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This meeting took place in 2015
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Hypoxia: From Basic Mechanisms to Therapeutics (E3)
Organizer(s) Cormac T. Taylor, M. Celeste Simon, Sean P. Colgan and Roland H. Wenger
May 12—17, 2015
Royal Dublin Society • Dublin, Ireland
Discounted Abstract Deadline: Jan 13, 2015
Abstract Deadline: Feb 12, 2015
Scholarship Deadline: Jan 13, 2015
Discounted Registration Deadline: Mar 12, 2015
Organized in Collaboration with Science Foundation Ireland. Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.
Summary of Meeting:
Tissue hypoxia occurs in a range of physiologic and pathophysiologic states. Consequently, the cellular response to hypoxia has important implications for both health and for diseases including (but not limited to) cancer, ischemia and chronic inflammation. Recently, the discovery and elucidation of specific hypoxia-inducible pathways has raised the possibility of developing new strategies for therapeutic benefit based on targeting hypoxia-sensitive pathways. The aim of this meeting is to disseminate up to date information on basic mechanisms of the cellular hypoxic response, discuss the impact of this response for health and disease and highlight the potential for developing new therapeutics based on our understanding of the pathways involved. It is anticipated that outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and fellows in the state-of-the-art and promoting new collaborations between clinicians, basic researchers and industrial partners. The Keystone Symposia Hypoxia meeting is widely accepted as the world’s leading conference addressing the topic and is a key date on the calendar for all researchers interested in this topic. We will bring together academic, clinical and industrial researchers to drive synergy through collaboration in developing the translational potential of targeting the HIF pathway for therapeutic benefit. This meeting will be held in conjunction with the European HypoxiaNET consortium.
View Scholarships/Awards
Tissue hypoxia occurs in a range of physiologic and pathophysiologic states. Consequently, the cellular response to hypoxia has important implications for both health and for diseases including (but not limited to) cancer, ischemia and chronic inflammation. Recently, the discovery and elucidation of specific hypoxia-inducible pathways has raised the possibility of developing new strategies for therapeutic benefit based on targeting hypoxia-sensitive pathways. The aim of this meeting is to disseminate up to date information on basic mechanisms of the cellular hypoxic response, discuss the impact of this response for health and disease and highlight the potential for developing new therapeutics based on our understanding of the pathways involved. It is anticipated that outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and fellows in the state-of-the-art and promoting new collaborations between clinicians, basic researchers and industrial partners. The Keystone Symposia Hypoxia meeting is widely accepted as the world’s leading conference addressing the topic and is a key date on the calendar for all researchers interested in this topic. We will bring together academic, clinical and industrial researchers to drive synergy through collaboration in developing the translational potential of targeting the HIF pathway for therapeutic benefit. This meeting will be held in conjunction with the European HypoxiaNET consortium.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, MAY 12
WEDNESDAY, MAY 13
THURSDAY, MAY 14
FRIDAY, MAY 15
SATURDAY, MAY 16
SUNDAY, MAY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, MAY 12
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Cormac Taylor,
University College Dublin, Ireland
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Oxygen and Nutrient Metabolism in Neurovascular Processes in Health and Disease
Oxygen and Nutrient Metabolism in Neurovascular Processes in Health and Disease
09:00—12:15
Hypoxia and Disease-Specific Targets
Meeting has ended...abstracts no longer viewable online.
*
Roland H. Wenger,
University of Zürich, Switzerland
Cormac Taylor,
University College Dublin, Ireland
Regulation of Inflammatory Pathways by Hypoxia
Regulation of Inflammatory Pathways by Hypoxia
Sean P. Colgan,
University of Colorado Denver, USA
HIF as a Target in Mucosal Inflammation
HIF as a Target in Mucosal Inflammation
Randall S. Johnson,
University of Cambridge, UK
HIF and Vascular Disease
HIF and Vascular Disease
Judith Sluimer,
Maastricht University, Netherlands
Short Talk: Myeloid PHD2 Deficiency Impairs Collagen Degradation Enhancing Murine Atherosclerotic Plaque Stability
Short Talk: Myeloid PHD2 Deficiency Impairs Collagen Degradation Enhancing Murine Atherosclerotic Plaque Stability
Claudia Gerri,
Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Role of the HIF Pathway in Cardiovascular System Development in Zebrafish
Short Talk: Role of the HIF Pathway in Cardiovascular System Development in Zebrafish
M. Celeste Simon,
University of Pennsylvania, USA
Hypoxia, Lipids and Cancer: Surviving the Harsh Tumor Microenvironment
Hypoxia, Lipids and Cancer: Surviving the Harsh Tumor Microenvironment
14:30—16:30
HypoxiaNET Workshop 1: Targeting Hypoxia-Sensitive Pathways
*
Christopher J. Schofield,
University of Oxford, UK
Perspectives on Iron Oxygenases as Therapeutic Targets
Perspectives on Iron Oxygenases as Therapeutic Targets
Gail Walkinshaw,
Fibrogen, USA
Therapeutic Applications for HIF Prolyl Hydroxylase Inhibitors
Therapeutic Applications for HIF Prolyl Hydroxylase Inhibitors
Laura Demopoulos,
GlaxoSmithKline, USA
The Promise of HIF Prolyl Hydroxylase Inhibitors: Clinical Applications
The Promise of HIF Prolyl Hydroxylase Inhibitors: Clinical Applications
Ingo Flamme,
Bayer Pharma AG, Germany
Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat)
Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat)
Ivan Coulter,
Sigmoid Pharma, Ireland
SmPill® Gastrointestinal Targeted Hydroxylase Inhibitors: HIF Where it Hurts
SmPill® Gastrointestinal Targeted Hydroxylase Inhibitors: HIF Where it Hurts
17:00—19:30
Hypoxia and Cancer
Meeting has ended...abstracts no longer viewable online.
*
Margaret Ashcroft,
University of Cambridge, UK
Julie-Aurore Losman,
Dana-Farber Cancer Institute, USA
Targeting Leukemia Cell Metabolism: Insights Gained from Studies of Mutant IDH
Targeting Leukemia Cell Metabolism: Insights Gained from Studies of Mutant IDH
Amato J. Giaccia,
Stanford University, USA
Suppression of PGC-1alpha Links the Clear Cell Phenotype with Tumor Growth in Renal Cell Carcinoma
Suppression of PGC-1alpha Links the Clear Cell Phenotype with Tumor Growth in Renal Cell Carcinoma
Emin Maltepe,
University of California, San Francisco, USA
Short Talk: HIGD1A Regulation of Tumor Metabolism and Growth
Short Talk: HIGD1A Regulation of Tumor Metabolism and Growth
Cormac Taylor,
University College Dublin, Ireland
Introduction to Salvador Moncada
Introduction to Salvador Moncada
Salvador Moncada,
University of Manchester, UK
Pursuing the Biology of O2/NO2 Interactions: Where Are We Now?
Pursuing the Biology of O2/NO2 Interactions: Where Are We Now?
08:00—11:15
HIF-Dependent Pathways
Meeting has ended...abstracts no longer viewable online.
*
Drorit Neumann,
Tel-Aviv University, Israel
Richard K. Bruick,
University of Texas Southwestern Medical Center, USA
Administration of a Small Molecule HIF-2 Inhibitor Reduces Iron Overload in a Mouse Model of Hemochromatosis
Administration of a Small Molecule HIF-2 Inhibitor Reduces Iron Overload in a Mouse Model of Hemochromatosis
Jacques Pouysségur,
University of Nice, France
Hypoxic Microenvironment and Control of Tumor Metabolism
Hypoxic Microenvironment and Control of Tumor Metabolism
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
Hypoxia-Inducible Factors Support the Breast Cancer Stem Cell Phenotype
Hypoxia-Inducible Factors Support the Breast Cancer Stem Cell Phenotype
Werner J. Kovacs,
ETH Zurich, Switzerland
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
Cunming Duan,
University of Michigan, USA
Short Talk: Dissecting Oxygen-Dependent and -Independent Actions of Hypoxia-Inducible Factor 3 Using CRISPR/Cas9-Based Gene Editing
Short Talk: Dissecting Oxygen-Dependent and -Independent Actions of Hypoxia-Inducible Factor 3 Using CRISPR/Cas9-Based Gene Editing
14:30—16:30
HypoxiaNET Workshop 2
*
Chris W. Pugh,
University of Oxford, UK
Eoin Cummins,
University College Dublin, Ireland
Oxygen and Carbon Dioxide Cross-Talk in the HIF Pathway
Oxygen and Carbon Dioxide Cross-Talk in the HIF Pathway
Louise E. Glover,
University of Colorado, USA
Metabolic Regulation of Epithelial Autophagy in Mucosal Inflammation
Metabolic Regulation of Epithelial Autophagy in Mucosal Inflammation
David R. Mole,
University of Oxford, UK
Pangenomic Studies of the HIF Transcriptional Response
Pangenomic Studies of the HIF Transcriptional Response
Julián Aragonés Lopez,
Research Institute Princesa, Spain
Role of HIF2alpha in Airway Response to Oxygen Fluctuations
Role of HIF2alpha in Airway Response to Oxygen Fluctuations
Martin Schneider,
University of Heidelberg, Germany
PHD-Inhibition in Surgery for Metastatic Colorectal Cancer
PHD-Inhibition in Surgery for Metastatic Colorectal Cancer
Edurne Berra,
CIC bioGUNE, Spain
New Insights into HIF Homeostasis
New Insights into HIF Homeostasis
Norbert Weissmann,
Justus-Liebig-University Giessen, Germany
Identification of Mechanisms Driving Hypoxia-Induced Pulmonary Hypertension and its Reversal
Identification of Mechanisms Driving Hypoxia-Induced Pulmonary Hypertension and its Reversal
17:00—19:00
HIF-Independent Pathways
Meeting has ended...abstracts no longer viewable online.
*
Edwin R. Chilvers,
Cambridge University, UK
Navdeep S. Chandel,
Northwestern University, USA
Mitochondria Regulate Hypoxic Signal Transduction
Mitochondria Regulate Hypoxic Signal Transduction
Moira K. Whyte,
University of Edinburgh, Queen's Medical Research Institute, UK
Regulation of Neutrophil Energetics by Hypoxia and the HIF/Hydroxylase Pathway: Consequences for Innate Immune Responses
Regulation of Neutrophil Energetics by Hypoxia and the HIF/Hydroxylase Pathway: Consequences for Innate Immune Responses
Safia Thaminy,
ETH Zürich, Switzerland
Short Talk: A Systems-Based Approach to Understand the Mechanisms of Cancer Progression Under Hypoxia
Short Talk: A Systems-Based Approach to Understand the Mechanisms of Cancer Progression Under Hypoxia
08:00—11:15
Hydroxylases and the Hypoxia Response
Meeting has ended...abstracts no longer viewable online.
*
L. Eric Huang,
University of Utah, USA
Peter J. Ratcliffe,
University of Oxford, UK
Genomic Analysis of the Response to Hypoxia
Genomic Analysis of the Response to Hypoxia
Sonia Rocha,
University of Liverpool, UK
Role of Prolyl-Hydroxylases in the Control of the Cell Cycle and Related Processes
Role of Prolyl-Hydroxylases in the Control of the Cell Cycle and Related Processes
Johanna Myllyharju,
University of Oulu, Finland
Prolyl 4-Hydroxylases and the Hypoxic Response
Prolyl 4-Hydroxylases and the Hypoxic Response
Daniel J. Peet,
University of Adelaide, Australia
Hypoxic Signaling by FIH-Mediated Asparaginyl Hydroxylation
Hypoxic Signaling by FIH-Mediated Asparaginyl Hydroxylation
Mathew Coleman,
University of Birmingham, UK
Short Talk: Characterization of FIH-Related Protein Hydroxylases
Short Talk: Characterization of FIH-Related Protein Hydroxylases
Qing Zhang,
University of North Carolina at Chapel Hill, USA
Short Talk: Control of NRF-PGC1alpha Complex and Mitochondrial Function by EglN2 in Breast Cancer
Short Talk: Control of NRF-PGC1alpha Complex and Mitochondrial Function by EglN2 in Breast Cancer
14:30—16:30
HypoxiaNET Workshop 3
*
Patrick Henry Maxwell,
University of Cambridge, UK
Will HIF Hydroxylase Inhibitors Be Useful Medicines?
Will HIF Hydroxylase Inhibitors Be Useful Medicines?
Agnes Görlach,
German Heart Center Munich, TU Munich, Germany
MAP Kinase Signaling and the Response to Hypoxia
MAP Kinase Signaling and the Response to Hypoxia
Ben Wielockx,
Technical University of Dresden, Germany
The PHD2-HIF2alpha-EPO Axis: A Central Regulator of Erythropoiesis and Beyond
The PHD2-HIF2alpha-EPO Axis: A Central Regulator of Erythropoiesis and Beyond
Peppi Koivunen,
University of Oulu, Finland
HIF Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
HIF Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
Eric L. Campbell,
, UK
Epithelial-Derived HIF-Dependent Factors Coordinate Resolution of Colitis
Epithelial-Derived HIF-Dependent Factors Coordinate Resolution of Colitis
Thomas Kietzmann,
University of Oulu, Finland
Fbw7 and USP28-Dependent Degradation of HIFs: Old Features and Novel Aspects
Fbw7 and USP28-Dependent Degradation of HIFs: Old Features and Novel Aspects
Sarah R. Walmsley,
University of Edinburgh, Queen's Medical Research Institute, UK
How Hypoxia and Hypoxic Pre-Conditioning Modify Outcomes of Bacterial Infection
How Hypoxia and Hypoxic Pre-Conditioning Modify Outcomes of Bacterial Infection
Silvia Pastorekova,
Biomedical Research Center, Slovak Academy of Sciences, Slovakia
Soluble Ectodomain of the Hypoxia-Induced Carbonic Anhydrase IX: More than a Circulating Cancer Biomarker
Soluble Ectodomain of the Hypoxia-Induced Carbonic Anhydrase IX: More than a Circulating Cancer Biomarker
17:00—19:15
Hypoxia and Genetics
Meeting has ended...abstracts no longer viewable online.
*
Peter A. Robbins,
University of Oxford, UK
Lorenz Poellinger,
Karolinska Institutet, Sweden
Epigenetic Mechanisms Regulating the Hypoxic Response
Epigenetic Mechanisms Regulating the Hypoxic Response
Josef Prchal,
University of Utah, USA
HIF as a Target in Erythropoiesis
HIF as a Target in Erythropoiesis
Ian Frew,
University of Zürich, Switzerland
Short Talk: Hif1a and Hif2a Are Both Required for the Formation of Vhl-Deficient Renal Cysts and Tumours
Short Talk: Hif1a and Hif2a Are Both Required for the Formation of Vhl-Deficient Renal Cysts and Tumours
Michail Sitkovsky,
Northeastern University, USA
Short Talk: Conceptually Novel “Anti-A2A-Adenosinergic” Molecular Motivation to Oxygenate Hypoxic Tumors in Combination with Immunotherapies of Cancer
Short Talk: Conceptually Novel “Anti-A2A-Adenosinergic” Molecular Motivation to Oxygenate Hypoxic Tumors in Combination with Immunotherapies of Cancer
08:00—11:45
Physiology of Hypoxic Pathways
Meeting has ended...abstracts no longer viewable online.
*
Paul McLoughlin,
University College Dublin, Ireland
Max Gassmann,
University of Zürich, Switzerland
Erythropoietin through Evolution, a Speculative View
Erythropoietin through Evolution, a Speculative View
Dörthe M. Katschinski,
Georg August University, Germany
Impact of Hypoxia and the Prolyl-4-Hydroxylase Domain Enzymes on Endocytosis and Cell Migration
Impact of Hypoxia and the Prolyl-4-Hydroxylase Domain Enzymes on Endocytosis and Cell Migration
José López-Barneo,
Hospital Universitario Virgen del Rocío, Spain
Carotid Body Oxygen Sensing
Carotid Body Oxygen Sensing
Volker H. Haase,
Vanderbilt University, USA
Mouse Models of Disrupted Oxygen Sensing
Mouse Models of Disrupted Oxygen Sensing
Nanduri R. Prabhakar,
University of Chicago, USA
Interplay between Gas Messengers: A Key Step in Carotid Body O2 Sensing
Interplay between Gas Messengers: A Key Step in Carotid Body O2 Sensing
Paul Moynagh,
National University of Ireland, Maynooth, Ireland
Short Talk: The E3 Ubiquitin Ligase Pellino3 Acts as a Regulator of HIF-1alpha and IL-1beta Expression in Insulin Resistance
Short Talk: The E3 Ubiquitin Ligase Pellino3 Acts as a Regulator of HIF-1alpha and IL-1beta Expression in Insulin Resistance
Elizabeth J. Campbell,
University of Otago, Christchurch, New Zealand
Short Talk: Using Physiological and Pharmacological Ascorbate to Manipulate HIF-1 Activity in Gulo-/- Mice
Short Talk: Using Physiological and Pharmacological Ascorbate to Manipulate HIF-1 Activity in Gulo-/- Mice
17:00—19:00
Hypoxia and Inflammation
Meeting has ended...abstracts no longer viewable online.
*
Thorsten Cramer,
RWTH Aachen University, Germany
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation - A Critical Role for HIF-1alpha
Metabolic Reprogramming in Innate Immunity and Inflammation - A Critical Role for HIF-1alpha
Yatrik Shah,
University of Michigan, USA
Intestinal HIF2alpha Signaling: A Critical Regulator of Intestinal Inflammation and Colon Cancer
Intestinal HIF2alpha Signaling: A Critical Regulator of Intestinal Inflammation and Colon Cancer
Massimiliano Mazzone,
KU Leuven – VIB, Belgium
Influence on Vessel Shape of Macrophage Metabolism in the Tumor Hypoxic Niche
Influence on Vessel Shape of Macrophage Metabolism in the Tumor Hypoxic Niche
Christian Stockmann,
PARCC – Paris Cardiovascular Research Center, France
Short Talk: The Hypoxic Response in Natural Killer Cells: Impact on Cancer Immune Surveillance and Tumor Angiogenesis
Short Talk: The Hypoxic Response in Natural Killer Cells: Impact on Cancer Immune Surveillance and Tumor Angiogenesis
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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