Santa Fe Community Convention Center Floorplan

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This meeting took place in 2015


Here are the related meetings in 2017:
Diabetes (J3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Diabetes and Metabolic Dysfunction (J6)


Organizer(s) Jeffrey E. Pessin, Alan R. Saltiel and Deborah M. Muoio
January 27—February 1, 2015
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 1, 2014
Abstract Deadline: Oct 28, 2014
Scholarship Deadline: Oct 1, 2014
Discounted Registration Deadline: Nov 25, 2014

Sponsored by Intercept Pharmaceuticals, Inc., the Journal of Molecular Cell Biology (JMCB), MedImmune, Novo Nordisk A/S and Pfizer Inc. Supported by an educational donation provided by Amgen.


Summary of Meeting:
Diabetes and obesity-related complications and associated metabolic disorders are major public health problems at the local, national and global levels. These metabolic defects underlie the basis for multiple debilitating diseases including heart disease, stroke, blindness, kidney disease, hypertension, neural degeneration, wound healing, amputations, periodontal disease and birth defects. This meeting will address several cutting-edge aspects of molecular, cellular, tissue and integrative system metabolism that account for the metabolic defects that occur in diabetes and obesity. Several of these themes overlap with the concurrent meeting on Mitochondria, Metabolism and Heart Failure and four concurrent sessions are planned addressing distinct and novel aspects of normal and dysregulation muscle (skeletal and cardiac) intracellular signaling, mitochondria function/dynamics, aging and energy balance. Leaders in each of these respective areas will not only address basic and integrative mechanisms in model systems, but several will address these issues in human pathology. The diabetes-specific sessions reflect several key aspects of metabolic dysregulation in which novel information is currently forthcoming, causing a paradigm shift compared to our previous understanding of these processes. These include new information about tissue cross-talk, the inter-relationship between the control of glucose production and fatty acid synthesis that underlies selective insulin resistance and the role of normal and dysregulated circadian rhythms on metabolic processes. These cutting-edge advances will provide a foundation for identifying future research directions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 27

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sweeney F

WEDNESDAY, JANUARY 28

07:00—09:00
Breakfast

Sweeney F, Main Level Breakouts
14:00—15:00
Poster Setup

Sweeney F, Main Level Breakouts
14:30—15:00
Coffee Available

Sweeney Ballroom Foyer
15:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
15:00—16:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Jeffrey E. Pessin, Albert Einstein College of Medicine, USA

* Richard N. Kitsis, Albert Einstein College of Medicine, USA

Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship Introduced by JLR Associate Editor, Ira Goldberg. Orchestrating Fatty Acid Flux to Adipose Tissue during Feast and Famine

16:00—19:00
Regulation of Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Rong Tian, University of Washington, USA

Christopher B. Newgard, Duke University Medical Center, USA
Role of the Gut Microbiota in the Pathogenesis and Treatment of Cardiometabolic Diseases

Dale Abel, University of Iowa, Carver College of Medicine, USA
Insulin Signaling in the Heart

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Muscular "Mediators" of Metabolism

Lawrence Kazak, Dana-Farber Cancer Institute, USA
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

THURSDAY, JANUARY 29

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—12:00
Mitochondrial Quality Control (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Heidi M. McBride, McGill University, Canada

Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control: How PINK1 and Parkin Survey Mitochondrial Fidelity and Respond with Selective Autophagy

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Roles of Lipid Droplet Lipolysis, Autophagy and Mitochondrial Fusion Dynamics in Fatty Acid Trafficking within Cells

Orian S. Shirihai, University of California, Los Angeles, USA
Mitochondrial Dynamics and Quality Control, a Conflict of Interest

Gerald W. Dorn, II, Washington University School of Medicine, USA
Mitochondrial Dynamics, Mitochondrial Quality Control and Heart Disease

Luca Scorrano, University of Padova, Italy
Keeping Mitochondria Cristae in Shape to Control Organ Damage and Metabolism

Peipei Ping, University of California, Los Angeles, USA
Data Science Approaches for Mitochondrial Discoveries

09:50—10:10
Coffee Break

Sweeney Ballroom Foyer
12:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
12:00—16:30
On Own for Lunch

16:00—16:30
Coffee Available

Sweeney Ballroom Foyer
16:30—19:20
Mechanisms of Dysregulated Glucogenogenesis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Alan R. Saltiel, University of Michigan, USA

Deborah M. Muoio, Duke University Medical Center, USA
Nutrient-Induced Mitochondrial Stress and Metabolic Inflexibility in Skeletal Muscle

Morris J. Birnbaum, Uninversity of Pennsylvania and Pfizer, Inc
Non-Autonomous Regulation of Hepatic Glucose Output by Insulin

Domenico Accili, Columbia University, USA
FOXO Signaling and Hepatic Glucose Production

Marc R. Montminy, The Salk Institute for Biological Studies, USA
Regulation of Hepatic Gluconeogenesis by the CREB Pathway

Carl S. Thummel, University of Utah School of Medicine, USA
Short Talk: The Molecular Basis of MODY1 and its Regulation by HNF4

Alexander S. Banks, Harvard Medical School, USA
Short Talk: Therapeutic Resolution of Insulin Resistance via MEK/ERK Inhibition and Reversal of PPARgamma Serine 273 Phosphorylation

16:30—19:00
Metabolism Under Stress in Heart Disease and Diabetes
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Sihem Boudina, University of Utah School of Medicine, USA

Rong Tian, University of Washington, USA
Metabolic Remodeling of the Heart

E. Douglas Lewandowski, University of Illinois at Chicago College of Medicine, USA
Remodeled Metabolism In and Around the Failing Heart

Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Institute, USA
Deciphering the Metabolic Basis of Heart Failure

Edward T. Chouchani, Dana Farber Cancer Institute, USA
Short Talk: Ischemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS

Benjamin A. Olenchock, Brigham and Women’s Hospital, USA
Short Talk: Inhibition of the Prolyl Hydroxylase EglN1 Is Sufficient for Local and Remote Cardiac Ischemic Protection: Role of Tryptophan Metabolism

19:05—20:05
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

FRIDAY, JANUARY 30

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:20
Emerging Synergy between Metabolism and the Gut Microbiome
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Christopher B. Newgard, Duke University Medical Center, USA

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors and the Hunger Game: From Feast to Famine

John F. Rawls, Duke University, USA
Microbial Regulation of Intestinal Lipid Metabolism and Gene Expression

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Insights into Insulin Signaling and Insulin Action in Muscle through Genetic Manipulation

Gökhan S. Hotamisligil, Harvard University, USA
Endoplasmic Reticulum and Mitochondria Integration in Response to Metabolic Stress

Gerard Karsenty, Columbia University Medical Center, USA
A Crosstalk between Glucose Uptake and Runx2 Determines the Onset of Osteoblast Differentiation and the Extent of Bone Formation

08:00—11:50
Cardiac Autophagy
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Konstantinos Drosatos, Temple University School of Medicine, USA

Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA
Autophagy in Cardioprotection and Impact of Metabolic Syndrome

Åsa B. Gustafsson, University of California, San Diego, USA
MCL-1 as a Critical Regulator of Mitochondrial Function and Cell Death

Elizabeth Murphy, NHLBI, National Institutes of Health, USA
Calcium Regulation of Mitochondrial Function

Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Ulk1 Plays a Crucial Role in Mitochondrial Autophagy in Cardiomyocytes

Christoph Maack, Universitätsklinikum des Saarlandes, Germany
Impact of the Mitochondrial/SR Interaction for Redox Regulation

Saptarsi M. Haldar, Gladstone Institutes and University of California, San Francisco, USA
Short Talk: Glucocorticoids Elicit Ergogenic Effects in Muscle via a Defined Transcriptional Pathway

Anja Karlstaedt, University of Texas Medical School at Houston, USA
Short Talk: Regulation of mTOR Activation during Acute Increases of Heart Work: The Role of Endogenous Substrates

09:40—10:00
Coffee Break

Sweeney Ballroom Foyer
11:20—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:20—16:30
On Own for Lunch

14:30—16:30
Workshop: Big Data to Knowledge (BD2K) (Joint)

Sweeney Ballroom C-E
* Jeffrey E. Pessin, Albert Einstein College of Medicine, USA

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Biomedical Big Data: Data Discovery and the Digital Enterprise

Abdelilah Arredouani, Qatar Foundation, Qatar
Non-Targeted Metabolomic Profiling Score Improves the Early Prediction of Type 2 Diabetes in the Prospective D.E.S.I.R. Study

Ida Donkin, Copenhagen University, Denmark
Spermatozoa from Lean and Obese Humans Carry Distinct Epigenetic Signatures

Olga Gupta, University of Texas Southwestern Medical Center, USA
Transcriptome Profiling of Omental Adipose Mesothelial Cells Reveals Differentially Expressed Transcripts Related to Inflammation

Ondrej Kuda, Institute of Physiology, Academy of Sciences of the Czech Republic, Czech Republic
Metabolipidomical Profiling of Adipose Tissue during Fatty Acid Re-Esterification

Xiaofeng Xin, Massachusetts Institute of Technology, USA
Systems Biology of Obesity-Induced Hepatic Insulin Resistance

Adam R. Wende, University of Alabama at Birmingham, USA
DNA Methylation and Corresponding Gene Expression Changes in the Diabetic Heart

Dietrich Rein, Metanomics Health, Germany
Validation of a Metabolomics-Based Biomarker for Heart Failure with Reduced Ejection Fraction

16:00—16:30
Coffee Available

Sweeney Ballroom Foyer
16:30—19:05
Mechanisms of Dysregulated Lipogenesis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Discovery of a Novel Class of Naturally-Occurring Lipids with Anti-Diabetic and Anti-Inflammatory Effects

Michael P. Czech, University of Massachusetts Medical School, USA
Adipose Lipogenesis in Control of Glucose Tolerance

Catherine Postic, Institut Cochin, France
ChREBP and Liver Steatosis

Alan R. Saltiel, University of Michigan, USA
Energy Expenditure Mediated by the Non-Canonical IKB Kinases

Praveen Sethupathy, University of North Carolina at Chapel Hill, USA
Short Talk: MicroRNA-Mediated Control of Metabolic Homeostasis

16:30—19:00
Mitochondria and Endoplasmic Reticulum-Mediated Cell Death
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Qiangrong Liang, New York Institute of Technology, College of Osteopathic Medicine, USA

Paolo Bernardi, University of Padova Medical School, Italy
The Mitochondrial Permeability Transition Pore

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
New Model of Mitochondrial Permeability Transition Pore (MPTP) Formation and Regulated Necrosis in the Heart

Kinya Otsu, , UK
Mitochondria, Cell Death and Inflammation

Wendy M. McKimpson, Albert Einstein College of Medicine, USA
The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote Beta-Cell Survival in Diabetes

Maik Hüttemann, Wayne State University, USA
Short Talk: Regulation of Mitochondrial Respiration and Apoptosis by Cytochrome c Phosphorylation

19:05—20:05
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakouts

SATURDAY, JANUARY 31

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Mitochondria, Metabolism and Aging (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Deborah M. Muoio, Duke University Medical Center, USA

David A. Sinclair, Harvard Medical School, USA
Coupling Nuclear and Mitochondrial Transcription

Douglas C. Wallace, Children's Hospital of Philadelphia, USA
Mitochondrial Mutations and Human Disease

Johan Auwerx, Ecole Polytechnique Federale de Lausanne - EPFL, Switzerland
Mitochondrial Function, Metabolism and Aging

Heidi M. McBride, McGill University, Canada
Redox Control of Mitochondrial Plasticity, Uncovering New Mechanisms that Link Function to Form

Peter S. Rabinovitch, University of Washington, USA
Short Talk: Short-Term Treatment with Mitochondrial Protective Peptide SS-31 Reverses Cardiac Aging in Mice

09:20—09:40
Coffee Break

Sweeney Ballroom Foyer
11:00—16:30
On Own for Lunch

14:00—16:00
Workshop: Inflammation in Diabetes, Obesity and Insulin Resistance

Sweeney Ballroom A-B
* Jeffrey E. Pessin, Albert Einstein College of Medicine, USA

Hyokjoon Kwon, Albert Einstein College of Medicine, USA
High Fat Diet-Induced Interleukin-13 Modulates Inflammation and Insulin Resistance

Yun Sok Lee, University of California, San Diego, USA
Saturated Fatty Acids Induce Uncoupled Mitochondrial Respiration and Trigger HIF-1alpha Causing Inflammation and Insulin Resistance in Obesity

Rubén García-Martín, Dresden University of Technology, Germany
Adipocyte Hypoxia-Inducible Factor 2 Protects from Whitening of the Brown Adipose Tissue and Metabolic Dysregulation in the Course of Diet-Induced Obesity

Sagar P. Bapat, The Salk Institute for Biological Studies, USA
Fat Regulatory T Cells Drive Age-Associated Insulin Resistance

Prameladevi Chinnasamy, Einstein College of Medicine, USA
Allograft Inflammatory Factor-1 in Obesity and Type II Diabetes

Caroline Tao, Amgen, USA
Dichotomous Role of Adipocyte Toll-Like Receptor 4 on Insulin Sensitivity

Sojin Lee, University of Pittsburgh School of Medicine, USA
FoxO1 Dictates M1 vs. M2 Polarization and Integrates Inflammation to Insulin Resistance in Diabetes

Hye-Eun Lee, Catholic University of Korea, South Korea
Suppression of NLRP3 Inflammasome Activation by Caffeic Acid Phenethyl Ester and its Significance in Modulation of Metabolic Diseases

16:00—16:30
Coffee Available

Sweeney Ballroom Foyer
16:30—18:45
Circadian Rhythms in Metabolic Networks
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Michael P. Czech, University of Massachusetts Medical School, USA

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Integrating Metabolism Around the Clock

Joseph T. Bass, Northwestern University, USA
Circadian Control of Metabolic Signaling

Ueli Schibler, University of Geneva, Switzerland
Systemic Regulation of Circadian Gene Expression

Jorge L. Ruas, Karolinska Institutet, Sweden
Short Talk: A Molecular Mechanism for Skeletal Muscle - Brain Crosstalk that Protects from Stress-Induced Depression

16:30—18:30
Toxins and Protectors of the Myocardium
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Maha Abdellatif, University of Medicine & Dentistry of New Jersey, USA

Ira J. Goldberg, New York University, USA
Lipid Uptake, the Route to Lipid Droplet Formation and Cardiomyocyte Toxicity

Kenneth Walsh, Boston University School of Medicine, USA
Molecular Links between Metabolic and Cardiovascular Diseases

Lorrie A. Kirshenbaum, University of Manitoba, St. Boniface Hospital Research Center, Canada
Bnip3 Mediated Loss of Mitochondrial UCP3-Cytochrome c Oxidase Complexes Underlies Respiratory Defects and Cardiac Failure in Anthracycline Cardiotoxicity

18:45—19:45
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sweeney F, Main Level Breakouts

SUNDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen Intercept Pharmaceuticals, Inc.
Journal of Molecular Cell Biology (JMCB) MedImmune
Novo Nordisk A/S Pfizer Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Journal of Lipid Research

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104616-01

Funding for this conference was made possible (in part) by 1 R13 DK104616-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

PLOS

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676