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This meeting took place in 2014


Here are the related meetings in 2018:
Cell Death, Inflammation and Adaptation to Tissue Stress (A6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Chemistry and Biology of Cell Death (Q6)


Organizer(s) Guy S. Salvesen, Matthew S. Bogyo and Jennie R. Lill
February 18—23, 2014
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 17, 2013
Abstract Deadline: Nov 21, 2013
Scholarship Deadline: Oct 17, 2013
Discounted Registration Deadline: Dec 17, 2013

Sponsored by Genentech, Inc. and Infinity Pharmaceuticals, Inc.


Summary of Meeting:
Cell death can occur through distinct mechanisms, and the signaling pathways leading to these lethal outcomes are becoming established. Although therapeutic strategies targeting specific cell death mediators were introduced over 10 years ago, the breadth of cell death mechanisms should present numerous additional possibilities for drug development. To better understand the Achilles’ heels for targeted therapy, we need to comprehend the chemistry behind cell death paradigms. Coupling the breadth of chemical biology with genetic analysis of cell death pathways in model organisms should provide not only a comprehensive understanding, but reveal tractable targets. This meeting will address the normal regulation and pathogenic dysfunction of distinct cell death modalities, discuss new modalities for therapeutic intervention and highlight chemical biology efforts that are leading to a better understanding of the role that cell death plays in health and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on “Mitochondrial Dynamics and Physiology,” which will share keynote addresses and a plenary session with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 18

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer

WEDNESDAY, FEBRUARY 19

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—10:00
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA

* Rodrigue Rossignol, University of Bordeaux, France

Vishva M. Dixit, Genentech, Inc., USA
Signaling Lessons from Death Receptors: The Inflammasome and Beyond

Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

10:00—10:20
Coffee Break

Sweeney F, Main Level Breakouts
10:20—12:00
Mitochondria and Death (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Sally A. Kornbluth, Duke University Medical Center, USA

* Heidi M. McBride, McGill University, Canada

David W. Andrews, Sunnybrook Research Institute, Canada
Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins

Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway Can Regulate Removal of Impaired Mitochondria by Autophagy

Dhyan Chandra, Roswell Park Cancer Institute, USA
Short Talk: Macromolecular Changes on Mitochondria and their Impact on DNA Damage-Induced Apoptotic Cell Death

Luca Scorrano, University of Padova, Italy
Role of Mitochondrial Dynamics in Embryogenesis

12:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
12:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
Fundamental Death Mechanisms
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Douglas R. Green, St. Jude Children's Research Hospital, USA
Apoptotic and Non-Apoptotic Developmental Cell Death in Mice

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of the BCL-2 Regulated (Mitochondrial) Apoptotic Pathway in Morphogenesis during Mouse Development

Peter E. Czabotar, Walter and Eliza Hall Institute of Medical Research, Australia
Crystal Structures of Bax and Bak Reveal Molecular Events Initiating Apoptosis

17:00—19:00
Mitochondrial Architecture
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* David C. Chan, California Institute of Technology, USA

Nikolaus Pfanner, University of Freiburg, Germany
Biogenesis and Architecture of Mitochondria

Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics

Peter Rehling, University Medical Centre Göttingen, Germany
Biogenesis of Mitochondrial Membrane Protein Complexes

Victoria L. Hewitt, Medical Research Council, UK
Short Talk: The Role of SAM and ERMES Complexes in Candida albicans Mitochondria

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

THURSDAY, FEBRUARY 20

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
07:30—08:00
Poster Setup

Sweeney F, Main Level Breakouts
08:00—19:00
Poster Viewing

Sweeney F, Main Level Breakouts
08:00—11:00
Chemical Biology
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Jennie R. Lill, Genentech, Inc., USA

Mark B. Hampton, University of Otago, New Zealand
Reactive Oxygen Species and Cell Death

Brent R. Stockwell, Columbia University, USA
Probing Cell Death with Small Molecules

Matthew S. Bogyo, Stanford University School of Medicine, USA
A Chemical Biology Approach for the Selective Imaging and Inhibition of Caspases

Sarah H. MacKenzie, North Carolina State University, USA
Short Talk: A Natural Peptide Binds to an Allosteric Site in Caspase-3

Sharan R. Srinivasan, University of Michigan, USA
Short Talk: Allosteric Inhibitor of Hsp70 Reveals its Role at the Intersection of Multiple Cell Death Pathways

Guillaume Lessene, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Novel, Potent and Selective Inhibitors of the Pro-Survival BCL-2 Family Member BCL-XL

08:00—11:00
Mitochondrial Dynamics
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* Jodi Nunnari, University of California, Davis, USA

Heidi M. McBride, McGill University, Canada
The Physiological Implications of Mitochondrial SUMOylation

Gia K. Voeltz, University of Colorado, Boulder, USA
Snapshots of ER-Mediated Mitochondrial Constriction Sites

Henry N. Higgs, Geisel School of Medicine at Dartmouth, USA
A Role for Actin, Formins and Myosin II in Mammalian Mitochondrial Fission

Stefan Strack, University of Iowa, USA
Regulation of Mitochondrial Fission in Neuronal Development and Synaptic Plasticity

Robert A. Screaton, Sunnybrook Research Institute, Canada
Short Talk: Genome-Wide RNAi Screen Identifies ROMO1 as an Essential Redox-Dependent Regulator of Mitochondrial Dynamics

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:00—12:00
Lunch

Sweeney F, Main Level Breakouts
12:00—14:30
Poster Session 2

Sweeney F, Main Level Breakouts
14:30—16:30
Workshop 1: Autophagy and Mitophagy

Sweeney Ballroom D-E
* Lisa M. Lindqvist, Walter and Eliza Hall Institute of Medical Research, Australia
Bcl-2, Bcl-xL and Mcl-1 Are Not Major Regulators of Autophagy

Juliane Cruz Campos, Cedars-Sinai Medical Center, USA
Disrupted Mitochondrial Dynamics and Impaired Autophagy in Heart Failure: Impact of Exercise Training

Isabella Caniggia, Lunenfeld-Tanenbaum Research Institute, Canada
Disruption of Sphingolipid Metabolism Augments Placental Autophagy

Kelly Sullivan, University of Colorado, USA
Mechanisms of p53-Dependent Cell Fate Choice

Aditya Murthy, Genentech, Inc., USA
A Crohn’s Disease Mutation in the Autophagy Gene Atg16L1 Facilitates its Caspase-Mediated Degradation

Gavin Clive Higgins, Baker IDI Heart and Diabetes Institute, Australia
Impaired Mitophagy Activity in Experimental Diabetic Nephropathy

Malle Kuum, University of Tartu, Estonia
Directed Laser Irradiation-Based Method to Study Selective Mitophagy in Neurons

Baris Bingol, Genentech, Inc., USA
DUBs Regulate the Parkin/PINK1 Mitophagy Pathway

14:30—16:30
Workshop 1: Mitochondrial Research and Drug Discovery

Sweeney Ballroom A-C
* Thomas Langer, CECAD Research Center, Germany

Ying Liu, Peking University, China
Endogenous Small Molecule Signals of C. elegans Mitochondrial Dysfunction Couple to the Induction of Detoxification and Pathogen Response Pathways

Bjoern Oettinghaus, University Hospital Basel, Switzerland
Induced Drp1 Ablation in the Adult Mouse Forebrain

Melissa Vos, University of Lübeck, Germany
Stimulation of the Electron Transport Chain as a Possible Therapeutic Strategy for Parkinson’s Disease

Daniel J. Gonzalez-Dunia, Inserm UMR1043, France
Bornavirus X Protein: A New Tool Against Neurodegenerative Disorders?

Simone Caielli, Baylor Institute for Immunology Research, USA
Incomplete Mitophagy in Human Neutrophils Leads to Extrusion of Mitochondrial Nucleoids

Erin Quan Toyama, The Salk Institute for Biological Studies, USA
Identification of MFF as a Direct Substrate for AMPK

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
"Deathomics"
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Matthew S. Bogyo, Stanford University School of Medicine, USA

Jennie R. Lill, Genentech, Inc., USA
Caspase Substrate Discovery

James A. Wells, University of California, San Francisco, USA
Caspase Kinetics

Harris G. Fienberg, Stanford University, USA
Network Rewiring Is Critical for Non-Genetic Resistance to TRAIL

James A. Clulow, Imperial College London, UK
Short Talk: Unravelling the Targets of Electrophilic Natural Products using Quantitative Activity-Based Chemical Proteomics

17:00—19:00
Mitochondria as Signaling Platform
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* Andrew G. Dillin, University of California, Berkeley, USA

Marcia C. Haigis, Harvard Medical School, USA
Mitochondrial Dynamics in Metabolic Adaptation

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
The Mitochondrial Pathway of Antiviral Innate Immune Response

David C. Chan, California Institute of Technology, USA
Molecular Regulation of Mitochondrial Dynamics

Andrea Rasola, Università degli Studi di Padova, Italy
Short Talk: The Mitochondrial Chaperone TRAP1 and Neoplastic Transformation

19:00
On Own for Dinner


FRIDAY, FEBRUARY 21

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Post-Translational Control of Cell Death
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
cIAPs and Sharpin Regulate TNF/MLKL Dependent Necroptotic Cell Death and Developments in Targeting this Axis in Disease

Henning Walczak, University College London, Cancer Institute, UK
New Traits of TRAIL in Cancer

Marion MacFarlane, MRC Toxicology Unit, UK
Death Receptor Mechanisms: The ‘FLIP’ Side of the DISC

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Proteolytic Crosstalk in Cell Death and Survival

Yoshihisa Kaizuka, National Institute for Materials Science, Japan
Short Talk: Signal Protein Clusters in Plasma Membranes Involved in Death Signaling and Adaptive Immunity

08:00—11:00
Quality Control
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* Richard J. Youle, NINDS, National Institutes of Health, USA

Cole M. Haynes, University of Massachusetts Medical School, USA
Coordinating Repair and Regeneration of Defective Mitochondrial via the UPRmt

Jared Rutter, University of Utah, USA
Functionalizing the Unannotated Mitochondrial Proteome

Dario C. Altieri, Wistar Institute, USA
Mitochondrial Chaperones

Koji Okamoto, Osaka University, Japan
Targeting Autophagy for Mitochondrial Clearance

Giovanni Bénard, INSERM, France
Short Talk: Mitochondrial Turnover and Energy Metabolism

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: RIP3/Necroptosis

Sweeney Ballroom D-E
* Kim Newton, Genentech, Inc., USA

Susana L. Orozco, University of Washington, USA
RIPK1 both Positively and Negatively Regulates RIPK3 Oligomerization and Necroptosis.

Carlos F. Lopez, Vanderbilt University, USA
Exploring how Cells Commit to Apoptotic or Necrotic Cell-Death

Francis Ka-Ming Chan, University of Massachusetts Medical School, USA
Necrotic and Non-Necrotic Functions of RIP3 in Injury-Induced Inflammation

Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University, Israel
RIPK1 Regulates Cell Death Driven Systemic Inflammation

Edward S. Mocarski, Emory University, USA
Small Molecule RIP3-Kinase Inhibitor-Induced Apoptosis

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
Death Meets Survival
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Pamela M. Holland, Surface Oncology, USA
Death Receptor Agonists for Cancer: Which Is the Right TRAIL?

Marion C. Bonnet, INSERM U976-Hopital St-Louis, France
Death and Survival of Keratinocytes

Kim Newton, Genentech, Inc., USA
Death by Kinases RIP1 and RIP3

Ben A. Croker, Boston Children's Hospital, USA
Short Talk: Fas Controls Neutrophil Lifespan during Viral Infection and Is Negatively Regulated by TLR and IL-18 Signaling

17:00—19:00
Stem Cells and Development
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* Luca Scorrano, University of Padova, Italy

Jahar Bhattacharya, College of Physicians & Surgeons, Columbia University, USA
Mitochondrial Transfer from Bone-Marrow-Derived Stromal Cells to Pulmonary Alveoli Protects Against Acute Lung Injury

Carla Koehler, University of California, Los Angeles, USA
Correcting Human Mitochondrial Mutations with Targeted RNA Import

Mireille Khacho, University of Ottawa, Canada
Short Talk: Mitochondrial Dynamics in the Regulation of Stem Cell Maintenance and Cell Fate Decisions

Alison M. Burkart, Joslin Diabetes Center, USA
Short Talk: Dissecting Relationships between Insulin Resistance and Mitochondrial Metabolism in Human iPS Cells

Konstanze F. Winklhofer, Physiological Chemistry, Ruhr University Bochum, Germany
Short Talk: Talk Title to be Announced

Michael A. Frohman, Stony Brook University, USA
Roles for the Lipid-Signaling Enzymes MitoPLD and Lipin 1 in Mitochondrial Dynamics, piRNA Biogenesis, and Spermatogenesis

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakouts

SATURDAY, FEBRUARY 22

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Leveraging Model Organisms
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Marion MacFarlane, MRC Toxicology Unit, UK

Eli Arama, Weizmann Institute of Science, Israel
A Mitochondrial-Based Rate-Limiting Mechanism for Caspase Activation during Sperm Differentiation in Drosophila

Hyung Don Ryoo, New York University Langone Medical Center, USA
Regulating the Subcellular Distribution of a Pro-Apoptotic Protein, Hid

Kim McCall, Boston University, USA
Non-Apoptotic Cell Death in Drosophila Oogenesis

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Regulation and Function of Autophagy during Cell Death

Keren Yacobi Sharon, Weizmann Institute of Science, Israel
Short Talk: Germ Cell Death: A Physiological Alternative Cell Death Pathway in Drosophila

Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Short Talk: C. elegans CED-3 Caspase Regulates Centrosome Asymmetry in an Apoptotic Death

08:00—11:00
Environmental Control of Mitochondrial Physiology
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
Andrew G. Dillin, University of California, Berkeley, USA
The Conserved Histone Lysine Demethylase PHF8 Regulates Mitochondrial ETC-Mediated Longevity

* Lluis Fajas, Université de Lausanne, Switzerland
Participation of CDK4 in the Regulation of Mitochondrial Metabolism and Energy Homeostasis

Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Lipid Metabolism, Mitochondria, and Memory T Cell Generation

Christian Frezza, Hutchison/MRC Research Centre, UK
Altered Mitochondrial Metabolism in Cancer

Sameer Kulkarni, Nestlè Institute of Health Sciences SA, Switzerland
Short Talk: Impact of Liver-Specific Deletion of Mfn1 and Mfn2 in Metabolic Health

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:15—17:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Physiology

Sweeney Ballroom A-C
* Cole M. Haynes, University of Massachusetts Medical School, USA

Mariusz Karbowski, Amgen Inc, USA
MARCH5-Dependent Regulation of the OMM-Associated Degradation (OMMAD) Pathway and Mitochondrial Steps in Apoptosis

Adam L. Hughes, University of Utah, USA
An Autophagy-Dependent Pathway for Removal of Individual Proteins from Dysfunctional Mitochondria

Noriyuki Matsuda, Tokyo Metropolitan Institute of Medical Science, Japan
Identification of the Genuine Substrate of PINK1 that Activates Parkin

Christof Osman, University of California, San Francisco, USA
Live-Cell Microscopy of Mitochondrial DNA Suggests a Mechanism for its Inheritance and Distribution

A. Phillip West, Yale University School of Medicine, USA
Altered Mitochondrial DNA Dynamics Elicits a Cell-Intrinsic Antiviral Signaling Program

Atsushi Tanaka, Yamagata University, Japan
Mechanisms and Process of Mitochondrial Collapse in Autophagy-Deficient Mice

Brian Alexander Roelofs, University of Maryland Baltimore, USA
Npl4 Is Required for p97 to Perform Mitochondrial Quality Control Functions

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
Systems Biology and Death Imaging
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom D-E
* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA

Peter Sorger, Harvard Medical School, USA
Measuring and Modeling Receptor Mediated Cell Death

Jessie Ochoa, University of California, Santa Cruz, USA
Short Talk: Cytological Profiling of Natural Products to Identify Modes of Action

Sally A. Kornbluth, Duke University Medical Center, USA
Control of Caspase 2 Activation

Pascal Meier, Institute of Cancer Research, UK
Regulation of the Ubiquitin E3 Ligase cIAP1

17:00—19:00
Mitochondria in Tissue Homeostasis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-C
* Jared Rutter, University of Utah, USA

Eric A. Shoubridge, McGill University, Canada
Posttranscriptional Regulation of Mitochondrial Gene Expression

Rodrigue Rossignol, University of Bordeaux, France
Oncogenic RAS Inhibits the LKB1-AMPK Axis and Repatterns Energy Metabolism

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Mitochondrial Metabolism in Cancer

Dongryeol Ryu, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: SIRT7 Regulates Mitochondrial Homeostasis via the Deacetylation and Activation of GABPbeta1

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment

Sweeney F, Main Level Breakouts

SUNDAY, FEBRUARY 23

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Genentech, Inc. Infinity Pharmaceuticals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Amgen Inc.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Biochemical Society / Biochemical Journal

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676