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Casa Grande Hotel Floorplan

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This meeting took place in 2015



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Cell Death Signaling in Cancer and the Immune System (S2)


Organizer(s) Gustavo Amarante-Mendes, Douglas R. Green and Kim Newton
October 28—November 2, 2014
Casa Grande Hotel • Guarujá, São Paulo Brazil
Discounted Abstract Deadline: Jun 26, 2014
Abstract Deadline: Jul 29, 2014
Scholarship Deadline: Jun 26, 2014
Discounted Registration Deadline: Aug 28, 2014

Organized in collaboration with the São Paulo Research Foundation (FAPESP) and the National Council for Scientific and Technological Development (CNPq) - Brazil. Sponsored by AbbVie Inc., Genentech, Inc. H3 Biomedicine Inc. and TESARO, Inc.

Summary of Meeting:
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury and infectious disease. Over the past decades, the fundamental molecular mechanisms underlying one form of cell death, apoptosis, have been largely defined. Other forms of cell death, such as programmed necrosis or autophagic cell death, are not as well understood. In this meeting, the pathways that impact on a cell’s decision to live or die will be presented in the context of physiology and disease, and ways to influence that decision therapeutically will be explored. The consequence of cell death for the body is also of great interest, as the clearance of dying cells impacts on other physiological processes. The successful elucidation of the molecular pathways controlling and mediating apoptosis has come to fruition as agents for cancer and other therapies are entering the clinic. Similar promise exists for other forms of cell death as our knowledge of these advances. In addition, we are beginning to understand how processes relating to cell death and survival play roles in other biological processes, such as the secretion of cytokines and the response to infection. This meeting brings together researchers in the fields of cell death and survival from around the world. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, OCTOBER 28

16:00—20:00
Arrival and Registration

18:00—19:00
Welcome Mixer


WEDNESDAY, OCTOBER 29

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Douglas R. Green, St. Jude Children's Research Hospital, USA

Vishva M. Dixit, Genentech, Inc., USA
Interplay between NOD Sensors that Mediated Pyroptosis

09:30—12:00
Cell Death Signaling I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Seamus J. Martin, Trinity College Dublin, Ireland

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
A Toolbox of Highly Selective Caspase Chemical Reagents

Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
How Cells Evade Apoptosis: From Neurons to Cancer

Stefan J. Riedl, Sanford-Burnham Medical Research Institute, USA
Short Talk: Structure and Mechanism: Death Domains in the Regulation of Immunity and Cancer

Douglas R. Green, St. Jude Children's Research Hospital, USA
How Cells Survive: Single Cell Analysis Reveals Properties of Non-Genetic Apoptosis Resistance

10:10—10:30
Coffee Break

12:00—13:00
Poster Setup

12:00—14:30
On Own for Lunch

13:00—22:00
Poster Viewing

14:30—16:30
Workshop 1: Cancer

* David W. Andrews, University of Toronto, Canada

Peter Huebener, University Hospital Hamburg-Eppendorf, Germany
HMGB1 Links Chronic Injury and Cancer in the Liver

Keehoon Jung, Harvard Medical School, Massachusetts General Hospital, USA
Targeting the Immune Microenvironment to Improve Colorectal Cancer Treatment

Nga Lam, Walter and Eliza Hall Institute, Australia
Understanding the Role of Bcl-G in Cell Death Signaling And Colorectal Cancer

Yannick Böge, University Hospital Zürich, Switzerland
An Apoptosis-Driven Pathway to Hepatocarcinogenesis

Hetal Brahmbhatt, McMaster University, Canada
Identification and Characterization of Small Molecules that Enhance the Pro-Apoptotic Activity of Bax

Stephen E. Girardin, University of Toronto, Canada
The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

Gabriel Ichim, Beatson Institute, UK
Limited Mitochondrial Permeabilisation Causes DNA-Damage and Genomic Instability in the Absence of Cell Death

Fabien Llambi, St. Jude Children's Research Hospital, USA
BOK is a Pro-Apoptotic Effector Protein Regulated by the Ubiquitin-Proteasome System

16:30—17:00
Coffee Available

17:00—19:00
Cell Death Signaling II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Shigekazu Nagata, Kyoto University, Japan

Marion MacFarlane, MRC Toxicology Unit, UK
c-FLIP-Mediated Regulation of Caspase-8 DED Chain Assembly Determines Cell Fate

Peter Vandenabeele, VIB, Ghent University, Belgium
Necroptosis versus Apoptosis

Francis Ka-Ming Chan, University of Massachusetts Medical School, USA
Playing with Fire: Necroptosis-Dependent and Independent Roles of RIPK3 in Inflammation

Silvia Alvarez-Diaz, Walter and Eliza Hall Institute, Australia
Short Talk: MLKL Plays a Critical Role Inducing Necroptosis within a Physiological Context

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


THURSDAY, OCTOBER 30

07:30—08:30
Breakfast

08:30—11:45
Cell Death and Cancer I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karen H. Vousden, Beatson Institute for Cancer Research, UK

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
How Does p53 Prevent Cancer?

David W. Andrews, University of Toronto, Canada
Regulation of Mitochondrial Membrane Permeabilization by Bcl-2 Family Proteins

Axel Witt, University Hospital Cologne, Germany
Short Talk: IAP Antagonization Induces Inflammatory Destruction of Vasculature Endothelium and Inhibits Tumor Growth

Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Control of Cell Fate by miRNA

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Cellular Cooperation in Normal Tissues and Tumors

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Short Talk: Mcl-1 Inhibitors for the Treatment of TNBC and Other Cancers

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

11:45—14:30
On Own for Lunch

13:00—22:00
Poster Viewing

14:30—16:30
Workshop 2: Host Defense

* Petr Broz, Biozentrum, University of Basel, Switzerland

* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Goutam Gupta, Los Alamos National Laboratory, USA
Preventing Host Cell Death by Engineering of Novel Innate Immune Defense

Luciana Paroneto Medina, Institute of Biomedical Sciences, University of São Paulo, Brazil
PGE2 as a Regulator of Experimental Autoimmune Encephalomyelitis (EAE)

Maria Andree, University of Cologne, Germany
BID-Dependent Release of Mitochondrial SMAC Dampens XIAP-Mediated Immunity Against Shigella

Dmitry M. Shayakhmetov, Emory University, USA
The Identification of the Novel Physiologically-Regulated Necrotic Cell Death Pathway Mediated by the Interferon-Regulatory Factor 3 (IRF3)

Eugenio D. Hottz, Oswaldo Cruz Foundation, Brazil
Activation of Inflammasome and Cell Death Pathways in Platelets Modulate Inflammatory Responses in Dengue

Bernardo S. Franklin, University of Bonn, Germany
The Extracellular Functions of the Inflammasomes

Jennifer Martinez, St. Jude Children's Research Hospital, USA
LC3-Associated Phagocytosis as a Critical Regulator of Inflammation

16:30—17:00
Coffee Available

17:00—19:00
Cell Death and Cancer II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Simone Fulda, University Hospital Frankfurt, Germany

Gerard I. Evan, University of Cambridge, UK
Killing Cancers without Killing Normal Tissues

Karen H. Vousden, Beatson Institute for Cancer Research, UK
Metabolic Control of Cancer Cell Fate Decisions

Anthony G. Letai, Dana-Farber Cancer Institute, USA
Kicking Cancer Right in the Mitochondria

Andreas Bergmann, University of Massachusetts Medical School, USA
Short Talk: Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


FRIDAY, OCTOBER 31

07:30—08:30
Breakfast

08:30—11:30
Cell Death and Host Defense I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA

Petr Broz, Biozentrum, University of Basel, Switzerland
Caspase-11 Activation Requires Lysis of Pathogen-Containing Vacuoles by IFN-Induced GTPases

Domagoj Vucic, Genentech, Inc., USA
IAP Proteins Regulate the Formation of Necrosome and Inflammasome Complexes

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasome Control of Disease

Karina R. Bortoluci, Federal University of São Paulo, Brazil
Lysosomal Pathway Induced by Cytosolic Flagellin in Cell Death and Immunity

Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1 and Caspase-8 Catalytic Activity Mediate Caspase-1 Activation in Response to Pathogen Blockade of Innate Immune Signaling

09:50—10:10
Coffee Break

11:30—13:00
Poster Setup

11:30—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
Cell Death and Host Defense II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Janelle S. Ayres, The Salk Institute, USA
Microbiota Control of Infection and Inflammation Induced Pathology

Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil
Short Talk: Novel Role for Galectin-1 in CTL Killing

Seamus J. Martin, Trinity College Dublin, Ireland
Cell Death and Inflammation: Revisiting the Danger Model

Avi Ashkenazi, Genentech, Inc., USA
Opposing UPR Signals Converge on DR5 to Control Apoptosis

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SATURDAY, NOVEMBER 1

07:30—08:30
Breakfast

08:30—11:45
Consequences of Cell Death
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter Vandenabeele, VIB, Ghent University, Belgium

Shigekazu Nagata, Kyoto University, Japan
Exposure of Phosphatidylserine during Apoptosis

Kim Newton, Genentech, USA
Necroptosis Signaling and Inflammation

Andrew Oberst, University of Washington, USA
Short Talk: Inflammatory and Immune Responses to Apoptosis and Necroptosis

Will Wood, University of Bristol, UK
Signal Prioritization: Recognizing Death and Damage in vivo

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Inflammatory Signaling, Autophagy and Dying Cell Clearance

Linda Julian, Beatson Institute for Cancer Research, UK
Short Talk: Apoptotic Blebbing in Tissue Homeostasis and Cancer

09:50—10:10
Coffee Break

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—18:15
Cell Death Therapies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kim Newton, Genentech, USA

Simone Fulda, University Hospital Frankfurt, Germany
Novel Opportunities to Target IAP Proteins for Cancer Therapy

David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia
Therapeutically Targeting the Bcl-2-Regulated Cell Survival Pathway

18:15—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil

Scott W. Lowe, HHMI/Memorial Sloan-Kettering Cancer Center, USA
Tumor Suppressor and Tumor Maintenance Genes

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


SUNDAY, NOVEMBER 2

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. Genentech, Inc.
H3 Biomedicine Inc. National Council for Scientific and Technological Development (CNPq) - Brazil
São Paulo Research Foundation (FAPESP) - Brazil TESARO, Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676