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This meeting took place in 2016



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Cell Biology and Immunology of Persistent Infection (A8)


Organizer(s) Herbert (Skip) W. Virgin, E. John Wherry, Anne O'Garra and Andrea Lynn Cox
January 31—February 4, 2016
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Oct 1, 2015
Abstract Deadline: Nov 3, 2015
Scholarship Deadline: Oct 1, 2015
Discounted Registration Deadline: Dec 1, 2015

Supported by the Directors' Fund

Summary of Meeting:
Persistent infections are a major source of morbidity and mortality around the world. However, it is increasingly clear that the bacterial microbiome, the virome and the mycobiome can have beneficial roles for the host. Chronic infections with pathogens represent a failure of sterilizing immunity, but the mechanisms responsible for persistence and the balance between host health and disease resulting from infection are not completely understood. Recent discoveries reveal that multiple components of both the infecting organism and the host response to infection determine infection outcome, illustrating that a range of disciplines must be brought together to understand the fundamental mechanisms of chronic infection. This meeting is designed to bring together diverse communities of researchers at the cutting edge of their fields to understand whether and how to manipulate persistent infections to prevent disease and enhance health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 4 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 5 in order to fully experience the meeting.

SUNDAY, JANUARY 31

16:00—20:00
Arrival and Registration

Curio Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Riverview

MONDAY, FEBRUARY 1

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Anne O'Garra, Francis Crick Institute, UK
Systems Approaches to Studying the Immune Response in Tuberculosis

09:00—11:00
Genetics and Systems Biology of Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Genetics, Autophagy and Checkpoints for Intracellular Pathogen Defense

W. Nicholas Haining, Dana-Farber Cancer Institute, USA
Epigenetic Landscape of T Cell Exhaustion

Elina I. Zuniga, University of California, San Diego, USA
Immune Adaptation During Chronic Viral Infection

Brad Rosenberg, Rockefeller University, USA
Short Talk: Transcriptomic Characterization of the Immune Response to Acute Hepatitis C Virus Infection

09:40—10:00
Coffee Break

Riverview
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1

Cascade Ballroom
* Elina I. Zuniga, University of California, San Diego, USA

Anneliese S. Ashhurst, Centenary Institute, Australia
CXCR6 Deficiency Alters Control of Chronic Mycobacterium tuberculosis Infection and the Inflammatory Kinetics of Acute Respiratory infection

Katelyn D. Miller, University of Pennsylvania, USA
Persistent Measles Virus in the Brain After Resolution of Acute Infection

Eugene Drokhlyansky, Harvard University, USA
Type I Interferon Response Can Limit Virus Spread in the Brain

Michael Eschbaumer, Oak Ridge Institute for Science and Education, USA
Host Factors Associated with Acute and Persistent Foot-and-Mouth Disease Virus Infection

Charles Grose, University of Iowa, USA
Varicella Virus Envelopment Pathway Intersects and Redirects the Autophagy Pathway

Hanne Marcella Dubois, VIB - Ghent University, Belgium
A Novel Innate Immune Response Induced by Murine Norovirus Infection

Eui-Cheol Shin, Graduate School of Medical Science and Engineering, KAIST, South Korea
IFN-lambda4 Potently Induces ISG15/USP18-Mediated IFN-alpha Unresponsiveness

Victor H. Carpio, University of Texas Medical Branch at Galveston, USA
IFN-gamma and IL-21 Double Producing T Cells are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection

16:30—17:00
Coffee Available

Riverview
17:00—19:00
Co-Infection and Microbiome in Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Andrea Lynn Cox, Johns Hopkins University, USA

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Transkingdom Interactions within the Metagenome Regulate Virus Infection and Immunity

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Microbiota-Immune System Interactions in the Intestine

George Kassiotis, Francis Crick Institute, UK
Immunity to Exogenous and Endogenous Retroviruses

Taylor S. Cohen, MedImmune LLC, USA
Short Talk: S. aureus Alpha Toxin Renders Macrophages Incapable of Defending Against Gram-Negative Lung Infections

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alberta/New Brunswick
19:30—22:00
Poster Session 1

Alberta/New Brunswick

TUESDAY, FEBRUARY 2

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Cell Biology of Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Christina L. Stallings, Washington University School of Medicine, USA
Role of Autophagy Proteins in Controlling Mycobacterium Tuberculosis Infection

Andrea Lynn Cox, Johns Hopkins University, USA
Inflammasome Regulation in Chronic HIV and HCV Infection

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Type I and III IFN Interactions and Effector Functions in Chronic Viral Infection

Cheryl L. Day, Emory University, USA
Short Talk: Differential NK Cell Reactivity to Mycobacterial Antigens in Mycobacterium tuberculosis-Infected and Uninfected Individuals in a TB-Endemic Setting

Ulf Dittmer, University of Duisburg-Essen, Germany
Short Talk: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing

09:20—09:40
Coffee Break

Riverview
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Riverview
17:00—19:00
Nutrition and Metabolism and Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Christina L. Stallings, Washington University School of Medicine, USA

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Long-Term Consequences of Infection for Tissue Immunity and Metabolism

Katja Simon, University of Oxford, UK
Autophagy in the Immune Response to Infection

Edward S. Mocarski, Emory University, USA
Necroptosis in Host Defense and Species Restriction of Herpesviruses

Debattama Sen, Harvard Medical School, USA
Short Talk: CD8+ T Cell Exhaustion is Associated with a Distinct Epigenetic Landscape

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alberta/New Brunswick
19:30—22:00
Poster Session 2

Alberta/New Brunswick

WEDNESDAY, FEBRUARY 3

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:15
Pharmacologic and Biologic Manipulation of Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Katja Simon, University of Oxford, UK

Man-Wah Tan, Genentech, Inc., USA
Using Antibody-Antibiotic Conjugates as Therapeutics against Persistent Intracellular Pathogens

Jennifer Philips, Washington University School of Medicine, USA
Mycobacterium Tuberculosis Inhibits Macrophage Autophagy and Lipid Catabolism

Ashwin Balagopal, Johns Hopkins University, USA
HIV-1 Control Decreases Intrahepatic Hepatitis C: A Study of Twin Viruses that Chronically Reside in the Liver

Rick L. Tarleton, University of Georgia, USA
Silent Invasion and Misdirected Immune Responses Allow for Parasite Persistence in Chagas Disease

Megan T. Baldridge, Washington University School of Medicine, USA
Short Talk: Transkingdom Metagenomic Interactions and IFN-lambda Determine Persistence of Enteric Norovirus Infection

Mary F. Fontana, University of California, San Francisco, USA
Short Talk: Insights into Human Malaria from a Novel Model of Asymptomatic Plasmodium Infection

09:20—09:40
Coffee Break

Riverview
11:15—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Riverview
17:00—19:00
Humoral Immunity and Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* E. John Wherry, University of Pennsylvania, USA

Dennis R. Burton, The Scripps Research Institute, USA
Broadly Neutralizing Antibodies to HIV and Vaccine Design and Evaluation

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
Non-Neutralizing Antibodies for Protection from Chronic Infection

Peter D. Crompton, National Institutes of Health, USA
Insights into the B Cell and Tfh Cell Biology Underlying the Inefficient Acquisition of Humoral Immunity to Malaria

Katherine Y. King, Baylor College of Medicine, USA
Short Talk: Chronic Infection Depletes Hematopoietic Stem Cells Through Apoptosis and Differentiation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alberta/New Brunswick
19:30—22:00
Poster Session 3

Alberta/New Brunswick

THURSDAY, FEBRUARY 4

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:15
T Cell-Mediated Immunity and Persistent Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Derek T. O'Hagan, GSK Vaccines, USA

E. John Wherry, University of Pennsylvania, USA
Molecular Basis of T cell Exhaustion: Insights for Immunotherapy

Barbara Rehermann, NIDDK, National Institutes of Health, USA
Innate and Adaptive Immune Responses in Viral Hepatitis

Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
Local Immunity to Chronic Herpesvirus Infection

Mala Maini, University College London, UK
Innate/Adaptive Immune Interactions in the Hepatitis B-Infected Liver

Kristen Elaine Pauken, University of Pennsylvania, USA
Short Talk: Epigenetic and Transcriptional Reprogramming of Exhausted CD8 T Cells Following PD-1 Pathway Blockade

Angela Pack, University of Georgia, USA
Short Talk: Trypanosoma cruzi Specific CD8+ T Cells Continue to Mediate Parasite Control Despite Chronic Antigen Exposure

09:20—09:40
Coffee Break

Riverview
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2

Cascade Ballroom
* Christina L. Stallings, Washington University School of Medicine, USA

Luka Cicin-Sain, Helmholtz Centre for Infection Research, Germany
Peptide Expression Context within Viral Genes Determines Direct T-Cell Responsiveness, Memory Inflation and Immune Protection by CMV Vectors

Isabel Barnstorf, ETH Zurich, Switzerland
Impact of Persistent Viral Infections on Immune Homeostasis in Mice

Nadia Martinez-Martin, Genentech, USA
Discovery of Host Receptors for Human Cytomegalovirus Immunomodulatory Proteins Using a Comprehensive Extracellular Protein library

Robert Orchard, Washington University School of Medicine, USA
Genome-Wide CRISPR Screen Identifies CD300lf as a Receptor for Murine Norovirus

Jernej Godec, Dana-Farber Cancer Institute, USA
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells and Limits Immunopathology in Chronic Infection

Birendra Kumar Prusty, Institute of Life Sciences, India
Immunomodulation during Murine Chronic Malaria

Simon Peter Preston, Walter and Eliza Hall Institute of Medical Research, Australia
Bim Deficiency Prevents PD-1 Mediated T Cell Attrition and Rescues CD8 T Cell Exhaustion

Pamela Marie Odorizzi, University of California, San Francisco, USA
Investigating the Effects of in utero Malaria Exposure on CD4+ T Cell Immunity in Infants

16:30—17:00
Coffee Available

Riverview
17:00—19:00
Vaccination Against Persistent Viral Infection
Meeting has ended...abstracts no longer viewable online.

Cascade Ballroom
* Anne O'Garra, Francis Crick Institute, UK

Derek T. O'Hagan, GSK Vaccines, USA
Opportunities and Challenges for Vaccines

Tiffany A. Reese, University of Texas Southwestern Medical Center, USA
Short Talk: Infection History of Mice Dictates Vaccine-Induced Gene Expression and Antibody Response

Paul Klenerman, University of Oxford, UK
Hepatitis C Virus Vaccines

Louis J. Picker, Oregon Health & Science University, USA
Vaccination against Lentivirus Infection

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Cascade Ballroom
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alberta/New Brunswick
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Alberta/New Brunswick

FRIDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

eBioscience, an Affymetrix company

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI122572-01

Funding for this conference was made possible (in part) by 1 R13 AI 122572 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

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Phone:+1 970-262-2676