Beaver Run Resort Floorplan

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This meeting took place in 2015


Here are the related meetings in 2017:
Lipidomics and Bioactive Lipids in Metabolism and Disease (B6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Systems Biology of Lipid Metabolism (B4)


Organizer(s) Matej Orešic, Antonio J. Vidal-Puig and Ana Maria Cuervo
February 9—13, 2015
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Oct 14, 2014
Abstract Deadline: Nov 13, 2014
Scholarship Deadline: Oct 14, 2014
Discounted Registration Deadline: Dec 10, 2014

Sponsored by Abide Therapeutics Inc.

Summary of Meeting:
Lipid homeostasis is fundamental to the maintenance of good health. Due to the enormous functional and structural diversity of lipids as well as their complex regulation at multiple spatial and temporal scales, lipids need to be studied not only at the level of biological pathways but also at the level of the biophysical systems they are part of, including cellular membranes or lipoprotein particles. From the perspective of systems biology, this adds an additional but necessary layer of complexity to the studies of lipids. This Keystone Symposia meeting will cover recent progress and perspectives in the studies of lipids as related to: 1) Cellular as well as systemic lipid metabolism; 2) Computational modeling of lipids; and 3) The role of lipids in the pathogenesis of several complex diseases including metabolic, immune and central nervous system disorders as well as cancer. Specifically, experts in this area will address whether alterations in lipid biology may be an important underlying pathogenic link among these disorders, which could explain the well documented metabolic co-morbidities such as between obesity and several other complex diseases. The meeting will bring together a highly interdisciplinary and outstanding group of scientists including biochemists, molecular and cellular biologists, clinical researchers and computational biologists. Such a diverse mix will facilitate the cross-disciplinary interactions needed to address current key questions in lipid biology in the context of translational medicine, as well as move the field of lipids forward by consolidating the use of systems biology approaches to study their involvement in the pathogenesis of common diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 9

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

TUESDAY, FEBRUARY 10

07:00—08:00
Breakfast

Summit Gallery
08:00—08:15
Welcome Remarks

Matej Orešic, Steno Diabetes Center, Denmark

Antonio J. Vidal-Puig, University of Cambridge, UK

Ana Maria Cuervo, Albert Einstein College of Medicine, USA

08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Dennis E. Vance, University of Alberta, Canada
What Is the Mechanism by which Lack of Phosphatidylethanolamine N-Methyltransferase Protects Mice from Obesity and Insulin Resistance?

09:15—11:45
Cellular Lipid Signaling and Metabolism
Meeting has ended...abstracts no longer viewable online.
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.

Peaks 4-5
* Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Interplay between Selective Autophagy and Lipid Metabolism

Eyleen J. O'Rourke, University of Virginia, USA
Deconstructing the C. elegans Metabomap

Neha Chauhan, Weill Cornell Medical College, USA
Greasing the Cell Cycle: Identification of the Morphogenesis Checkpoint Kinase Swe1 as a Lipolysis-Dependent Cell Cycle Regulator

Rona Aviram, Weizmann Institute of Science, Israel
Short Talk: Around the Clock Lipidomics: Insight into Circadian Oscillations of Lipids in Subcellular Compartments

Jurre J. Kamphorst, CR-UK Beatson Institute and University of Glasgow, UK
Short Talk: Hypoxia Induces Fatty Acid Metabolic Changes in Cancer Cells

09:40—10:00
Coffee Break

Foyer
11:45—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Modeling of Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.

Peaks 4-5
* Michael J.O. Wakelam, Babraham Institute, UK

Jens Nielsen, Chalmers University of Technology, Sweden
Integrative Analysis of Lipid Metabolism through Genome-Scale Modeling of Metabolism

Ilpo Vattulainen, Tampere University of Technology, Finland
Molecular Simulations of Lipid Membranes, Lipid-Protein Interactions and Lipoproteins

Matej Orešic, Steno Diabetes Center, Denmark
Lipid Pathways Behind the Acquired Obesity and the Associated Co-Morbidities

Natal A. van Riel, Eindhoven University of Technology, Netherlands
Short Talk: A Systems Biology Approach Reveals the Physiological Origin of Increased Plasma HDL Levels and Hepatic Steatosis Induced by Liver X Receptor Activation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

WEDNESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Lipids in Obesity and its Metabolic Co-Morbidities
Meeting has ended...abstracts no longer viewable online.
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.

Peaks 4-5
* Matej Orešic, Steno Diabetes Center, Denmark

Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose Tissue Expandability, Lipotoxicity and the Metabolic Syndrome

Elizabeth J. Parks, University of Missouri, USA
Fatty Acid Metabolism in Obesity and Fatty Liver

Rudolf Zechner, University of Graz, Austria
Lipolyis in Health and Disease

David E. Moller, Eli Lilly and Company, USA
Novel Drug Targets - Modulating Fatty Acid Metabolism as a Therapeutic Approach for Metabolic Disorders

Kelli M. Sas, University of Michigan, USA
Short Talk: Increased beta-Oxidation and Mitochondrial Dysfunction in Diabetic Nephropathy

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Lipids in Immune System Regulation
Meeting has ended...abstracts no longer viewable online.
This session covers studies of lipids on the interface of metabolism and the immune system.

Peaks 4-5
* Antonio J. Vidal-Puig, University of Cambridge, UK

Anthony W. Ferrante, Columbia University, USA
Immune Regulation of Lipid Metabolism

Marielle Koeberlin, CeMM Research Center for Molecular Medicine, Austria
Short Talk: Functional Mapping of the Lipid Landscape in Innate Immunity

Valerie B. O'Donnell, Cardiff University, UK
Discovery and characterization of new lipids generated by immune cells using mass spectrometry

Tuulia Hyötyläinen, Novo Nordisk/Steno Diabetes Center, Denmark
Altered Lipid Metabolism Preceding Onset of Islet Autoimmunity and Type 1 Diabetes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

THURSDAY, FEBRUARY 12

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Lipid Metabolism and the Brain
Meeting has ended...abstracts no longer viewable online.
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.

Peaks 4-5
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Cheryl Wellington, University of British Columbia, Canada
HDL Metabolism in the Brain

Satchidananda Panda, The Salk Institute for Biological Studies, USA
Eating Pattern in Circadian Regulation of Lipid Metabolism

Xianlin Han, Sanford Burnham Medical Research Institute, USA
Lipidomics Approaches to Study Alzheimer's Disease

Karl Fernandes, University of Montreal, Canada
Short Talk: Aberrant Fatty Acid Metabolism at the Brain-CSF Barrier in Alzheimer’s Disease

Paul Amminger, University of Melbourne, Australia
Polyunsaturated Fatty Acids in Emerging Psychotic Disorders

Dale D.O. Martin, University of British Columbia, Canada
Short Talk: Assembly of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System

09:20—09:40
Coffee Break

Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Lipids in Cancer
Meeting has ended...abstracts no longer viewable online.
This session overviews the progress in the study of cancer as a co-morbidity of obesity, with specific focus on lipids as an underlying link.

Peaks 4-5
* Jurre J. Kamphorst, CR-UK Beatson Institute and University of Glasgow, UK

Raffaella Gadaleta, Imperial College London UK and University of Bari, Italy
Bile Acids and Cancer: The Role of FXR

Michael J.O. Wakelam, Babraham Institute, UK
Lipidomic Analysis of Tumor Cells and Tissues

Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
Metabolic Reprogramming in Cancer Supports Cell Growth and Survival

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Peaks 1-3

FRIDAY, FEBRUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Abide Therapeutics Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Mabtech Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104458-01

Funding for this conference was made possible (in part) by 1 R13 DK104458-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676