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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

  • Full participant list, including joint meeting participants
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  • Scholarship Information
  • Lodging Information

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NOTES:
This meeting occurs in 2015.
This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.


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Long Noncoding RNAs: From Evolution to Function (C7)

Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown


March 15—20, 2015

Keystone Resort, Keystone, Colorado, USA


Sponsored by Cell Research, Isis Pharmaceuticals, Inc. and Regeneron Pharmaceuticals, Inc.


DEADLINES:
Scholarship Deadline: Nov 18, 2014 [details]
Discounted Abstract Deadline: Nov 18, 2014 [details]
Abstract Deadline: Dec 16, 2014 [details]
Discounted Registration Deadline: Jan 15, 2015 [details]

Submit an Abstract Register Yourself Deadlines and Fees
Deadlines and Fees for 2015-C7 ''Long Noncoding RNAs: From Evolution to Function''
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Rates and Deadlines listed below are for the 2015-C7 "Long Noncoding RNAs: From Evolution to Function" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On November 18, 2014 100.00 USD*
- 50.00 USD discount
Abstract Deadline
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After November 18, 2014 until December 16, 2014 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
November 18, 2014 n/a
Discounted NON-STUDENT Registration
More details
Before and On January 15, 2015 775.00 USD
(includes 150.00 discount)
Regular NON-STUDENT Registration
More details
After January 15, 2015 925.00 USD
Discounted STUDENT Registration
More details
Before and On January 15, 2015 550.00 USD
(includes 150.00 discount)
Regular STUDENT Registration
More details
After January 15, 2015 700.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will    accept no liability for money loss through bank charges, transfers or currency fluctuations.

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About Discounted Abstract Deadline
About Global Health Travel Award Deadline
About Scholarship Deadline
About Abstract Deadline
About Discounted Registration Deadline

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 15

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


MONDAY, MARCH 16

07:00—08:00
Breakfast

08:00—09:30
Keynote Session
Registered attendees can view abstracts starting on 02/15/2015

Thomas R. Cech, HHMI/University of Colorado, USA
The RNA Worlds, Primordial and Modern: The lncRNAome in Focus

Lynne E. Maquat, University of Rochester Medical Center, USA
LncRNA-Mediated mRNA Decay via the dsRNA-Binding Protein Staufen

09:30—11:45
The Multidimensional lncRNA Landscape
Registered attendees can view abstracts starting on 02/15/2015

NOTE: This session will interrogate the genomic and subcellular cartography of long non-coding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.

Jonathan S. Weissman, University of California, San Francisco, USA
Riboseq and Proteogenomics to Define an Empirical LncRNAome

Jennifer Harrow, Wellcome Trust Sanger Institute, UK
Identifying and Cataloguing Functional LncRNAs in Reference Genomes

John S. Mattick, Garvan Institute of Medical Research, Australia
The Human Genome as the Zip File Extraordinaire

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 1

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
LncRNA Form and Function
Registered attendees can view abstracts starting on 02/15/2015

NOTE: This session will introduce current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs, and lncRNA post-transcriptional modifications.

Phillip A. Sharp, Massachusetts Institute of Technology, USA
LncRNA 3’end Stabilization and uasRNAs

Howard Y. Chang, Stanford University, USA
High-Throughput Analysis of lncRNP Structure and Function

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Regulatory RNAs

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 17

07:00—08:00
Breakfast

08:00—11:00
LncRNA Evolution: Non-Conserved Functions and Species Uniqueness
Registered attendees can view abstracts starting on 02/15/2015

NOTE: Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.

Leonard Lipovich, Wayne State University, USA
The Primate-Specific LncRNAome: Roles in Species Uniqueness, Human Brain, and Cancer

Chris Ponting, MRC, University of Oxford, UK
LncRNA Repertoires and Functions Across Mammalian and Fruitfly Lineages

Ingrid Grummt, German Cancer Research Center, Germany
DNA:RNA Triplexes Guide Chromatin Modifiers to Regulatory Gene Sequences

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
In vivo Roles of lncRNAs: The Promises and Limitations of Animal Models
Registered attendees can view abstracts starting on 02/15/2015

NOTE: Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.

Alexandra Henrion-Caude, Necker Hospital - Imagine Foundation, France
MiRage in HOTAIR: Primate-Specific Short and Long ncRNAs, Metabolism, and Mendelian Disease

Sven Diederichs, German Cancer Research Center DKFZ, Germany
Long Noncoding RNA Function in Cancer

Saba Valadkhan, Case Western Reserve University, USA
A Bi-Functional Long Non-Coding RNA Links Neuronal Differentiation to Survival after Stress

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 18

07:00—08:00
Breakfast

08:00—11:00
LncRNA Mechanisms: Diversity and Heterogeneity
Registered attendees can view abstracts starting on 02/15/2015

NOTE: Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.

Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs

Jeannie T. Lee, Massachusetts General Hospital, USA
Epigenetic Regulation by Long Non-Coding RNAs

Ramin Shiekhattar, University of Miami, USA
The Mechanistic Centrality of lncRNAs in Enhancer Function

Kevin V. Morris, The Scripps Research Institute, USA
Non-Coding RNA Epigenetic Regulation and Targeted Editing of the Genome

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 3

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Conserved lncRNA Functions
Registered attendees can view abstracts starting on 02/15/2015

NOTE: This session will serve as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.

John L. Rinn, Harvard University, USA
Linking RNA from Mouse to Mechanism

James (Ben) Brown, Lawrence Berkeley National Laboratory, USA
Epigenetic Inheritance of Stress Response Phenotypes Is Largely Independent of the Initial Stressor, Conserved from Ecdysozoa to Mammals, and Governed by Male Germline-Specific Antisense lncRNAs

Lingling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Sno-lncRNAs: Splicing Regulators in Primate Evolution

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 19

07:00—08:00
Breakfast

08:00—11:00
Transcription Factors and lncRNAs: Direct Endogenous Riboregulation
Registered attendees can view abstracts starting on 02/15/2015

NOTE: A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session will discuss the impact of these interactions on gene regulation.

Bethany A. Janowski, University of Texas Southwestern Medical Center, USA
Regulation of Nuclear Hormone Receptors by Endogenous Long Non-Coding RNAs

Vladimir Bajic, King Abdullah University of Science and Technology, Saudi Arabia
Protein-Coding and LncRNA Genes Are Regulated Differently: Feedback Loops with LncRNA-interacting Transcription Factors

Michael G. Rosenfeld, HHMI, University of California, San Diego, USA
Nuclear Receptor Trans-Repression, LncRNAs, and Nuclear Architecture

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 4

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:15
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Registered attendees can view abstracts starting on 02/15/2015

NOTE: This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.

Frank W. Rigo, Isis Pharmaceuticals, USA
LncRNA Inhibition by Antisense Oligonucleotides: Preclinical Outcomes Despite Non-Conserved Functions

James Barsoum, RaNA Therapeutics Inc., USA
Selective Activation of Gene Expression by Targeting Long Non-Coding RNA

Piero Carninci, RIKEN Yokohama Institute/TransSINE Technologies Inc.
Quantification of LncRNA Promoteromes at a Single-Base Resolution: Toward lncRNA Sense-Antisense Therapeutics

Claes Wahlestedt, University of Miami/CURNA-OPKO
Long Noncoding RNAs: Therapeutic Opportunities

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 20

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Isis Pharmaceuticals, Inc.
Regeneron Pharmaceuticals, Inc.
 

We gratefully acknowledge additional support for this conference from:

RaNA Therapeutics Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Isis Pharmaceuticals, Inc.


RaNA Therapeutics Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676