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This meeting took place in 2014


Here are the related meetings in 2015:
Viral Immunity (A2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Pathogenesis of Respiratory Viruses (J5)


Organizer(s) Adolfo García-Sastre and Peter J.M. Openshaw
January 19—24, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 9, 2013
Abstract Deadline: Oct 31, 2013
Scholarship Deadline: Oct 9, 2013
Discounted Registration Deadline: Nov 19, 2013

Sponsored by AstraZeneca


Summary of Meeting:
Respiratory viruses are a major cause of infectious disease and death in humans. The Keystone Symposia meeting on "Pathogenesis of Respiratory Viruses" will discuss some of the latest advances in our understanding of the biology and pathogenesis of this group of viruses, including major human pathogens such as influenza viruses, respiratory syncytial virus, parainfluenza virus, rhinoviruses, coronaviruses and adenoviruses. There will be a special emphasis on influenza and respiratory syncytial virus. This meeting will bring together experts in virology, viral pathogenesis and viral immunity to discuss factors contributing to viral replication, tropism, disease and immunity in the respiratory tract. Opportunities for synergistic interactions will be significantly enhanced by the concurrent meeting on "Innate Immunity to Viral Infections," resulting in a more integrated view of viral disease and immunity.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 19

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 20

07:00—08:00
Breakfast

08:00—10:00
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

* Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK
RLRs in Immunity to Viruses

Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Why Do Influenza Viruses Undergo Antigenic Drift and Shift and What Can We Do About It?

10:00—10:20
Coffee Break

10:20—12:00
Viral Entry and Replication
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Glycoprotein structure, viral entry and genome replication.

* Yoshihiro Kawaoka, University of Wisconsin/University of Tokyo, USA

Ian A. Wilson, The Scripps Research Institute, USA
Structural Basis of Influenza HA Function and Neutralization

James E. Crowe, Jr., Vanderbilt University Medical Center, USA
Host-Virus Interactions during RSV Infection

Robert A. Lamb, Northwestern University, USA
The Mechanism of Entry into Cells by Membrane Fusion for Respiratory Negative Strand Viruses


Following Session is for Innate Immunity to Viral Infections (J6)

10:20—12:00
Antiviral Strategies Across Taxa
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.

* Sara R. Cherry, University of Pennsylvania School of Medicine, USA

Luciano A. Marraffini, Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus

Jean-Luc Imler, Institut de Biologie Moléculaire et Cellulaire, France
Sensing and Signaling Viral Infection in Drosophila

Shou-Wei Ding, University of California, Riverside, USA
RNAi as an Antiviral Strategy across Species, including Vertebrates

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Virus-Host Interactions

* James E. Crowe, Jr., Vanderbilt University Medical Center, USA

* Cecilia Johansson, Imperial College London, UK

Victor Stalinraj, Erasmus Medical Center, Netherlands
Characterization of DPP4 as the Functional Receptor for Middle East Respiratory Syndrome Coronavirus

Monika Bajorek, Imperial College London, UK
Human RSV M Protein Interactions with Host Proteins Reveal New Cellular Ligands Involved in Viral Nuclear Localization and Innate Defense

Kavestri Yegambaram, University of Auckland, New Zealand
Protein Interactions Underpinning Movement of the Viral Polymerase Diverge in the Paramyxovirinae

Patricia S. Domingues, University of Glasgow, UK
Non-Canonical Interplay between Influenza Virus and the Host SUMO System

Raymond J. Pickles, University of North Carolina, Chapel Hill, USA
Respiratory Syncytial Virus NS2 Protein Promotes Shedding of Virus-Infected Epithelial Cells Resulting in Acute Distal Airway Obstruction

Christopher Brooke, NIAID, National Institutes of Health, USA
Illuminating the Dark Matter of Influenza A Virus Infection: Dynamic Viral Gene Expression Patterns within the “Non-Infectious” Virus Population

Nicholas S. Heaton, Icahn School of Medicine at Mount Sinai, USA
Genome-Wide Mutagenesis of Influenza Virus: Unique Plasticity of the Hemagglutinin and NS1 Proteins

Hugh D. Mitchell, Pacific Northwest National Laboratory, USA
Integration of Proteomics Data Focuses Pathogenicity Pathways from Influenza Infection


Following Session is for Innate Immunity to Viral Infections (J6)

14:30—16:30
Workshop 1: Innate Virus Sensors

* John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA

David E. Levy, New York University School of Medicine, USA
Regulation of IFN Production and Response during Viral Infections

Eva-Katharina Pauli, Boston College, USA
USP15 Promotes RIG-I Antiviral Signaling by Stabilizing TRIM25

Sun Hur, Harvard Medical School, USA
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent and Ubiquitin-Independent Manner

Hao-Sen Chiang, Massachusetts General Hospital, USA
GEF-H1 Mediates Microtubule-Dependent Sensing of Nucleic Acids for Antiviral Host Defenses

Chen Seng Ng, Kyoto University, Japan
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses

Søren Riis Paludan, University of Aarhus, Denmark
Gammaherpesviruses Evade Innate Immune Activation via Cytosolic DNA Sensors to Allow Establishment of Chronic Infection

Pingwei Li, Texas A&M University, USA
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA- Induced Oligomerization

16:30—17:00
Coffee Available

17:00—19:00
Virus-Host Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Host factors required for replication, impact of viral infection in cell functions.

* Tracy Hussell, University of Manchester, UK

Yoshihiro Kawaoka, University of Wisconsin/University of Tokyo, USA
Influenza Virus Pathogenesis and Transmission

Ursula J. Buchholz, NIAID, National Institutes of Health, USA
Evasion of the Adaptive Immune Response by HRSV and HMPV

J. Kenneth Baillie, University of Edinburgh, UK
Host Genetic Susceptibility and Viral Pathogenesis

Sharon K. Kuss, University of Texas Southwestern Medical Center, USA
Short Talk: Influenza A Virus RNA Splicing is Regulated by Cellular Proteins NS1-BP and hnRNP K


Following Session is for Innate Immunity to Viral Infections (J6)

17:00—19:00
Effector Responses and Viral Evasion
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Zhijian 'James' Chen, HHMI/University of Texas Southwestern Medical Center, USA

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Autophagy Nutrient Signaling and Antiviral Defenses

Kanako Kuniyoshi, iOsaka University, Japan
Short Talk: Pivotal Role of RNA-Binding E3 Ubiquitin Ligase Mex3c in RIG-I-Mediated Antiviral Innate Immunity

Michael Gale, Jr., University of Washington, USA
Differential Innate Antiviral Effector Responses Impart Outcome of Pathogenic and Nonpathogenic Flavivirus Infection

Andrew G. Bowie, Trinity Biomedical Sciences Institute, Ireland
Unexpected Roles for the TLR Adaptors TRAM and SARM in Anti-Viral Gene Induction

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 21

07:00—08:00
Breakfast

08:00—11:15
Virus Detection by the Host (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).

* Charles M. Rice, Rockefeller University, USA

Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
C-Type Lectin Receptors as Virus Sensors or ‘Dupes’

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Long Non-Coding RNA and Innate Immunity

Zhijian 'James' Chen, HHMI/University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic DNA

Juris Grasis, San Diego State University, USA
Short Talk: Viral Recognition in the Basal Metazoan Hydra

Akshay A. D'Cruz, , Australia
Short Talk: A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response

Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Talk Title to be Announced

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Innate Immunity in Pathogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

* Ben Hale, University of Glasgow, UK

Peter Staeheli, University of Freiburg, Germany
Role of Interferon in Influenza Virus Defense

Cecilia Johansson, Imperial College London, UK
Interferon Responses to Respiratory Syncytial Virus (RSV) Infection

Deborah J. Lenschow, Washington University School of Medicine, USA
Regulation of the Host Response to Viral Infection by ISG15

Amy C. Graham, Montana State University, USA
Short Talk: Influenza A Virus Activates Mast Cells to Enhance Viral-Induced Pathology


Following Session is for Innate Immunity to Viral Infections (J6)

17:00—19:00
Signaling Responses to Virus Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: MAVS, STING, inflammasome.

* Andrew G. Bowie, Trinity Biomedical Sciences Institute, Ireland

Yong-Jun Liu, MedImmune, USA
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells

Kate L. Jeffrey, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Antiviral Defense in Mammals Mediated by Argonautes 2 and 4

Glen N. Barber, University of Miami, USA
STING at the Crossroads of Cell-Intrinsic DNA Sensing

Veit Hornung, University Hospital, University of Bonn, Germany
Spreading of Antiviral Immunity via Gap Junctions

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 22

07:00—08:00
Breakfast

08:00—11:00
Induction of Immunity at Epithelial Surfaces (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Dendritic cells, innate responses in the lung, inflammation.

* Peter J.M. Openshaw, Imperial College London, UK

Tracy Hussell, University of Manchester, UK
Airway Immune Homeostasis

Andreas Wack, National Institute for Medical Research, UK
Short Talk: Interferon in Flu

Ricardo Rajsbaum, Mount Sinai School of Medicine, USA
Short Talk: Activation of Ikk Epsilon

Harry B. Greenberg, Stanford University, USA
Rotaviruses and Vaccines: Host Range, Pathogenesis and Innate Immunity - A Ménage a Trois

Nicholas W. Lukacs, University of Michigan, USA
Talk Title to be Announced

Akiko Iwasaki, Yale University School of Medicine, USA
Linking Innate Recognition of Viruses to Adaptive Immunity

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Host Responses

* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

* Ursula J. Buchholz, NIAID, National Institutes of Health, USA

Bas Baaten, Sanford-Burnham Medical Research Institute, USA
Antiviral Immunity to Influenza Virus at the Aged Nasal Mucosa

Tim Beaumont, AIMM Therapeutics, Netherlands
Human B Cells Specific for the RSV F Prefusion Protein are Highly Prevalent and Efficiently Reduce Respiratory Tract Infection by RSV

Emily A. Hemann, University of Iowa, USA
The Contribution of Direct Infection of Pulmonary Plasmacytoid Dendritic Cells to Robust CD8 T Cell Responses in the Lungs during Influenza A Virus Infection

Rebecca J. Ortiz Marty, Nationwide Children's Hospital Research Institute, USA
Epitope Specificity and Function of T-Cell Responses during Acute RSV Bronchiolitis and Memory in Children and Adults

Saranya Sridhar, Imperial College, UK
CD8+ T Cells Correlate with Protection against Symptomatic Illness Following Natural Pandemic Influenza Infection in Humans

Jeffrey C. Boyington, Vaccine Research Center, NIAID, National Institutes of Health, USA
Rational Design of an Influenza Hemagglutinin Stem Immunogen Enables Elicitation of Stem-Directed Neutralizing Antibodies

Nicole L. Kallewaard, MedImmune, USA
Characterization of Novel Human Monoclonal Antibodies that Neutralize all Influenza A Viruses

M. Gordon Joyce, NIAID, National Institutes of Health, USA
Structure-Based Respiratory Syncytial Virus Vaccine Design


Following Session is for Innate Immunity to Viral Infections (J6)

14:30—16:30
Workshop 2: Antiviral Strategies

* Søren Riis Paludan, University of Aarhus, Denmark

Curt M. Horvath, Northwestern University, USA
Genomic Analysis Reveals Novel Sites of Virus-Induced RNA Transcription

Saumendra N. Sarkar, University of Pittsburgh Cancer Institute, USA
Mechanisms of Antiviral Activity of Human OASL

Jennifer H. Stuart, University of Cambridge, UK
Dual Mechanisms of Inhibition of Interferon Responses by Vaccinia Virus Protein C6

John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA
Host Restriction Factor SAMHD1 Limits Human Retrovirus Infection of Monocytes via STING-Mediated Apoptosis

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Expression Screens Identify a Viral Bias in Interferon-Induced Effector Specificity and a Requirement for cGAS in Antiviral Immunity

Sumana Sanyal, Hong Kong University-Pasteur Research Center, Hong Kong
Viral Exploitation of Host Intracellular Trafficking Pathways upon Interferon Induction

Silke Paust, Baylor College of Medicine, USA
Vaccine Induced Memory NK Cells Protect from Lethal Influenza Infection

16:30—17:00
Coffee Available

17:00—19:00
Specific Immunity: The Good and the Bad
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kanta Subbarao, NIAID, National Institutes of Health, USA

Peter J.M. Openshaw, Imperial College London, UK
Immunity to Respiratory Syncytial Virus (RSV) Infection

Patrick C. Wilson, University of Chicago, USA
Diversity Drives the Human B Cell Response to Influenza

Ethan C. Settembre, Novartis Vaccines, USA
Improving the Global Influenza Vaccine System

Cory J. Knudson, University of Iowa, USA
Short Talk: Memory CD8 T Cells Provide Protection against Respiratory Syncytial Virus Infection at the Cost of Severe Pulmonary Immunopathology


Following Session is for Innate Immunity to Viral Infections (J6)

17:00—19:00
Defense from Retroviruses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).

* Alexander (Sasha) Tarakhovsky, Rockefeller University, USA

Stephen P. Goff, Columbia University, USA
Silencing of Retroviral DNAs in Embryonic Stem Cells: Transacting Proteins, Chromatin Modifications, and Timing

Maroof Hasan, University of Texas Southwestern Medical Center, USA
Short Talk: Tail-Anchored TREX1 Prevents Liberation of Free Glycans with Immunogenic Potential through a DNase-Independent Function

Jan Rehwinkel, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Nucleotide Starvation: A SAMHD1-Dependent Strategy for Cell-Intrinsic Anti-Retroviral Defense

Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the HIV-1 Capsid Protein Lattice

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 23

07:00—08:00
Breakfast

08:00—11:15
Virulence and Coinfections
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Monika Bajorek, Imperial College London, UK

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Subversion of Innate Pathways by Influenza Virus

* Thomas J. Braciale, University of Virginia, USA
Respiratory Dendritic Cells in the Control of Anti-Viral Effector and Memory T Cell Responses

Jonathan A. McCullers, University of Tennessee Health Sciences Center, USA
The Importance of Virus-Mediated Immune Dysfunction in Secondary Bacterial Pneumonia following Influenza

Lance K. Blevins, Wake Forest School of Medicine, USA
Short Talk: Coinfection with S. Pneumoniae Results in Decreases in Both the Quality and Quantity of Influenza Specific CD8+ T Cells

Agnieszka Rynda-Apple, Montana State University, USA
Short Talk: Regulation of IFN-? by IL-13 Dictates the Susceptibility to Secondary Post-Influenza MRSA Pneumonia

Charles J. Russell, St. Jude Children's Research Hospital, USA
Short Talk: Dynamics of Primary Parainfluenza Virus Infection and Protection from Reinfection are Determined by the Mode of Transmission while Pathogenesis is Determined by Distinct Viral and Host Factors

Denise E. de Almeida Nagata, University of Michigan, USA
Short Talk: Epigenetic Control by TGFbeta1-Inducible SMYD3 H3K4 Methyltransferase Influences iTreg Development and Respiratory Syncytial Virus-Related Disease Progression


Following Session is for Innate Immunity to Viral Infections (J6)

08:00—11:15
IFNs and ISGs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)

* Veit Hornung, University Hospital, University of Bonn, Germany

Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Epigenetic Regulation of Antiviral Immunity

Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Nucleic Acid Binding Proteins with Antiviral Properties

Maria-Carla Saleh, Institut Pasteur, France
Short Talk: Evidence of Long-Lasting Antiviral Immunity in Insects

Charles M. Rice, Rockefeller University, USA
Antiviral Activities of Interferon-Stimulated Genes

Sonja M. Best, NIAID, National Institutes of Health, USA
Short Talk: The Mechanism of Type I Interferon Antagonism by NS5 from Encephalitic Flaviviruses, TBEV and WNV

Gaya Amarasinghe, Washington University School of Medicine, USA
A Structural Element at the 5'-End of Viral RNA Antagonizes IFIT1-Mediated Cell-Intrinsic Immunity

09:20—09:40
Coffee Break

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Regulation and Resolution of Inflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Immunoregulation, resolvins

* Peter J.M. Openshaw, Imperial College London, UK

Bali Pulendran, Emory University, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology

Bruce D. Levy, Brigham and Women's Hospital, USA
Specialized Pro-Resolving Mediators Promote the Resolution of Pathogen-Mediated Inflammation

Luis Enjuanes, CNB-CSIC, Spain
MERS and SARS Pathogenesis and Vaccines

Ryan A. Langlois, University of Minnesota, USA
Short Talk: Long-Term Influenza A Virus Infected Cells are Critical for Repair of Respiratory Damage


Following Session is for Innate Immunity to Viral Infections (J6)

17:00—19:00
Antiviral Innate Immunity in Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Inflammation and immunopathology, interferonopathies (AGS, lupus).

* Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK

Yanick Crow, Institut Imagine, France
Human Type I Interferonopathies

Carla V. Rothlin, Yale University, USA
Negative Regulation of Type I Interferons

Roland W. Kolbeck, MedImmune, LLC, USA
New Approaches to the Treatment of Interferon-Driven Autoimmunity

Romain Bouziat, University of Chicago, USA
Short Talk: Role of Reoviral Infections and Type 1 Interferon in Celiac Disease

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 24

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

AstraZeneca

We gratefully acknowledge additional support for this conference from:

MedImmune

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI110083-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676