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Resort at Squaw Creek Floorplan

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This meeting took place in 2014



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Stem Cells and Reprogramming (Z4)


Organizer(s) Deepak Srivastava and Shinya Yamanaka
April 6—11, 2014
Resort at Squaw Creek • Olympic Valley, California USA
Discounted Abstract Deadline: Dec 10, 2013
Abstract Deadline: Jan 15, 2014
Scholarship Deadline: Dec 10, 2013
Discounted Registration Deadline: Feb 6, 2014

Sponsored by California Institute for Regenerative Medicine (CIRM), Life Technologies Corporation, Novartis Institutes for BioMedical Research, Sangamo BioSciences, Inc. and Vertex Pharmaceuticals Incorporated.


Summary of Meeting:
The fields of developmental and stem cell biology have revealed complex networks that regulate fundamental cell fate decisions. Such information was leveraged first to reprogram cells to induced pluripotent stem cells, and more recently to induce cell fate transitions from one somatic cell state directly into another, without involving a pluripotent stem cell phase. This conference will focus on the mechanisms underlying cellular pluripotency, differentiation, and reprogramming. These will include the understanding of signaling, transcriptional, translational and epigenetic events regulating cell fate transitions. The utility of such cellular regulation for disease modeling and regenerative medicine for multiple organ systems will be examined. Translational efforts in academic and industry that are moving toward regenerative medicine will be highlighted, as will efforts to use stem cell biology for drug discovery and evaluating drug toxicity. The emerging intersection of human genetics and stem cell biology that will lead to more personalized medicine will be a thematic focus woven into most sessions of this conference.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 6

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


MONDAY, APRIL 7

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Karl Deisseroth, Stanford University, USA

09:00—09:30
Coffee Break

09:30—11:45
Regulation of Pluripotency I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

John B. Gurdon, University of Cambridge, UK
Transcriptional Reprogramming by Amphibian Eggs and Oocytes

Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco
Recent Progress in iPS Cell Research and Application

Austin G. Smith, University of Cambridge, UK
Ground-State Pluripotency

Bryce W. Carey, Rockefeller University, USA
Short Talk: Metabolism Links Self-Renewal to Chromatin Regulation in Naïve Pluripotency

Carol F. Webb, Oklahoma Medical Research Foundation, USA
Short Talk: ARID3a Acts as a Barrier to Reprogramming by Repressing Human Oct4 Transcription


Following Session is for Engineering Cell Fate and Function (Z3)

09:30—11:45
Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeffrey A. Hubbell, École Polytechnique Fédérale de Lausanne, Switzerland

Jeffrey Karp, Brigham and Women's Hospital, Harvard Medical School, USA
Towards Bioengineered Control of Cell Fate Post-Transplantation

Darrell J. Irvine, Massachusetts Institute of Technology, USA
Engineering T Cells for Cancer and Infectious Disease

Ana I. Teixeira, Karolinska Institutet, Sweden
Short Talk: Spatial Control of Membrane Receptor Function Using Ligand Nano-Calipers

Armon Sharei, Harvard Medical School, USA
Short Talk: Engineering Immune Cell Function Using a Vector-Free Intracellular Delivery Platform

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

* Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco

Marina Bershteyn, University of California, San Francisco, USA
Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells

Chulan Kwon, Johns Hopkins University, USA
Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors

Wenze Niu, University of Texas Southwestern Medical Center, USA
Stepwise Conversion of Striatal Astrocytes to Neuroblasts and Mature Neurons in vivo

Siim Pauklin, Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, UK
Cell Fate Propensity Depends on the Cell Cycle State of the Stem Cell

Abdenour Soufi, University of Pennsylvania, USA
Nucleosome-Binding Affinity as a Primary Determinant of the Pioneer Activity of Reprogramming Factors

Nadja Zeltner, Memorial Sloan-Kettering Institute, USA
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia

Joel W. Blanchard, The Scripps Research Institute, USA
Induction of Somatic Sensory Neural Lineage from Human and Mouse Fibroblasts

16:30—17:00
Coffee Available

17:00—19:00
Regulation of Pluripotency II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Austin G. Smith, University of Cambridge, UK

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
iPS Cell Technology, Gene Editing and Disease Research

Robert H. Blelloch, University of California, San Francisco, USA
Alternative Paths to Induced Pluripotency as Defined by Two MicroRNA Loci

Kathrin Plath, University of California, Los Angeles, USA
Insights into Reprogramming to Pluripotency

Ori Bar-Nur, Harvard University, USA
Short Talk: Small Compounds Facilitate Rapid and Synchronous Reprogramming of Somatic Cells into iPS Cells by Defined Factors


Following Session is for Engineering Cell Fate and Function (Z3)

17:00—19:00
From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell Interactions in Systems)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jennifer Elisseeff, Johns Hopkins University, USA

Shulamit Levenberg, Technion - Israel Institute of Technology, Israel
Cell Organization into 3D Tissue Structures

Peter W. Zandstra, University of Toronto, Canada
Engineering Pluripotent Stem Cell Fate to Enable Human Cell- and Tissue-Based Drug Screening and Development

Nathan Palpant, University of Washington School of Medicine, USA
Short Talk: In vitro Titration of Wnt/beta-Catenin Signaling Enables Efficient Fate Specification of Lateral Plate Mesoderm Derivatives

Helen M. Blau, Stanford University, USA
Synergy of Biochemical and Biophysical Cues Rejuvenates the Aged Stem Cell Population which Restores Strength to Aged Muscles

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, APRIL 8

07:00—08:00
Breakfast

08:00—11:15
Direct Reprogramming (Transdifferentiation)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Helen M. Blau, Stanford University, USA

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Reprogramming Approaches for Cardiovascular Disease

Marius Wernig, Stanford University School of Medicine, USA
Direct Lineage Reprogramming toward the Neural Lineage

Gong Chen, Pennsylvania State University, USA
Direct Neural Reprogramming in vivo for Brain Repair

Sheng Ding, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
A Chemical Approach to Controlling Cell Fate

Eva C. Thoma, Hoffmann-La Roche AG, Switzerland
Short Talk: Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

Yi-Ju Chen, University of Pennsylvania, USA
Short Talk: De novo Formation of Insulin-Producing “Neo-Beta-Cell Islets” from Intestinal Crypts


Following Session is for Engineering Cell Fate and Function (Z3)

08:00—11:15
Redirecting Natural Processes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Samuel I. Stupp, Northwestern University, USA

David J. Mooney, Harvard University, USA
Biomaterials to Control Immune Cell Trafficking and Activation

Jeffrey A. Hubbell, École Polytechnique Fédérale de Lausanne, Switzerland
Molecular Engineering of Growth Factor – ECM Interactions

Eric Lagasse, University of Pittsburgh, USA
Growing a Surrogate Organ in Lymph Node: From an Experimental Approach to Potential Cinical Applications

Jennifer Elisseeff, Johns Hopkins University, USA
Biomaterial Approaches for Controlling Cell Function and Healing Processes

Zhen Ma, University of California, Berkeley, USA
Short Talk: Biophysical Cues for Spatially Differentiating Human Induced Pluripotent Stem Cells into Cardiac Lineage

Gustavo P. Garlet, São Paulo University, Brazil
Short Talk: Tregs Chemoattraction Triggers the Redirecting of MSCs Toward a Pro-Reparative and Pro-Immunosuppressive Phenotype that Actively Contributes to Experimental Periodontitis Attenuation

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Epigenetics of Reprogramming and Differentiation. Session sponsored by Development.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Support for these organizer-selected speakers generously provided by this journal.

* Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Epigenetic Landscape of Pluripotent Stem Cells

Joanna Wysocka, Stanford University School of Medicine, USA
Enhancer Landscapes in Pluripotency and Differentiation

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Epigenetic Regulation of Cardiac Lineage Development

Alessandro Bertero, University of Cambridge, UK
Short Talk: Activin Signaling Controls the Epigenetic Landscape of Human Pluripotent Stem Cells


Following Session is for Engineering Cell Fate and Function (Z3)

17:00—19:15
Models of Human Tissues - Healthy and Diseased
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jason A. Burdick, University of Pennsylvania, USA

Melody A. Swartz, Swiss Federal Institute of Technology, Switzerland
Manipulating Lymphatic Endothelial Cells for Immunomodulation

Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Microengineered Human Organs on Chips

Claudia Fischbach-Teschl, Cornell University, USA
Engineering Meets Cancer Biology: Experimental Models of Tumor Angiogenesis and Metastasis

Fiona M. Watt, King's College London School of Medicine, UK
Examining the Interactions between Keratinocytes and their Niche in Normal Epidermis and in Tumors

19:00—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, APRIL 9

07:00—08:00
Breakfast

08:00—11:15
Modeling of Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Hideyuki Okano, Keio University School of Medicine, Japan

Fred H. Gage, The Salk Institute for Biological Studies, USA
Modeling of Complex Neurologic Disease

Adam Rosenthal, iPierian, Inc., USA
iPSC Models of Alzheimer's Disease: From Platform to Therapeutic Candidate

Clive N. Svendsen, Cedars-Sinai Regenerative Medicine Institute, USA
Modeling Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD) Using iPS Cells

Lior Gepstein, Technion-Israel Institute of Technology, Israel
Modeling of Inherited Cardiac Disorders Using Induced Pluripotent Stem Cells

A. Sophie de Boer, Harvard University, USA
Short Talk: Genetic Validation of a Therapeutic Target Derived from a Stem Cell Model of ALS

Chun-Li Zhang, University of Texas Southwestern Medical Center, USA
Short Talk: Modeling Human Disease by Using Fibroblast-Converted Functional Motor Neurons


Following Session is for Engineering Cell Fate and Function (Z3)

08:00—11:00
In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David J. Mooney, Harvard University, USA

Daniel G. Anderson, Massachusetts Institute of Technology, USA
Combinatorial Development of Biomaterials for Cellular Delivery

Jason A. Burdick, University of Pennsylvania, USA
Engineering Cardiac Tissue Response Post-Infarction through Biomaterial Design

Samuel I. Stupp, Northwestern University, USA
Signaling and Targeting Cells with Extracellular Supramolecular Structures

Joseph T. Rodgers, Stanford University, USA
Short Talk: Harnessing Physiologic Responses by Quiescent Stem Cells to Improve Wound Repair and Tissue Regeneration

Yubing Sun, University of Michigan, Ann Arbor, USA
Short Talk: Biophysical Regulation of Functional Motor Neuron Generation from Human Pluripotent Stem Cells

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Clinical Progress for Stem Cell Therapies. Organized in collaboration with California Institute for Regenerative Medicine (CIRM)

* Ellen Feigal, California Institute for Regenerative Medicine - CIRM, USA

Eva L. Feldman, University of Michigan, USA
Intraspinal Stem Cell Transplantation in ALS: Results of a Phase I Clinical Trial

Robert Lanza, Advanced Cell Technology, USA
ES- and iPS-Derived Cells for Clinical Trials

Philip D. Gregory, Sangamo BioSciences, Inc., USA
Genome Editing with Zinc Finger Nucleases: A Novel Apporach to HIV Therapy

Kevin A. D'Amour, ViaCyte, Inc., USA
Development of an Encapsulated Stem Cell-Based Therapy for Diabetes

Tracy C. Grikscheit, Children's Hospital Los Angeles, USA
Defining the Function of Tissue-Engineered Intestine Generated from Human Postnatal Progenitor Cells in a Murine Model

16:30—17:00
Coffee Available

17:00—19:15
iPS Models of Disease (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christopher S. Chen, Boston University, USA

Lorenz Studer, Memorial Sloan-Kettering Cancer Center, USA
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia

George Q. Daley, HHMI/Children's Hospital Boston, USA
Dissecting Reprogramming, Differentiation and Conversion with Network Biology

Sangeeta N. Bhatia, Massachusetts Institute of Technology, USA
Disease Modeling of Human Hepatotropic Infections in iPS Cells

Mo A. Mandegar, University of California, San Francisco, USA
Short Talk: Cardiac Disease Modeling Using Engineered Human iPS Cell-Derived Cardiomyocytes

Michela Deleidi, DZNE, Germany
Short Talk: Modeling GBA1-Associated Parkinson's Disease Using Patient iPSCs Reveals Defects in the Lysosomal Machinery and Calcium Homeostasis

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, APRIL 10

07:00—08:00
Breakfast

08:00—11:15
Translational Applications of Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Fred H. Gage, The Salk Institute for Biological Studies, USA

Hideyuki Okano, Keio University School of Medicine, Japan
Modeling Neurological and Psychiatric Disorders Using iPSCs Technologies and Transgenic Non-Human Primates

Masayo Takahashi, RIKEN Center for Developmental Biology, Japan
Retinal Cell Therapy Using iPS Cells

Leonard I. Zon, HHMI/Children's Hospital Boston, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment

Lei (Stanley) Qi, University of California, San Francisco, USA
Short Talk: Engineering of the Genome Using CRSPR Technology

Christina Theodoris, University of California, San Francisco, USA
Short Talk: iPSC-based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Calcific Aortic Valve Disease


Following Session is for Engineering Cell Fate and Function (Z3)

08:00—11:15
Engineering Mammalian Cells with Synthetic Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Darrell J. Irvine, Massachusetts Institute of Technology, USA

Ron Weiss, Massachusetts Institute of Technology, USA
Synthetic Biology: From Parts to Modules to Therapeutic Systems

Patrick D. Hsu, Broad Institute of MIT and Harvard, USA
Genome Engineering: Technologies and Applications

Wendell A. Lim, University of California, San Francisco, USA
Exploring and Exploiting the Design Principles of Cell Signaling Networks

Martin Fussenegger, ETH Zürich, Switzerland
Prosthetic Networks – Synthetic Biology-Inspired Treatment Strategies for Metabolic Disorders

Victor D. Fedorov, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: iCARs: Novel Engineered Cell-Intrinsic Safety Switches for Prevention of Immunotherapy Toxicities

Samantha A. Morris, Boston Children's Hospital, USA
Short Talk: Enhancing Cellular Engineering through Network Biology

09:20—09:40
Coffee Break

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sangeeta N. Bhatia, Massachusetts Institute of Technology, USA

Christopher S. Chen, Boston University, USA
Mechanoregulation: Linking Adhesion, Force, Form and Function

Jennifer A. Lewis, Harvard University, USA
3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

Kristi S. Anseth, HHMI/University of Colorado, USA
Phototunable Hydrogels as Dynamic Cell Niches

Helen M. Blau, Stanford University, USA
Short Talk: Rejuvenated Muscle Stem Cell Population Increases Strength in Aged Muscles

Haiyang Chen, Carnegie Institution for Science, USA
Short Talk: Nuclear Lamina Regulates Stem-Cell Niche Organization through Integration Nuclear Structure and EGFR Signaling

19:15—20:15
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, APRIL 11

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

California Institute for Regenerative Medicine (CIRM) Life Technologies Corporation
Novartis Institutes for BioMedical Research Sangamo BioSciences, Inc.
Vertex Pharmaceuticals Incorporated
 

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Development, The Company of Biologists Ltd
eLife
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Center for Advancing Translational Sciences (NCATS)

Grant No. 1R13HD079122-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Sangamo BioSciences, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2668

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