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This meeting took place in 2016



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Systems Immunology: From Molecular Networks to Human Biology (A1)


Organizer(s) Ronald N. Germain, Aviv Regev, Nir Hacohen and Dana Pe'er
January 10—14, 2016
Big Sky Resort • Big Sky, Montana USA
Discounted Abstract Deadline: Sep 21, 2015
Abstract Deadline: Oct 20, 2015
Scholarship Deadline: Sep 21, 2015
Discounted Registration Deadline: Nov 10, 2015

Sponsored by Cell Signaling Technology, Inc., Roche and Takeda Pharmaceutical Company Limited

Summary of Meeting:
This meeting on “Systems Immunology” will constitute a unique opportunity for the field to transition from reductionist studies that have been the focus of past meetings on lymphocyte activation to a more integrated approach to the study of immune physiology and pathology from the molecular (signal transduction) to the medical (human clinical studies) scales. It will highlight the latest advances in large-scale, quantitative data collection and computational analysis as applied to biochemical aspects of immune cell activation and function, multicellular behavior in tissues and model organisms, and human immune function in health and disease. Emphasis will be placed on understanding how biological function emerges from the interaction of multiple components in networks and pathways, on the construction of quantitative models that permit predictions about systems behavior that can be tested experimentally, and on identification of reliable biomarkers and insight into disease pathogenesis that can be acquired from deep analysis of large-scale, multi-parameter data collection in humans. The speakers hail from various areas in systems immunology, ranging from those modeling discrete biochemical pathways and cell activation processes, to those developing new tools for measurement of such molecular events, to imagers studying immune cells in situ, to those doing omic-scale studies on humans in response to vaccines or in patients suffering from autoimmune or immunodeficiency syndromes. The meeting should attract participants across the range of immunological disciplines, from the most basic to the clinical, and be of interest to systems biologists in general.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 15 in order to fully experience the meeting.

SUNDAY, JANUARY 10

16:00—20:00
Arrival and Registration

Lower Atrium
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Jefferson

MONDAY, JANUARY 11

07:00—08:00
Breakfast

Gallatin
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Nir Hacohen, Massachusetts General Hospital, USA
Genes, Networks and Variations of the Immune Response

09:00—11:00
Immunoreceptor Signaling I: Receptors and Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Grégoire Altan-Bonnet, National Cancer Institute, National Institutes of Health, USA

Smita Krishnaswamy, Yale School of Medicine, USA
Tracking the Impact of Immunotherapy Across the Phenotypic Landscape

Suzanne Gaudet, Dana-Farber Cancer Institute/Harvard Medical School, USA
NF-kappaB Signaling Dynamics and the Control of Transcription and Cell Fate

Bridget S. Wilson, University of New Mexico Health Science Center, USA
Short Talk: Dynamic Interactions of Pre-BCR Homodimers Provide Finely-Tuned Tonic Signals for Survival

09:40—10:00
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
11:00—14:30
On Own for Lunch

13:00—14:00
Publishing Forum

* Angela Colmone, Science Translational Medicine, USA

* Craig Mak, Cell Press, USA

* Thomas Lemberger, Molecular Systems Biology, Germany

* Corinne Williams, Journal of Clinical Investigation, USA

14:30—16:30
Workshop 1: Signaling

Jefferson/Madison
Mary H. Young, Center for Infectious Disease Research, USA
T Cell Receptor Signaling and Toll-Like Receptor Signaling Converge to Amplify T Cell Responses

Arnon Arazi, Broad Institute, USA
Th17 Differentiation is an Emergent Collective Behavior, Driven by Cellular Heterogeneity

* Rachel A. Gottschalk, NIAID, National Institutes of Health, USA
Contextual Control of TLR-Induced Responses by Divergent Signaling Thresholds

Michael J.T. Stubbington, European Bioinformatics Institute, UK
Simultaneously Inferring T Cell Fate and Clonality from Single Cell Transcriptomes

Wenji Ma, Columbia University, USA
Single Cell and Bulk Transcriptome Analysis Reveals Differentiation Mechanism of Human Dendritic Cell

Ricardo Noel Ramirez, University of California, Irvine, USA
High-Resolution Epigenomic Analysis of Human Myeloid Differentiation Reveals Temporal and Cell-Specific Patterns of the Immune Regulatory Network

Miri Adler, Weizmann Institute of Science, Israel
Cell Circuits for Tissue Homeostasis

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Immunoreceptor Signaling II: New Methods for Probing Cell Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Nir Hacohen, Massachusetts General Hospital, USA

Veit Hornung, Ludwig-Maximilians-University Munich, Germany
CRISPR/Cas Approaches to Analysis of Immune Cell Signaling

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Engineered Systems for Analysis of Signaling Pathways in Primary Lymphocytes Using Quantitative Proteomics

Iain D.C. Fraser, NIAID, National Institutes of Health, USA
Interrogating Immune Signaling Systems with High-Throughput/High-Content Screening

Felix Meissner, Max Planck Institute of Biochemistry, Germany
Short Talk: Proteome Atlas of Circulating Human Immune Cells Reveals Intercellular Communication Structures

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
19:30—22:00
Poster Session 1

Gallatin

TUESDAY, JANUARY 12

07:00—08:00
Breakfast

Gallatin
08:00—11:15
Modeling Signaling Pathways and Transcriptional Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Dana Pe'er, Columbia University, USA

Alan Aderem, Center for Infectious Disease Research, USA
Dissecting the Innate Immune System Using Tools of Systems Biology

Aviv Regev, Massachusetts Institute of Technology/Broad Institute, USA
Signaling Networks in Th17 CD4 T Cells

Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
Gene Regulatory Networks Orchestrating Cell Fate Dynamics of Activated B Cells

Ellen V. Rothenberg, California Institute of Technology, USA
Transcriptional Networks in Developing Lymphocytes

Aaron J. Arvey, Gilead, USA
Short Talk: Genetic and Epigenetic Variation in the Lineage Specification of Regulatory T Cells

Vladimir Litvak, University of Massachusetts Medical School, USA
Short Talk: Decoding Transcriptional and Epigenetic Regulatory Networks in Macrophages

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Human Systems Immunology

Jefferson/Madison
Lisa Marie Kronstad, Stanford University, USA
Human Natural Killer Cell Sensing of Influenza A Viruses

John P. Barton, Massachusetts Institute of Technology, USA
Intra-Host HIV Evolution to Evade Cellular Immunity is Predictable

* Brittany A. Goods, Massachusetts Institute of Technology, USA
Functional Inflammatory Profiles Distinguish Myelin-Reactive T Cells from Patients with Multiple Sclerosis

Andrew Fiore-Gartland, Fred Hutchinson Cancer Research Institute, USA
Modular Cytokine Analysis Reveals Innate Correlates of Influenza Outcome in a Multicenter Study

Ning Jiang, University of Texas, Austin, USA
Accurate and High-Coverage Immune Repertoire Sequencing Reveals Characteristics of Antibody Repertoire Diversification in Young Children

Irit Gat-Viks, Tel-Aviv University, Israel
Modeling the Genetic and Immunological Basis of in vivo Phenotypes

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Single Cell Analysis Modeling I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Aviv Regev, Massachusetts Institute of Technology/Broad Institute, USA

Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immunity: Creating a Quantitative Spatiotemporal Understanding of Host Defense

Catherine A. Blish, Stanford University School of Medicine, USA
Defining Protective Immunologic Signatures

Michael Meyer-Hermann, Helmholtz Centre for Infection Research, Germany
Germinal Centres in vivo and in silico

Kelly Wen Li Chen, Massachusetts Institute of Technology, USA
Short Talk: Investigation of Cytokine-Mediated Intercellular Crosstalk in Normal and Inflammatory Conditions

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
19:30—22:00
Poster Session 2

Gallatin

WEDNESDAY, JANUARY 13

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Single Cell Analysis Modeling II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Dana Pe'er, Columbia University, USA
Modeling Cellular Responses

Sarah Teichmann, Wellcome Trust Sanger Institute, UK
Understanding Cellular Heterogeneity

Grégoire Altan-Bonnet, National Cancer Institute, National Institutes of Health, USA
Modeling the Spatio-Temporal Heterogeneity of Cell-to-Cell Communications

Martin Meier-Schellersheim, NIAID, National Institutes of Health, USA
Computational Modelling Elucidates How MAPK Crosstalk Regulates Sensitivity of Macrophages Toward TLR4 Stimulation

Sayak Mukherjee, Ohio State University, USA
Short Talk: Reconstruction of Single Cell Signaling Trajectories using Snapshot Cytometry Data

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Systems Analysis of Cancer and Model Organisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* Suzanne Gaudet, Dana-Farber Cancer Institute/Harvard Medical School, USA

Andrea Califano, Columbia University, USA
Systematic Elucidation of Druggable Dependencies in Human Malignancies: A New Take on Precision Medicine

Kathryn Miller-Jensen, Yale University, USA
Discovering Macrophage Paracrine Signaling Networks from Single-Cell Data

Catherine A.A. Beauchemin, Ryerson University, Canada
Modelling Viral Infection in vivo and in vitro

Edward S. Lee, University of Glasgow, UK
Short Talk: Novel Computational Approaches to TCR Repertoire Analysis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
19:30—22:00
Poster Session 3

Gallatin

THURSDAY, JANUARY 14

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Human Systems Immunology: Methods
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
* David Furman, Stanford University, USA

Damien Chaussabel, Sidra Medical and Research Center, Qatar
Systems Approaches to Health Maintenance and Immunological Knowledge Discovery

Alexandra-Chloé Villani, Broad Institute of MIT and Harvard, USA
Short Talk: Talk Title to be Announced

Linas Mazutis, Vilnius University, Lithuania
Short Talk: Barcoding and Sequencing Thousands of Individual Cells using Droplet Microfluidics

Matthew H. Spitzer, Stanford University, USA
Modeling Systems-Wide Immunity Reveals Coordinated Responses in Health and Cancer

John Tsang, NIAID, National Institutes of Health, USA
From Single Cells to Networks to Human Populations: Assessing and Utilizing Heterogeneity of the Immune System

Ayelet Alpert, Technion-Israel Institute of Technology, Israel
Short Talk: Baseline Matters: The Effect of Initial Immune State on Outcome of Septic Patients

09:20—09:40
Coffee Break

Lower Atrium
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Methodological Advances in Systems Immunology

Jefferson/Madison
* Matthew H. Spitzer, Stanford University, USA

Nathan Paul Manes, National Institutes of Health, USA
Targeted Proteomics-Driven Computational Modeling of the Chemotaxis and Toll-like Receptor Signaling Pathways in Macrophages

Andrey Morgun, Oregon State University, USA
Transkingdom Networks as a Model of Host-Microbiota Interactions

Denis Schapiro, University of Zurich, Switzerland
Imaging Mass Cytometry Reveals Neighboring Cell Interactions Amongst the Heterogeneity of Breast Cancer

Brian Kidd, Icahn School of Medicine at Mount Sinai, USA
Mapping the Effects of Drugs on the Immune System

Nienke Moret, Harvard University, USA
Controlling Regulatory T Cell Heterogeneity by Chemical Modification of Signaling Pathways

16:30—17:00
Coffee Available

Lower Atrium
17:00—18:45
Human Systems Immunology: Biomedical Applications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jefferson/Madison
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Long-term Consequences of Infection for Tissue Immunity and Metabolism

* Anne O'Garra, Francis Crick Institute, UK
Systems Studies of Human Immune Responses to Infection

Arup K. Chakraborty, Massachusetts Institute of Technology, USA
How to Hit HIV Where it Hurts by Integrating Sequencing, Statistical Inference, Mechanistic Models and Human Data

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Jefferson/Madison
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Gallatin

FRIDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Signaling Technology, Inc. Roche
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI120448-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676