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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

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This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.

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Twitter hashtag for this meeting: #KSlncRNA

Long Noncoding RNAs: From Evolution to Function (C7)

Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown

March 15—20, 2015

Keystone Resort, Keystone, Colorado, USA

Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics

IT’S NOT TOO LATE TO SUBMIT YOUR ABSTRACT. Email your formatted abstract to or call +1 970-262-1230/+1 800-253-0685.
Abstracts received can no longer be considered for oral short talks; poster display opportunities remain open.
Scholarship Deadline: Nov 18, 2014 [details]
Discounted Abstract Deadline: Nov 18, 2014 [details]
Abstract Deadline: Dec 16, 2014 [details]
Discounted Registration Deadline: Jan 15, 2015 [details]

Register Yourself Deadlines and Fees
Deadlines and Fees for 2015-C7 ''Long Noncoding RNAs: From Evolution to Function''
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Rates and Deadlines listed below are for the 2015-C7 "Long Noncoding RNAs: From Evolution to Function" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On November 18, 2014 100.00 USD*
- 50.00 USD discount
Abstract Deadline
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After November 18, 2014 until January 15, 2015 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
More details
November 18, 2014 n/a
Discounted NON-STUDENT Registration
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Before and On January 15, 2015 775.00 USD
(includes 150.00 discount)
Regular NON-STUDENT Registration
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After January 15, 2015 925.00 USD
Discounted STUDENT Registration
More details
Before and On January 15, 2015 550.00 USD
(includes 150.00 discount)
Regular STUDENT Registration
More details
After January 15, 2015 700.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will    accept no liability for money loss through bank charges, transfers or currency fluctuations.

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About Discounted Abstract Deadline
About Global Health Travel Award Deadline
About Scholarship Deadline
About Abstract Deadline
About Discounted Registration Deadline
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


Arrival and Registration

Welcome Mixer
No registration fees are used to fund alcohol served at this function.



Keynote Session
Registered attendees can view abstracts starting on 02/15/2015

Thomas R. Cech, HHMI/University of Colorado, USA
A Short History of Noncoding RNA Research

Lynne E. Maquat, University of Rochester Medical Center, USA
Control of Gene Expression via lncRNAs and mRNAs that Contain SINEs

The Multidimensional lncRNA Landscape
Registered attendees can view abstracts starting on 02/15/2015
This session will interrogate the genomic and subcellular cartography of long non-coding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.

Jonathan S. Weissman, University of California, San Francisco, USA
Exploring Translation Outside of Canonical Protein Coding Region with Ribosome Profiling

John S. Mattick, Garvan Institute of Medical Research, Australia
The Human Genome as the Zip File Extraordinaire

Karyn Schmidt, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Characterization of a lncRNA Contributing to Melanoma Invasion

Hans E. Johansson, Biosearch Technologies, Inc., USA
Short Talk: Duplex Imaging of Pre-lncRNAs and Mature lncRNAs by Stellaris® RNA Fluorescence in situ Hybridization (RNA FISH)

Coffee Break

Poster Setup

Poster Viewing

On Own for Lunch

Workshop 1

Mitchell R. O'Connell, University of California, Berkeley, USA
Programmable RNA Targeting and Cleavage by CRISPR/Cas9

Richard G. Jenner, University College London, UK
Polycomb Repressive Complex 2 Directly Interacts with RNA through Suz12 and Is Independent of Chromatin Association

Mathew Thayer, Oregon Health and Science University, USA
Large Non-Coding RNA Genes Control Chromosome-Wide Replication Timing and Stability

Martin A. Smith, Garvan Institute of Medical Research, Australia
The Modular Transcriptome: Unraveling a Network of Functional, Structured Non-Coding RNA Domains

Yuya Ogawa, Cincinnati Children's Hospital Medical Center, USA
Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome

Zhuo Zhou, NIDDK, National Institutes of Health, USA
RNA-Dependent Triplex Formation Regulates Expression of Erythroid Genes

Jhumku D. Kohtz, Feinberg School of Medicine, Northwestern University, Children's Research, USA
The Ultraconserved Evf2 lncRNA Reduces Seizure Susceptibility in Mice

Nenad Bartonicek, Garvan Institute of Medical Research, Australia
Uncovering Hidden Genes in Intergenic GWAS Regions

Coffee Available

LncRNA Form and Function
Registered attendees can view abstracts starting on 02/15/2015
This session will introduce current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs, and lncRNA post-transcriptional modifications.

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Origins of Long Noncoding RNAs and New Families of Argonaute-Associated Nuclear RNAs

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Circular RNAs in the Mammalian Brain

Sergio Covarrubias, University of California, San Francisco, USA
Short Talk: Genome-Wide Interrogation of Long Non-Coding RNAs Involved in Apoptosis Using Ultra-Complex Pooled CRISPRi-based Libraries

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 1



LncRNA Evolution: Non-Conserved Functions and Species Uniqueness
Registered attendees can view abstracts starting on 02/15/2015
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.

Leonard Lipovich, Wayne State University, USA
The Primate-Specific LncRNAome: Roles in Species Uniqueness, Human Brain, and Cancer

Chris Ponting, MRC, University of Oxford, UK
Explorations of lncRNA Repertoires and Functions

Ingrid Grummt, German Cancer Research Center, Germany
DNA:RNA Triplexes Guide Chromatin Modifiers to Regulatory Gene Sequences

Jennifer Harrow, Wellcome Trust Sanger Institute, UK
Identifying and Cataloguing Functional LncRNAs in Reference Genomes

Hazuki Takahashi, RIKEN, Japan
Short Talk: SINEUPs: Novel Antisense ncRNA can Enhance Protein Translation

Mridula (Millie) K. Ray, Harvard University, Massachusetts General Hospital, USA
Short Talk: lncRNAs Interact with PRC1 to Impact Development in Human and Zebrafish

Coffee Break

Poster Setup

Poster Viewing

On Own for Lunch

Workshop 2

Katelin R. Haynes, University of Queensland Diamantina Institute, Australia
Identification of Monocyte-Specific eRNAs at an Intergenic GWAS Locus associated with Ankylosing Spondylitis Reveals Potential Mechanism in Disease

Brian S. Clark, Johns Hopkins University, USA
Dynamic Expression of lncRNAs and Examination of their Role in Retinal Progenitor Competence

Rohit Malik, University of Michigan, USA
Integrative Analysis of Androgen Receptor Regulated Long Non-Coding RNA in Prostate Cancer

Nicholas Lister, University of New South Wales, Australia
Promoter associated Transcripts are Required for PTENpg1 Antisense RNA Directed Epigenetic Regulation of PTEN

Kevin G. Nyberg, University of Maryland, College Park, USA
Comparative Transcriptomics of Long Intergenic Noncoding RNAs in Drosophila

Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Structural Studies of Long Non-Coding RNAs

Anindya Dutta, University of Virginia, USA
Long Noncoding RNAs, H19 and MUNC, Promote Skeletal Muscle Differentiation by Two Different Mechanisms

Per A. Johnsson, Karolinska Institutet, Sweden
A Novel Role of PTENpg1 asRNA in Drug Response and Outcome in Melanoma

David J. Waxman, Boston University, USA
Mouse Liver lincRNAs: Gene Structures, Chromatin States, Conservation and Regulation of Sex-Specific Transcription by Pituitary Growth Hormone (GH)

Coffee Available

In vivo Roles of lncRNAs: The Promises and Limitations of Animal Models
Registered attendees can view abstracts starting on 02/15/2015
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.

Alexandra Henrion-Caude, Necker Hospital - Imagine Foundation, France
Learning about Human lncRNA by Repetition and Reduction

Sven Diederichs, German Cancer Research Center DKFZ, Germany
Long Noncoding RNA Function in Cancer

Saba Valadkhan, Case Western Reserve University, USA
A Bi-Functional Long Noncoding RNA Links Neuronal Differentiation to Survival after Stress

Ciro Bonetti, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Mouse Models to Dissect Oncogenic and Tumor-Suppressive Functions of lincRNAs

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 2



LncRNA Mechanisms: Diversity and Heterogeneity
Registered attendees can view abstracts starting on 02/15/2015
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.

Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs

Jeannie T. Lee, Massachusetts General Hospital, USA
RNA-Protein Interactions in Epigenetic Regulation

Ramin Shiekhattar, University of Miami, USA
Biogenesis and Mechanism of Action of Enhancer RNA

Kevin V. Morris, School of Biotechnology and Biomolecular Sciences, Australia
RNA Directed Modulation of Phenotypic Plasticity in Human Cells

Reini F. Luco, CNRS, France
Short Talk: A Long Non-Coding RNA Regulates Chromatin-Mediated Modulation of Alternative Splicing

Matthew G. Schwartz, Harvard Medical School, USA
Short Talk: The Role of Long Noncoding RNAs in Regulating Chicken Limb Development

Coffee Break

Poster Setup

Poster Viewing

On Own for Lunch

Workshop 3

Evan S. Forsythe, University of Arizona, USA
Phylogenetic Analysis of lincRNA Origins and Evolution in the Plant Family Brassicaceae

Shrikanth S. Gadad, University of Texas Southwestern Medical Center at Dallas, USA
Functional Characterization of an Estrogen Regulated Long Noncoding RNA that Controls the Growth of Breast Cancer Cells

Colleen McHugh, California Institute of Technology, USA
Uncovering Mechanisms of lncRNA Function through Comprehensive Identification of Direct lncRNA-Interacting Proteins in vivo

Boris Guennewig†, Garvan Instittute of Medical Research, Australia
Functional Characterization of the Human Brain Transcriptome in Parkinson’s Disease

Vivek Chandra†, University of California- San Diego, USA
In Lymphoid Progenitors, a Novel lncRNA, Termed AJAX, Repositions the EBF1 Locus from the Heterochromatic to the Euchromatic Compartment, to Orchestrate Early B Cell Development

Sanjida H. Rangwala, National Institutes of Health, USA
Curation and Evidence Reporting of Eukaryotic RefSeq Long Non-Coding RNA Genes and Transcripts

Fabien Dachet†, University of Illinois at Chicago-School of Medicine, USA
Epigenetic Organization of Protein Coding and Large Non Coding Transcripts in Electrically Active Human Brain

Luis Arnes, Columbia University, USA
Examining the Role of Novel Long Noncoding RNAs in beta Cell Biology

Coffee Available

Conserved lncRNA Functions
Registered attendees can view abstracts starting on 02/15/2015
This session will serve as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.

John L. Rinn, Harvard University, USA
Linking RNA from Mouse to Mechanism

James (Ben) Brown, Lawrence Berkeley National Laboratory, USA
Long Non-Coding RNAs and Adaptive Responses to Environmental Stressors

Jennifer F. Kugel, University of Colorado, Boulder, USA
Regulation of RNA polymerase II by SINE encoded ncRNAs

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 3



Transcription Factors and lncRNAs: Direct Endogenous Riboregulation
Registered attendees can view abstracts starting on 02/15/2015
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session will discuss the impact of these interactions on gene regulation.

David R. Corey, University of Texas Southwestern Medical Center, USA
Talk Title to be Announced

Vladimir Bajic, King Abdullah University of Science and Technology, Saudi Arabia
Protein-Coding and LncRNA Genes Are Regulated Differently: Feedback Loops with LncRNA-interacting Transcription Factors

Michael G. Rosenfeld, HHMI, University of California, San Diego, USA
Enhancer Signatures eRNAs and Nuclear Architecture in Regulated Gene Transcription

Eleonora Leucci, KU Leuven, Belgium
Short Talk: Targeting the Melanoma-Specific Long Non-Coding RNA LINC01212 as an Effective Antimelanoma Strategy

Jesse Engreitz, Broad Institute of Harvard and MIT, USA
Short Talk: Many Nuclear-Localized lincRNAs Regulate Gene Expression in cis

Susan A. Boackle, University of Colorado School of Medicine, USA
Short Talk: Altered Expression of Long Noncoding RNA Is Associated with a Lupus-Associated Variant in Complement Receptor 2

Coffee Break

On Own for Lunch

Workshop 4

Veronica Peschansky, University of Miami, USA
Fragile X-Associated lncRNA FMR4 Is Trans-Active, Involved in Neural Development and Localized to Chromatin

Fan Lai, University of Miami, USA
Integrator Mediates the Biogenesis of Enhancer RNAs

Maren Mayer, Dharmacon, Part of GE Healthcare, USA
Knockdown of Long Non Coding RNAs in Breast Cancer

Valerie Brid O'Leary, Helmholtz Zentrum Muenchen, Germany
PARTICLE – A Long Non-Coding RNA Modulator of Cellular Methylation in Response to Low Dose Irradiation

Musa M. Mhlanga, CSIR, South Africa
HIV-1 Targets MAP2K1/ERK2 to Evade lincRNA-p21 Mediated Apoptosis

Maninjay K. Atianand, University of Massachusetts Medical School, USA
LincRNA-Eps Controls Immune Responses in Macrophage and Mice

Caio F. Damski, University of New South Wales, Australia
Saving the Devil; lncRNA Directed Epigenetic Changes in a Contagious Cancer

Coffee Available

LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Registered attendees can view abstracts starting on 02/15/2015
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.

Frank W. Rigo, Isis Pharmaceuticals, USA
Towards a Therapy for Angelman Syndrome by Targeting a Long Non-Coding RNA to Active UBE3A

James Barsoum, RaNA Therapeutics Inc., USA
Selective Activation of Gene Expression by Targeting Long Noncoding RNA

Piero Carninci, RIKEN Yokohama Institute/TransSINE Technologies Inc.
SINEUPs: Antisense Long Non-Coding RNAs That Enhance Protein Translation

Claes Wahlestedt, University of Miami/CURNA-OPKO
Long Noncoding RNAs: Therapeutic Opportunities

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is generously provided by other supporters of Keystone Symposia.



*Session Chair †Invited, not yet responded.

Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Isis Pharmaceuticals, Inc.
Regeneron Pharmaceuticals, Inc. Sarepta Therapeutics

We gratefully acknowledge additional support for this conference from:

Biosearch Technologies Dharmacon, part of GE Healthcare
Exiqon A/S RaNA Therapeutics Inc.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13HG008329-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Isis Pharmaceuticals, Inc.

RaNA Therapeutics Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email:,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email:,
Phone:+1 970-262-2676