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This meeting took place in 2016



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Small RNA Silencing: Little Guides, Big Biology (A6)


Organizer(s) Phillip D. Zamore, Yukihide Tomari and Mihaela Zavolan
January 24—28, 2016
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 28, 2015
Abstract Deadline: Oct 28, 2015
Scholarship Deadline: Sep 28, 2015
Discounted Registration Deadline: Nov 23, 2015

Supported by the Directors' Fund

Summary of Meeting:
Small RNAs have emerged as remarkably pervasive and versatile regulators of gene expression in species ranging from viruses to animals. Although diverse in biogenesis and mode of action, these small, ~21 nucleotide riboregulators, including microRNAs, small interfering RNAs (siRNAs) and PIWI-interacting RNAs, act as guides for Argonaute proteins. As part of these ribonucleoprotein complexes, small RNAs regulate virtually every step of gene expression, playing key roles in nearly every biological process. Nucleic acid-guided Argonautes can be found in eubacteria, archaea, and eukaryotes, suggesting ancient origins of the RNA interference (RNAi) mechanisms. Furthermore, prokaryotes have an RNA-guided immune system — the CRISPR system — that shares functional similarities with RNAi. Although our understanding of these small RNA pathways has progressed rapidly in the past decade, new questions continue to emerge, reflecting our ever more precise and comprehensive methods to quantify the abundance of molecular species and, consequently, the regulatory impact of small RNAs. This meeting seeks to catalyze the open exchange of ideas about the molecular mechanisms by which small RNAs are made and function, the quantitative interplay among small RNAs, between small RNAs and targets, and, ultimately, the consequences of these interactions for cellular function, in normal and pathological states. Special emphasis is placed on showcasing the work of young investigators, and on complementary approaches for studying gene regulation by small RNAs. Finally, the meeting seeks to continue the intellectually rigorous but congenial atmosphere that is the tradition of this exciting field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 29 in order to fully experience the meeting.

SUNDAY, JANUARY 24

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, JANUARY 25

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Phillip D. Zamore, University of Massachusetts Medical School, USA

Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
The piRNA Pathway - A Small RNA Based Genome Defense System

09:00—11:30
Small RNAs in Genome Regulation I
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Celina Juliano, University of California, Davis, USA

Danesh Moazed, Harvard Medical School, USA
Heterochromatic Gene Silencing by small RNAs in S. pombe

Kuniaki Saito, Keio University School of Medicine, Japan
Short Talk: Piwi Promotes Transcriptional Silencing by Regulating Chromatin Compaction

Maria Placentino, Institute of Molecular Biology, Germany
Short Talk: Maternal piRNAs are Essential for Germline Development Following de-novo Establishment of Endo-siRNAs in Caenorhabditis elegans

Alexei A. Aravin, California Institute of Technology, USA
Genome Defense by piRNA

09:40—10:00
Coffee Break

Longs Peak Foyer
11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: miRNAs

Grays Peak
* Martin J. Simard, CRCHU de Québec-Université Laval, Canada

Amy E. Pasquinelli, University of California, San Diego, USA
Distinct Targeting by Let-7 miRNA Family Members

Natalia Pinzon, Centre National de la Recherche Scientifique, France
Titration of miRNAs by mRNAs: A Novel Function for Conserved miRNA Binding Sites

Matteo Osella, Università degli Studi di Torino, Italy
Modelling microRNA Regulation and its Role in Noise Buffering

Francesco Nicassio, Istituto Italiano di Tecnologia, Italy
Insights into Function and Regulation of MicroRNAs by Decoding Degradation Dynamics

Yukihide Tomari, University of Tokyo, Japan
Biochemical and Genetic Approaches to Understanding the MicroRNA Pathway

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Small RNAs in Genome Regulation II
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Katalin Fejes-Tóth, California Institute of Technology, USA

Michael Terns, University of Georgia, USA
RNA-Guided Invader Defense: CRISPR-Cas Systems

Yijun Qi, Tsinghua University, China
Small RNAs and Genome Stability

Fabrizio d'Adda di Fagagna, IFOM Foundation, National Research Council, Italy
Short Talk: RNA: RNA Interactions Control the DNA Damage Response at Individual Genomic Sites

William Theurkauf, University of Massachusetts Medical Center, USA
Gene Conversion Drives Non-Mendelian Inheritance of Transposons and piRNA Clusters in Drosophila melanogaster

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, JANUARY 26

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Diversity of RNA Regulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Olivia Rissland, Hospital for Sick Children Research Institute, Canada

David C. Baulcombe, University of Cambridge, UK
RNA Silencing in Plants

Michael J. Axtell, Pennsylvania State University, USA
Small RNA-Producing Genes in Plants: Improved Methods and Novel Discoveries

Xuemei Chen, University of California, Riverside, USA
AMP1, ER, and small RNAs

Michel J. Tassetto, University of California, San Francisco, USA
Short Talk: Circulating Immune Cells Mediate the Amplification and Memory of a Systemic Nucleic Acid-Based Antiviral Response in Drosophila

Valeria Yartseva, Yale University School of Medicine, USA
Short Talk: The Hidden Code Behind the Genetic Code: Codon Optimality Regulate mRNA Translation and Stability

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
miRNA-Mediated Gene Regulation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: piRNAs

Grays Peak
* Julie M. Claycomb, University of Toronto, Canada

Mikiko C. Siomi, University of Tokyo, Japan
piRNA Biogenesis in Drosophila

Mofang Liu, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, China
Male Infertility Caused by Ubiquitination-deficient Mutations in Human Piwi (Hiwi)

Eric A. Miska, University of Cambridge, UK
Transgenerational Epigenetic Inheritance and RNAe

Zsolt Gabor Venkei, University of Michigan, USA
The Role of Kinesin in piRNA Pathway in Drosophila melanogaster Testis

Phillip D. Zamore, University of Massachusetts Medical School, USA
piRNAs

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mechanisms of Small RNAs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jinbiao Ma, Fudan University, China

V. Narry Kim, Seoul National University, South Korea
Primary MicroRNA Processing by DROSHA

Ian MacRae, The Scripps Research Institute, USA
Structure and Mechanism of Argonaute Proteins

Fuguo Jiang, University of California, Berkeley, USA
Short Talk: A Cas9-Guide RNA Complex Pre-Organized for Target DNA Recognition

Kotaro Nakanishi, Ohio State University, USA
Structural and Functional Insights into Mechanisms of Argonaute Proteins

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, JANUARY 27

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Small RNAs in Disease and Therapy
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Nicole Deglon, Lausanne University Hospital, Switzerland

Anastasia Khvorova, University of Massachusetts Medical School, USA
Expanding Chemical Diversity of Therapeutic Oligonucleotides for Treatment of Neurodegenerative Disorders

Si-ping Han, California Institute of Technology, USA
Short Talk: Towards Selective Treatment of Diseased Cells via RNA Transcript Activated Conditional-siRNAs

Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA
Therapeutic siRNAs for Human Disease

David M. Rodman, miRagen Therapeutics, USA
Therapeutic Targeting of microRNAs

Fumikazu Shinohara, Kyowa Hakko Kirin Co., Ltd., Japan
Short Talk: Modifications at 5’ End of siRNA Guide Strand Increase siRNA-AGO2 Binding and siRNA Efficacy

Socheata Ly, University of Massachusetts Medical School, USA
Short Talk: Visualization of Self-delivering Hydrophobically Modified siRNA Cellular Internalization

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Heterochromatin Reprogramming with Small RNA

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
MicroRNAs in the Regulation of Cell Fate I
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Olivia Rissland, Hospital for Sick Children Research Institute, Canada

Donal O'Carroll, University of Edinburgh, UK
Differential Importance of Tut4/7-Mediated Uridylation in vivo

Victor R. Ambros, University of Massachusetts, USA
MicroRNAs in Worm Development

Chao-Po Lin, University of California, Berkeley, USA
Short Talk: Deficiency of microRNA miR-34a Expands Cell Fate Potential in Pluripotent Stem Cells

Richard W. Carthew, Northwestern University, USA
Study of the Mechanism and Function of microRNAs in Drosophila

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, JANUARY 28

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
MicroRNAs in the Regulation of Cell Fate II
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Alena Shkumatava, Institut Curie-Centre de Recherche, France

Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland
MicroRNA Function in Vivo: Biology and Regulation

Carrie B. Wiese, Vanderbilt University, USA
Short Talk: Myeloid-Originating miR-223 Regulates Systemic Glucose and Cholesterol via HDL Intercellular Communication

Markus Stoffel, ETH Zürich, Switzerland
miR-7 is an Essential Regulator of Endocrine Function

Anne M. Delany, University of Connecticut Health, USA
Short Talk: MicroRNA Regulation of Circadian Rhythm in the Osteoblastic Lineage

Stefanie Dimmeler, University of Frankfurt, Germany
miRNAs in the Cardiovascular System

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Regulatory RNAs

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Emerging Technologies and Computational Modeling

Grays Peak
* Eric C. Lai, Sloan-Kettering Institute, USA

Zhiping Weng, University of Massachusetts, USA
New Computational Methods for Understanding Gene Regulation by Small RNAs

Andrea Riba, University of Basel, Switzerland
Explicit Modeling of siRNA Off-Targets Improves the Recovery of Gene Specific Contribution to Phenotypes

Stefan L. Ameres, Institute of Molecular Biotechnology, Austria
Kinetic Analysis of Small RNA Silencing Pathways in Living Cells

Daniel Cifuentes, Boston University, USA
Uncovering the RNA-Protein Interaction Network that Control Vertebrate Embryogenesis

Mihaela Zavolan, Biozentrum, University of Basel, Switzerland
Exploiting Single Cell Level Heterogeneity to Uncover in Vivo Hierarchies of miRNA Targets

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Small RNAs in Worms
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* René F. Ketting, Institute for Molecular Biology, Germany

Andrew Fire, Stanford University, USA
Continuing Education of the Small RNA-ome: Some Mechanisms by which Cells Alter (and Maintain) their Repertoires of Effector RNAs

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
C. elegans Silencing Specializations

Craig C. Mello, University of Massachusetts Medical School, USA
RNA-Guided Genome Surveillance

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

FRIDAY, JANUARY 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Dharmacon, part of GE Healthcare TriLink BioTechnologies, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Alnylam Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676