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This meeting took place in 2014



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Frontiers of Structural Biology (Z2)


Organizer(s) Andrew B. Ward and Wayne A. Hendrickson
March 30—April 4, 2014
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 4, 2013
Abstract Deadline: Jan 8, 2014
Scholarship Deadline: Dec 4, 2013
Discounted Registration Deadline: Jan 30, 2014

Supported by the Directors' Fund


Summary of Meeting:
Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure-based drug design. The field of structural biology now operates on a scale from atoms to cells, and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. The goal of this meeting is to connect leaders in the structural biology field, with particular emphasis on novel methods/technology development, highlights of complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high-throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so), the meting highlights innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists who employ a variety of experimental techniques, the meeting should suppor the dissemination of cutting-edge advances and promote interaction among the vibrant international structural biology community.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 30

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


MONDAY, MARCH 31

07:00—08:00
Breakfast

08:00—08:10
Opening Remarks (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Andrew B. Ward, The Scripps Research Institute, USA

08:10—09:10
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Seven Transmembrane Receptors

09:10—12:30
Cutting-Edge Biophysics to Study Membrane Protein Conformational Changes (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Reinhard Grisshammer, NIH/NINDS, Algeria

H. Eric Xu, Van Andel Research Institute, USA
Toward a Structure of Rhodopsin-Arrestin Complex: Challenges in XFEL Data Processing and Structure Solution

Petra Fromme, Arizona State University, USA
Femtosecond Nanocrystallography of Membrane Proteins

Wayne L. Hubbell, University of California, Los Angeles, USA
Site-Directed Spin Labeling Strategies to Explore Conformational Dynamics of GPCRs

Ron O. Dror, Stanford University, USA
Structural Basis for Allosteric Modulation of GPCRs

Martin J. Lohse, Universität Würzburg, Germany
In vivo Studies of GPCR Conformational Changes Using Fluorescence-Based Assays

09:40—10:00
Coffee Break

12:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Advances in Methodologies and Tools for Structural Biology

* Christopher P. Jaroniec, Ohio State University, USA

Andre A. S. T. Ribeiro, Columbia University, USA
Determination of Signaling Pathways in Proteins Through Network Theory

Gydo van Zundert, Utrecht University, Netherlands
Integrative Modeling of Biomolecular Complexes: HADDOCKing with Cryo-EM Data

Peter K. Kasson, University of Virginia, USA
And Yet it Moves: Molecular Simulation Combined with Spectroscopic Methods to Probe Dynamic Function

Wyatt Strutz, NanoTemper Technologies, USA
Some like it Hot: Determination of Biomolecular Interactions Using MicroScale Thermophoresis

Matteo Dal Peraro, École Polytechnique Fédérale de Lausanne (EPFL)
Unveiling the Structure of Pathogenic Macromolecular Machines Using Integrative Dynamic Modeling

Yuba R. Bhandari, National Cancer Institute, USA
Three-Dimensional Structure Determination of Large RNAs Using Small-Angle X-Ray Scattering

14:30—16:30
Workshop 1

* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

James H. Felce, University of Oxford, UK
GPCR Family Structure - Explained by Receptor Organisation?

Marta Filizola, Icahn School of Medicine at Mount Sinai, USA
Associations between G Protein-Coupled Receptors in an Explicit Membrane Investigated by Massive Molecular Dynamics Simulations

Kim C. Jonas, Imperial College London, UK
Single Molecule Analysis of GPCR Transactivation via PD-PALM Reveals Oligomeric Complexes that Regulate Signal Sensitivity

Christoph Klenk, University of Zurich, Switzerland
A Generic System for Increased Expression and Stabilization of G Protein-Coupled Receptors by Directed Evolution

Aashish Manglik, Stanford University, USA
Leveraging Combinational Biology Methods to Understand GPCR Function

Susmith Mukund, Genentech, USA
Probing Mechanisms of Glucagon Receptor Inhibition by Antibodies

Dimitrios Stamou, Bionanotechnology and Nanomedicine Laboratory, Denmark
Single-Molecule Conformational Dynamics and Direct Observation of Multiple GPCR Dimerization Interfaces

16:30—17:00
Coffee Available

17:00—19:15
Utilizing Next Generation Technologies for Structural Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kurt Wüthrich, ETH Zürich / The Scripps Research Institute, Switzerland

Aled M. Edwards, University of Toronto, Canada
Structural Genomics in Aid of Drug Discovery

David P. Marciano, The Scripps Research Institute, USA
Short Talk: Rational Design of Novel PPARG Modulators with HDX

Ian A. Wilson, The Scripps Research Institute, USA
Multidisciplinary Approaches for Tackling Challenging Problems in Human Health and Disease

Wayne A. Hendrickson, Columbia University, USA
Diversity of Transmembrane Ion Channels Explored in a Structural Genomics Approach

Dmitry Lyumkis, The Scripps Research Institute, USA
Short Talk: Direct Detectors and Single Particle Dissection of Conformational and Compositional Heterogeneity

17:00—19:15
Family C and Frizzled GPCRs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Brian K. Kobilka, Stanford University School of Medicine, USA

Jean-Philippe Pin, Montpellier University, France
Structural Dynamics of Metabotropic Glutamate Receptors

Robert Lütjens, Addex Therapeutics, Switzerland
Discovery of Allosteric Modulators of Metabotropic Glutamate Receptors

Gunnar Schulte, Karolinska Institutet, Sweden
New Insights into Frizzled Signaling through Heterotrimeric G Proteins

Vadim Cherezov, The Scripps Research Institute, USA
Structural Basis of Small Molecule Recognition by the Human Smoothened (Class Frizzled) 7TM

19:15—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, APRIL 1

07:00—08:00
Breakfast

08:00—11:00
Structural and Functional Insights through the Use of Hybrid Methods
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA

Gregory Alushin, NHLBI, National Institutes of Health, USA
Hybrid Approaches to Define the Effect of GTP Hydrolysis and Taxol Binding on Microtubule Structure and Stability

Susan S. Taylor, University of California, San Diego, USA
PKA: Assembly of Dynamic Isoform-Specific Macromolecular Signaling Complexes

Kurt Wüthrich, ETH Zürich / The Scripps Research Institute, Switzerland
Solution NMR Studies of GPCR Conformational Polymorphisms and Function-Related Rate Processes

Ponni Rajagopal, University of Washington, USA
Short Talk: Hybrid Methodologies for Elucidating Structure and Function of a Chaperone

08:00—11:15
Family B GPCRs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Brigitte L. Kieffer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France

Kaspar Hollenstein, Heptares Therapeutics, UK
Using Conformational Thermostabilization to Determine the Structures of Class B G Protein-Coupled Receptors

Patrick M. Sexton, Monash University, Australia
GLP1 Receptor Signaling in Response to Peptides and Allosteric Modulators

Kathleen M. Caron, University of North Carolina at Chapel Hill, USA
Role of RAMPs in Disease

Jean-Pierre Vilardaga, University of Pittsburgh, USA
GPCR in Noncanonical Signaling Mode

Maria H. Pedersen, Institute for Neuroscience and Pharmacology, Denmark
Short Talk: Free Fatty Acid Receptor FFAR1/GPR40 - Combined Gq and Gs Signaling Mediates Hormone Secretion by Ago-Allosteric Super-Agonists

Minyoung Park, Rockefeller University, USA
Short Talk: Site-Specific Labeling on Ghrelin Receptor via Genetically-Encoded Unnatural Amino Acid

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Benjamin R. Myers, Stanford University School of Medicine, USA
Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the 7TM Oncoprotein Smoothened

Tony Ngo, Victor Chang Cardiac Research Institute, Australia
N-Terminal Metalloprotease Processing Regulates Trafficking and Function of the Orphan G Protein-Coupled Receptor, GPR37L1

Whitney M. Nolte, Pfizer, USA
A Small Molecule Potentiator of Orthosteric Ligand Activity at the Glucagon-Like Peptide-1 Receptor Acts through Covalent Modification

M. Flori Sassano, University of North Carolina, USA
An Open-Source Platform for the Remarkably Facile Genome-Wide Interrogation of the Druggable GPCR-ome

Silvia Sposini, Imperial College London, UK
Post-Endocytic Sorting of the Luteinizing Hormone Receptor is Mediated by a Novel APPL1-Dependent Mechanism

Amantha Thathiah, Catholic University of Leuven, Belgium
GPCR Signaling Dysfunction in Alzheimer’s Disease

Nagarajan Vaidehi, City of Hope National Medical Center, USA
Insights into Thermostability of G-protein Coupled Receptors

16:30—17:00
Coffee Available

17:00—19:00
Structural Biology of Cellular Processes and Complexes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susan S. Taylor, University of California, San Diego, USA

Christopher P. Jaroniec, Ohio State University, USA
Structural and Dynamic Studies of Protein Assemblies by Solid State NMR Spectroscopy

Tatyana Polenova, University of Delaware, USA
Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies by MAS NMR Spectroscopy

Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA
Structure-Function Studies of Cytosolic DNA Sensors Governing the Interferon Response

Nathan D. Thomsen, University of California, San Francisco, USA
Short Talk: Reading between the Lines: Trapping Transient Protein Conformers for Structural Analysis, Functional Proteomics and Therapeutic Discovery

17:00—19:00
New Insights into GPCR Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Roger K. Sunahara, University of Michigan Medical School, USA

Arthur Christopoulos, Monash University, Australia
Orthosteric and Allosteric Ligand Biased Signaling

Vsevolod V. Gurevich, Vanderbilt University, USA
Arrestin Shape-Shifting and Design of Signaling-Biased Mutants

John J.G. Tesmer, University of Michigan, USA
Structure and Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

Kamila M. Skieterska, Ghent University, Belgium
Short Talk: Non-Degradative and Non-Lysine Mediated Ubiquitination of the Dopamine D4 Receptor

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, APRIL 2

07:00—08:00
Breakfast

08:00—11:00
Advances in Membrane Protein Structure Solution
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John Briggs, European Molecular Biology Laboratory, Germany

Liz Carpenter, University of Oxford, UK
Structural Genomics of Human Membrane Proteins has Given Diverse Insights into ABC Transporter Function (ABCB10), Premature Aging (ZMPSTE24) and Channel Conformations (TREK-2)

Claus J. Loland, University of Copenhagen, Denmark
Short Talk: Investigating Conformational Changes in a Neurotransmitter Transporter Homologue with Transition Metal-Ion FRET

Andrew B. Ward, The Scripps Research Institute, USA
Structural Studies of Viral Envelope Proteins

Jennifer L. Johnson, Georgia Institute of Technology, USA
Short Talk: The Development of Engineered Crystallization Chaperones to Promote Membrane Protein Crystallization

John Rubinstein, University of Toronto, Canada
Electron Cryomicroscopy of Rotary ATPases

08:00—11:15
Activation of GPCRs and G Proteins
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Martin J. Lohse, Universität Würzburg, Germany

Mark von Zastrow, University of California, San Francisco, USA
GPCR Signaling from Endosomes

Andrew B. Tobin, University of Leicester, UK
Novel Animal Models to Define GPCR Therapeutic Potential

Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
The Structural Basis for Ligand Efficacy in the Beta1-Adrenoceptor

Roger K. Sunahara, University of Michigan Medical School, USA
The Mechanism of G Protein Activation through Interactions with GPCRs and How Nucleotide Release from G Proteins in Turn Allosterically Modulates Ligand Binding at the Orthosteric Site

Alexey Bondar, University of South Bohemia in Ceske Budejovice, Czech Republic
Short Talk: In vivo Imaging and Quantitation of Interactions between Gi/o Protein Subunits and GPCRs by Two-Photon Polarization Microscopy

Susanne Nuber, University of Würzburg, Germany
Short Talk: FRET Based beta-Arrestin2 Biosensors Reveal Receptor Specific Conformational Movements in Real Time and Living Cells

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: High-Throughput and Integrative Structural Biology

* Marc A. Elsliger, The Scripps Research Institute, USA
The Joint Center for Structural Genomics – A PSI:Biology Center for High-Throughput Structure Determination

Kelly Kai Li Hew, Nanyang Technological University, Singapore
Systems Structural Biology on Human Herpesviruses

Jürgen Haas, Swiss Institute of Bioinformatics, Switzerland
The ProteinModelPortal - How Good Is My Prediction? –First Results from the Continuous Automated Model EvaluatiOn (CAMEO)

Allyn J. Schoeffler, Genentech, USA
The Dynamics of cIAP1 Are Precisely Tuned for Rapid Activation

Ekaterina V. Filippova, Northwestern University, USA
Functional and Structural Characterization of GNAT Family of Acetyltransferases

Jeong Hyun Lee, The Scripps Research Institute, USA
Rapidly Uncovering New Epitopes on Viral Envelope Glycoproteins Using EM

Lenore Sparks, European Molecular Biology Laboratory, Germany
Positioning the Nup214 Subcomplex and Nup358 into the Human Nuclear Pore Complex

Peter S. Lee, The Scripps Research Institute, USA
Head Hunting: Targeting the Influenza Hemagglutinin Receptor Binding Site

16:30—17:00
Coffee Available

17:00—19:00
Advances in Imaging Cellular Structure
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Andrew B. Ward, The Scripps Research Institute, USA

Carolyn A. Larabell, University of California, San Francisco, USA
Correlated Fluorescence and X-Ray Tomography of Nuclear Organization and Chromatin Topology

John Briggs, European Molecular Biology Laboratory, Germany
Determining Structures in situ – Advances in Subtomogram Averaging and in Correlative Light/Electron Microscopy

Erik M. Jorgensen, University of Utah, USA
Flash-and-Freeze Electron Microscopy Reveals Dynamic Cellular Events

17:00—19:00
Targeting GPCRs in Cancer and Inflammation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Patrick M. Sexton, Monash University, Australia

Xavier J. Leroy, Actelion Pharmaceuticals Ltd, Switzerland
FPR2 Agonists in Inflammatory Disease

Michael Hanson, Receptos Inc., USA
S1P1 Receptor Structure and Ligand Analysis

Suzie Chen, Rutgers University, USA
Metabotropic Glutamate Receptor Signaling in Cancer

Sophie J. Bradley, MRC Toxicology Unit, UK
Short Talk: Targeting Muscarinic Receptors Rescues the Cognitive Deficit in Prion Neurodegenerative Disease in Mice

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, APRIL 3

07:00—08:00
Breakfast

08:00—11:00
Extending Structural Knowledge through Informatics and Modeling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ian A. Wilson, The Scripps Research Institute, USA

Peter D. Kwong, NIAID, National Institutes of Health, USA
Informatics and Structure in Vaccine Design

Jens Meiler, Vanderbilt University, USA
Modeling Membrane Proteins from Limited Experimental Data

Andrej Sali, University of California, San Francisco, USA
Integrative Structural Biology

Paul Robustelli, Columbia University, USA
Short Talk: Tuning the Conformational Dynamics and Enzymatic Activity of Ribonuclease H

Julien R. C. Bergeron, University of British Columbia, Canada
Short Talk: Architecture and Assembly of the Type 3 Secretion System Basal Body

08:00—11:15
Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Arthur Christopoulos, Monash University, Australia

Brigitte L. Kieffer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
In vivo Signaling of Opioid Receptors

Sebastien Granier, Institut de Génomique Fonctionnelle, France
Opioid Receptor Structural Pharmacology

Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Structure-Based Drug Discovery Applied to CNS GPCRs

Gustavo Fenalti, The Scripps Research Institute, USA
Short Talk: Molecular Control of Delta-Opioid Receptor Signaling

David M. Thal, Monash Institute of Pharmaceutical Sciences, Australia
Short Talk: Structural Studies of the M4 Muscarinic Acetylcholine Receptor

A.J. Venkatakrishnan, MRC Laboratory of Molecular Biology, UK
Short Talk: Decoupled Modules of Atomic Contacts Mediate Stability and Orchestrate Activation of GPCRs

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—18:15
Applications of Computation and Design
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jens Meiler, Vanderbilt University, USA

William F. DeGrado, University of California, San Francisco, USA
Analysis and Design of Proton Transporters

Todd Yeates, University of California, Los Angeles, USA
Engineering Self-Assembling Protein Materials: Design Principles and Applications

17:00—18:15
Structure and Dynamics of GPCRs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Reinhard Grisshammer, NIH/NINDS, Algeria
Structure of the Agonist-Bound Neurotensin Receptor NTS1

Vsevolod Katritch, The Scripps Research Institute, USA
Structures of the Major Antithrombotic Target P2Y12R Provide Key Insights into Function and Pharmacology of Purinergic GPCRs

18:15—19:15
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Brian K. Kobilka, Stanford University School of Medicine, USA
Structural Insights into G Protein Coupled Receptor Signaling

19:15—19:30
Concluding Remarks (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Andrew B. Ward, The Scripps Research Institute, USA

19:30—20:30
Social Hour

20:00—21:00
Lite Bites

20:00—23:00
Entertainment


FRIDAY, APRIL 4

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


New Era Enterprises, Inc.

Bruker Corporation FEI Company
ISOTEC, a member of the Sigma-Aldrich Group
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM109390-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Keio University School of Medicine


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Cells Tissues Organs

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2668

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