Fairmont Banff Springs Floorplan

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This meeting took place in 2015


Here are the related meetings in 2018:
Progress and Pathways Toward an Effective HIV Vaccine (J6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

HIV Vaccines (X5)


Organizer(s) Giuseppe Pantaleo, Rafick P. Sekaly and Leonidas Stamatatos
March 22—27, 2015
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Nov 19, 2014
Abstract Deadline: Dec 17, 2014
Scholarship Deadline: Nov 19, 2014
Discounted Registration Deadline: Jan 20, 2015

Sponsored by Merck & Co., Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation


Summary of Meeting:
As the 30th anniversary of the discovery of HIV has come and gone, HIV remains a catastrophic public health concern, with an estimated global prevalence of 34 million HIV-infected persons. Despite the remarkable advances in the development of several biomedical interventions for the prevention of HIV, the importance of developing an effective HIV vaccine has been recognized by a wide spectrum of the scientific community and civil society. Important milestones for the HIV vaccine field were the demonstration that a vaccine regimen could reduce HIV acquisition and the identification of binding IgG envelope (env) antibodies as potential correlates of protection from HIV acquisition. However, broad neutralizing antibodies (bNAbs) are thought to be the main mechanism of protection of the currently available effective vaccines. This meeting addresses the major scientific gaps in the generation of env bNAbs. Major areas covered by the meeting include: 1) Understanding the development of bNAbs in natural infections and following vaccination; 2) Determining predictors of response to vaccines; 3) Reviewing advances in envelope immunogen design; 4) The therapeutic use of bNAbs; 5) The application of novel technologies to monitor the immune response; and 6) The development of therapeutic strategies aimed to functional HIV cure. The meeting will bring together interdisciplinary groups with outstanding expertise in B- and T-cell biology, structural biology, vaccinology and clinical science. It will therefore provide insight into the attendees how innovative basic observations from the bench side may translate into the clinical development of vaccines and therapeutic interventions.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 22

16:00—20:00
Arrival and Registration

Van Horne Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 23

07:00—08:00
Breakfast

Mezzanine 2
08:00—09:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Patrick C. Wilson, University of Chicago, USA

* Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland

Max D. Cooper, Emory University, USA
Comparative Analysis of Alternative Adaptive Immune Systems

Anthony S. Fauci, NIAID, National Institutes of Health, USA
Toward an HIV Vaccine: A Scientific Journey

09:30—09:50
Coffee Break

Van Horne Foyer
09:50—11:45
Antibody Therapy (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
Jeffrey V. Ravetch, Rockefeller University, USA
Fc Effector Functions

Gary J. Nabel, Sanofi, USA
The Challenges and Promise of Broadly Neutralizing Abs for HIV Prevention and Treatment

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Passive Immunization

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 1: Envelope Structure and Immunogen Design Efforts

Van Horne Ballroom C
* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA

* John P. Moore, Weill Medical College of Cornell University, USA
Production and Properties of Multiple Native-Like SOSIP.664 Trimers

Gabriel Ozorowski, The Scripps Research Institute, USA
Characterization and Design of HIV-1 Env SOSIP gp140 Trimers

Jose Maximiliano Medina-Ramírez, University of Amsterdam, Netherlands
A Native-Like HIV-1 Envelope Trimer that Engages Multiple Germline Precursors of Broadly Neutralizing Antibodies

Guillaume B. E. Stewart-Jones, National Institutes of Health, USA
Crystal Structures of Glycosylated JR-FL and BG505 SOSIP Trimers at 3.7Å Resolution Reveal how N-Linked Glycosylation Shield the Glycan Free CD4 Binding Site

M. Gordon Joyce, U.S. Military HIV Research Program, USA
Designed HIV-1 Env Molecules from Multiple Clades that Display Structural and Antigenic Characteristics of the Mature Prefusion HIV-1 Env

Javier Guenaga, IAVI Neutralizing Antibody Center at TSRI, USA
Structure-Guided Identification of gp120 Residues that Increase the Propensity of Env Sequences to Form Native-Like Soluble Trimers

Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
Identification of New HR1 Proline Substitutions that Stabilize the Cleavage-Independent, Well-Ordered, Native Flexibly Linked (NFL) Trimers

Wei Cheng, University of Michigan, USA
Optical Trapping Virometry Reveals the Positive Cooperativity of HIV-1 Envelope Glycoproteins in Mediating Viral Infection

14:30—16:30
Workshop 1: B1 Cell Biology

Van Horne Ballroom A/B
* Thomas L. Rothstein, Western Michigan University, USA

* Gregg J. Silverman, New York University Langone Medical Center, USA

Cecilia Cavazzoni, Federal University of Rio de Janeiro, Brazil
Characterization of the Repertoire of Natural Antibodies Anti-HSC70

Gudrun F. Debes, University of Pennsylvania, USA
IL-10 Producing Innate-Like B Cells Are Part of the Skin Immune System and Require alpha4-beta1 Integrin to Migrate between the Peritoneum and Inflamed Skin

Stephanie Glaesener, Hannover Medical School, Germany
Pneumovax23© Directly Stimulates B Cells in vivo Generating a Predominant IgA Response Early after Vaccination

Benchang Guo, Feinstein Institute for Medical Research, USA
RasGRP1 Shapes Autoreactive Receptor Repertoire in B1a Cells which Prevents Autoimmune Disease

Matthias Hahn, University Medical Center Mainz, Germany
Over-Expression of an Alternative Splice Variant of the Negative NF-kappaB Regulator CYLD Leads to the Development of B-CLL in Mice

Nichol E. Holodick, Feinstein Institute for Medical Research, USA
Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age

Rudolf Übelhart, University Hospital Ulm, Germany
Structural Differences between IgD and IgM Control B Cell Responsiveness and the Activation of Innate-Like B1 Cells

Andre M. Vale, Universidade Federal do Rio de Janeiro, Brazil
Maintenance of B Cells with Hydrophobic CDR-H3 Intervals within the Peritoneal Cavity

14:30—16:30
Workshop 2: B Cell Selection and Tolerance

Theatre
* Eric Meffre, Yale University School of Medicine, USA

* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA

Lars Nitschke, University of Erlangen, Germany
Siglec-G: A B Cell Inhibitory Receptor Controlling Autoimmunity

Martin S. Naradikian, University of Pennsylvania, USA
IL-4 and IL-21 Reciprocally Regulate T-BET Expression in Activated B Cells

Jean-Nicolas Schickel, Adimab, LLC, USA
AID Expression in Human B Cell Precursors Is Essential for Central B-Cell Tolerance

Masayuki Kuraoka, Duke University, USA
BCR and TLR Synergy Elicits High Levels of AID Expression in Immature/T1 B Cells to Ensure Central B-Cell Tolerance

Kristin M.S. Schroeder, National Jewish Health, USA
B Cell Tolerance Mechanisms Limit Protective HIV Antibody Responses

Thomas Hägglöf, Karolinska Institutet, Sweden
Neutrophils License NKT Cells to Regulate Self-Reactive B Cell Responses

Christopher M. Tipton, Emory University, USA
Diversity, Cellular Origin and Autoreactivity of Antibody-Secreting Cell Expansions in Acute Systemic Lupus Erythematosus

Aaron J. Marshall, University of Manitoba, Canada
TAPP Adaptors Control Akt-Dependent Metabolic Activation of B Cells and Suppress Autoimmunity via Binding to the SHIP Product PI(3,4)P2

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Natural and Vaccine-Induced Development of Antibody Response
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Susan Zolla-Pazner, New York University School of Medicine, USA

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Developmental Pathways of Broadly Neutralizing Antibodies

Pamela J. Bjorkman, California Institute of Technology, USA
Overcoming HIV-1 Evasion of Antibody Avidity with Intra-Spike Crosslinking Reagents

Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden
Diversity and Evolution of HIV Env Vaccine-Induced B Cell Responses

Todd C. Bradley, Duke University Medical Center, USA
Short Talk: HIV-1 CD4 Binding Site-Directed Autologous Tier-2 Neutralizing Antibody Lineage Elicited by Immunization with a Swarm of HIV-1 Envs from an African Individual

17:00—19:15
Peripheral B Cell Development and Function
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Michael P. Cancro, University of Pennsylvania, USA
New Paths to Peripheral B Cell Tolerance and Differentiation

Andrea Cerutti, Mount Sinai School of Medicine, USA
Marginal Zone B Cells

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Molecular Requirements for Productive Humoral Immunity in Humans - The Power of PIDs

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Molecular Dynamics of Memory B Cell Responses

Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: High Throughput Ig Sequencing of Paired Blood and Spleen Samples Allows a Redefinition of IgM Memory Subsets in Humans

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

TUESDAY, MARCH 24

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
B/T Cell Interactions (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
B Cell Guidance Cues and the Antibody Response

* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
T Cell Help to B Cells: Follicular Helper CD4 T Cell (Tfh) Biology

Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
T Follicular Helper (Tfh) Cells in Health and Chronic HIV Infection

Claudia Cicala, NIAID, National Institutes of Health, USA
Short Talk: Targeting alpha4beta7 Integrin Reduces Mucosal Transmission and Dissemination of SIV

Gabriel D. Victora, Rockefeller University, USA
Short Talk: Clonal Dynamics and Evolution in Germinal Centers

David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Short Talk: Distinct Impact of B Cell-Intrinsic Type 1 vs Type 2 Interferon Signals in GC B Cell Tolerance

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:45
Hands-On Computer Session on Los Alamos Sequence Database

Beatty
11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: New Immunization Tactics

Van Horne Ballroom C
* Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA

* Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Rena D. Astronomo, Fred Hutchinson Cancer Research Center, USA
Low Concentrations of Broadly-Neutralizing Antibodies (bnAbs) Protect Against Early Events of Mucosal HIV-1 Infection in a Human ex vivo Vaginal Explant Model

Jinghe Huang, NIAID, National Institutes of Health, USA
Isolation of a Broad and Potent CD4-Binding Site Monoclonal Antibody with Novel Binding Characteristics

Joseph G. Jardine, The Scripps Research Institute, USA
In vivo Activation of GL-VRC01 Class Antibodies in Transgenic Mice by Germline-Targeted Immunizations

Huaxin Liao, Duke University Medical Center, USA
HIV-1 CH505 Env Immunogens Initiated CD4 Binding Site Antibody Lineage in Rhesus macaques

Aaron Louie, National Institutes of Health, USA
HIV-Specific Antibodies Derived from Exhausted Memory B Cells of Infected Individuals Show Deficiencies in Neutralization and Somatic Hypermutation

Delphine C. Malherbe, Oregon Health & Science University, USA
Early Breadth Clade C Env Immunogens Elicit Cross-Clade NAbs and Env-Specific Tfh Responses

Jose M. Martinez-Navio, University of Miami - LSTP, USA
Host Anti-Antibody Responses following AAV-Mediated Delivery of Antibodies Against HIV and SIV

Rogier W. Sanders, Weill Medical College of Cornell University, USA
HIV Neutralizing Antibodies Induced by Native-Like Envelope Trimers

14:30—16:30
Workshop 3: Vaccines and Immunity

Van Horne Ballroom A/B
* Bonnie B. Blomberg, University of Miami School of Medicine, USA

Paul V. Thomas, NIAID, National Institutes of Health, USA
Structural Definition of a Novel Set of Converged Broadly Neutralizing Influenza Antibodies Elicited in H5N1 Vaccinees

Goetz R. Ehrhardt, University of Toronto, Canada
Biomarker Discovery on Memory B Cells and Plasma Cells Using Monoclonal VLR Antibodies

Carole Henry, University of Chicago, USA
Pre-Existing Human Antibodies Neutralize the Novel Influenza H7N9 Strain

Mattias Forsell, Umeå University, Sweden
Activation of Circulating Platelets Leads to the Release of Potent Antiviral IgG

Hana Golding, Center for Biologics Evaluation and Research, US Food and Drug Administration, USA
Exploring Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines: Impact of Adjuvants and Prime-Boost Approaches

Gregory C. Ippolito, University of Texas at Austin, USA
New Molecular and Proteomic Techniques for the "Deep" Profiling of Vaccine-Elicited Cellular and Serological Antibody Repertoires

Greg A. Kirchenbaum, Vaccine and Gene Therapy Institute of Florida, USA
Longitudinal Profiling of Young and Elderly Individuals in Response to Seasonal Influenza Vaccination

Ignacio Sanz, Emory University, School of Medicine, USA
Identification of Long-lived Plasma Cells in Human Bone Marrow

14:30—16:30
Workshop 4: B Cell Development and Signaling

Theatre
Julia Jellusova, Sanford Burnham Medical Research Institute, USA
GSK3 Regulates B Cell Metabolism, Cell Growth and Proliferation

Nikita S. Kolhatkar, University of Washington, USA
The Role of Altered Antigen Receptor Signaling in Wiskott Aldrich Syndrome

Ai Kotani, Tokai University, Japan
A Single miRNA Substitutes for Requirement of EBF1 in B Lineage Commitment

Jinmin Lee, NIAID, National Institutes of Health, USA
Defining the Oligomeric State on B Cell Receptors on the Surfaces of Human Naïve and Memory B Cells Using Super-Resolution Fluorescence Microscopy

Stephen K. H. Li, Western University, Canada
Identification of a Negative Regulatory Role for the E26 Transformation-Specific Transcription Factor Spi-C in the Murine B Cell Lineage

Hongsheng Wang, NIAID, National Institutes of Health, USA
An Essential Role of Transcription Factors PU.1 and IRF8 in Follicular B Cell Development and the Germinal Center Response

* Duane R. Wesemann, Brigham and Women's Hospital, Harvard Medical School, USA
Role of Environment in the Shaping of the Primary Immunoglobulin Repertoire

Maryaline Coffre, New York University School of Medicine, USA
Dicer-Dependent Non-Coding RNAs Are Essential for B Cell Development and Maturation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Predictors of Response to Vaccines
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Dennis R. Burton, The Scripps Research Institute, USA

Rafick-Pierre Sékaly, Case Western Reserve University, USA
Genetic and Epigenetic Determinants of Vaccine Responses

Tobias Kollmann, University of British Columbia, Canada
Predictors of Vaccine Responses in Children

17:00—19:15
Memory and Plasma Cell Differentiation and Fate
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin, Germany

Patrick C. Wilson, University of Chicago, USA
Immune Memory Shapes B Cell Responses to Influenza

David M. Allman, University of Pennsylvania, USA
Plasma Cell Subpopulations in the Bone Marrow

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Signaling and Selection in GC B Cells

Kim Good-Jacobson, Monash University, Australia
Short Talk: c-Myb Establishes a Transcriptional Network in Germinal Center B Cells that Controls T-bet, Class Selection and Long-Term Immunity

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

WEDNESDAY, MARCH 25

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Anti-Viral B Cell Responses (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
Barton F. Haynes, Duke University Medical Center, USA
Ontogenicity of Broadly Neutralizing Antibodies during HIV-1 Infection

John R. Mascola, NIAID, National Institutes of Health, USA
Antibody Responses to HIV

* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA
Characterization of Recombinant HIV-1 Envelopes that Bind Germline Forms of Broadly Neutralizing Antibodies

Ian A. Wilson, The Scripps Research Institute, USA
Broad Neutralization of Influenza Viruses

Pia Dosenovic, Rockefeller University, USA
Short Talk: Development of HIV-1 Broadly Neutralizing Antibodies in Human Variable Region Knock-In Mice

Scott D. Boyd, Stanford University, USA
Short Talk: Storage and Recall of Anti-Influenza Antibodies in Younger and Older Adults

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:45
Hands-on Computer Session on Los Alamos Immunology Database

Beatty
11:15—12:15
Meet the Editors

Van Horne Ballroom A/B
* Catarina Sacristán, Cell Press, USA

Alison Farrell, Nature Publishing Group, USA

Fabiola V. Rivas, Immunity/Cell Press, USA

Liz Thompson, Immunity, Cell Press, USA

Sri Devi Narasimhan, Cell Press, USA

Gabriel A. Gasque, PLOS Biology, USA

Kristen L. Mueller, Science Magazine, USA

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session

Van Horne Ballroom C
* Susan Moir, NIAID, National Institutes of Health, USA

* Matthieu Perreau, University Hospital of Lausanne, Switzerland

James J. Knox, University of Pennsylvania, USA
HIV Infection Induces the Expansion of T-Bet Expressing B Lymphocytes

Thomas Liechti, Institute of Medical Virology, Switzerland
Tracing B Cell Subset Changes during Acute and Chronic HIV-1 Infection and Restoration upon ART Initiation

Chung Park, NIAID, National Institutes of Health, USA
Lymph Node B Cells Survey Interfollicular SIGN-R1+ Macrophages that Capture HIV-1 gp120

D. Noah Sather, Center for Infectious Disease Research, USA
Repertoire Analysis of the B Cell Receptor-Encoding Loci in Humans and Rhesus macaques by Next Generation Sequencing

Chaim A. Schramm, NIAID, National Institutes of Health, USA
Longitudinal Deep-Sequencing of the VRC01-Antibody Lineage Reveals High Evolutionary Rate and Extraordinary Diversity

Zizhang Sheng, Columbia University, USA
Evolutionary Rate Dynamics of HIV-1 Broadly Neutralizing Antibody Lineages

14:30—16:30
Workshop 5: Affinity Maturation and Class Switch

Van Horne Ballroom A/B
* Kim Good-Jacobson, Monash University, Australia

* Garnett H. Kelsoe, Duke University and Medical Center, USA

Alexander D. Gitlin, Rockefeller University, USA
Clonal Selection in the Germinal Center by Regulated Proliferation and Hypermutation

Stephen P. Methot, Institut de Recherches Cliniques de Montreal, Canada
Consecutive Interactions with HSP90 and eEF1A1 Underlie a Functional Maturation and Storage Pathway of AID in the Cytoplasm

Heping Xu, Cincinnati Children's Hospital Medical Center, USA
Regulation of Bifurcating B Cell Responses by IRF4 and IRF8-Mediated Reciprocal Feedback

Zhiyong Yang, University of California, San Francisco, USA
Plasma Cell Differentiation Driven by Antigen-Independent Signaling Activity of the IgE B Cell Receptor

Rushad Pavri, Institute for Molecular Pathology, Vienna BioCenter, Austria
The Role of the Mcm Complex in Class Switch Recombination

Jennifer L. Yates, Wadsworth Center, New York State Department of Health, USA
Innate iNKT Cells Provide T-Dependent Type 2 Help for B Cells: Expanding the Helper Paradigm

Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
The Imbalanced Signaling between PTEN and Phosphoinositide 3-Kinase Impairs Class Switch Recombination

Nobuo Sakaguchi, Kumamoto University, Japan
Regulation of Selective Non-Coding RNA Species Involved in B-Cell Maturation by AID-Interacting Molecule GANP

14:30—16:30
Workshop 4: Ab Based Therapy for Prevention and for Cure

Theatre
* Richard A. Koup, NIAID, National Institutes of Health, USA

* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Sara Ferrando-Martinez, NIAID, National Institutes of Health, USA
Follicular CD8 T Cells Have Superior Cytolytic Capacity and Mediate a Redirected Killing of HIV-Infected Cells by Bispecific Antibodies

M. Anthony Moody, Duke University Medical Center, USA
Elevated Prevalence of Autoantibodies in HIV-Infected Individuals with Plasma Broadly Reactive Neutralizing Antibodies (bnAbs) Compared to Infected Individuals Lacking Plasma bnAbs

Ariel Halper-Stromberg, Rockefeller University, USA
Targeting the HIV-1 Reservoir in Humanized Mice Using Broadly Neutralizing Antibodies and Viral Inducers

Ann J. Hessell, Oregon Health & Science University, USA
Post-Exposure Treatment with Neutralizing mAbs Ablates SHIV Infection in Infant Rhesus macaques and Limits Establishment of Latent Viral Reservoirs

Smita S. Iyer, Emory University, USA
Co-Delivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CD4+ T Follicular Helper Cell Response in Rhesus macaques

Amarendra Pegu, NIAID, National Institutes of Health, USA
Efficacy of Antibody Therapy in Acute SHIV-Infected Macaques

Akshaya Ramesh, Boston University School of Medicine, USA
Macaque Immunogenetics through de-novo Genome Assemblies

Veronika Schmid, University of Regensburg, Germany
Characterization of Anti-HIV-1 Envelope Antibodies Using a FACS Based High Throughput Mapping Platform

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Envelope Structure
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Peter D. Kwong, NIAID, National Institutes of Health, USA

Sriram Subramaniam, National Institutes of Health, USA
Structural Mechanism of HIV Entry

Dennis R. Burton, The Scripps Research Institute, USA
Envelope-Glycosylation and Antibody-Recognition

Walther Mothes, Yale University School of Medicine, USA
Conformational Dynamics of Single HIV-1 Envelope Trimers on Native Virions

Andrew B. Ward, The Scripps Research Institute, USA
Short Talk: High-Resolution Cryo-EM Studies of HIV-1 Envelope

17:00—19:30
Antibody Maturation and Class Switch
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
Molecular Mechanism of AID-Mediated SHM and SCR

Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms that Direct Specificity and Outcome of Activation-Induced Cytidine Deaminase (AID) Activity

Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA
AID Targeting

Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: DNA Polymerases Iota and Zeta Standoff during Antibody Hypermutation

Uttiya Basu, Columbia University, USA
Short Talk: In B Cells, High-Throughput Proteomic Screen Identifies Co-Factors for RNA Exosome that Facilitates AID Access to Both Strands of Transcribed DNA

Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA
Short Talk: Uracil DNA Glycosylase of Gammaherpesvirus Alters B Cell Class Switch Recombination

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

THURSDAY, MARCH 26

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
HIV Vaccine Clinical Development
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Peggy Johnston, Bill & Melinda Gates Foundation, USA

* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Overview of HIV Clinical Vaccine Development

Nelson L. Michael, Walter Reed Army Institute of Research, USA
Immune Correlates of Protection

Nathalie Garçon, Bioaster, France
Challenges in the Preclinical and Clinical Development of Novel Adjuvants

Kristin L. Boswell, NIAID, National Institutes of Health, USA
Short Talk: Characterization of CD150 Expression and Function on SHIV-Specific TFH Cells

Rebecca M. Lynch, George Washington University, USA
Short Talk: Virologic Impact of VRC01-Infusion in HIV-1 Infected Subjects

08:00—11:30
B Cell Immune Deficiencies
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Anne Durandy, Institut Imagine, France
Immunoglobulin Class Switch Recombination Deficiencies: An Update

Klaus Warnatz, University Clinic Freiburg, Germany
NF-kappaB in B Cell Differentiation - From an Immunodeficient Standpoint

Mary Ellen Conley, Rockefeller University, USA
Defects in Early B Cell Development

Lennart Hammarström, Karolinska Institute, Sweden
Defects in Late B Cell Development - Lessons from WES and WGS

Jacob M. Rosenberg, Stanford University, USA
Short Talk: The Landscape and Function of Anti-Cytokine Autoantibodies in Health and Primary Immunodeficiency

Fabienne Mackay, Monash University, Australia
Short Talk: The TACI Receptor Regulates T-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death

Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Non-Coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 5: B/T Cell Interactions

Van Horne Ballroom C
* Rama Rao Amara, Emory University, USA

Robert Abbott, Northeastern University, USA
The A2a Adenosine Receptor Is Required for Affinity Maturation in the Germinal Center

Atef F. Allam, Walter Reed Institute of Research, USA
TFH Cells Accumulate in the Female Reproductive Tract and in Peyer’s Patches of Humanized DRAG Mice, Are Highly Permissive to HIV-1, and Show Impaired Cytokine Production Over the Course of HIV-1 Infection

John P. Barton, Massachusetts Institute of Technology, USA
Computational Prediction of Intra-Individual HIV Evolution to Evade Cellular Immune Selection Pressure

Thorsten Demberg, NCI, National Institutes of Health, USA
Persistent Loss and Dysregulation of Marginal Zone B-Cells after SHIVSF162P4 Challenge Despite Control of Viremia

Colin Havenar-Daughton, La Jolla Institute of Allergy and Immunology, USA
T Follicular Helper Cell and Germinal Center B Cell Responses to HIV gp140 Protein + TLR-Encapsulated Nanoparticle Immunization in Rhesus macaques

Joyce K. Hu, La Jolla Institute of Allergy and Immunology, USA
Characterization of Antibody and Tfh Cell Responses after BG505 SOSIP.664 Trimer Immunizations in Mice

Yin Xu, University of New South Wales, Australia
HIV Entry into T Follicular Helper (Tfh) Cells May Be Associated with CCR5+ Pre-Tfh Cells in Lymph Nodes

14:30—16:30
Workshop 6: System Immunology and Modeling

Theatre
* Sarah Cobey, University of Chicago, USA

* Uri Hershberg, Drexel University, USA

Brandon DeKosky, University of Kansas, USA
Paired VH:VL Analysis of Naïve B-Cell Repertoires and Comparison to Antigen-Experienced B-Cell Repertoires in Healthy Human Donors

Thomas B. Kepler, Boston University, USA
B Cell Clonal Dynamics during Sequential Immunizations

Frederick A. Matsen IV, Fred Hutchinson Cancer Research Center, USA
Quantifying Evolutionary Constraints on B Cell Affinity Maturation

Lauren M. Childs, Virginia Tech, USA
Affinity Maturation of B Cells in the Presence of Competing Antigens

Jason A. Vander Heiden, Yale University, USA
High-Throughput Immunoglobulin Sequencing Informatics: Insights into B Cell Trafficking Patterns in Multiple Sclerosis

Gregory W. Schwartz, Drexel University, USA
Conserved Amino Acid Diversity in B Cell Repertoires Connects between Selection at the Germline and Somatic Levels

Tom MacCarthy, Stony Brook University, USA
The Number of Overlapping AID Hotspots within Germline Immunoglobulin Heavy Chain V-Regions Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia

Rajagopal Murugan, German Cancer Research Institute, Germany
High Throughput Analysis of B Cell Clonal Expansion and Antibody Selection to Controlled Plasmodium falciparum Infection

14:30—16:30
Workshop 7: B Cell Related Diseases

Van Horne Ballroom A/B
* Ignacio Sanz, Emory University, School of Medicine, USA

* Fabienne Mackay, Monash University, Australia

John H. Kehrl, NIAID, National Institutes of Health, USA
B Lymphocyte Specific Loss of Ric-8A Causes a Galpha Protein Deficit and Severe Humoral Immunodeficiency

Cindy Eunhee Lee, Australian National University, Australia
Autosomal Dominant B Cell Deficiency with Alopecia Due to a Mutation in NF-kappaB2 that Results in Unprocessable p100

Nadine Hövelmeyer, University of Mainz, Germany
The Transcription Factor Bcl-3 Regulates the Development of Marginal Zone, Germinal Center and B1 B Cells

Wanli Liu, Tsinghua University, China
Membrane Sequestration of the mIgG Cytoplasmic Tail Confers a Safety Trigger Mechanism for the Enhanced Activation of IgG-Memory B Cell

Jürgen Wienands, Georg August University of Goettingen, Germany
Absence of CIN85 Expression Presents with X-Chromosome-Linked Antibody Deficiency in Humans

Lynnea Rae Waters, University of California, Los Angeles, USA
T Follicular Helper Cell Differentiation Is Blocked by Lkb1 Inhibition of NF-kappaB in B Cells

Wei Cao, UT MD Anderson Cancer Center, USA
Humoral Autoimmunity Is Promoted by Type I Interferon-Induced Interferon gamma but Restricted by ROS-Producing Neutrophils

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
HIV Functional Cure and/or Eradication
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland

Persephone Borrow, University of Oxford, UK
Relationship between CD4+ T Cell Subsets and the Neutralization Breadth of the Antibody Response Generated during HIV-1 Infection

Matthieu Perreau, University Hospital of Lausanne, Switzerland
Combined Immunological/Virological Therapies for HIV Functional Cure/Eradication

Michael Farzan, The Scripps Research Institute, USA
AAV-Expressed eCD4-Ig Provides Durable Protection from Multiple SHIV Challenges

17:00—19:00
B Cell Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Martin G. Weigert, University of Chicago, USA

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Endosomal and Cytosolic Nucleic Acid Sensors in Autoimmunity

Hedda Wardemann, German Cancer Research Center, Germany
Single Cell-Based High-Throughput Analysis of Human B Cell Antibody Responses

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Follicular Dendritic Cells Are Essential for Maintenance of Autoreactive B Cells

Haochu Huang, University of Chicago, USA
Short Talk: Spontaneous B Cell Class Switching in the Thymus and Tolerance

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 27

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation Merck & Co., Inc.

We gratefully acknowledge additional support for this conference from:

Canadian HIV Vaccine Initiative Research Mabtech Inc.
ProSci Inc.
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676