Sheraton Steamboat Resort Floorplan

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This meeting took place in 2015


Here are the related meetings in 2016:
Stem Cells and Regeneration in the Digestive Organs (X6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Transcriptional and Epigenetic Influences on Stem Cell States (C9)


Organizer(s) Thomas P. Zwaka, Rudolf Jaenisch and Joanna Wysocka
March 23—28, 2015
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Nov 20, 2014
Abstract Deadline: Dec 19, 2014
Scholarship Deadline: Nov 20, 2014
Discounted Registration Deadline: Jan 22, 2015

Sponsored by Cell Research, Incyte Corporation, Journal of Molecular Cell Biology (JMCB) and Thermo Fisher Scientific Inc.

Summary of Meeting:
An ambitious goal in modern biology is to understand stem cell states. Although much is known about both the behavior of stem cells under various conditions and the molecular details of stem cell identity, there is a gap between these two bodies of knowledge. This meeting sets out to bridge this gap, with a focus on transcriptional and epigenetic control of stem cell function. Advances in these areas will enable us to devise new strategies not only to probe stem cell biology more deeply, but to model disease and to develop cellular therapies. This Keystone Symposia meeting will bring together researchers who strive to: 1) Describe transcriptional and epigenetic mechanisms that control specific stem cell behaviors; 2) Generate predictive models of stem cell fate determination; 3) Delineate the influence of cell cycle and signaling on stem cell state; and 4) Understand mechanisms governing cell fate change, including differentiation, reprogramming and transdifferentiation. Ultimately, the meeting will provide an opportunity to view copious empirical data on stem cell behavior through a molecular lens, and will bring together scientists from basic research fields, such as transcriptional control, chromatin modification and developmental biology, with disease-oriented and translational researchers who are developing therapies or modeling specific diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 23

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

TUESDAY, MARCH 24

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA

Azim Surani, University of Cambridge, UK
Mammalian Germline: Specification and Reprogramming for Totipotency and Development

09:00—11:30
Transcriptional Control of Stemness
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Joanna Wysocka, Stanford University School of Medicine, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Connecting Enhancers and Transcriptional Control

Jacob H. Hanna, Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Molecular Mechanisms for Inducing and Maintaining Distinct Pluripotent States

Kristian Helin, University of Copenhagen, Denmark
Role of Polycomb Group Proteins and Histone Demethylases in Transcriptional Regulation and Stemness

Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
Short Talk: 3-D Genome Folding Is Partially Reprogrammed in Induced Pluripotent Stem Cells

Qiao Zhou, Harvard Stem Cell Institute, USA
Short Talk: Reprogramming Gastrointestinal Stem Cells to Provide a Renewable Source of Insulin+ beta Cells

09:20—09:40
Coffee Break

Foyer
11:30—13:00
Poster Setup

Sunshine/Rainbow/Twilight
13:00—22:00
Poster Viewing

Sunshine/Rainbow/Twilight
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Epigenetic Memories in the Germline
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Azim Surani, University of Cambridge, UK

Margaret T. Fuller, Stanford University, USA
Cell Type-Specific Transcriptional Repression Programs Proper Differentiation of a Stem Cell Lineage

Bradley R. Cairns, HHMI/University of Utah, USA
Chromatin-Transcription Dynamics in Developing Germline Stem Cells

Stephen Dalton, University of Georgia, USA
Signaling Pathways and the Cell Cycle Converge to Regulate Epigenetics and Cell Fate Decisions in Stem Cells

Fredrik Lanner, Karolinska Institutet, Sweden
Short Talk: Single Cell Transcriptional Analysis: Delineating Cell Lineage and Pluripotency during Human Blastocyst Formation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
19:30—22:00
Poster Session 1

Sunshine/Rainbow/Twilight

WEDNESDAY, MARCH 25

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:00
Chromatin Features and Stem Cell Identity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Joanna Wysocka, Stanford University School of Medicine, USA
Epigenetic Regulation of Differentiation

Magdalena Zernicka-Goetz, University of Cambridge, UK
Mechanisms for Determining Cell Identity and Embryo Architecture

Kathrin Plath, University of California, Los Angeles, USA
Understanding how the "Yamanaka" Factors Induce Pluripotency

Ulrich Elling, Institute of Molecular Biotechnology, Austria
Short Talk: A Systematic Multiplex Analysis of Chromatin Factors Identifies Roadblocks of Reprogramming

Ichiro Hiratani, RIKEN Center for Developmental Biology, Japan
Short Talk: Identifying Novel Regulators of the Inactive X Chromosome Architecture

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine/Rainbow/Twilight
13:00—22:00
Poster Viewing

Sunshine/Rainbow/Twilight
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Modeling Stem Cell States
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Kathrin Plath, University of California, Los Angeles, USA

Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Transcriptional Complexity in Stem Cells

Alexander van Oudenaarden, Hubrecht Institute, Netherlands
Single-Cell mRNA Sequencing Reveals Rare Intestinal Cell Types

Fernando D. Camargo, Boston Children's Hospital, USA
Transcriptional Regulation by the Hippo/YAP Signaling Pathway

Victor C. Li, Harvard Medical School, USA
Short Talk: A Role for Cell Cycle-Associated Processes in Embryonic Stem Cell Differentiation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
19:30—22:00
Poster Session 2

Sunshine/Rainbow/Twilight

THURSDAY, MARCH 26

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:15
Signaling in Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
Alexander Meissner, Harvard University, Broad Institute, USA
Regulation of DNA Methylation in Stem Cells

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Neural Differentiation of Embryonic Stem Cells

* Margaret A. Goodell, Baylor College of Medicine, USA
DNMT3A in Normal and Malignant Hematopoiesis

Austin G. Smith, University of Cambridge, UK
Embryonic Stem Cells: Of Mouse and Man

Tonis Org, University of California, Los Angeles, USA
Short Talk: Scl Dictates Hematopoietic versus Cardiac Fate Choice in Mesoderm via Primed Enhancers

Elena Ezhkova, Icahn School of Medicine at Mount Sinai, USA
Short Talk: An Unconventional Polycomb Repressive Mechanism Regulates Skin Stem Cell Maintenance and Differentiation

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine/Rainbow/Twilight
13:00—22:00
Poster Viewing

Sunshine/Rainbow/Twilight
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop: Functional Chromatin Domains in Stem Cells

Storm Peak/Mt. Werner
* Kenneth S. Zaret, University of Pennsylvania, USA

Yan Xu, Guangzhou Institutes of Biomedicine and Health, China
Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming

Kathryn E. Malecek, University of Chicago, USA
Characterization and Function of Novel Oxidized-Methylcytosine Binding Proteins

Jean-Pierre Etchegaray, Massachusetts General Hospital, Harvard Medical School, USA
The Histone Deacetylase SIRT6 Controls Embryonic Stem Cell Fate via TET-Dependent Oxidation of 5mC into 5hmC

Guang Hu, NIEHS, National Institutes of Health, USA
The INO80 Chromatin Remodeling Complex Promotes Pluripotency Gene Activation in ESC Self-Renewal

Kihyun Lee, Memorial Sloan Kettering Institute / Cornell University, USA
Divergent Role of GATA Factors in Human Pancreatic and Cardiac Development

Yechiel Elkabetz, Tel Aviv University, Israel
Consecutive Building Blocks of Human Neural Stem Cell Ontogeny Derived from Pluripotent Stem Cells: Fundamentals and Implications

Elizabeth A. Mason, University of Melbourne, Australia
Gene Expression Variability Is a Unifying Element of the Pluripotency Network and Stem Cell Sub-Populations

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell Cycle and Growth Regulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Magdalena Zernicka-Goetz, University of Cambridge, UK

Peter W. Reddien, Whitehead Institute, USA
Planarians as a Model System for Stem Cell Biology

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Cell Competition in Pluripotent Stem Cells

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Linking Epigenetics and Signaling in the Early Mammalian Embryo

Raga Krishnakumar, University of California, San Francisco, USA
Short Talk: Foxd3 Regulates Developmental Timing of Gene Expression by Simultaneously Establishing and Repressing Enhancers

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
19:30—22:00
Poster Session 3

Sunshine/Rainbow/Twilight

FRIDAY, MARCH 27

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:15
Challenging Fate: Reprogramming and Transdifferentiation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
iPS Cell Technology, Gene Editing and Disease Research

Konrad Hochedlinger, Massachusetts General Hospital, USA
Programming and Reprogramming Cell Fate

Marius Wernig, Stanford University, USA
Mechanisms and Applications of Direct Lineage Neuronal Reprogramming

George Q. Daley, HHMI/Boston Children's Hospital, USA
CellNet: Enhancing Cellular Engineering through Network Biology

Jaclyn J. Ho, University of California, Berkeley, USA
Short Talk: Regulation of DNA Demethylation by the XPC DNA Repair Complex during Human Somatic Cell Reprogramming

Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Modeling Disease-Associated Chromosomal Deletions in Human Pluripotent Stem Cells

09:20—09:40
Coffee Break

Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Mechanisms of Differentiation and Identity Choice
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
* Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA

Wolf Reik, Babraham Institute, UK
Epigenetic Reprogramming in Mammalian Development

Kenneth S. Zaret, University of Pennsylvania, USA
Chromatin Features that Facilitate and Impede Cellular Reprogramming

Daniel A. Lim, University of California, San Francisco, USA
Epigenetic Determinants of Neural Stem Cells

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Storm Peak/Mt. Werner
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sunshine

SATURDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Incyte Corporation
Journal of Molecular Cell Biology (JMCB) Thermo Fisher Scientific Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676