Whistler Conference Centre Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2016


Here are the related meetings in 2017:
Epigenetics and Human Disease: Progress from Mechanisms to Therapeutics (A9)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Chromatin and Epigenetics (C2)


Organizer(s) Luciano Di Croce and Yang Shi
March 20—24, 2016
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 18, 2015
Abstract Deadline: Dec 16, 2015
Scholarship Deadline: Nov 18, 2015
Discounted Registration Deadline: Jan 20, 2016

Sponsored by Cell Research, Cell Signaling Technology, Inc., Constellation Pharmaceuticals, Incyte Corporation, Janssen R&D: Pharmaceutical Companies of Johnson & Johnson and Merck & Co., Inc.

Summary of Meeting:
The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 20 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 24 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 25 in order to fully experience the meeting.

SUNDAY, MARCH 20

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, MARCH 21

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:00
Epigenetic Pathways
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Luciano Di Croce, Centre for Genomic Regulation, Spain

Shelley L. Berger, University of Pennsylvania, USA
Histone Acetylation Pathways in Learning and Memory

Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Histone Methylation Regulation, Recognition and Link to Human Disease

Tony Kouzarides, University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer

Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Epigenetic Regulation of Adult Stem Cell Function in Homeostasis, Aging and Cancer

Ian Chambers, University of Edinburgh, UK
Short Talk: Extinction of Esrrb Triggers the Dismantling of Naïve Pluripotency and Marks Commitment to Differentiation

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00—14:30
On Own for Lunch

14:30—15:30
Workshop 1: ENCODE Data Analysis and Visualization

Sea to Sky B/C
* Feng Yue, Pennsylvania State University, USA

15:30—16:30
Workshop 2: Epigenomic Annotation of Genetic Variants using the Washington University Epigenome Browser

Sea to Sky B/C
* Ting Wang, Washington University, USA

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
DNA Methylation in Stem Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Wolf Reik, Babraham Institute, UK

Bing Ren, Ludwig Institute for Cancer Research, USA
Global Analysis of Transcriptional Enhancers in Embryonic Stem Cells

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Proteins and 5-Methylcytosine Oxidation

Or P. Gozani, Stanford University, USA
New Roles for Lysine Methylation Signaling in Epigenetic and Disease Regulation

Sandra Peiró, Fundació IMIM, Spain
Short Talk: H3K4ox-mediated Chromatin Condensation Protects Breast Cancer Cells from the DNA Damage Repair Machinery

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

TUESDAY, MARCH 22

07:00—08:00
Breakfast

Sea to Sky A
07:30—08:00
Poster Setup

Sea to Sky A
08:00—17:00
Poster Viewing

Sea to Sky A
08:00—11:15
Epigenetic Chromatin Complexes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Giacomo Cavalli, Institute of Human Genetics, France

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Danny F. Reinberg, HHMI/New York University, USA
Chromatin Regulation by Polycomb Complexes

Luciano Di Croce, Centre for Genomic Regulation, Spain
Polycomb Orchestrates Gene Regulation Dynamics in Cell Differentiation and Cancer

Yujiang Geno Shi, Harvard Medical School, USA
Glucose Signaling to Reprogramming Chromatin via a Molecular Switch on TET2

Adrian P. Bracken, Trinity College Dublin, Ireland
Short Talk: Polycomb Repressive Complex 2 (PRC2) in Proliferation Control and Cancer

Mafalda Almeida, University of Oxford, UK
Short Talk: Mechanisms of Xist-dependent Polycomb Recruitment

09:20—09:40
Coffee Break

Grand Foyer
11:15—12:00
Lunch

Sea to Sky A
12:00—14:30
Poster Session 2

Sea to Sky A
14:30—16:30
Workshop 3: Connecting ncRNA, Stem Cells and Higher-Ordered Chromatin Structure

Sea to Sky B/C
Rebecca Berrens, Babraham Institute, UK
Acute Demethylation of Transposons in ES Cells Reveals Regulation by Small RNA Pathways

* M. Ryan Corces, Stanford University, USA
Lineage-specific and Single Cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution

Alessandro Bonetti, RIKEN Yokohama, Japan
Identification and Characterization of Non-coding RNAs Associated with Chromatin in Pluripotency

Paula Freire-Pritchett, Babraham Institute, UK
Global Rewiring of Enhancer-promoter Interactions during Early Lineage Commitment in Human Embryonic Stem Cells

Kunle Demuren, Massachusetts Institute of Technology, USA
Determining Molecular Mediators of Enhancer Activation during Cardiomyocyte Differentiation

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Chromatin Organization
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Shelley L. Berger, University of Pennsylvania, USA

François Fuks, Université Libre De Bruxelles, Belgium
Mechanisms of TETs & Hydroxymethylation

Francois Aymard, University of Toulouse, France
Short Talk: Chromosome and Chromatin Dynamics during Double Strand Break Repair

Abraham S. Weintraub, Massachusetts Institute of Technology, USA
Short Talk: Activation of Proto-Oncogenes by Disruption of Chromosome Neighborhoods

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Replication-Coupled Silencing and Spreading with RNAi

Tian Tian, Center for Genomic Regulation, Spain
Short Talk: Whsc1 is Required for the Exit from Pluripotency and Efficient Meso-endoderm Differentiation

19:00
On Own for Dinner


WEDNESDAY, MARCH 23

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Chromatin in Stem Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain

Kristian Helin, University of Copenhagen, Denmark
Histone Methylation in Transcriptional Regulation, Differentiation and Cancer

Giacomo Cavalli, Institute of Human Genetics, France
Genome Regulation by Polycomb Proteins, between Epigenetic Inheritance and Dynamic Gene Regulation

Wolf Reik, Babraham Institute, UK
Epigenetic Reprogramming in Mammalian Development

Rab K. Prinjha, GlaxoSmithKline, UK
Epigenetic Targets for the Treatment of Human Diseases

Alexander J. Ruthenburg, University of Chicago, USA
Short Talk: Biochemical Fractionation Reveals Highly Selective Binding Partners for 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in DNA

Chao Lu, Rockefeller University, USA
Short Talk: Oncohistone Mutations Reprogram Chromatin Landscape to Impair Cell Differentiation

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 4: How RNA Modifications Impact Chromatin Structure and Stem Cell Fate

Sea to Sky B/C
E. Megan Flynn, Genentech, Inc., USA
Specificity of Human Bromodomains for Histone H3, H4 Peptides

Felice Frey, Max-Planck Institute of Biohemistry, Germany
Molecular Basis for Targeting PRC1 to Polycomb Response Elements

Yoshihiro Matsumura, University of Tokyo, Japan
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipogenesis

Yuanyuan Li, Tsinghua University, School of Medicine, China
Journal of Biological Chemistry, Herb Tabor Young Investigator: Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

Sharmistha Kundu, Massachusetts General Hospital, USA
3D-Architecture Remodeling of Chromatin by PRC1

* Marc-Werner Dobenecker, Rockefeller University, USA
The Role of PRC2 in Systemic Inflammation and Autoimmunity

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Chromatin and Cancer
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Or P. Gozani, Stanford University, USA

Johnathan R. Whetstine, Massachusetts General Hospital, USA
Epigenetic Mechanisms Driving Copy Number Alterations and Drug Resistant Gene Selection

Robert J. Sims, Constellation Pharmaceuticals, USA
Bromodomain Inhibition as a Strategy to Target Oncogenic Signaling Pathways

Bradley E. Bernstein, Massachusetts General Hospital, USA
Epigenetic Mechanisms of Brain Tumor Initiation and Evolution

Prathamesh Thangaraj Nadar Ponniah, Technion Israel Institute of Technology, Israel
Short Talk: RNA-dependent Chromatin Localization of KDM4D Lysine Demethylase Promotes H3K9me3 Demethylation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 3

Sea to Sky A

THURSDAY, MARCH 24

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
ncRNA and Enhancers
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Tony Kouzarides, University of Cambridge, UK

Victor G. Corces, Emory University, USA
The Role of Architectural Proteins in the 3D Organization of the Genome

Saverio Minucci, IEO Milan, Italy
Chromatin Alterations in Leukemogenesis

James J. Morrow, Case Western Reserve University School of Medicine, USA
Short Talk: Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence

Jacques Drouin, Institut de Recherches Cliniques de Montréal, Canada
Short Talk: Talk Title to be Announced

Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Chromatin Topology during Embryonic Development

Keiko Ozato, NICHD, National Institutes of Health, USA
Short Talk: Epigenetic Chromatin Marks in Innate Immune Responses: Functional Consequences

Kiyomi Raye Kaneshiro, University of California, Santa Cruz, USA
Short Talk: Transmission of Gamete-Inherited Chromatin States

09:20—09:40
Coffee Break

Grand Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Regulation of Transcription in Stem Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Yang Shi, Children's Hospital Boston, Harvard Medical School, USA

Jeannie T. Lee, Massachusetts General Hospital, USA
The Roles of Long Noncoding RNA in Epigenetic Regulation

Masami Horikoshi, University of Tokyo, Japan
Short Talk: Uncovering Ancient Transcription Systems with a Novel Evolutionary Indicator

Melanie A. Eckersley-Maslin, Babraham Institute, UK
Short Talk: MERVL Endogenous Retrovirus Activation Induces Genome-Wide DNA Demethylation

Raja Jothi, NIEHS, National Institutes of Health, USA
Short Talk: Transcription at Intragenic Enhancers Attenuate Gene Expression

Chuan He, University of Chicago, USA
Reversible RNA Methylation in Gene Expression Regulation

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sea to Sky B/C
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

FRIDAY, MARCH 25

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Cell Signaling Technology, Inc.
Constellation Pharmaceuticals Incyte Corporation
Janssen R&D: Pharmaceutical Companies of Johnson & Johnson Merck & Co., Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


Journal of Biological Chemistry

Abcam plc March of Dimes Foundation, Grant No. 4-FY15-442
TriLink BioTechnologies, Inc. Zymo Research Corporation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA206169-01

Funding for this conference was made possible (in part) by 1R13CA206169-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676