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This meeting took place in 2016



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Neurological Disorders of Intracellular Trafficking (A7)


Organizer(s) Dennis Drayna and Bettina Winckler
January 31—February 4, 2016
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 30, 2015
Abstract Deadline: Nov 2, 2015
Scholarship Deadline: Sep 30, 2015
Discounted Registration Deadline: Dec 1, 2015

Sponsored by FORUM Pharmaceuticals Inc.

Summary of Meeting:
Deficits in intracellular trafficking are a newly emerging, unifying theme in a broad range of neurological disorders, including Alzheimer’s Disease, Huntington's Disease, Parkinson’s Disease and many others. Specific treatments for these disorders are either limited or unavailable. The meeting will look at how these trafficking deficits produce neuropathology, why these disorders are limited to the nervous system and how to elucidate trafficking networks and control points to identify novel drug targets. Specifically, it aims to: 1) Advance state-of-the-art knowledge in the cell biology of intracellular trafficking, the genetics of trafficking disorders, the clinical neurology of trafficking disorders and the methods used to identify drug targets; 2) Facilitate interactions between stakeholder groups who have traditionally had only limited contact; and 3) Identify common themes, novel approaches and new collaborations to address the many large gaps in knowledge about trafficking disorders. For the first time, the meeting will bring together groups that have traditionally not interacted, including cell biologists who study trafficking but have predominantly studied non-neural cells, clinical neurologists who do not typically work in cell biology, geneticists who have discovered causative genes for a wide range of neurological disorders but typically have limited expertise in the biological function of the gene products they identify, and drug developers, to cross-fertilize ideas and generate new collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 5 in order to fully experience the meeting.

SUNDAY, JANUARY 31

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, FEBRUARY 1

07:00—08:00
Breakfast

Longs Peak
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Scott D. Emr, Cornell University, USA
Sorting Out Traffic in the Secretory and Endocytic Pathways: Yeast Genetics Points the Way

09:00—11:00
Genetics: Multigenic Neurologic Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Lian Li, Emory University School of Medicine, USA
SIMPLE Mutations, Endosomal Trafficking, and Peripheral Neuropathy

Matthew J. Farrer, University of British Columbia, Canada
Genetics of Parkinson’s Disease and Other Movement Disorders

Shaoyu Lin, University of Southern California, USA
Short Talk: Haploinsufficiency for Guanine Exchange Factor Activity Leads to Neurodegeneration in C9ORF72 ALS/FTD

09:40—10:00
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Genetics: Lessons from Single Genes in Neurologic Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Craig D. Blackstone, National Institutes of Health, USA

Dennis Drayna, NIDCD, National Institutes of Health, USA
Intracellular Trafficking Mutations in Persistent Stuttering

Rose E. Goodchild, VIB VZW, Belgium
The DYT1 Dystonia Protein, TorsinA, Promotes Membrane Biogenesis

Stéphane Lefrançois, INRS, Canada
CLN5 Regulates the CLN3-Rab7 Interaction by Modulating CLN3 Conformation

Rachel J. Allison, Cambridge Institute for Medical Research, UK
Short Talk: Spastin Controls Lysosome Function by Promoting ER-Mediated Endosomal Tubule Fission

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak
19:30—22:00
Poster Session 1

Longs Peak

TUESDAY, FEBRUARY 2

07:00—08:00
Breakfast

Longs Peak
08:00—11:30
The Biology of Intracellular Trafficking
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Scott D. Emr, Cornell University, USA

Jennifer Hirst, University of Cambridge, UK
The AP-5 Adaptor Protein Complex and Hereditary Spastic Paraplegia

Mark von Zastrow, University of California, San Francisco, USA
GPCR Signaling and Endocytic Pathways

Phyllis I. Hanson, Washington University School of Medicine, USA
Short Talk: ESCRT-III in Endosomal Trafficking

Bettina Winckler, University of Virginia, USA
Neuronal Endosomes in Health and Disease

Rui Dong, Yale University / HHMI, USA
Short Talk: The Impact on Intracellular Trafficking of VAP, a Protein Implicated in a Familial Form of Amyotrophic Lateral Sclerosis

George S. Bloom, University of Virginia, USA
Short Talk: mTOR and Neuronal Cell Cycle Re-Entry: How Insulin Resistance Promotes Alzheimer’s Disease

09:20—09:40
Coffee Break

Longs Peak Foyer
11:30—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Intracellular Trafficking in Neurological Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Ellen Sidransky, NHGRI, National Institutes of Health, USA

Shawn Ferguson, Yale University, USA
Axonal Lysosome Transport and Maturation Defects in Alzheimer’s Disease

Luigi Puglielli, University of Wisconsin-Madison, USA
Increased Expression of AT-1/SLC33A1 Causes Autism by Destabilizing the Secretory Pathway

Rohan Teasdale, University of Queensland, Australia
Parkinson's-Associated VPS35 Mutations Alter Retromer Cellular Functions

Destiney Buelto, University of Michigan, USA
Short Talk: Unique Role of the Yeast ArfGAP Age2 in Clathrin-Dependent Endosomal Trafficking

Elin K. Esbjörner, Chalmers University of Technology, Sweden
Short Talk: Multidimensional Microscopy Approaches to Capture Protein Misfolding Reactions Related to Vesicular Trafficking Organelles and Alzheimer’s Disease

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak
19:30—22:00
Poster Session 2

Longs Peak

WEDNESDAY, FEBRUARY 3

07:00—08:00
Breakfast

Longs Peak
08:00—11:15
Neurobiology of Intracellular Trafficking
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Shawn Ferguson, Yale University, USA

Mary McCaffrey, University College Cork, Ireland
The Importance of Rab11, Rab14, the Rab11-FIPs and Endosomal Recycling in Neuronal Processes

Jose A. Esteban, Centro de Biologia Molecular Severo Ochoa, Spain
PIP3 Signaling and AMPA Receptor Trafficking During Synaptic Plasticity

Ulrich Hengst, Columbia University, USA
Regulation of Retrograde Transport in Axons through Local Synthesis of Dynein Adaptor Proteins

Tija Jacob, University of Pittsburgh School of Medicine, USA
Synaptic Tethering of alpha 5 GABA A Receptors Regulates Dendrite Outgrowth and Maturation

Adam Oaks, George Washington University, USA
Short Talk: Cc2d1a Regulates Intracellular Trafficking and Signaling in Neurons

Cameron Day, University of Utah, USA
Short Talk: Adaptation of Viral Trafficking for Arc-Mediated Synaptic Plasticity

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Clinical Neurology and Trafficking Disorders I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Ray Truant, McMaster University, Canada

Eric M. Morrow, Brown University, USA
Cellular Mechanisms in Christianson Syndrome, a Novel Endosomal Disorder

Craig D. Blackstone, National Institutes of Health, USA
ER Shaping Proteins and Hereditary Spastic Paraplegias

Zbigniew K. Wszolek, Mayo Clinic College of Medicine, USA
Perry Syndrome

Michael D. Ehlers, Biogen, USA
Impaired Beta-Arrestin Recruitment and Reduced Desensitization by Non-Catechol Agonism of the D1 Dopamine Receptor

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak
19:30—22:00
Poster Viewing

Longs Peak

THURSDAY, FEBRUARY 4

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Clinical Neurology and Trafficking Disorders II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Patrick A. Lewis, University of Reading, UK
Regulation of Macroautophagy by Leucine Rich Repeat Kinase 2

Juliane Winkelmann, Helmholtz Zentrum München, Germany
Genetics of Restless Legs Syndrome and other Movement Disorders

Ellen Sidransky, NHGRI, National Institutes of Health, USA
Parkinson's Disease and Lysosomal Storage Disorders

Patrizia Casaccia, Mount Sinai School of Medicine, USA
Inhibitors of Nuclear Transport as Potential Therapeutic Targets for Axonal Damage in Inflammatory Demyelination

Kevin Luethy, KU Leuven, Belgium
Short Talk: Arf6 Blocks Synaptic Vesicle Transport to the Endosome and Suppresses Sky/TBC1D24, a Protein Mutated in Epilepsy

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Translational Research Opportunities in Neuronal Trafficking Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Tija Jacob, University of Pittsburgh School of Medicine, USA

Wim Annaert, VIB & KU Leuven, Belgium
Biological Relevance of gamma-Secretase Heterogeneity in Alzheimer’s Disease – An Alternative Avenue for Therapeutic Intervention?

Michael Lee, University of Minnesota, USA
p53-Dependent Regulation of Autophagy by c-Abl in Parkinson’s Disease

Ray Truant, McMaster University, Canada
Huntingtin Trafficking in Response to ROS and DNA Damage Leads to a Therapeutic Lead for Huntington's Disease

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs Peak
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs Peak

FRIDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

FORUM Pharmaceuticals Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

CEDARLANE Pfizer Inc.
The Stuttering Foundation
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS095383-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676