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This meeting took place in 2015



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Endoderm Lineages in Development and Disease (B2)


Organizer(s) Lori Sussel, Hans-Willem E. Snoeck, James M. Wells and Aaron M. Zorn
February 8—13, 2015
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 7, 2014
Abstract Deadline: Nov 11, 2014
Scholarship Deadline: Oct 7, 2014
Discounted Registration Deadline: Dec 8, 2014

Supported by the Directors' Fund

Summary of Meeting:
The endoderm gives rise to a vast array of highly specialized epithelial cell types lining the respiratory and gastrointestinal tracts and contributes to associated organs such as the thyroid, thymus, lungs, liver, biliary system and pancreas. Basic studies of endoderm organ development and postnatal function have revealed the molecular basis of human congenital diseases, identified new regenerative pathways and made it possible to grow endoderm organ tissues in vitro. While endoderm organs vary in their form and function, there are many shared mechanisms that govern the development and homeostasis of these organs. This Keystone Symposia meeting will highlight recent advances in our understanding of endoderm organ development during embryogenesis and how this knowledge has led to successful efforts at generating human endoderm organ cells and tissues from pluripotent stem cells. It brings together researchers who span the different endoderm organ systems to compare and contrast molecular mechanisms, experimental approaches and new approaches for translating basic research. Discussions will focus on how success in one organ might be duplicated in other organ systems.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 8

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, FEBRUARY 9

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Hans-Willem E. Snoeck, Columbia University Medical Center, USA

Brigid L. M. Hogan, Duke University Medical Center, USA
Development, Maintenance and Repair of the Lung

09:00—11:15
Endoderm Formation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Heiko Lickert, Institute of Diabetes and Regeneration, Germany

Kat Hadjantonakis, Sloan-Kettering Institute, USA
Cell Dynamics and the Emergence of Endoderm in the Early Mouse Embryo

Kyra A. Campbell, Institute of Research in Biomedicine, Spain
Short Talk: The Precise Cellular Behaviors Orchestrated by GATA Factor Activity during Endoderm Formation in Drosophila

Ken W.Y. Cho, University of California, Irvine, USA
Genome-Wide View of the Early Xenopus Endoderm Regulatory Program

Ludovic Vallier, Wellcome Trust Sanger Institute, UK
Cell Cycle Controls Endoderm Specification of Human Pluripotent Stem Cells

09:40—10:00
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Endoderm Patterning
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Elizabeth J. Robertson, University of Oxford, UK

Aaron M. Zorn, Cincinnati Children's Hospital Medical Center, USA
Endoderm Patterning and Early Organogenesis

Francesca M. Spagnoli, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Control of Cellular Plasticity between Liver and Pancreas

Lori Sussel, University of Colorado, USA
Induction and Maintenance of Pancreatic Endoderm

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Novel Players in Pancreas Formation and Function

Allen Wang, University of California, San Diego, USA
Short Talk: A Poised Enhancer Landscape Is Indicative of Developmental Competence during Endodermal Lineage Diversification of Human Embryonic Stem Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, FEBRUARY 10

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Organ Induction
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Nancy R. Manley, University of Georgia, USA

Susan E. Mango, Harvard University, USA
Higher-Order Organization of the Nucleus as Embryos Transition from Developmental Plasticity to Differentiation

Clare C. Blackburn, University of Edinburgh, UK
Inducing a Thymus in vivo, and in vitro

John M. Shannon, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Specification of Respiratory Endoderm Occurs Early in Embryogenesis

Elke A. Ober, University of Copenhagen, Denmark
Cell-Cell Interactions Controlling Liver Bud Morphogenesis

Li Chen, University of Houston, USA
Short Talk: A Molecular Switch Regulating Pancreatic and Heart Development

Wellington V. Cardoso, Columbia University Medical Center, USA
Hippo-Yap Control of Lung Epithelial Morphogenesis and Differentiation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Endoderm Tissue Morphogenesis

Grays Peak
* Aaron M. Zorn, Cincinnati Children's Hospital Medical Center, USA

Nanette M. Nascone-Yoder, North Carolina State University, USA
A Novel Role for Acetylcholinesterase in Endoderm Morphogenesis

Nandan L. Nerurkar, Harvard Medical School, USA
FGF-Mediated Tension Gradients Drive Antero-Posterior Endoderm Movements to Form the Avian Hindgut

Tyler R. Huycke, Harvard Medical School, USA
Generating Morphological Variation in the Developing Chick Gut

Sonja Nowotschin, Sloan-Kettering Institute, USA
Linking Gut Endoderm Morphogenesis with Germ Layer Segregation

Mitsuru Morimoto, RIKEN Center for Developmental Biology, Japan
A Non-Proliferating Tissue Enlargement Controlling the Trachea Tubulogenesis

Darrell N. Kotton, Boston University, USA
Generation of Functional, Engraftable Thyroid and Lung Organoids via ESC/iPSC-Derived Nkx2-1+ Endodermal Progenitors

Mostafa Bakhti, Helmholtz Zentrum München, Germany
Synaptotagmin13 Regulates Apical-Basal Polarity and Spindle Positioning in Pancreatic Ductal Progenitors for Endocrine Lineage Formation

Kimberly D. Tremblay, University of Massachusetts, USA
The Anterior and Posterior Liver Bud each Produce Discreet Portions of the Embryonic Liver

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Organogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* James M. Wells, Cincinnati Children's Hospital Research Foundation, USA

Anne Grapin-Botton, University of Copenhagen, Denmark
Cells Behaving as Communities during Pancreas Development

Philip T. Pauerstein, Stanford University School of Medicine, USA
Short Talk: Peripheral Semaphorin Signals Control Pancreatic Islet Morphogenesis

Deborah L. Gumucio, University of Michigan, USA
Making Villi

Edward E. Morrisey, University of Pennsylvania, USA
Molecular Pathways Governing Lung Development

Astrid Gillich, Stanford University School of Medicine, USA
Short Talk: A Model for Alveolar Development in the Mouse Lung

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Postnatal Stem Cells and Regeneration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Xin Sun, University of Wisconsin-Madison, USA

Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA
Chromatin Modifications in Intestinal Stem and Progenitor Cell Renewal

Benjamin Ohlstein, Columbia University Medical Center, USA
Regulating Stem Cell Number in the Drosophila Intestine: You Can Go Home Again

Linda C. Samuelson, University of Michigan, USA
Short Talk: Notch Pathway Regulation of Gastrointestinal Stem Cells

Holger Willenbring, University of California, San Francisco, USA
Regeneration of the Liver

Jason Rock, University of California, San Francisco, USA
Mechanisms of Adult Lung Regeneration

Andrew J. Lechner, University of California, San Francisco, USA
Short Talk: Immune Cell Regulation of Adult Alveologenesis Post-Pneumonectomy

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Ben Z. Stanger, University of Pennsylvania Perelman School of Medicine, USA

Trudy G. Oliver, Huntsman Cancer Institute, USA
Sox2 Cooperates with Lkb1 Loss to Promote Squamous Cell Lung Cancer

Noah Shroyer, Baylor College of Medicine, USA
Intestinal Stem Cells and Colon Cancer

Yoku Hayakawa, Columbia University, USA
Short Talk: CXCL12-CXCR4 Axis Supports Proximal Gastric Stem Cell Niche and Contributes to Cancer Development

Timothy C. Wang, Columbia University, USA
Dclk1 Labels Facultative Pancreatic Stem and Cancer-Initiating Cells

Nathan M. Krah, University of Utah, USA
Short Talk: PTF1A Is a Pancreas-Specific Tumor Suppressor

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, FEBRUARY 12

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Stem Cell-Derived Endoderm Organs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Darrell N. Kotton, Boston University, USA

Hans-Willem E. Snoeck, Columbia University Medical Center, USA
Development of Human Anterior Foregut Derivatives

Jason R. Spence, University of Michigan Health System, USA
Short Talk: In vitro Generation of Human Pluripotent Stem Cell Derived Lung Organoids

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Tissues as Models of Gastrointestinal Development and Disease

Valerie Gouon-Evans, Mount Sinai Hospital, USA
Identification of an Endoderm-Derived KDR+ Progenitor with a Bi-Potent Hepatic and Endothelial Fate

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Specification of Pancreatic and Hepatic Endoderm from Human Pluripotent Stem Cells

Danwei Huangfu, Memorial Sloan-Kettering Cancer Institute, USA
Short Talk: hESC-Based Functional Human Genetics for Systematic Interrogation of Mechanisms of Pancreatic Development and Diabetes

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Epigenetic and Noncoding RNA Regulation of Endoderm

Grays Peak
* Lori Sussel, University of Colorado, USA

Rui Fan, Ludwig Maximilian University, Germany
The Histone Methyltransferase Setdb1 Is Essential for Endoderm Development

Marie-Liesse Asselin-Labat, Walter and Eliza Hall Institute, Australia
The Histone Methyltransferase Ezh2 Is Essential for Lung Development and Controls Lineage Specification

Nisha Patel, Genentech, Inc., USA
Chromatin Remodeling Establishes Endocrine Lineage Commitment in Multi-Potent Pancreatic Progenitors

Daniel T. Swarr, Children's Hospital of Philadelphia, USA
The Long Non-Coding RNA Fanci Directs Early Endoderm and Lung Development by Regulating Expression of Foxa2

David M. Ornitz, Washington University School of Medicine, USA
Micro RNA Regulation of FGF9 in Lung Development Reveals a Link between DICER1 Loss and the Pathogenesis of Pleuropulmonary Blastoma

Kaveh Daneshvar, Massachusetts General Hospital, Harvard Medical School, USA
TGF-beta Induced Long Non-Coding RNA lncGSC Is a Regulator of Endodermal Differentiation

Michael J. Herriges, University of Pennsylvania, USA
The lincRNA NANCI Is Essential for Nkx2-1 Expression and Lung Development

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Endoderm Development and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Edward E. Morrisey, University of Pennsylvania, USA

Didier Y. R. Stainier, Max Planck Institute for Heart and Lung Research, Germany
GI Disease Modeling in Zebrafish

Elaine Storm, Genentech, Inc., USA
Short Talk: Targeting Developmental Pathways in Cancer

Gustavo Mostoslavsky, Boston University, USA
Short Talk: Modeling Familial Adenomatous Polyposis with Induced Pluripotent Stem Cells

Ben Z. Stanger, University of Pennsylvania Perelman School of Medicine, USA
Tumor as Embryo: Using the Tools of Development to Understand Cancer Biology

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

FRIDAY, FEBRUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation, Grant No. 4-FY14-523

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD081875-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676