Beaver Run Resort Floorplan

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This meeting took place in 2016



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Stem Cells and Cancer (C1)


Organizer(s) Austin Gurney, Connie J. Eaves and Jane E. Visvader
March 6—10, 2016
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Nov 4, 2015
Abstract Deadline: Dec 7, 2015
Scholarship Deadline: Nov 4, 2015
Discounted Registration Deadline: Jan 6, 2016

Sponsored by Bayer HealthCare Pharmaceuticals, BioLegend, Inc., Journal of Molecular Cell Biology (JMCB), OncoMed Pharmaceuticals, Inc. and Roche

Summary of Meeting:
Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This Keystone Symposia meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 10 with a keynote address and closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 11 in order to fully experience the meeting.

SUNDAY, MARCH 6

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, MARCH 7

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
Provide a stimulating and dynamic overview of some of the major ideas and trends shaping the field.

Colorado Ballroom
* Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Oxidative Stress Inhibits Distant Metastasis by Human Melanoma Cells

09:00—11:15
Stem Cell Concepts and Models
Meeting has ended...abstracts no longer viewable online.
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.

Colorado Ballroom
* Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia
Deciphering the Mammary Epithelial Hierarchy

Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Modeling Myeloid Malignancies with Human Pluripotent Stem Cells

Ali Turhan, University Paris Sud 11, France
Modeling Cancer Using Human iPSC

Marc Leushacke, ASTAR Institute of Medical Biology, Singapore
Short Talk: Lgr5+ Stem Cells in Epithelial Homeostasis and Disease of the Stomach

09:40—10:00
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Meeting has ended...abstracts no longer viewable online.
Cooperativity, niche and immune interaction.

Colorado Ballroom
* Carla F. Kim, Boston Children's Hospital, USA
Lung Cancer Stem Cells

Dominique A. Bonnet, Cancer Research UK, UK
Modulation of Mesenchymal Stroma Cells by Acute Myeloid Leukemia

Christian Steidl, University of British Columbia, Canada
Targeting the Tumor-Host Cellular Interface in Lymphoid Malignancies

Takahiko Murayama, University of Tokyo, Japan
Short Talk: CD74-NRG1, a Fusion Gene Product, Leads to ErbB-NFkappaB-IGF2 Autocrine/Paracrine Circuit and Confers Cancer Stem Cell Properties

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, MARCH 8

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Tumorigenesis
Meeting has ended...abstracts no longer viewable online.
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.

Colorado Ballroom
* Connie J. Eaves, British Columbia Cancer Agency, Canada
Barcoding to Analyze De Novo Generated and Established Human Breast Cancers

Richard J. Gilbertson, University of Cambridge, UK
Multi-Organ Mapping of Cancer Risk

Hanno Glimm, National Center for Tumor Diseases, Germany
Stem Cell Kinetics in Gastrointestinal Cancers

Emmanuelle Passegué, University of California, San Francisco, USA
Hijacking of Emergency Myelopoiesis Pathways in Myeloid Leukemia

Xiling Shen, Duke University
Short Talk: lncRNA and microRNA Synergize to Regulate Colon Cancer Stem Cell Asymmetry and Plasticity

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop

Colorado Ballroom
* Nagarajan Kannan, BC Cancer Research Center, Canada
Human Mammary Luminal Progenitor Cells use Oxidative Stress Signals to Regulate Signaling and Growth

Alexander T. Pearson, University of Michigan, USA
Using Single-Cell Observations and Mathematical Modeling to Predict Tumor Cell Growth and Cancer Stem Cell Proportion In-Vitro and In-Vivo

Bryan A. Smith, University of California, Los Angeles, USA
A Basal Stem Cell Signature Identifies Aggressive Prostate Cancer Phenotypes

Min Wang, OncoMed Pharmaceuticals, USA
Identification of a Pancreatic Tumorigenic CSC Gene Signature and Demonstration of its Suppression in Pancreas PDX Models and in Patient Tumors by Treatment with an Anti-CSC Antibody, Tarextumab (TRXT)

Nils Degrauwe, University of Lausanne, Switzerland
IMP2 Provides an Alternative to LIN28B for Glioma Stem Cell Maintenance

Tuomas Tammela, Koch Institute for Integrative Cancer Research at MIT, USA
Molecular Mechanisms Orchestrating Intratumoral Heterogeneity in Kras-Driven Carcinomas

Diwakar R. Pattabiraman, Whitehead Institute for Biomedical Research, USA
Activation of PKA Induces a Mesenchymal-to-Epithelial Transition and Loss of Tumor-Initiating Ability of Breast Carcinomas

Jatin Roper, Koch Institute for Integrative Cancer Research at MIT, USA
Sequential Genome Editing in CRISPR/Cas9-based Colorectal Cancer Mouse Models

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Disregulation of Stem/Developmental Pathways
Meeting has ended...abstracts no longer viewable online.
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.

Colorado Ballroom
* Stefano Piccolo, University of Padua, Italy
Yap/Taz Regulation in Stem Cells and Cancer

Jon C. Aster, Brigham and Women's Hospital, USA
Myb-Notch-p63 Transcriptional Hierarchies in Adenoid Cystic Carcinoma

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Mechanisms Influencing Intestinal Tumorigenesis

Zahra Kabiri, Duke University, USA
Short Talk: RSPO3 is the Gatekeeper of Wnt/Beta-Catenin Signaling in Intestinal Stem Cell Niche

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, MARCH 9

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Understanding Tumor Heterogeneity
Meeting has ended...abstracts no longer viewable online.
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.

Colorado Ballroom
* Michael F. Clarke, Stanford University, USA
Clinical Implications of Regulators of Self-Renewal in Cancer

Dean G. Tang, University of Texas MD Anderson Cancer Center, USA
Prostate Cancer Stem Cells: Molecular Understanding and Clinical Implications

Samuel Aparicio, University of British Columbia, Canada
Genomic and Clonal Analysis of Breast Cancer

Catherine A. O'Brien, University Health Network, Canada
Regulation of Self-Renewal in Colon Cancer Stem Cells

Devraj Basu, University of Pennsylvania, USA
Short Talk: Transition Between Two Distinct Stem Cell-Like States in Head and Neck Cancer is Mediated by JARID1B

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Emerging Targets
Meeting has ended...abstracts no longer viewable online.
New therapeutic opportunities to target CSCs.

Colorado Ballroom
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Cancer Cells-Exploiting Cancer Metabolic Vulnerabilities

* Tessa L. Holyoake, University of Glasgow, UK
CML - Aiming for Cure

Biniam Adane, University of Colorado School of Medicine, USA
Short Talk: The Role of NADPH Oxidase 2 in Normal and Malignant Hematopoiesis

Jingwei Cheng, Dana-Farber Cancer Institute, USA
Short Talk: TRRAP-EP400-Tip60 Complex and Max Interaction is Required in iPS Generation and Oncogenesis Promotion

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

THURSDAY, MARCH 10

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Targeting Cancer Stem Cells: Trials and Translation
Meeting has ended...abstracts no longer viewable online.
Therapeutic strategies for targeting CSC in the clinic.

Colorado Ballroom
* Austin Gurney, OncoMed Pharmaceuticals, Inc., USA
Therapeutic Agents Targeting the Wnt, Notch, and RSPO/LGR Pathways in Cancer

Jonathan A. Pachter, Verastem, USA
Targeting Cancer Stem Cells with Selective Inhibitors of FAK and PI3K/mTOR

Feng Cong, Novartis Institutes for BioMedical Research, USA
Small Molecule Inhibitors of Wnt Signaling for Cancer

Scott J. Dylla, Stemcentrx, Inc., USA
Short Talk: A DLL3-targeted ADC Eradicates High-Grade Pulmonary Neuroendocrine Tumor-Initiating Cells

09:20—09:40
Coffee Break

Foyer
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—17:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada

Hans C. Clevers, Hubrecht Institute, Netherlands
Lgr5 Stem Cell Organoids and Disease

17:45—19:30
New Horizons
Meeting has ended...abstracts no longer viewable online.
CSC metabolism, ROS involvement-control, epigenetics and miRNA.

Colorado Ballroom
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada

Huiping Liu, Case Western Reserve University, USA
MicroRNAs Regulating Breast Cancer Stem Cells and Metastasis

Luke Gilbert, University of California, San Francisco, USA
Retooling CRISPR to Turn Genes On and Off

David M. Gilbert, Florida State University, USA
Investigations of Altered DNA Replication Timing in Human Pediatric Leukemia

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Breckenridge Ballroom

FRIDAY, MARCH 11

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals BioLegend, Inc.
Journal of Molecular Cell Biology (JMCB) OncoMed Pharmaceuticals, Inc.
Roche
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

ACS Sensors PeproTech, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA200143-01

Funding for this conference was made possible (in part) by 1R13CA200143-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676