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This meeting took place in 2014


Here are the related meetings in 2015:
Integrating Metabolism and Tumor Biology (J1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tumor Metabolism (X6)


Organizer(s) William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson
March 16—21, 2014
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 18, 2013
Abstract Deadline: Dec 17, 2013
Scholarship Deadline: Nov 18, 2013
Discounted Registration Deadline: Jan 15, 2014

Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc. Supported by an educational donation provided by Amgen.


Summary of Meeting:
The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. Moreover, it has become apparent that a number of proteins that regulate processes pertinent to cellular transformation, such as enzymes that affect chromatin structure, respond to specific cellular metabolites. Finally, technologies for monitoring cellular metabolism are improving rapidly including technologies that lend themselves to non-invasive imaging. The goals of this meeting are to bring together a diverse group of scientists from academia and industry with basic and translational interests surrounding cancer metabolism. A particular focus will be on metabolic enzymes as potential targets for treating and/or imaging cancer cells. Toward this end this meeting engages a diverse group of scientists including biologists, chemists and engineers. This meeting provides participants with a greater understanding of the language and logic of cellular metabolism and provides a sense of the translational opportunities emerging from our growing knowledge of the role that altered metabolism plays in cancer.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 16

16:00—20:00
Arrival and Registration


MONDAY, MARCH 17

07:00—08:00
Breakfast

08:00—09:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

M. Celeste Simon, HHMI/University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism

Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Acetate Consumption as a Potential Vulnerability of Certain Types of Human Tumors

09:30—09:50
Coffee Break

09:50—12:30
Novel Metabolic Pathways in Cancer I (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Tumor Growth and Survival

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acids, Sugars and Cancer Metabolism

Karen H. Vousden, Beatson Institute for Cancer Research, UK
p53-Pathway Mediated Metabolic Regulation

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Versatility in Cancer Cells

Douglas R. Green, St. Jude Children's Research Hospital, USA
Balancing Act: Caspases and RIP Kinases in Cell Death and Development

12:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:30—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Succinate Dehydrogenase and Fumarate Hydratase
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Patrick J. Pollard, University of Edinburgh, UK
Oncometabolites: Linking Altered Metabolism With Cancer?

Eyal Gottlieb, Cancer Research UK, Beatson Institute, UK
Revealing New Metabolic Networks in FH-Deficient Tumors

Navdeep S. Chandel, Northwestern University, USA
Targeting Mitochondrial Metabolism for Cancer Therapy

Paul-Joseph P. Aspuria, Cedars-Sinai Medical Center, USA
Short Talk: Succinate Dehydrogenase Inhibition Leads to Epithelial-Mesenchymal Transition and Reprogrammed Carbon Metabolism


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00
Metabolism and Angiogenesis: Bidirectional Cross-Talk
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK

Zoltan P. Arany, Beth Israel Deaconess Medical Center, USA
Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes

Massimo Santoro, Vesalius Research Center, Belgium
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells

M. Luisa Iruela-Arispe, University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes

Markus Jabs, German Cancer Research Center, Germany
Short Talk: Notch Signaling Regulates Systemic Energy Metabolism

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 18

07:00—08:00
Breakfast

08:00—11:15
Isocitrate Dehydrogenase
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The von Hippel-Lindau Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer Metabolism

Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Epigenetic Control by Mutant IDH

Elizabeth Maher, University of Texas Southwestern Medical Center, USA
Metabolic Imaging of IDH Mutant Brain Tumors

Katharine Yen, Agios Pharmaceuticals, USA
AG-221 Offers a Survival Advantage in a Primary Human IDH2 Mutant AML Xenograft Model

Christian M. Metallo, University of California, San Diego, USA
Short Talk: Exploiting Oncogenic IDH Mutations to Identify Therapeutic Targets and Annotate Compartmentalized Pathway Function

Yoko Ogawara, National Cancer Center Research Institute, Japan
Short Talk: Critical Roles of the IDH2 Mutation in Development and Maintenance of Acute Myeloid Leukemia


Following Session is for Metabolism and Angiogenesis (X5)

08:00—11:15
Metabolism and Vascular Branching
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* M. Luisa Iruela-Arispe, University of California, Los Angeles, USA

Michael Potente, Max-Planck-Institute for Heart and Lung Research, Germany
Linking Angiogenesis and Metabolism through FOXO Transcription Factors

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Targeting Endothelial Metabolism: Principles and Strategies

Annika Keller, University Hospital Zürich and Uppsala University, Switzerland
Endothelial-Pericyte Signaling and Brain Disease

Kari K. Alitalo, University of Helsinki, Finland
VEGF-B in Metabolic Reprogramming and Cardiovascular Disease

Hilary A. Coller, University of California, Los Angeles, USA
Tumor Stromal Cells

Peter D. Westenskow, The Scripps Research Institute, USA
Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide Erucamide for Maintenance of the Ocular Vasculature

Pengchun Yu, Yale School of Medicine, USA
Short Talk: Regulation of Lymphangiogenesis by FGF Signaling

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Lactate and Monocarboxylate Transporters
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ubaldo E. Martinez Outschoorn, Thomas Jefferson University, USA
Talk Title to be Announced

Jacques Pouysségur, University of Nice, France
Targeting Lactate/H+ Symporters for Cancer Therapy

John Kurhanewicz, University of California, San Francisco, USA
Using in Vivo Hyperpolarized 13C MR Imaging for Measuring Metabolic Fluxes Important to Prostate Cancer Progression and Therapeutic Response

Sunghee Park, Duke University Medical Center, USA
Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled Mitochondrial Oxidative Metabolism in Breast Cancer


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00
Novel Metabolic Pathways in Cancer II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* M. Celeste Simon, HHMI/University of Pennsylvania, USA

James M. Phang, NCI at Frederick, National Institutes of Health, USA
The Proline Regulatory Axis: Metabolic Reprogramming in Cancer

Yury I. Miller, University of California, San Diego, USA
Cholesterol Efflux and Angiogenesis

Natalie Sheng Jie Lim†, National University Singapore, Singapore
Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase Inhibitor and Lysophospholipid Approach

Hwee Ying Lim, National University of Singapore, Singapore
Role of Lymphatic Vessels in Cholesterol Clearance and the Involvement of High-Density Lipoproteins in Regulating Lymphatic Function

Brian W. Wong, Vesalius Research Center, Belgium
Short Talk: Investigating the Metabolism of Venous and Lymphatic Endothelial Cells

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 19

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—19:00
Poster Viewing

08:00—11:15
Metabolism and Epigenetic Enzymes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Lucy A. Godley, University of Chicago, USA
Regulation of Hematopoiesis by 5-Hydroxymethylcytosine

Chuan He, University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation

Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging

Paul Guilhamon, University College London Cancer Institute, UK
Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New Interaction Partner for TET2

Hong-Wu Chen, University of California, Davis, USA
Short Talk: Reprogramming Metabolism for Cancer Therapeutic Resistance by Histone Methylases


Following Session is for Metabolism and Angiogenesis (X5)

08:00—11:15
Metabolism and Anti-Angiogenic Therapy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Dai Fukumura, Massachusetts General Hospital, USA
Vascular Normalization and Metabolic Microenvironment

Patrizia Agostinis, KU Leuven, Belgium
Tumor Vessel Normalization by Chloroquine Independent on Autophagy Blockage

Olivier Feron, UC Louvain, Belgium
Targeting Lactate and Glutamine Metabolism in Endothelial Cells

Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy

Guy Eelen, Vesalius Research Center, KU Leuven, Belgium
Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells Leads to Vessel Branching Defects

Stephanie M. Cossette, Medical College of Wisconsin, USA
Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an AMPK Family Member that Is Essential for Cardiac Metabolism in vivo

09:20—09:40
Coffee Break

11:15—12:00
Lunch

12:00—14:30
Poster Session 3

14:30—16:30
Workshop: Monitoring Metabolism

Hilary A. Coller, University of California, Los Angeles, USA
Metabolism of Quiescent Cells

Linda C. Hsieh-Wilson, California Institute of Technology, USA
The Interplay of Protein Glycosylation and Cancer Metabolism

Alan Saghatelian, Harvard University, USA
Protein-Metabolite Interactions

Sakino Toue, Institute for Innovation, Japan
Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue Chemical Derivatization for Visualizing Multiple Amino Acids in Human Colon Cancer Xenografts

16:30—17:00
Coffee Available

17:00—19:00
Lipid Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Daniel K. Nomura, University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms

Gerald Hoefler, Medical University of Graz, Austria
Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor Gene

Ernst R. Lengyel, University of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes

Jurre J. Kamphorst, CRUK Beatson Institute and University of Glasgow, UK
Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Fatty Acids from Lysophospholipids


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00
Metabolism and Pathological Angiogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Yoshiaki Kubota, Keio University, Japan
Oxidative Stress as a Target for Anti-Angiogenic Therapy

* Michael Simons, Yale University, USA
Vascular Fate Determination

Massimiliano Mazzone, KU Leuven, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer

Tony Walshe, Berg Biosystems, USA
Short Talk: Mitochondrial Oxidative Phosphorylation and Redox Signaling Govern Endothelial Cell Fate Decisions

19:00—
On Own for Dinner


THURSDAY, MARCH 20

07:00—08:00
Breakfast

08:00—11:00
Novel Cancer Metabolic Targets (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Almut Schulze, University of Würzburg, Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

Jonathan Hurov, Agios Pharmaceuticals, USA
Investigation of Glutaminase (GLS1) Dependency in Cancer Cells

Tom O'Brien, Genentech, Inc., USA
and

Peter K. Jackson, Stanford University, USA
Inhibiting Glycolysis with a New LDHA Inhibitor

Brooke M. Emerling, Weill Cornell Medical College, USA
Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases Results in Impaired Growth of p53 Deficient Tumors by Mediating Changes in Metabolism

Kristen E.N. Scott, The Scripps Research Institute, USA
Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is Required for B-Lymphoma Survival

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Novel Cancer Metabolic Targets II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Crosstalk between Metabolic and Signaling Pathways in Cancer

Sandaruwan Geeganage, Eli Lilly and Company, USA
Targeting Metabolic Reprogramming for Cancer – A Pharma Perspective

Nissim Hay, University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00
Metabolism and Angiogenesis: Therapeutic Implications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Massimiliano Mazzone, KU Leuven, Belgium

Sara Zanivan, Beatson Institute for Cancer Research, UK
Elucidating Endothelial Metabolism Using Quantitative Proteomics

Ulrike Harjes, University of Oxford, UK
Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding Protein 4

Miguel Quintela-Fandino, Spanish National Cancer Research Centre, Spain
Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment Plus Phenformin in Breast Cancer

Anuradha Doddaballapur, Institute of Cardiovascular Regeneration, Germany
Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate Endothelial Metabolism by Repressing PFKFB3

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 21

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen Bayer HealthCare Pharmaceuticals
Pfizer Inc. Takeda Pharmaceutical Company Limited
TESARO, Inc.
 

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Seahorse Bioscience, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA183152-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


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