Tivoli Hotel and Congress Center Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2015



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Crossroads of Lipid Metabolism and Diabetes (D6)


Organizer(s) Russell A. DeBose-Boyd, Sudha Biddinger and Alan D. Attie
April 19—24, 2015
Tivoli Hotel and Congress Center • Copenhagen, Denmark
Discounted Abstract Deadline: Dec 17, 2014
Abstract Deadline: Jan 20, 2015
Scholarship Deadline: Dec 17, 2014
Discounted Registration Deadline: Feb 18, 2015

Lead Sponsor: Novo Nordisk A/S. Other Sponsors: MedImmune, Merck & Co., Inc. and Pfizer Inc.

Summary of Meeting:
The prevalence of obesity and Type 2 diabetes are reaching epidemic proportions throughout the world. One of the key features of these insulin-resistant disorders is disturbances in lipid metabolism. Overproduction of fatty acids in the liver leads to hypertriglyceridemia and low HDL cholesterol, which are important risk factors for the development of atherosclerosis, the most common cause of death among diabetic patients. In addition, excess fatty acid production and the accumulation of hepatic cholesterol promote the development of non-alcoholic steatohepatitis (NASH), which has become one of the leading indications for liver transplantation. In addition, disturbances in bile acid metabolism may also contribute to the development of atherosclerosis, as well as gallstones. The goal of this meeting is to provide attendees with the latest advances in the understanding of mechanisms governing the metabolism of lipids and how these pathways become dysregulated in the insulin resistant state. Elucidation of mechanisms underlying lipid metabolism may reveal new therapeutic strategies to combat atherosclerosis and other complications of diabetic patients. This program will stimulate interactions that are likely to augment and accelerate this process.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 19

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, APRIL 20

07:30—08:30
Breakfast

Own Hotel
08:30—08:45
Welcome Remarks
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Alan D. Attie, University of Wisconsin-Madison, USA

Anders Nykjaer, Aarhus University, Denmark
Living in a Butter Well

08:45—09:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
Joseph L. Witztum, University of California, San Diego, USA
Lipoprotein Oxidation and Atherosclerosis

09:45—12:00
LXR in Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Cynthia Hong, Pfizer, USA

Alan R. Tall, Columbia University, USA
TTC39B Modulates LXR, HDL Levels, Atherosclerosis and Steato-Hepatitis

Ira G. Schulman, University of Virginia Health System, USA
Control of Cholesterol Transport and HDL Function by Liver X Receptors

Christopher K. Glass, University of California, San Diego, USA
Regulation of the LXR/SREBP Axis in Macrophages

Noam Zelcer, Academic Medical Center, University of Amsterdam, Netherlands
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-Ubiquitin Ligase IDOL

10:10—10:30
Coffee Break

Foyer
12:00—13:00
Poster Setup

Columbine/Harlekin
13:00—22:00
Poster Viewing

Columbine/Harlekin
12:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Regulators and Arbiters of Lipoprotein Metabolism
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Alan R. Tall, Columbia University, USA

Anders Nykjaer, Aarhus University, Denmark
Sortilin Receptors in Regulation of Cholesterol and Glucose Metabolism

Jeffrey Esko, University of California, San Diego, USA
Apoc-III In Triglyceride-Rich Lipoprotein Clearance

Nabil G. Seidah, Clinical Research Institute of Montreal, Canada
The Biology and Pathophysiology of PCSK9

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
19:30—22:00
Poster Session 1

Columbine/Harlekin

TUESDAY, APRIL 21

07:30—08:30
Breakfast

Own Hotel
08:30—11:45
Insulin and Bile Acid Signaling
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Morris J. Birnbaum, University of Pennsylvania and Pfizer, Inc.

Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Flavin-Containing Monooxygenase 3 as a Novel Player in Diabetes-Associated Cardiovascular Disease

Domenico Accili, Columbia University, USA
Bile Acids and Insulin Signaling

Fredrik Bäckhed, University of Gothenburg, Sweden
Interaction between Bile Acids and Gut Microbiome in Relation to Host Metabolism

David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
Dissecting the Tissue-Specific Actions of Endocrine FGF Signaling

Anna Worthmann, University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Brown Adipose Tissue Activation Regulates Bile Acid Metabolism and Shapes the Gut Microbiome

Mete Civelek, University of California, Los Angeles, USA
Short Talk: Systems Genetics Analyses of Human Adipose Tissue Gene Expression Identify KLF14-Driven Trans Regulatory Transcript Network for Metabolic Disorders

09:50—10:10
Coffee Break

Foyer
11:45—13:00
Poster Setup

Columbine/Harlekin
13:00—22:00
Poster Viewing

Columbine/Harlekin
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Insulin Control of Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Fabienne Foufelle, Centre de Recherches des Cordeliers, France

Morris J. Birnbaum, University of Pennsylvania and Pfizer, Inc.
The Regulation of Adipocyte Lipolysis by Insulin

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Lessons about the Biology of Adipose Tissue and Insulin Resistance from Novel Models of Lipodystrophy

Manju Kumari, Beth Israel Deaconess Medical Center, USA
Short Talk: Role of IRF3 in Glucose and Energy Metabolism

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
19:30—22:00
Poster Session 2

Columbine/Harlekin

WEDNESDAY, APRIL 22

07:30—08:30
Breakfast

Own Hotel
08:30—11:30
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Alan D. Attie, University of Wisconsin-Madison, USA
The Role of Sorcs1 in Diabetes Susceptibility

Markus Stoffel, ETH Zürich, Switzerland
Foxa2 and Regulation of Lipid Metabolism

Timothy F. Osborne, Sanford-Burnham Medical Research Institute, USA
Journal of Lipid Research Lectureship Introduced by JLR Editor-in-Chief, Joseph L. Witztum: SREBPs as Integrators of Lipid Metabolism and Cell Physiology

Karen-Marie Pedersen, Aarhus University, Denmark
Short Talk: SorCS1, Encoded by the Alzheimer’s Disease and Type 2 Diabetes Susceptibility Gene SORCS1, Is a Potent Regulator of Peripheral Insulin Sensitivity

Jeffrey A. Kohn, Emory University, USA
Short Talk: An Allosteric Network in LRH-1 Mediates Phospholipid-Driven Gene Regulation

Lucia Krott, University Medical Center Hamburg Eppendorf, Germany
Short Talk: Adaptor Protein PID1 Is a Molecular Switch for LRP1 Function in Liver and Adipose Tissue

09:50—10:10
Coffee Break

Foyer
11:30—13:00
Poster Setup

Columbine/Harlekin
13:00—22:00
Poster Viewing

Columbine/Harlekin
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Nutrient Control of Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA

Matthew D. Hirschey, Duke University, USA
Mitochondrial Regulation of Lipid Metabolism

Marcia C. Haigis, Harvard Medical School, USA
Mitochondrial Dysfunction and Metabolic Disease

Catherine Postic, Institut Cochin, France
LXR Protects Mice Expressing a Constitutive Isoform of ChREBP from Non-Alcoholic Steatohepatitis (NASH)

Hervé Guillou, Institut National de la Recherche Agronomique, France
Short Talk: Liver PPARalpha Is Crucial for Whole Body Energy Homeostasis and Protects from NAFLDs

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
19:30—22:00
Poster Session 3

Columbine/Harlekin

THURSDAY, APRIL 23

07:30—08:30
Breakfast

Own Hotel
08:30—11:30
Cellular Control of Lipid Synthesis
Meeting has ended...abstracts no longer viewable online.

Columbine/Harlekin
* Timothy F. Osborne, Sanford-Burnham Medical Research Institute, USA

Guosheng Liang, University of Texas Southwestern Medical Center, USA
Role of SREBP Pathway in Development of Hepatic Steatosis

Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Sterol and Nonsterol Signals Regulating ERAD of HMG CoA Reductase

Fabienne Foufelle, Centre de Recherches des Cordeliers, France
ER Stress Pathways in NAFLD

Jae Bum Kim, Seoul National University, Institute of Molecular Biology and Genetics, IMBG, South Korea
Short Talk: Off Switching Processes of Hepatic SREBP1c for Lipid Homeostasis upon Fasting

Shihyin Tsai, Buck Institute for Research on Aging, USA
Short Talk: Activated Muscle 4E-BP1 Signaling Improves Metabolic Parameters in Age- and Obesity-Induced Metabolic Deregulation

S.R. Murthy Madiraju, Montreal Diabetes Research Center, CR-CHUM, Canada
Short Talk: Deletion of ABHD6, a Monoacylglycerol Lipase, Induces Adipose Browning and Prevents Obesity and Type-2 Diabetes

09:50—10:10
Coffee Break

Foyer
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Carstensen Foyer
17:00—19:15
Therapeutic Targets for Molecular Disease
Meeting has ended...abstracts no longer viewable online.

Carstensen
* Alan D. Attie, University of Wisconsin-Madison, USA

Rosanne M. Crooke, Ionis Pharmaceuticals, Inc., USA
Antisense Inhibition of Cardiovascular Risk Factors: From Bench to Clinic

Viktoria Gusarova, Regeneron Pharmaceuticals, USA
Alirocumab, Fully Human Antibody to PCSK9, Reduces LDL-C in Preclinical and Clinical Studies

Shirly Pinto, Merck & Co., Inc., USA
Therapeutic Approaches for Lipid Modulation

Ruth E. Gimeno, Eli Lilly & Company, USA
FGF21 as a Therapeutic Target: New Insights

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Columbine/Harlekin

FRIDAY, APRIL 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Lead Sponsor for generously supporting this meeting:

Novo Nordisk A/S
 

Keystone Symposia thanks our Sponsors for generously supporting this meeting:

MedImmune Merck & Co., Inc.
Pfizer Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Journal of Lipid Research

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL126455-01

Funding for this conference was made possible (in part) by 1R13HL126455-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


Isis Pharmaceuticals, Inc.


Regeneron Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676