Maritim Hotel & Conference Center Dresden Floorplan

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This meeting took place in 2016


Here are the related meetings in 2017:
Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease (X5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2)


Organizer(s) Thomas Tuschl, Veit Hornung and Karl-Peter Hopfner
May 8—12, 2016
Maritim Hotel & Conference Center Dresden • Dresden, Germany
Discounted Abstract Deadline: Jan 7, 2016
Abstract Deadline: Feb 9, 2016
Scholarship Deadline: Jan 7, 2016
Discounted Registration Deadline: Mar 8, 2016

Sponsored by DFG Deutsche Forschungsgemeinschaft

Summary of Meeting:
Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2’,5’-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, May 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 13 in order to fully experience the meeting.

SUNDAY, MAY 8

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, MAY 9

07:30—08:30
Breakfast

Individual Hotels
08:00—08:30
Poster Setup

Saal 4/5
08:30—19:00
Poster Viewing

Saal 4/5
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
Key Discoveries

Saal 4/5
* Thomas Tuschl, HHMI/Rockefeller University, USA

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
The cGAS Pathway of Cytosolic DNA Sensing and Its Role in Health and Diseases

09:30—12:00
Sensing of Microbial and Viral RNA and DNA by the Innate Immune System
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Kensuke Miyake, Institute of Medical Science, University of Tokyo, Japan
RNA-Sensing and Trafficking of TLR7 in Plasmacytoid Dendritic Cells

* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Long Non-Coding RNAs

Petro Starokadomskyy, University of Texas Southwestern Medical Center, USA
Short Talk: DNA Polymerase-alpha Regulates Type I Interferon Activation through Cytosolic RNA:DNA Synthesis

Kachiko Hayashi, Yale University, USA
Short Talk: Toll-Like Receptor 9 Trafficking and Signaling for Type I Interferons Requires PIKfyve Activity

10:10—10:30
Coffee Break

Foyer
12:00—12:45
Lunch

Conference Ctr Restaurant
12:30—14:30
Poster Session 1

Saal 4/5
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Sensing of Microbial and Viral RNA and DNA by the Innate Immune System II
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Molecular Mechanisms of Nucleic Acid Pattern Recognition

Timothy W. Behrens, Genentech, Inc., USA
Nucleic Acid Sensing and Interferon Signatures

Russell E. Vance, University of California, Berkeley, USA
No Perfect PAMPs? Innate Immune Recognition of Nucleic Acids versus Proteins

Tan Nguyen, Walter and Eliza Hall Institute, Australia
Short Talk: Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

19:00
On Own for Dinner


TUESDAY, MAY 10

07:30—08:30
Breakfast

Individual Hotels
08:30—11:45
Structural Biology of Innate Immune Sensing
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Integrated ATP Dependent Mechanism for RIG-I’s Distinction between Self and Non-Self RNA

Sun Hur, Harvard Medical School, USA
Molecular Mechanism of RIG-I-Like Receptors

Alexei Korennykh, Princeton University, USA
Innate Immune Signaling via RNA Cleavage

Hao Wu, Harvard Medical School, USA
Structural Elucidation of Inflammasome Activation and Regulation

Pingwei Li, Texas A&M University, USA
Short Talk: The Structural Basis of IRF-3 Recruitment, Activation, and Targeting in Innate Immunity

Philip J. Kranzusch, University of California, Berkeley, USA
Short Talk: Ancient cGAS-STING Pathways Reveal Evolution of Human Innate Immunity

09:50—10:10
Coffee Break

Foyer
11:45—15:00
On Own for Lunch

11:45—13:00
Poster Setup

Saal 4/5
13:00—20:30
Poster Viewing

Saal 4/5
15:00—15:30
Coffee Available

Foyer
15:30—17:30
Virology and Innate Inflammatory Responses
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Jae U. Jung, Keck School of Medicine of USC, USA
Host Nucleic Acid Sensing and Viral Evasion

Ian Thomas Lamborn, NIAID, National Institutes of Health, USA
Short Talk: Human MDA5 Protects Against Severe Respiratory Infections

* Nicolas Manel, Institut Curie, France
Sensing Mechanisms of Viral Infection

Fanxiu Zhu, Florida State University, USA
Short Talk: KicGAS, KSHV Inhibitor of cGAS

Kareen Bartsch, Christian-Albrechts-University, Germany
Short Talk: RNaseH2 Deficiency Leads to Cytosolic Accumulation of Immunostimulatory DNA that is Removed by Autophagy

17:30—18:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Conference Ctr Restaurant
18:00—20:30
Poster Session 2

Saal 4/5

WEDNESDAY, MAY 11

07:30—08:30
Breakfast

Individual Hotels
07:30—08:00
Poster Setup

Saal 4/5
08:00—17:00
Poster Viewing

Saal 4/5
08:30—11:30
Nucleic Acid Chemistry and Biology in Stress and Innate Immune Response
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Thomas Tuschl, HHMI/Rockefeller University, USA
Intra- and Extracellular Diagnostic RNAseq Approaches and Their Use in Inflammatory Diseases

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structure and Function of Innate Immune Sensors and Adaptors

Charles E. Samuel, University of California, Santa Barbara, USA
Roles of A-to-I RNA Editing by Adenosine Deaminase ADAR1 in Innate Immunity RNA Sensing

* Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Defects in mRNA Maturation and Localization

Swapnil Devarkar, Rutgers University, USA
Short Talk: Structural and Mechanistic Basis for Self Versus Non-self RNA Discrimination by the Innate Immune Receptor RIG-I

09:50—10:10
Coffee Break

Foyer
11:30—12:30
Lunch

Conference Ctr Restaurant
12:00—14:30
Poster Session 3

Saal 4/5
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Nucleic Acid Drug Developments and Strategies to Suppress Innate Immunity Responses
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Gunther Hartmann, Universitätsklinikum Bonn, Germany
Targeting RIG-I for the Immunotherapy of Cancer

Thomas W. Dubensky, Jr., Aduro Biotech, USA
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

* Regina Heidenreich, CureVac GmbH, Germany
mRNA Vaccination for the Immunotherapy of Infectious Diseases and Cancer

Manuel Ascano, Jr., Vanderbilt University, USA
Short Talk: Towards the Small Molecule Modulation of Cyclic GMP-AMP Synthase Activity

19:00
On Own for Dinner


THURSDAY, MAY 12

07:30—08:30
Breakfast

Individual Hotels
08:30—11:30
Inborn Genetic Defects in Nucleic Acid Sensing I
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Raphaela Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA
Activated STING in a Vascular and Pulmonary Syndrome (SAVI) and Treatment Strategies Reducing Interferon Signaling

Yanick Crow, Institut Imagine, France
Human Type I Interferonopathies

Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Human Genetic Alterations Contributing to Systemic Lupus Erythematosus

* Virginia Pascual, Baylor Research Institute, USA
Novel Insights into the Role of Innate Immunity in Human SLE

Rayk Behrendt, Faculty of Medicine Carl Gustav Carus TU Dresden, Germany
Short Talk: SAMHD1-Deficiency causes Simultaneous Stimulation of the RLR and cGAS-STING Pathways

09:50—10:10
Coffee Break

Foyer
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Inborn Genetic Defects in Nucleic Acid Sensing II
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
Gerald S. Shadel, Yale School of Medicine, USA
Mitochondrial DNA Stress in Innate Immune Signalling and Cancer

Daniel B. Stetson, University of Washington, USA
Nucleic Acid Detection in Autoimmunity

* Andrew Jackson, University of Edinburgh, UK
RNase H2 mutations Lead to Defective Ribonucleotide Excision Repair and cGAS/STING-Dependent Innate Immune Activation

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Saal 4/5
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Saal 3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saal 3

FRIDAY, MAY 13

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

DFG Deutsche Forschungsgemeinschaft

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Aduro Biotech BIOLOG Life Science Institute

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI122351-01

Funding for this conference was made possible [in part] by 1 R13 AI 122351 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676