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This meeting took place in 2014


Here are the related meetings in 2015:
The Golden Anniversary of B Cell Discovery (X6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Biology of B Cell Responses (Q4)


Organizer(s) Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweig
February 9—14, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 16, 2013
Abstract Deadline: Nov 14, 2013
Scholarship Deadline: Oct 16, 2013
Discounted Registration Deadline: Dec 10, 2013

Sponsored by BioLegend, Inc. and Celgene Corporation.


Summary of Meeting:
The requirements and processes relevant for the induction of protective B cell responses remain largely unclear, and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of this meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection and B cell tumors. The specific aims are to: 1) Identify factors involved in the developmental programming and function of B cells; 2) Elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance; 3) Define how B cell responses are initiated and regulated; 4) Provide insight into the mechanisms and dynamics underlying germinal center responses; and 5) Establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early-stage and established researchers to engage in interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at an international level. Interactions will be fostered across disciplines. Access to the parallel meeting on “Prophylactic and Therapeutic Antibodies” will provide all attendees with the unique opportunity to engage in expanded interdisciplinary interaction with translational scientists from academia and industry.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 9

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 10

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Deciphering the Guidance Cue Code for B Cell Immunity

08:00—09:15
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Margaret Karow, Amgen Inc., USA
Introductory Remarks

Joseph Miletich, Amgen, USA
Antibody Therapeutic Indications: Expanding Beyond Cancer and Inflammatory Diseases

09:00—11:35
Programming B Cell Physiology
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Barry P. Sleckman, Washington University School of Medicine, USA
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks

Cornelis Murre, University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate

Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Pre B Cell Development

* Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation

Amy L. Kenter, University of Illinois College of Medicine, USA
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo

09:15—11:30
Novel Antibody Therapy for Pain
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* Margaret Karow, Amgen Inc., USA

Mark T. Brown, Pfizer, USA
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain

John A. Latham, Alder BioPharmaceuticals, USA
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine

Stephen P. Squinto, Alexion Pharmaceuticals, Inc., USA
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases

09:40—10:00
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:35—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: From B Cell Selection and Homeostasis to Programming and Functions

* Michael P. Cancro, University of Pennsylvania, USA

* Frances E. Lund, University of Alabama at Birmingham, USA

Jeffrey J. Bednarski, Washington University School of Medicine, USA
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC

Hannes Bergmann, John Curtin School of Medical Research, Australian National University, Australia
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival

Barbara Bertocci, INSERM 783, France
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation

Keith M. Hamel, University of Chicago, USA
The Epigenetic Reader Cecr2 in B-Lymphopoiesis

Yogesh S. Jeelall, John Curtin School of Medical Research, Australian National University, Australia
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production

Beatriz León, University of Alabama at Birmingham, USA
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells

Matthew S. Macauley, The Scripps Research Institute, USA
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens

Trang T.T. Nguyen, Center for Comparative Medicine, University of California, Davis, USA
Secreted IgM Enforces B Cell Central Tolerance Induction

14:00—16:30
Workshop 1: Crossing the Blood-Brain Barrier

Jean E. Lachowicz, Angiochem, Canada
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors

* Robert G. Thorne, University of Wisconsin-Madison, USA
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments to Central Nervous System Target Sites

Denise D. Karaoglu, AbbVie Bioresearch Center, USA
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection

Morten Hanefeld Dziegiel, Copenhagen University Hospital, Denmark
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies

Graham K. Farrington, Biogen Idec, USA
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity

16:30—17:00
Coffee Available

17:00—19:15
Self-Tolerance and Autoimmunity
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* Christopher C. Goodnow, Australian National University, Australia
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation

Roberta Pelanda, National Jewish Health, USA
Positive and Negative Selection of Primary B Cells

Robert C. Rickert, Sanford-Burnham Medical Research Institute, USA
Short Talk: B Cell Tolerance to Gut-Associated Antigens

Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans

17:00—19:00
Treating Chronic Diseases of Metabolism with Antibody-Based Therapeutics
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* John A. Latham, Alder BioPharmaceuticals, USA

Neil Stahl, Regeneron Pharmaceuticals, USA
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies

Peter Libby, Brigham and Women's Hospital, USA
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment

Estelle Trifilieff, Novartis Institutes for Biomedical Research, Switzerland
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 11

07:00—08:00
Breakfast

08:00—11:00
Initiating and Regulating B Cell Responses
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* Hedda Wardemann, German Cancer Research Center, Germany

Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Calcium Signaling in B Lymphocytes

Jeffrey V. Ravetch, Rockefeller University, USA
Regulating B Cell Activation

Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds

Maria A. Curotto de Lafaille, Singapore Immunology Network, Singapore
Short Talk: Regulation of IgE Cell Differentiation and Memory

Kai-Michael Toellner, University of Birmingham Medical School, UK
Short Talk: Regulation of B Cell Responses by Antibody

08:00—11:00
Tailoring Therapeutics to Meet the Demands of Prophylactic and Long-Term Therapy
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* Marc Retter, Amgen Inc., USA

Herren Wu, MedImmune, USA
Engineering Biosuperiors

Javier Chaparro-Riggers, Rinat-Pfizer Inc., USA
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody

Tomoyuki Igawa, Chugai Pharmaceutical, Japan
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A

Chung-Ming Hsieh, AbbVie Bioresearch Center, USA
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: B Cell Activation and Control of B Cell Responses

* Anthony L. DeFranco, University of California, San Francisco, USA

* Jürgen Wienands, Georg August University of Goettingen, Germany

Wenxia Song, University of Maryland, USA
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance

Alberto Martin, University of Toronto, Canada
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination

Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome

Carla R. Nowosad, MRC National Institute for Medical Research, UK
Determining the Architecture and Function of Immune Synapses within B Cell Populations

Mark R. Boothby, Vanderbilt University Medical Center, USA
Signaling Pathways in B Cell Survival and Humoral Memory

Isabelle Robert, Institute of Genetics and Molecular and Cellular Biology
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3

Pia Dosenovic, Rockefeller University, USA
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA

14:30—16:30
Workshop 3: B Cell Responses to Foreign Antigens

* Nicole Baumgarth, University of California, Davis, USA

Roberto DiNiro, University of Pittsburgh, USA
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation

Rebecca A. Elsner, University of California, Davis, USA
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses

Eliver Eid Bou Ghosn, Stanford University, USA
HSC-Independent Development of Antigen-Specific B-1a Memory

E. Ashley Moseman, NINDS, National Institutes of Health, USA
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection

Noel T. Pauli, University of Chicago, USA
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans

Kristin M. Shotts, University of Colorado-Anshutz, USA
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells

Cristina Gil-Cruz, Cantonal Hospital St. Gallen, Switzerland
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens

Adnan R. Khan, Trinity Biomedical Sciences Institute, Ireland
"The Breg Gets the Worm:" How Helminths Can Shed a Light on Regulatory B Cells

16:30—17:00
Coffee Available

17:00—19:15
B Cell Responses to Foreign Antigens
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection

* Patrick C. Wilson, University of Chicago, USA
B Cell Immunity to Influenza in Humans

Hedda Wardemann, German Cancer Research Center, Germany
B Cell Clonal Selection

Scott D. Boyd, Stanford University, USA
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans

17:00—19:00
Overcoming Challenging Indications for Antibody Therapeutics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Margaret Karow, Amgen Inc., USA

Bruce L. Roberts, Genzyme Corporation, USA
New Insights into the Mechanism of Action of Alemtuzumab

Ronald A. Ignotz, University of Massachusetts Medical School, USA
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice

Andreas Grauer, Amgen, USA
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L and Sclerostin

Ronald B. DeMattos, Lilly Research Laboratories, USA
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 12

07:00—08:00
Breakfast

08:00—11:30
Regulating B Cell Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Intra-Clonal Analysis of B Cell Memory

Carola G. Vinuesa, Australian National University, Australia
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)

* Hai Qi, Tsinghua University, China
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells

Hui Hu, University of Alabama at Birmingham, USA
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation

Andre Ballesteros-Tato, University of Alabama, Birmingham, USA
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2

08:00—11:00
Prophylaxis versus Therapeutic Treatment of Infectious Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael A. Barry, Mayo Clinic, USA

Arturo Casadevall, Albert Einstein College of Medicine, USA
A New Synthesis for Antibody-Mediated Immunity

Deborah C. Molrine, University of Massachusetts Medical School, USA
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination

Charles Ken Stover, MedImmune, LLC, USA
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections

Gene Tan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus

09:20—09:40
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:30—14:30
On Own for Lunch and Recreation

14:30—16:45
Workshop 4: Follicular Helpers and Germinal Center Biology

* Ann M. Haberman, Yale University School of Medicine, USA

* Takaharu Okada, RIKEN, Japan

Simon N. Willis, Walter and Eliza Hall Institute, Australia
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism

Peter Sage, Harvard Medical School, USA
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells

Michela Locci, La Jolla Institute for Allergy and Immunology, USA
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells

Tharu M. Fernando, Weill Cornell Graduate School of Medical Sciences, USA
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance

Seung Goo Kang, The Scripps Research Institute, USA
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs

Florian Weisel, University of Pittsburgh, USA
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

Alexander Gitlin, Rockefeller University, USA
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center

Roy Ramiscal, John Curtin School of Medical Research, Australian National University, Australia
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells

Ziv Shulman, Rockefeller University, USA
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers

14:00—16:30
Workshop 2: When an Antibody Isn’t Enough

* Hilde Revets, Ablynx, Belgium

Barbara S. Fox, Avaxia Biologics, Inc., USA
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract

Anthony B. Cooper, Excelimmune, USA
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics

Rastislav Tamaskovic, University of Zürich, Switzerland
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors

Kipp Weiskopf, Stanford University, USA
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer

Nicholas J. Veomett, Weill Cornell Medical College, USA
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities

14:30—16:30
Workshop 5: B Cell Memory

* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin, Germany

* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Jean-Nicolas Schickel, Yale University, USA
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria

Alexander Frühwirth, Institute for Research in Biomedicine, Switzerland
Identification of a Marker for Recently Activated Memory B Cells

Pierre J. Milpied, The Scripps Research Institute, USA
Intraclonal Analysis of Memory B Cell Functional Plasticity

Justin J. Taylor, Fred Hutchinson Cancer Research Center, USA
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response

Niklas Engels, Georg August University Goettingen, Germany
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells

Tyani D. Chan, Garvan Institute of Medical Research, Australia
Novel Regulatory Control of IgE Antibody Responses

Kathryn A. Pape, University of Minnesota, USA
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells

Kaval Kaur, University of Chicago, USA
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination

16:30—17:00
Coffee Available

17:00—19:15
Germinal Center Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

David M. Tarlinton, Walter and Eliza Hall Institute of Medical Research, Australia
The Impact of Arginine Methylation on B-Cell Responsiveness

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
The Ins and Outs of Germinal Centers: Selection, Generation and Identity

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Germinal Center Biology

* Gabriel D. Victora, Whitehead Institute for Biomedical Research, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers

Roger Sciammas, Houston Methodist Hospital Research Institute, USA
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

17:00—19:15
In vivo Induction of Therapeutic Antibodies for Prophylactic Treatment of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase

Ronald G. Crystal, Weill Medical College of Cornell University, USA
Viral Vectors as Platforms for Anti-Addiction Vaccines

Lelia Delamarre, Genentech, Inc., USA
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells

Seleeke F. Flingai, University of Pennsylvania, USA
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo

Erin Crossey, University of New Mexico, USA
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 13

07:00—08:00
Breakfast

08:00—11:30
Generation of Diversity (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Max D. Cooper, Emory University, USA
Immune System Ontogeny and Phylogeny

David G. Schatz, Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation

Cristina Rada, MRC Laboratory of Molecular Biology, UK
Ig Gene Mutagenesis

Frederick W. Alt, Boston Children's Hospital, USA
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events

* F. Nina Papavasiliou, Rockefeller University, USA
Short Talk: Generation of Diversity: Beyond Genomic Changes

Changchun Xiao, The Scripps Research Institute, USA
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways

Carol E. Schrader, University of Massachusetts, USA
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes

09:20—09:40
Coffee Break

11:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 6: Ig Diversity and Biology of B Cell Tumors

* Eric Meffre, Yale University School of Medicine, USA

Nobuo Sakaguchi, Kumamoto University, Japan
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification

Wai Yen Alfred Lim, MRC Laboratory of Molecular Biology, UK
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line

Xiaohua Wang, Albert Einstein College of Medicine, USA
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation

Amanda C. Drennan, University of Wisconsin-Madison, USA
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma

Virginia G. de Yébenes, Centro Nacional de Investigaciones Cardiovasculares, Spain
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction

Daniel Gadala-Maria, Yale University, USA
Genotyping Methods for Improving Detection of Immunoglobulin Mutations

Adrienne Greenough, Duke University, USA
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome

Sébastien Storck, Institut Necker-Enfants Malades, France
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes

14:00—16:30
Workshop 3: What We Are Learning about Antibody Therapeutics

* Peter Brams, Bristol-Myers Squibb, USA

Fabricio Montalvao, Institut Pasteur, France
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging

Karin A. van Schie, Sanquin Research, University of Amsterdam, Netherlands
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing

Nancy E. Everds, Amgen, Inc, USA
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells

Stefan Barghorn, AbbVie, Germany
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy

Mark J. Kwakkenbos, AIMM Therapeutics, Netherlands
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability

Nathan J. Alves, Indiana University, USA
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)

16:30—17:00
Coffee Available

17:00—19:15
B Cell Cancer Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Modeling B Cell Lymphomagenesis in Mice

Louis M. Staudt, NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas

Riccardo Dalla-Favera, Columbia University, USA
Molecular Genetics of Diffuse Large B Cell Lymphoma

* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma

Uttiya Basu, Columbia University, USA
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome

17:00—19:00
What We've Learned from Antibody Treatment of Inflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Neil Graham, Regeneron Pharmaceuticals, USA

Meena Subramanyam, Biogen Idec, USA
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned

Neil Graham, Regeneron Pharmaceuticals, USA
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor

Thomas A. Waldmann, National Institutes of Health, USA
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BioLegend, Inc. Celgene Corporation

We gratefully acknowledge additional support for this conference from:

MedImmune

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI109612-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676