Cells in Inflammatory Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yong-Jun Liu, MedImmune, USA

Shimon Sakaguchi, Osaka University, Japan
Roles of Treg Cells in Inflammation

Chen Dong, Tsinghua University, China
Regulation and Modulation of Th17 and Tfh Cells in Inflammation

K. Frank Austen, Harvard Medical School, USA
Integration of Three Cysteinyl Leukotriene Receptors and their Preferred Ligands into Models of Dectin-2-Dependent ‘Asthma’

Wanjun Chen, NIDCR, National Institutes of Health, USA
TGF-beta and Regulatory T Cells in Immune Responses and Inflammation

Bin Li, Institut Pasteur of Shanghai, China
Short Talk: Posttranslational Regulation of FOXP3 and Treg Stability Under Inflammation

Yisong Wan, University of North Carolina at Chapel Hill, USA
Short Talk: An Unexpected Essential Function of Smad4 for T Cell Function and Autoimmunity

Xi Yang, University of Pittsburgh, USA
Short Talk: ATF4 Is Induced by ROS and Regulates Th1 and Th17 Responses

09:50—10:10
Coffee Break
11:30—12:30
Lunch
12:00—14:30
Poster Session 2
14:30—16:30
Workshop 2
* Marc Veldhoen, Babraham Institute, UK

Sylvia Cheung, University of British Columbia, Canada
Interleukin-10 Triggers Rapid Anti-Inflammatory Responses through SHIP1

Sarah L. Gaffen, University of Pittsburgh, USA
Feedback Inhibition of IL-17 Signal Transduction by A20/TNFAIP3 and the Anaphase Promoting Complex Protein 5

Heth R. Turnquist, University of Pittsburgh, USA
IL-33 Promotes Dendritic Cell Expansion of a Distinct Foxp3+ Treg Subset Suppressing Type 1 Immunity

Matthew R. Hepworth, Institute of Immunology, USA
Innate Lymphoid Cells Regulate CD4+ T Cell Responses to Commensal Bacteria via MHCII

Marina Saresella, Fondazione don C. Gnocchi IRCCS ONLUS, Italy
Toll-Like Receptor 3 Differently Modulates Inflammation in Progressive or Benign Multiple Sclerosis

Peter Tougaard, University of Copenhagen, Denmark
The Impact of the Cytokine TL1A on Gut Homeostasis in Mice

Jan-Eric Turner, Universitätsklinikum Hamburg-Eppendorf, Germany
IL-9-Mediated Survival of Type 2 Innate Lymphoid Cells Promotes Damage Control in Helminth-Induced Lung Inflammation

Estefania Claudio, NIAID, National Institutes of Health, USA
IL-25-Mediated Activation of Lung Dendritic Cells Is Central to House Dust Mite-Induced Generation of Th9 Cells and Airway Remodeling

16:30—17:00
Coffee Available
17:00—19:00
Cytokine Networks at Barrier Surfaces
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sarah L. Gaffen, University of Pittsburgh, USA

Jason G. Cyster, HHMI/University of California, San Francisco, USA
EBI2 and Oxysterols in Immune Cell Guidance and Regulation

Fumio Takei, University of British Columbia and BC Cancer Agency, Canada
Cytokine Regulation of ILC2, Th2 Cells and Allergic Lung Inflammation

Jay K. Kolls, University of Pittsburgh School of Medicine, USA
Adaptive and Innate Response in Respiratory Infection

Jose Ordovas-Montanes, Harvard Medical School, USA
Short Talk: Sensory Nerve Fibers Drive Interleukin-23 Mediated Psoriasis-Like Skin Inflammation

17:00—19:15
Treatments with Small Molecules
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Virginia Pascual, Baylor Institute for Immunology Research, USA

Andreas Billich, Novartis Institutes for BioMedical Research, Switzerland
Fingolimod/FTY720 (Gilenya) in the Treatment of Multiple Sclerosis: Mode-of-Action and Clinical Experience

John Bertin, GlaxoSmithKline, USA
Therapeutic Targeting of RIP1 Kinase and Necroptosis

Vanessa C. Taylor, Rigel Inc., USA
Short Talk: Novel Small Molecule Inhibitors of Interleukin-1 Receptor Associated Kinase-1 and -4 (IRAK-1 and IRAK-4) Identified by Cell-Based Screening Are Effective in Rodent Models of Inflammation

Gordon Alton, Visionary Pharmaceuticals, USA
Short Talk: RORgt Inverse Agonists for the Treatment of Inflammatory Bowel Disease

19:00—
On Own for Dinner

MONDAY, JANUARY 20

07:30—08:30
Breakfast
08:30—11:30
Environmental Factors that Influence Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jay K. Kolls, University of Pittsburgh School of Medicine, USA

Max D. Cooper, Emory University, USA
Comparative Analysis of Alternative Adaptive Immune Systems

Marc Veldhoen, Babraham Institute, UK
EMBO Young Investigator Lecture: Influence of Environmental Factors on Lymphocyte Biology

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Unexpected Targets and Triggers of Autoimmunity

Federica Sallusto, Institute for Research in Biomedicine, Universtà della Svizzera Italiana, Switzerland
Cytokine Regulation of Human T Cell Subsets

Parizad Torabi-Parizi, National Institutes of Health, USA
Short Talk: Imaging-Based Insights into Effector CD4+ T Cell Behavior in Peripheral Tissues

08:30—12:00
Translational Research
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Shimon Sakaguchi, Osaka University, Japan

David A. Hafler, Yale University School of Medicine, USA
From Genetics to Immune Targets

Virginia Pascual, Baylor Institute for Immunology Research, USA
Systemic Approaches in Systemic Disease

Farrah Kheradmand, Baylor College of Medicine, USA
Smoke-Induced Reduction of PPAR-gamma Drives Emphysema

Howard L. Weiner, Brigham & Women’s Hospital, USA
Treatment of Inflammatory and Autoimmune Diseases by Mucosal Induction of Regulatory T Cells

Bryan J. Vander Lugt, Genentech, Inc., USA
Short Talk: Transcriptional Programming of Dendritic Cells for Priming Immunogenic and Tolerogenic MHCII-Restricted T Cell Responses

Andrew P. Fontenot, University of Colorado Denver, USA
Short Talk: Regulatory T Cells Modulate Granulomatous Inflammation in an HLA-DP2 Transgenic Murine Model of Beryllium-Induced Disease

Colby Zaph, University of British Columbia, Canada
Short Talk: Epigenetic Regulation of ILC2 Development and Function

09:50—10:10
Coffee Break
11:30—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:30—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Cellular Intrinsic Factors that Influence Cytokine Responses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Fan Pan, Johns Hopkins University School of Medicine, USA
Hypoxia Response and Th17 Regulation

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Regulation of IL-17 Production in Recently Activated Human Th17 Cells

K. Mark Ansel, University of California, San Francisco, USA
MicroRNA Regulation in Immunity

Kiyoshi Hirahara, Chiba University, Japan
Short Talk: Asymmetry of STAT Action to Define Specificity and Redundancy of IL-27 and IL-6 Signals

17:00—19:15
Inflammation and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yisong Wan, University of North Carolina at Chapel Hill, USA

Michael Karin, University of California, San Diego, USA
Liver Inflammation and Cancer

Raymond N. DuBois, Arizona State University, USA
The Role of Inflammation and Inflammatory Mediators in Progression of Colorectal Cancer

Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Immune Cells as Targets for Anti-Cancer Therapy

Sacha J. Holland, Rigel, Inc., USA
Short Talk: Protein Kinase C (PKC) Family Inhibitor R896 and PKC-theta-Selective Inhibitor R683 Block T Cell Activation and Suppress Immune-Mediated Disease in Rodents

Shu-Hsia Chen, Mount Sinai School of Medicine, USA
Short Talk: CMTM4, a Novel Chemokine Regulator that Controls Inflammatory Responses in Tumor Microenvironment

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

TUESDAY, JANUARY 21

07:30—08:30
Breakfast
08:30—11:45
Targeting Immune Modulators in Autoimmunity and Cancer (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Tadamitsu Kishimoto, Osaka University, Japan
IL-6: A Balance between Arid5a and Regnase-1 in Autoimmune Inflammatory Disease

Dhavalkumar D. Patel, Novartis Institutes for BioMedical Research, Switzerland
Treatment of Inflammatory Diseases with Anti-IL17

Daniel J. Cua, Merck Research Laboratories, USA
Targeting IL-23 in Inflammatory Disorders

Ira Mellman, Genentech, Inc., USA
Targeting the PD1/PDL1 Axis for Cancer Immunotherapy Alone and in Combination

Fabian Buller, Covagen AG, Switzerland
Short Talk: COVA322: A Novel, Bispecific TNF/IL-17A Inhibitor for the Treatment of Inflammatory Diseases Moving toward the Clinic

Daniel Hawiger, St. Louis University, USA
Short Talk: Long-Lasting Immune Tolerance Mediated by Dendritic Cells Depends on Functions of Homeodomain Only Protein (Hopx) in Peripherally Induced Regulatory T Cells

09:50—10:10
Coffee Break
11:45—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Clinical Application of Immune Modulators
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Silvia Monticelli, Institute for Research in Biomedicine, Switzerland

John J. O'Shea, NIAMS, National Institutes of Health, USA
Targeting Cytokine Signaling: That's a Fact, Jak

Adrian C. Hayday, King's College London School of Medicine, UK
The Contribution of gamma delta T Cells to Afferent Immunogenicity in Mice and in the Clinic

Maria Grazia Roncarolo, San Raffaele Scientific Institute, Italy
Cell-Based Immune Therapy for Tolerance Induction

Hosahalli Subramanya, Aurigene Discovery Technologies Ltd., India
Short Talk: Efficacy of Novel and Selective RORgamma Inverse Agonists in Psoriasis and Asthma Models

17:00—19:15
Immune Tolerance Re-Establishment
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Wanjun Chen, NIDCR, National Institutes of Health, USA

Jeffrey A. Bluestone, University of California, San Francisco, USA
Anti-CD3, Tregs and Treg-Friendly Therapeutics to Induce Tolerance

Bruce R. Blazar, University of Minnesota, USA
The Use of ex vivo Expanded Regulatory T Cells (Tregs) for the Prevention of Graft-versus-Host Disease (GVHD)

Stephen D. Miller, Northwestern University Medical School, USA
MARCO-Targeting Carboxylated PLG Nanoparticles Promote Tolerance Induction and Suppression of Inflammatory Monocytes

Hazel Claire Poyntz, Malaghan Institute of Medical Research, New Zealand
Short Talk: Intestinal Microbial Composition as Immunotherapy for Allergy Prevention

Helena Kiefel, Stanford University School of Medicine, USA
Short Talk: Intestinal T Cell Expression of a G-Protein-Coupled Receptor for Short Chain Fatty Acids: Role in T Cell Homeostasis and Colitis

19:15—20:15
Social Hour with Lite Bites
20:00—23:00
Entertainment

WEDNESDAY, JANUARY 22

 
Departure

*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen. AstraZeneca
BioLegend, Inc. Takeda Pharmaceutical Company Limited
Theravance, Inc.
 

We gratefully acknowledge additional support for this conference from:

R&D Systems, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Novartis Pharma AG


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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