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This meeting took place in 2016



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Immunity in Skin Development, Homeostasis and Disease (B5)


Organizer(s) Frank O. Nestle, Richard L. Gallo, Fiona M. Watt and Paul A. Khavari
February 28—March 2, 2016
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 28, 2015
Abstract Deadline: Dec 1, 2015
Scholarship Deadline: Oct 28, 2015
Discounted Registration Deadline: Jan 5, 2016

Supported by an educational grant from Lilly

Summary of Meeting:
Skin is the largest human organ and the primary interface between the human body and the environment. As such, skin plays a key role in health and well-being. Hundreds of different diseases are manifested in skin – e.g., infectious diseases, autoimmune and autoinflammatory diseases, skin cancers – and skin is a very common site of disease, leading to a substantial fraction of all visits to healthcare providers each year. Skin is also a major avenue for drug delivery and an area of increasing focus by industry, both because of unmet medical needs as well as skin’s ready accessibility relative to other organs. For example, both melanoma and psoriasis are proof-of-principle disease areas where insights into mechanism have led to therapeutic breakthroughs using targeted therapies for major patient benefit. Significant headway has been made in recent years in our understanding of normal development, homeostasis and repair in skin. With this progress has come increasing recognition of the role played by interactions between the many different types of cells in skin. A key set of interactions are those between skin cells such as keratinocytes and cells of the immune system. This meeting will provide a unique setting for in-depth discussions between skin biologists, dermatologists, immunologists and cancer biologists. More specifically, the meeting aims to: 1) Review and discuss recent progress in understanding the role of immune function in skin development, homeostasis and pathology; 2) Review and discuss the molecular and cellular basis of pathogenesis in skin diseases and targeted therapies; 3) Highlight areas of progress as well as needs and opportunities for further research; 4) Clarify concepts and models regarding interactions between skin and the immune system; 5) Highlight how research findings will be, or might be, extended to understanding disease and creating treatments; and 6) Stimulate new collaborations and foster the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 28 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 2 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 3 in order to fully experience the meeting.

SUNDAY, FEBRUARY 28

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, FEBRUARY 29

07:00—08:00
Breakfast

Granhall
08:00—08:15
Opening Remarks, Remembering Andy Robertson
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
* Frank Oliver Nestle, King's College, London, UK

* Richard L. Gallo, University of California, San Diego, USA

Georg Stingl, University of Vienna, Austria
Cutaneous Immunity in Health and Disease – Changing Paradigms, Novel Concepts and their Translation

09:15—12:00
Role of Immunity in Epithelial Differentiation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
Anthony Oro, Stanford University, USA
Immunologic and Environmental Regulators of Hair Growth

Paul A. Khavari, Stanford University, USA
Genomic Control of Epidermal Differentiation

Masayuki Amagai, Keio University, Japan
Skin Barrier Homeostasis by Stratum Corneum and Tight Junction

* Fiona M. Watt, King's College London School of Medicine, UK
Interactions between the Epidermis, Immune System and Commensal Bacteria in Tumor Formation

09:50—10:10
Coffee Break

Pre Function
12:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
12:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Pre Function
17:00—19:15
Immunity and Dysregulation of Epithelial Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Manolis Pasparakis, University of Cologne, Germany
Epithelial NF-kappaB and RIP Kinase Signaling in Skin Inflammation

Niwa Ali, University of California, San Francisco, USA
Short Talk: Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Franklin Zhong, Institute of Medical Biology, Singapore
Short Talk: Germline NLRP1 Mutations Cause an Inherited Skin Cancer Syndrome via Spontaneous Inflammasome Activation

* Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Inflammatory Skin Diseases and AP-1 (Fos/Jun)

19:15—20:15
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, MARCH 1

07:00—08:00
Breakfast

Granhall
08:00—11:15
Skin Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
Michel Gilliet, University Hospital of Lausanne, Switzerland
Innate Skin Immunity

Rachael A. Clark, Brigham and Women's Hospital, USA
Skin Resident T Cells

Robert L. Modlin, University of California, Los Angeles, USA
The Role of Langerhans Cells in Host Defense Against Bacterial Infection in Skin

Lingjuan Zhang, University California, San Diego, USA
Short Talk: Interferon Beta Production by the Epidermis is Mediated by an Antimicrobial Peptide and the MAVS Signaling Pathway

James Daniel Beckett, Johns Hopkins University, USA
Short Talk: Implication of Innate Immunity in the Pathogenesis of Scleroderma

* Richard L. Gallo, University of California, San Diego, USA
The Coordinated, Layered Innate Defense System of the Skin

09:20—09:40
Coffee Break

Pre Function
11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Environment and the Skin

Mountain/Lake
Niroshana Anandasabapathy, Harvard Medical School, USA
Core Skin DC Signatures Control Immune Tolerance to Skin Cancer and Limit Anti-Tumor Immunity

Hisato Iriki, Keio University, Japan
Deletion of T Cells Specific to Desmoglein 3, a Pemphigus Autoantigen, by Peripheral Tolerance

Sakeen Kashem, University of Minnesota, USA
Nociceptive Sensory Fibers Induce IL-23 from CD301b+ Dermal Dendritic Cell and Drive Protective Cutaneous Immunity

* Padraic Fallon, Trinity College Dublin, Ireland
Microbiome Regulation of IL-17 Mediated-Skin Inflammation due to Filaggrin Deficiency

Allyson Lindsay Byrd, NHGRI, National Institutes of Health, USA
Tracking Strains of Staphylococci during Human Atopic Dermatitis Disease Progression

Sarah Jill de Jong, Rockefeller University, USA
EV3 Deficiency as a New Genetic Etiology of Epidermodysplasia Verruciformis

Dawn Zhang Eichenfield, University of California, San Diego, USA
Tissue Damage Signals Repurpose Transcription Factors to Direct a Rev-erb Sensitive Wound Repair Program in Macrophages

Thomas H. Leung, University of Pennsylvania, USA
Role of Immunity in Mouse Appendage Regeneration

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Skin Microbiome
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
Christina E. Zielinski, Technical University Munich, Germany
Regulation of Pro- and Anti-Inflammatory Human T Helper Cell Functions by the Microenvironment

Björn Andersson, Karolinska Institutet, Sweden
Characterization of the Skin Microbiome in a Large European Skin Disease Cohort

Tiffany Scharschmidt, University of California, San Francisco, USA
Short Talk: Commensal Microbes Augment Expression of the Hair Follicle Chemokine CCL20 to Facilitate Accumulation of Tregs in Neonatal Skin

* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Impact of the Skin Microbiota on Skin Immunity and Inflammation

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Granhall
08:00—11:15
Immune Pathways and Therapeutic Targets in Skin Disease I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
James G. Krueger, Rockefeller University, USA
Principles of Targeted Therapies

Emma Guttman, Mount Sinai Hospital, USA
A Paradigm Shift in the Pathogenesis and Therapeutics of Atopic Dermatitis

John J. O'Shea, NIAMS, National Institutes of Health, USA
Jak Kinases in Tissue Immunity

Wenjun Ouyang, Amgen, Inc., USA
IL-20 Subfamily Cytokines in Skin Inflammation and Wound Healing

* Frank Oliver Nestle, King's College, London, UK
Skin Inflammation: Gene and Environment Interplay

09:20—09:40
Coffee Break

Pre Function
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Inflammatory Skin Disease: More than Skin Deep. Sponsored by the National Psoriasis Foundation in Memory of Andy Robertson.

Mountain/Lake
Michael D. Rosenblum, University of California, San Francisco, USA
Tregs in Skin Facilitate Epithelial Stem Cell Differentiation

Kevin D. Cooper, Case Western Reserve University, USA
Vascular and Thrombotic Consequences of Chronic Skin Inflammation

* Angela M. Christiano, Columbia University, USA
Efficacy of JAK Inhibitors in the Treatment of Alopecia Areata

Teruki Dainichi, Kyoto University Graduate School of Medicine, Japan
Imiquimod-Induced Psoriasis-Like Dermatitis Depends on TRAF6-Mediated Transcriptional Activation of Keratinocytes

16:30—17:00
Coffee Available

Pre Function
17:00—18:45
Immune Pathways and Therapeutic Targets in Skin Disease II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mountain/Lake
Lisa A. Beck, University of Rochester Medical Center, USA
Targeting Type 2 Skin Inflammation: Implications for Atopic Disease

Thomas Krieg, University of Cologne, Germany
Cellular and Molecular Mechanisms of Fibrosis - Scleroderma as a Model Disease

* Thomas S. Kupper, Brigham and Women's Hospital, USA
Lineage Commitment of Memory T Cell Precursors: Implications for Allergic Contact Dermatitis and Other Skin Diseases

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions

Mountain/Lake
* Fiona M. Watt, King's College London School of Medicine, UK

* Paul A. Khavari, Stanford University, USA

19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

THURSDAY, MARCH 3

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Educational grant from Lilly

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

ACS Sensors
Educational grant from Celgene Corporation

National Psoriasis Foundation
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AR069440-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Phone:+1 970-262-2690

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