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This meeting took place in 2015


Here are the related meetings in 2017:
New Developments in Our Basic Understanding of Tuberculosis (A5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Host Response in Tuberculosis (J3)


Organizer(s) JoAnne L. Flynn and Willem A. Hanekom
January 22—27, 2015
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Sep 29, 2014
Abstract Deadline: Oct 22, 2014
Scholarship Deadline: Sep 29, 2014
Discounted Registration Deadline: Nov 20, 2014

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation


Summary of Meeting:
Tuberculosis remains a major cause of morbidity and mortality globally. Control of the epidemic is hampered by limited understanding of basic processes underlying disease and protection. This symposium will focus on basic science in humans; major themes will include immune processes that have emerged as important for pathogenesis or protection. Translation of basic science advances into novel strategies to prevent and manage human tuberculosis will also be discussed. While preclinical progress will be addressed throughout the meeting, emphasis of direct relevance to human tuberculosis will be part of each presentation. The meeting will be held jointly with a Keystone Symposia meeting on “Granulomas in Infectious and Non-Infectious Diseases.” Granulomas are a pathologic hallmark of tuberculosis, so the pairing of these two meetings will enhance opportunities for interdisciplinary interactions and for learning about other granulomatous systems and providing insights into how this knowledge may be applied to our understanding of tuberculosis. The specific aims for this meeting are to: 1) Gather scientists interested in basic pathogenesis and immunologic responses in tuberculosis to present and discuss cutting-edge tuberculosis research; 2) Integrate basic and clinical research findings with a view to improving treatment and prevention of disease in humans; 3) Provide mentoring opportunities for junior scientists with senior scientists interested in tuberculosis research; and 4) Focus on gaps in knowledge about the events in natural infection, as well as vulnerability points for intervening in the infection process.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 22

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sweeney F

FRIDAY, JANUARY 23

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
07:30—08:00
Poster Setup

Sweeney F, Main Level Breakouts
08:00—17:00
Poster Viewing

Sweeney F, Main Level Breakouts
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Setting the stage for addressing tuberculosis from a human perspective--from basic to clinical research.

Sweeney Ballroom A-D
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA

Clifton E. Barry III, NIAID, National Institutes of Health, USA
Human Tuberculosis: The Movie

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* Thomas A. Wynn, NIAID, National Institutes of Health, USA

Alberto Mantovani, Humanitas University, Italy
Macrophage Plasticity and Polarization in Granulomatous Inflammation

09:00—11:15
Immunity in the Lung
Meeting has ended...abstracts no longer viewable online.
Events in the airway and interactions with early cells influence outcome.

Sweeney Ballroom A-D
* Alan Sher, NIAID, National Institutes of Health, USA

David M. Lewinsohn, Oregon Health & Science University, USA
MAITs and Protection Against TB

Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK
TB/HIV Interactions in the Airways

Gerhard Walzl, Stellenbosch University, South Africa
Human TB Treatment Response Studies Using PET/CT Imaging: Inconvenient Observations

Wendy A. Burgers, University of Cape Town, South Africa
Short Talk: Defects in Multiple Mycobacterial T Helper Subsets in Blood and Lungs in Early HIV Infection

09:00—11:15
Granulomas Associated with Type-1 Immunity
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
Paul Kaye, University of York, UK
Understanding Granuloma Heterogeneity in Visceral Leishmaniasis

Martin Rottenberg, Karolinska Institutet, Sweden
SOCS3 in either Myeloid or T Cells Conveys Resistance to Infection with Mycobacterium tuberculosis

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Childhood Infectious Diseases

Evelina Guirado, Ohio State University, USA
Short Talk: Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model

09:40—10:00
Coffee Break

Sweeney Ballroom Foyer
11:15—12:15
Lunch

12:00—14:30
Poster Session 1

Sweeney F, Main Level Breakouts
14:30—16:30
Workshop: Novel Approaches to Treatment of Tuberculosis

Sweeney Ballroom A-D
* Christopher M. Sassetti, University of Massachusetts Medical School, USA

* Brian C. VanderVen, Cornell University, USA
Chemical Screening against Mycobacterium tuberculosis in Macrophages Identifies Inhibitors of Cholesterol Utilization

Frederick K. Balagaddé, K-RITH KwaZulu-Natal Research Institute for TB & HIV, South Africa
Confinement-Induced Drug-Tolerance in Microfluidic Bioreactors

Robert Blomgran, Linköping University, Sweden
Pharmacological Inhibition of mTORC1 Is Not the Treatment for HIV Mycobacterium tuberculosis Co-Infection

Meenal Datta, Massachusetts General Hospital, USA
Anti-VEGF Treatment Normalizes Tuberculosis Granuloma Vasculature and Improves Small Molecule Delivery

Scott M. Irwin, Colorado State University, USA
Bedaquiline and its Metabolite Display Reduced Penetration into Caseous Necrotic Pulmonary Lesions in C3HeB/FeJ Mice

Ekta Lachmandas, Radboud University Medical Center, Netherlands
Rewiring of Cellular Metabolism via the AKT/mTOR Pathway Forms the Basis of Host Defense against Mycobacterium tuberculosis

Tige R. Rustad, Seattle BioMed, USA
The Wiring Diagram of Mycobacterium tuberculosis: Generating and Using an Experimentally-Derived Transcriptional Regulatory Map

Suraj P. Parihar, University of Cape Town, South Africa
Role of Statins against Mycobacterium tuberculosis Infection

14:30—16:30
Workshop 1: Basic Biology

Coronado / DeVargas
* Matyas Sandor, University of Wisconsin-Madison, USA

Matthew McPeek, East Carolina University, USA
MicroRNAs Targeting PPAR? Pathways Are Elevated in Bronchoalveolar Lavage (BAL) Cells from Sarcoidosis Patients and from Mice Bearing Carbon Nanotube Induced Granulomas

Marie Lipoldova, Institute of Molecular Genetics, Czech Republic
Analysis of Granuloma Formation and Characteristics Using Defined Genomic Constructs

Deepak Kaushal, Tulane National Primate Research Center, USA
Role of Sensor Kinase DosS in Virulence of Mycobacterium tuberculosis in C3HeB/FeJ Mice with Classical Granulomatous Lesions

Teresa A. Hudock, Tulane National Primate Research Center, USA
Transcriptome Analysis of Mycobacterium tuberculosis in Primate Lung Granulomas

Albert Byungyun Jeon, Colorado State University, USA
Reversal of Phenotypic and Genotypic Antimicrobial Drug Resistance in Mycobacterium tuberculosis with 2 Aminoimadazole-Based Small Molecule Adjuvants

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Early Events after TB Infection
Meeting has ended...abstracts no longer viewable online.
Early events in the infectious process.

Sweeney Ballroom A-D
* Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK

Thomas R. Hawn, University of Washington, USA
Innate Immunogenetics of TB in Humans

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy in Tuberculosis

Sabine Ehrt, Weill Cornell Medical College, USA
Survival in the Phagosome: Resist to Persist

Ludovic P. Desvignes, New York University School of Medicine, USA
Short Talk: Dynamics of Early Growth and Spread of Mycobacterium tuberculosis in vivo Reveal Sequential Infection of Myeloid Cell Populations

17:00—19:00
Infectious and Non-Infectious Granulomatous Disease
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* Paul Kaye, University of York, UK

Margherita T. Cantorna, Pennsylvania State University, USA
The Implications of Vitamin D Status on T Cells, the Microbiome and Crohn’s Disease

R. Balfour Sartor, University of North Carolina at Chapel Hill, USA
Granulomatous Enterocolitis and Inflammation in Crohn's Disease: Intersection of Functionally Abnormal Bacteria and Defective Innate and Adaptive Immune Responses

Andreea Geamanu, Wayne State University, USA
Short Talk: Metabolomics Links Alterations in Fatty Acid Metabolism, Inflammation and Gut Microbiota in Sarcoidosis

Damien J.C. Montamat-Sicotte, McGill Research Institute RI-MUHC, Canada
Short Talk: NOD2: Innate Immunity, Bacterial Infection and Chronic Inflammation


SATURDAY, JANUARY 24

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:30
Pathogenic Mechanisms in Chronic Granulomatous Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-D
* Vishva M. Dixit, Genentech, Inc., USA

JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Heterogeneity: Global and Local

Gilla Kaplan, Bill & Melinda Gates Foundation, USA
Lesion-Specific Immune Activation in Granulomas of Patients with Pulmonary Tuberculosis

Thomas A. Wynn, NIAID, National Institutes of Health, USA
Mechanisms of Fibrosis

Lalita Ramakrishnan, University of Cambridge, UK
Mechanisms and Consequences of Tuberculous Granuloma Necrosis

Shahin Shafiani, Center for Infectious Disease Research, USA
Short Talk: Foxp3+ Regulatory T Cells Are Host-Protective during Chronic Tuberculosis and Promote a Pathogen-Specific Immune Response

Philana Ling Lin, University of Pittsburgh, USA
Short Talk: Spatial Patterns of Granuloma Development Differ between Infection and Reactivation

Igor B. Kramnik, Boston University, USA
Short Talk: Necrosis in Granulomas: Mechanism and Therapeutic Approaches

09:20—09:40
Coffee Break

Sweeney Ballroom Foyer
11:30—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Bacterial Interactions with Host Cells
Meeting has ended...abstracts no longer viewable online.
Mycobacterium tuberculosis interactions with host

Sweeney Ballroom A-D
* Jennifer Philips, Washington University School of Medicine, USA

Sarah M. Fortune, Harvard School of Public Health, USA
Dissecting Bacterial Survival, Replication and Mutation in the Host Environment

W. Henry Boom, Case Western Reserve University, USA
Evasion of T Cell Immunity by Mycobacterium tuberculosis

Christopher M. Sassetti, University of Massachusetts Medical School, USA
Systematic Genetic Approaches to Understand TB Pathogenesis

Jordi B. Torrelles, Ohio State University, USA
Short Talk: Lung Mucosa Lining Fluid Modifies Mycobacterium tuberculosis to Reprogram Neutrophil Killing Mechanisms to Preserve the Anti-Inflammatory Integrity of the Lung

17:00—19:00
Role of Myeloid Cells in Granuloma Formation
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* P'ng Loke, New York University School of Medicine, USA

Peter J. Murray, St. Jude Children's Research Hospital, USA
Amino Acid Metabolism by Innate Immune Cells in Granulomatous Inflammation

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Langerhans Cell Histiocytosis, a Pediatric Granulomatous Disease

Vishva M. Dixit, Genentech, Inc., USA
Necroptosis - Role in Inflammation

Keke C. Fairfax, Purdue University, USA
Short Talk: Schistosoma mansoni Infection Induces Anti-Atherogenic Transcriptional Changes in Hepatic Macrophages

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

SUNDAY, JANUARY 25

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Risk of TB Disease
Meeting has ended...abstracts no longer viewable online.
Factors that influence risk of disease

Sweeney Ballroom A-D
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Thomas J. Scriba, University of Cape Town, South Africa
Prospective Correlates of Risk of TB Disease

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
Inflammatory Cytokine Networks during TB

January Weiner, Max Planck Institute of Infection Biology, Germany
TB Biomarkers Across Cohorts and Sample Types

Joel D. Ernst, New York University School of Medicine, USA
Antigen Conservation and Diversity in Human Tuberculosis

Rustin Lovewell, University of Massachusetts Medical School, USA
Short Talk: The Role of Neutrophils in Progressive Tuberculosis

Diane Joyce Ordway, Colorado State University, USA
Short Talk: BCG Efficacy in Guinea Pigs Naturally Exposed to Patients with Tuberculosis

08:00—11:00
Granulomas Associated with Type-2 Immunity
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* Padmini Salgame, Rutgers University, USA

Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Reprogramming of Myeloid Cells during Granuloma Formation

William C. Gause, Rutgers New Jersey Medical School, USA
Regulation of Type-2 Inflammation and Pathology in the Lung and Gut during Nematode Infection

P'ng Loke, New York University School of Medicine, USA
Alternatively Activated Macrophages during Granuloma Formation in Schistosomiasis

Michael H. Hsieh, Children's National Medical Center, USA
Type-2 Granulomas and Bladder Cancer

Jessica C. Jang, University of California, Riverside, USA
Short Talk: Human Resistin Is Induced in Multiple Helminth Infections and Promotes Proinflammatory Cytokines and Monocyte-Rich Lung Granulomas

09:20—09:40
Coffee Break

Sweeney Ballroom Foyer
11:15—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
B Cells Responses to TB
Meeting has ended...abstracts no longer viewable online.
The neglected lymphocyte in TB

Sweeney Ballroom A-D
* Shabaana Khader, Washington University School of Medicine, USA

John R. Chan, Albert Einstein College of Medicine, USA
B Cells Promote Granulomatous Inflammation during Chronic Mycobacterium tuberculosis Infection

Andrea M. Cooper, University of Leicester, UK
The Role of B Cells in Defining T Cell Location in TB

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
A Case for Antibody Fc-Effector Function in Tb Containment

Alan Bénard, Institut de Pharmacologie et de Biologie Structurale, France
Short Talk: B Cells Modulate Inflammation during Mycobacterium tuberculosis Infection in a MyD88- and Type I Interferon-Dependent Manner

17:00—19:00
Granulomatous Diseases of the Lung
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* Daniel L. Barber, NIAID, National Institutes of Health, USA

Randall J. Basaraba, Colorado State University, USA
Granuloma-Targeted Therapy in the Treatment of Tuberculosis

Andrew P. Fontenot, University of Colorado Denver, USA
Gene-Environment Interactions and the Development of Chronic Beryllium Disease

Luigina Romani, University di Perugia, Italy
Chronic Inflammation in Fungal Diseases: From Basic Science to Therapeutic Intervention

Bryce C. Asay, Colorado State University, USA
Short Talk: Heterogeneity in Lesion Types in C3HeB/FeJ Mice Is Modulated by Specific Characteristics of the Mycobacterium tuberculosis Strain Used

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakouts

MONDAY, JANUARY 26

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Protective Immunity and Vaccines
Meeting has ended...abstracts no longer viewable online.
Protection against TB

Sweeney Ballroom A-D
* Thomas G. Evans, Aeras, USA

Denise Kirschner, University of Michigan, USA
A Novel Two-Pronged Approach to Biomarker Discovery in Tuberculosis

Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
Vaccines against TB: Where Are We Going?

D. Branch Moody, Brigham and Women's Hospital, USA
Building Technology-Based T Cell Response to Non-Polymorphic CD1 Proteins

Robert A. Seder, NIAID, National Institutes of Health, USA
What Is Needed to Protect Against TB?

Stephen M. Carpenter, University of Massachusetts Medical School, USA
Short Talk: Heavily-Armed but Outnumbered: A Selective Loss of Memory CD8+ T Cells during Tuberculosis May Eclipse the Benefit of Vaccination

Guangwu Xu, Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University, USA
Short Talk: Cytomegalovirus Vector-Based Tuberculosis Vaccines Provide Superior Protection to BCG after Intra-Bronchial mTb Challenge of Indian-Origin Rhesus macaques

08:00—11:15
Computational Modeling, Imaging and Treatment
Meeting has ended...abstracts no longer viewable online.

Coronado / DeVargas
* Andrew P. Fontenot, University of Colorado Denver, USA

Annemarie H. Meijer, Leiden University, Netherlands
In vivo Study of Anti-Mycobacterial Autophagy and Granuloma Formation in the Zebrafish Model

Ronald N. Germain, NIAID, National Institutes of Health, USA
Live Imaging Anti-Mycobacterial Immunity

Matyas Sandor, University of Wisconsin-Madison, USA
Mycobacterial Granuloma Dynamics: Repopulation, Reformation and Cellular Traffic

Steven Holland, NIAID, National Institutes of Health, USA
Genetics and Treatment of Chronic Granulomatous Disease

Elsje Pienaar, University of Michigan, USA
Short Talk: Interplay between Mycobacterial Metabolism and Granuloma Dynamics in Tuberculosis

David M. Tobin, Duke University Medical Center, USA
Short Talk: Interception of Host Angiogenic Signaling Limits Mycobacterial Growth

09:20—09:40
Coffee Break

Sweeney Ballroom Foyer
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Clinical and Translational

Coronado / DeVargas
* David M. Tobin, Duke University Medical Center, USA

Delia Goletti, National Institute for Infectious Diseases, Italy
Can Blood or Urine IP-10 Discriminate between Active and Non Active Tuberculosis in Children from High Endemic Areas?

Lobelia Samavati, Wayne State University School of Medicine, USA
Development of a Sarcoidosis Library to Detect Sarcoidosis and Tuberculosis by a Panel of Novel Biomarkers

Daniel Torocsik, Karolinska Institutet, Sweden
Immunohistochemical Characterization of FXIII-A+ Cells in Non-Infectious Granulomatous Skin Lesions

Javeed Ali Shah, University of Washington, USA
TOLLIP Variants Are Associated with Susceptibility to Leprosy and Dermal Expression of TOLLIP and IL-1Ra in Nepal

Ho Namkoong, Keio University School of Medicine, Japan
Clarithromycin Expands CD11b+Gr-1+Cells to Ameliorate Post-Influenza Pneumococcal Pneumonia

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
TB and Co-Morbidities (Joint)
Meeting has ended...abstracts no longer viewable online.
Interactions of TB with other diseases

Sweeney Ballroom A-D
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Padmini Salgame, Rutgers University, USA
TB and Worms

Hardy Kornfeld, University of Massachusetts Medical School, USA
TB and Diabetes

Jovvian George Parakkal, National Institute for Research in Tuberculosis, India
Short Talk: Influence of Helminth Infections on the Innate and Adaptive Immune Responses to Pulmonary Tuberculosis

Robert J. Wilkinson, University of Cape Town, South Africa
Talk Title to be Announced

19:00—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-D
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sweeney F, Main Level Breakouts

TUESDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI114099-01

Funding for this conference was made possible [in part] by 1 R13 AI 114099 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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